23-Demycinosyltylosin
AlkaPlorer ID: AK026288
Synonym: 'Demycinosyltylosin', '23-O-Demycinosyltylosin', '23-Demycinosyltylosin', 'Antibiotic YO 9010'
IUPAC Name: 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
Structure
SMILES: CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(C)=C/[C@@H]1CO
InChI: InChI=1S/C38H63NO13/c1-10-29-26(19-41)15-20(2)11-12-27(42)21(3)16-25(13-14-40)34(22(4)28(43)17-30(44)50-29)52-37-33(45)32(39(8)9)35(23(5)49-37)51-31-18-38(7,47)36(46)24(6)48-31/h11-12,14-15,21-26,28-29,31-37,41,43,45-47H,10,13,16-19H2,1-9H3/b12-11+,20-15+/t21-,22+,23-,24+,25+,26-,28-,29-,31+,32-,33-,34-,35-,36+,37+,38-/m1/s1
InChIKey: ZVOOGERIHVAODX-LXKXJHEOSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces fradiae | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 741.916
TPSA？: 201.75
MolLogP？: 1.673500000000005
Number of H-Donors: 5
Number of H-Acceptors: 14
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Anaerococcus prevotii | Anaerococcus prevotii | MIC | 8.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Bacteroides fragilis | Bacteroides fragilis | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Bacteroides fragilis | Bacteroides fragilis | MIC | 4.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Bacteroides thetaiotaomicron | Bacteroides thetaiotaomicron | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Chlamydia trachomatis | Chlamydia trachomatis | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Clostridioides difficile | Clostridioides difficile | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Clostridium perfringens | Clostridium perfringens | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Clostridium septicum | Clostridium septicum | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Collinsella aerofaciens | Collinsella aerofaciens | MIC | 0.12 | ug.mL-1 | 10.1021/jm00403a025 |
| Cutibacterium acnes | Cutibacterium acnes | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |
| Eikenella corrodens | Eikenella corrodens | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Enterococcus faecium | Enterococcus faecium | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Fusobacterium | Fusobacterium | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Fusobacterium necrophorum | Fusobacterium necrophorum | MIC | 0.12 | ug.mL-1 | 10.1021/jm00403a025 |
| Haemophilus influenzae | Haemophilus influenzae | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Haemophilus influenzae | Haemophilus influenzae | MIC | 4.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Haemophilus influenzae | Haemophilus influenzae | MIC | 8.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Haemophilus parainfluenzae | Haemophilus parainfluenzae | MIC | 8.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Peptoniphilus asaccharolyticus | Peptoniphilus asaccharolyticus | MIC | 0.03 | ug.mL-1 | 10.1021/jm00403a025 |
| Peptostreptococcus anaerobius | Peptostreptococcus anaerobius | MIC | 4.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Phocaeicola vulgatus | Phocaeicola vulgatus | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Prevotella melaninogenica | Prevotella melaninogenica | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Prevotella melaninogenica | Prevotella melaninogenica | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 2.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC | 128.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus | Streptococcus | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus | Streptococcus | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus | Streptococcus | MIC | 1.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 0.5 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 128.0 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus pyogenes | Streptococcus pyogenes | ED50 | 1.9 | mg.kg-1 | 10.1021/jm00403a025 |
| Streptococcus pyogenes | Streptococcus pyogenes | ED50 | 82.0 | mg.kg-1 | 10.1021/jm00403a025 |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus sanguinis | Streptococcus sanguinis | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |
| Streptococcus viridans | Streptococcus viridans | MIC | 128.0 | ug.mL-1 | 10.1021/jm00403a025 |
| None | Unchecked | MIC | 0.25 | ug.mL-1 | 10.1021/jm00403a025 |