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name Structure Reference Source Properties Activities Metabolism

Vorinostat

AlkaPlorer ID: AK027103

Synonym: None

IUPAC Name: N'-hydroxy-N-phenyloctanediamide

Structure

SMILES: ON=C(O)CCCCCCC(O)=NC1=CC=CC=C1

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InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

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InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N

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Reference

PubChem CID: 5311

CAS: 149647-78-9

NPASS: NPC476483

COCONUT: CNP0077780

Properties Information

Molecule Weight: 264.325

TPSA？: 85.41000000000001

MolLogP？: 3.960900000000003

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agaricus bisporus Tyrosinase Inhibition nan % 10.1021/jm401053m
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase IC50 1000.0 nM 10.1016/j.bmcl.2009.04.102
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase Kd 300.0 nM 10.1016/j.bmc.2011.11.041
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase Ki 1000.0 nM 10.1016/j.bmcl.2009.04.102
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase Ki 1300.0 nM 10.1016/j.bmcl.2009.04.102
Bos taurus Calf thymus DNA Activity nan None 10.1016/j.ejmech.2022.114634
Bos taurus Calf thymus DNA Activity nan None 10.1039/C6MD00681G
Candida albicans Candida albicans FIC 1.0 ug ml-1 10.1016/j.ejmech.2021.113961
Candida albicans Candida albicans FIC 16.0 ug ml-1 10.1016/j.ejmech.2021.113961
Candida albicans Candida albicans FICI 0.13 None 10.1021/acs.jmedchem.0c01763
Candida albicans Candida albicans FICI 0.25 None 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans FICI 0.266 None 10.1016/j.ejmech.2021.113961
Candida albicans Candida albicans FICI 0.51 None 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans FICI 1.02 None 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 0.25 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 0.5 ug.mL-1 10.1016/j.bmcl.2006.12.028
Candida albicans Candida albicans MIC50 0.5 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 1.0 ug.mL-1 10.1016/j.bmcl.2006.12.028
Candida albicans Candida albicans MIC50 1.0 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 16.0 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 32.0 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC50 64.0 ug.mL-1 10.1021/acs.jmedchem.8b00393
Candida albicans Candida albicans MIC80 0.25 ug.mL-1 10.1021/acs.jmedchem.0c01763
Candida albicans Candida albicans MIC80 8.0 ug.mL-1 10.1021/acs.jmedchem.0c01763
Candida albicans Candida albicans MIC80 64.0 ug.mL-1 10.1016/j.ejmech.2021.113524
Candida albicans Candida albicans MIC80 64.0 ug.mL-1 10.1016/j.ejmech.2021.113961
Candida albicans Candida albicans MIC80 64.0 ug.mL-1 10.1021/acs.jmedchem.0c00102
Candida albicans Candida albicans MIC80 64.0 ug.mL-1 10.1021/acs.jmedchem.0c01763
Candida albicans Candida albicans MIC80 nan None 10.1016/j.ejmech.2021.113524
Candida albicans Candida albicans MIC90 2.0 ug.mL-1 10.1016/j.bmcl.2006.12.028
Candida albicans Candida albicans MIC90 8.0 ug.mL-1 10.1016/j.bmcl.2006.12.028
Candida tropicalis Candida tropicalis MIC80 64.0 ug.mL-1 10.1016/j.ejmech.2021.113524
Candida tropicalis Candida tropicalis MIC80 64.0 ug.mL-1 10.1021/acs.jmedchem.0c00102
Canis lupus familiaris Canis familiaris Cp 0.96 uM 10.1021/jm200388e
Canis lupus familiaris Liver T1/2 1.0 hr 10.1021/jm2003552
Chlorocebus sabaeus Vero EC50 5200.0 nM 10.1021/acs.jmedchem.5b00539
Chlorocebus sabaeus Vero IC50 1.2 ug.mL-1 10.1016/j.bmc.2009.10.042
Chlorocebus sabaeus Vero IC50 1.375 ug.mL-1 10.1021/jm100507q
Chlorocebus sabaeus Vero IC50 900.0 nM 10.1021/jm400467w
Chlorocebus sabaeus Vero IC50 1450.0 nM 10.1016/j.ejmech.2018.08.073
Chlorocebus sabaeus Vero IC50 1450.0 nM 10.1016/j.ejmech.2020.112904
Chlorocebus sabaeus Vero IC50 4100.0 nM 10.1016/j.bmc.2021.116185
Chlorocebus sabaeus Vero IC50 4100.0 nM 10.1021/acs.jmedchem.5b00099
Chlorocebus sabaeus Vero IC50 4465.0 nM 10.1016/j.bmc.2020.115345
Chlorocebus sabaeus Vero LC50 950.0 nM 10.1128/aac.00439-08
Cryptococcus neoformans Cryptococcus neoformans MIC80 64.0 ug.mL-1 10.1016/j.ejmech.2021.113524
Cryptococcus neoformans Cryptococcus neoformans MIC80 64.0 ug.mL-1 10.1021/acs.jmedchem.0c00102
Giardia intestinalis Giardia intestinalis IC50 56.0 nM 10.1016/j.bmcl.2014.12.051
Hepacivirus hominis Hepatitis C virus EC50 360.0 nM 10.1021/jm501330g
Hepacivirus hominis Hepatitis C virus EC50 560.0 nM 10.1016/j.bmcl.2019.06.006
Homo sapiens 518A2 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens 5637 IC50 2321.29 nM 10.6019/CHEMBL1201861
Homo sapiens 639-V IC50 3460.57 nM 10.6019/CHEMBL1201861
Homo sapiens 647-V IC50 5991.48 nM 10.6019/CHEMBL1201861
Homo sapiens 697 IC50 473.41 nM 10.6019/CHEMBL1201861
Homo sapiens 769-P IC50 5867.18 nM 10.6019/CHEMBL1201861
Homo sapiens 786-0 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens 786-0 GI50 3200.0 nM 10.1021/jm201496g
Homo sapiens 786-0 IC50 4787.73 nM 10.6019/CHEMBL1201861
Homo sapiens 8305C IC50 2866.45 nM 10.6019/CHEMBL1201861
Homo sapiens 8505C IC50 1023.31 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 2339.06 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 2033.03 nM 10.6019/CHEMBL1201861
Homo sapiens A 172 IC50 7861.72 nM 10.6019/CHEMBL1201861
Homo sapiens A204 IC50 4358.03 nM 10.6019/CHEMBL1201861
Homo sapiens A2058 IC50 5059.08 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 Activity nan None 10.1016/j.ejmech.2021.113971
Homo sapiens A2780 Activity nan None 10.1021/jm301254q
Homo sapiens A2780 CC50 2600.0 nM 10.1021/jm9004303
Homo sapiens A2780 FC 4.02 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.2 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.56 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.62 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.67 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.68 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.69 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.72 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.73 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.74 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.77 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.79 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.86 None 10.1021/jm301254q
Homo sapiens A2780 FICI 0.91 None 10.1021/jm301254q
Homo sapiens A2780 GC50 1.0 uM 10.1016/j.bmc.2017.04.043
Homo sapiens A2780 GI50 3150.0 nM 10.1021/jm101177s
Homo sapiens A2780 IC50 430.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens A2780 IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens A2780 IC50 1160.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens A2780 IC50 1620.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens A2780 IC50 1620.0 nM 10.1021/jm2003552
Homo sapiens A2780 IC50 1900.0 nM 10.1016/j.bmcl.2013.07.001
Homo sapiens A2780 IC50 2040.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens A2780 IC50 2100.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens A2780 IC50 2100.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens A2780 IC50 2420.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens A2780 IC50 2420.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens A2780 IC50 2420.0 nM 10.1021/jm301254q
Homo sapiens A2780 IC50 2600.0 nM 10.1021/jm800079s
Homo sapiens A2780 IC50 3120.0 nM 10.1021/jm301254q
Homo sapiens A2780 IC50 4059.66 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 IC50 8820.0 nM 10.1016/j.bmcl.2023.129305
Homo sapiens A2780 IC50 nan None 10.1021/jm0703136
Homo sapiens A2780 Inhibition 53.0 % 10.1021/jm5008209
Homo sapiens A2780 TGI 39.0 % 10.1021/jm2003552
Homo sapiens A2780S IC50 5541.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens A-375 IC50 2680.0 nM 10.1016/j.ejmech.2020.112073
Homo sapiens A-375 IC50 2827.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens A-375 IC50 4100.0 nM 10.1016/j.bmcl.2017.01.044
Homo sapiens A-375 IC50 10245.25 nM 10.6019/CHEMBL1201861
Homo sapiens A388 IC50 19030.31 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 400.59 nM 10.6019/CHEMBL1201861
Homo sapiens A-427 IC50 920.84 nM 10.6019/CHEMBL1201861
Homo sapiens A-431 GI50 4480.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens A-431 IC50 630.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens A-431 IC50 1470.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens A-431 IC50 2563.35 nM 10.6019/CHEMBL1201861
Homo sapiens A-431 IC50 3500.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens A-431 IC50 4200.0 nM 10.1021/jm0703136
Homo sapiens A-431 IC50 4200.0 nM 10.1021/jm100665z
Homo sapiens A-431 IC50 5130.0 nM 10.1016/j.bmc.2012.05.034
Homo sapiens A498 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens A498 GI50 1400.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens A498 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens A498 IC50 3208.71 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 25080.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens A4-Fuk IC50 644.91 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity 1.15 % 10.1039/C9MD00306A
Homo sapiens A549 Activity 1.35 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 2.29 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 3.87 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 6.41 % 10.1021/acs.jmedchem.8b00209
Homo sapiens A549 Activity 7.17 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 8.58 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 8.64 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 9.61 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 10.83 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 11.0 % 10.1021/jm300197a
Homo sapiens A549 Activity 13.27 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 13.52 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 16.78 % 10.1039/C9MD00306A
Homo sapiens A549 Activity 17.72 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 18.1 % 10.1021/acs.jmedchem.8b00209
Homo sapiens A549 Activity 19.2 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 23.22 % 10.1039/C9MD00306A
Homo sapiens A549 Activity 24.0 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 24.97 % 10.1039/C9MD00306A
Homo sapiens A549 Activity 32.33 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 33.4 % 10.1021/acs.jmedchem.8b00209
Homo sapiens A549 Activity 39.53 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 42.1 % 10.1021/acs.jmedchem.8b00209
Homo sapiens A549 Activity 50.0 % 10.1021/acs.jmedchem.0c01704
Homo sapiens A549 Activity 50.86 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 51.0 % 10.1016/j.bmcl.2015.11.086
Homo sapiens A549 Activity 56.84 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 58.86 % 10.1039/C9MD00306A
Homo sapiens A549 Activity 60.3 % 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity 67.28 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 67.66 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity 85.2 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 Activity nan None 10.1016/j.bmcl.2010.08.113
Homo sapiens A549 Activity nan None 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 Activity nan None 10.1016/j.ejmech.2017.11.092
Homo sapiens A549 Activity nan None 10.1021/acs.jmedchem.2c00130
Homo sapiens A549 Activity nan None 10.1021/acsmedchemlett.8b00440
Homo sapiens A549 CC50 1800.0 nM 10.1021/jm9004303
Homo sapiens A549 CI 0.9 None 10.1021/acs.jmedchem.1c01311
Homo sapiens A549 EC50 8300.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens A549 GI 4.7 % 10.1021/jm300197a
Homo sapiens A549 GI 95.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens A549 GI50 410.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens A549 GI50 790.0 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens A549 GI50 1020.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens A549 GI50 1020.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens A549 GI50 1020.0 nM 10.1016/j.ejmech.2020.112086
Homo sapiens A549 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens A549 GI50 1730.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens A549 GI50 1780.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens A549 GI50 1850.0 nM 10.1021/jm300197a
Homo sapiens A549 GI50 2620.0 nM 10.1016/j.bmc.2019.115250
Homo sapiens A549 GI50 3100.0 nM 10.1021/jm201496g
Homo sapiens A549 GI50 3130.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens A549 GI50 5020.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens A549 GI50 5270.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens A549 GI50 5400.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens A549 GI50 5700.0 nM 10.1021/jm101177s
Homo sapiens A549 GI50 19450.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens A549 GI50 200000.0 nM 10.1016/j.bmcl.2009.09.100
Homo sapiens A549 IC50 12.5 nM 10.1016/j.ejmech.2020.112628
Homo sapiens A549 IC50 476.86 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens A549 IC50 590.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens A549 IC50 640.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens A549 IC50 690.0 nM 10.1016/j.bmc.2011.06.046
Homo sapiens A549 IC50 740.0 nM 10.1021/jm101605z
Homo sapiens A549 IC50 760.0 nM 10.1016/j.bmc.2010.05.011
Homo sapiens A549 IC50 860.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens A549 IC50 868.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens A549 IC50 890.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens A549 IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens A549 IC50 1079.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens A549 IC50 1079.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens A549 IC50 1080.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens A549 IC50 1080.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens A549 IC50 1100.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens A549 IC50 1350.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens A549 IC50 1500.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens A549 IC50 1540.0 nM 10.1021/jm401899x
Homo sapiens A549 IC50 1650.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens A549 IC50 1650.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens A549 IC50 1670.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens A549 IC50 1690.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens A549 IC50 1700.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens A549 IC50 1700.0 nM 10.1016/j.ejmech.2020.112651
Homo sapiens A549 IC50 1700.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens A549 IC50 1746.95 nM 10.1016/j.bmc.2018.08.008
Homo sapiens A549 IC50 1800.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens A549 IC50 1800.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens A549 IC50 1800.0 nM 10.1021/jm0703136
Homo sapiens A549 IC50 1800.0 nM 10.1021/jm100665z
Homo sapiens A549 IC50 1800.0 nM 10.1021/jm800079s
Homo sapiens A549 IC50 2010.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 IC50 2100.0 nM 10.1016/j.bmcl.2020.127610
Homo sapiens A549 IC50 2200.0 nM 10.1021/jm800988r
Homo sapiens A549 IC50 2240.0 nM 10.1021/acs.jmedchem.8b01590
Homo sapiens A549 IC50 2270.0 nM 10.1021/jm400634n
Homo sapiens A549 IC50 2360.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens A549 IC50 2390.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens A549 IC50 2420.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens A549 IC50 2448.93 nM 10.6019/CHEMBL1201861
Homo sapiens A549 IC50 2570.0 nM 10.1016/j.ejmech.2020.112831
Homo sapiens A549 IC50 2610.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens A549 IC50 2630.0 nM 10.1021/acsmedchemlett.7b00487
Homo sapiens A549 IC50 2651.1 nM 10.1016/j.ejmech.2020.112628
Homo sapiens A549 IC50 2790.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens A549 IC50 2900.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens A549 IC50 2930.0 nM 10.1039/C9MD00306A
Homo sapiens A549 IC50 3140.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens A549 IC50 3500.0 nM 10.1016/j.bmc.2021.116454
Homo sapiens A549 IC50 3700.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens A549 IC50 3700.0 nM 10.1021/np400263f
Homo sapiens A549 IC50 3800.0 nM 10.1021/ml300366t
Homo sapiens A549 IC50 3900.0 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens A549 IC50 3900.0 nM 10.1021/jm401877m
Homo sapiens A549 IC50 4120.0 nM 10.1021/acsmedchemlett.8b00440
Homo sapiens A549 IC50 4250.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens A549 IC50 4300.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens A549 IC50 4372.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens A549 IC50 4400.0 nM 10.1021/acs.jnatprod.2c00101
Homo sapiens A549 IC50 4400.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens A549 IC50 4500.0 nM 10.1021/jm400179b
Homo sapiens A549 IC50 4970.0 nM 10.1039/C4MD00203B
Homo sapiens A549 IC50 5000.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens A549 IC50 5320.0 nM 10.1016/j.bmc.2015.06.024
Homo sapiens A549 IC50 5370.0 nM 10.1039/C5MD00247H
Homo sapiens A549 IC50 5740.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens A549 IC50 7060.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens A549 IC50 7320.0 nM 10.1016/j.ejmech.2021.113893
Homo sapiens A549 IC50 7440.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens A549 IC50 7490.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens A549 IC50 9130.0 nM 10.1016/j.bmc.2022.116626
Homo sapiens A549 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens A549 IC50 10000.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens A549 IC50 12460.0 nM 10.1039/C5MD00247H
Homo sapiens A549 IC50 12600.0 nM 10.1021/jm7011408
Homo sapiens A549 IC50 15730.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens A549 IC50 17900.0 nM 10.1016/j.bmcl.2013.04.067
Homo sapiens A549 IC50 27800.0 nM 10.1016/j.bmc.2012.05.034
Homo sapiens A549 IC50 78760.0 nM 10.1039/C5MD00247H
Homo sapiens A549 IC50 80300.0 nM 10.1016/j.bmcl.2013.04.067
Homo sapiens A549 IC50 100000.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens A549 IC50 600000.0 nM 10.1016/j.ejmech.2009.06.010
Homo sapiens A549 IC50 nan None 10.1021/acsmedchemlett.7b00504
Homo sapiens A549 Inhibition nan % 10.1016/j.ejmech.2015.04.014
Homo sapiens A549 Ratio IC50 1.0 None 10.1021/jm400179b
Homo sapiens A549 TGI 57.3 % 10.1021/acs.jmedchem.8b00664
Homo sapiens A549 TIME 720.0 hr 10.1021/jm300197a
Homo sapiens A673 IC50 2258.62 nM 10.6019/CHEMBL1201861
Homo sapiens A704 IC50 5030.6 nM 10.6019/CHEMBL1201861
Homo sapiens ABC-1 IC50 2604.6 nM 10.6019/CHEMBL1201861
Homo sapiens ACHN Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens ACHN GI50 650.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens ACHN GI50 730.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens ACHN GI50 730.0 nM 10.1021/jm0613828
Homo sapiens ACHN GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens ACHN GI50 2220.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens ACHN GI50 4220.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens ACHN GI50 4220.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens ACHN GI50 4220.0 nM 10.1021/acs.jmedchem.5b00062
Homo sapiens ACHN GI50 4220.0 nM 10.1021/jm3009376
Homo sapiens ACHN IC50 2080.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens ACHN IC50 9249.75 nM 10.6019/CHEMBL1201861
Homo sapiens ACN IC50 10867.88 nM 10.6019/CHEMBL1201861
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor Ki nan None 10.1021/acs.jmedchem.1c01155
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens AGS IC50 4000.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens AGS IC50 4230.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens ALK tyrosine kinase receptor IC50 nan None 10.1016/j.ejmech.2021.113672
Homo sapiens ALL-PO IC50 814.66 nM 10.6019/CHEMBL1201861
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens AM-38 IC50 2773.55 nM 10.6019/CHEMBL1201861
Homo sapiens Amyloid-beta A4 protein IC50 20000.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Amyloid-beta A4 protein Inhibition 0.0 % 10.1016/j.ejmech.2020.112193
Homo sapiens AN3-CA IC50 6034.41 nM 10.6019/CHEMBL1201861
Homo sapiens Androgen Receptor Inhibition nan % 10.1016/j.bmcl.2016.09.058
Homo sapiens Angiotensin-converting enzyme Inhibition nan % 10.1021/jm401053m
Homo sapiens Apoptosis regulator BAX EC50 10000.0 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens Apoptosis regulator Bcl-2 EC50 nan None 10.1021/acs.jmedchem.0c01454
Homo sapiens Apoptosis regulator Bcl-X EC50 nan None 10.1021/acs.jmedchem.0c01454
Homo sapiens Arachidonate 12-lipoxygenase INH 50.0 uM 10.1021/acs.jmedchem.6b01507
Homo sapiens Arachidonate 15-lipoxygenase INH 50.0 uM 10.1021/acs.jmedchem.6b01507
Homo sapiens Arachidonate 5-lipoxygenase INH 50.0 uM 10.1021/acs.jmedchem.6b01507
Homo sapiens ASPC1 GI50 5440.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens ASPC1 IC50 0.69 ug.mL-1 10.1016/j.bmcl.2011.07.124
Homo sapiens ASPC1 IC50 411.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens ASPC1 IC50 2711.7 nM 10.6019/CHEMBL1201861
Homo sapiens ASPC1 IC50 3090.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens ASPC1 IC50 3200.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens ASPC1 IC50 3200.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens ASPC1 IC50 3660.0 nM 10.1016/j.ejmech.2013.10.045
Homo sapiens ASPC1 IC50 100000.0 nM 10.1021/jm0703136
Homo sapiens ATN-1 IC50 740.28 nM 10.6019/CHEMBL1201861
Homo sapiens AU565 IC50 5097.02 nM 10.6019/CHEMBL1201861
Homo sapiens BALL-1 IC50 208222.87 nM 10.6019/CHEMBL1201861
Homo sapiens BB30-HNC IC50 10871.07 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 12395.57 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 3033.14 nM 10.6019/CHEMBL1201861
Homo sapiens Bcap37 IC50 3098.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens BCPAP IC50 501.42 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 526.96 nM 10.6019/CHEMBL1201861
Homo sapiens BE(2)-C Activity nan None 10.1021/jm5008962
Homo sapiens BEAS-2B IC50 50000.0 nM 10.1039/C9MD00306A
Homo sapiens Becker IC50 3750.12 nM 10.6019/CHEMBL1201861
Homo sapiens Bel-7402 Activity 45.4 % 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel-7402 Activity nan None 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel-7402 GI 10.75 % 10.1016/j.bmcl.2010.03.112
Homo sapiens Bel-7402 GI 38.75 % 10.1016/j.bmcl.2010.03.112
Homo sapiens Bel-7402 GI 54.83 % 10.1016/j.bmcl.2010.03.112
Homo sapiens Bel-7402 GI 65.74 % 10.1007/s00044-011-9879-7
Homo sapiens Bel-7402 GI 65.74 % 10.1016/j.bmcl.2010.03.112
Homo sapiens Bel-7402 GI90 17.0 uM 10.1021/jm3011838
Homo sapiens Bel-7402 IC50 4207.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens Bel-7402 IC50 4700.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens Bel-7402 IC50 4720.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel-7402 IC50 7100.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens Bel-7402 IC50 27350.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Bel7402/5-FU Activity 5.82 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 14.73 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 16.05 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity 63.4 % 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU Activity nan None 10.1016/j.ejmech.2019.02.054
Homo sapiens Bel7402/5-FU IC50 9830.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens BEN IC50 9821.59 nM 10.6019/CHEMBL1201861
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens BFTC-905 IC50 2855.23 nM 10.6019/CHEMBL1201861
Homo sapiens BFTC-909 IC50 7006.41 nM 10.6019/CHEMBL1201861
Homo sapiens BGC-823 GI50 3090.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens BGC-823 GI90 7.5 uM 10.1021/jm3011838
Homo sapiens BGC-823 IC50 2940.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens BGC-823 IC50 12980.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens BHT-101 IC50 244.18 nM 10.6019/CHEMBL1201861
Homo sapiens BHY IC50 4124.95 nM 10.6019/CHEMBL1201861
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens BJ Activity nan None 10.1021/jm901561u
Homo sapiens BJ EC50 597.0 nM None
Homo sapiens BJ EC50 5152.0 nM None
Homo sapiens BJ EC50 14114.0 nM None
Homo sapiens BJ EC50 15757.0 nM None
Homo sapiens BJ IC50 100000.0 nM 10.1021/jm901561u
Homo sapiens BPH-1 IC50 2658.5 nM 10.6019/CHEMBL1201861
Homo sapiens Bradykinin B1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens BRD4/HDAC1 Inhibition nan % 10.1016/j.bmcl.2017.07.054
Homo sapiens Bromodomain-containing protein 2 IC50 nan None 10.1021/acs.jmedchem.9b02178
Homo sapiens Bromodomain-containing protein 3 IC50 nan None 10.1021/acs.jmedchem.9b02178
Homo sapiens Bromodomain-containing protein 4 IC50 10.0 nM 10.1016/j.bmcl.2017.07.054
Homo sapiens Bromodomain-containing protein 4 IC50 43.13 nM 10.1016/j.bmcl.2020.127671
Homo sapiens Bromodomain-containing protein 4 IC50 740.0 nM 10.1016/j.bmc.2017.04.043
Homo sapiens Bromodomain-containing protein 4 IC50 10000.0 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Bromodomain-containing protein 4 IC50 50000.0 nM 10.1039/C3MD00285C
Homo sapiens Bromodomain-containing protein 4 IC50 nan None 10.1021/acs.jmedchem.9b02178
Homo sapiens Bromodomain-containing protein 4 Inhibition 2.0 % 10.1016/j.bmcl.2017.07.054
Homo sapiens Bromodomain-containing protein 4 Inhibition 10.0 % 10.1016/j.bmcl.2017.07.054
Homo sapiens Bromodomain-containing protein 4 Inhibition 88.0 % 10.1021/acs.jmedchem.0c00491
Homo sapiens Bromodomain-containing protein 4 Inhibition nan % 10.1016/j.bmc.2017.04.043
Homo sapiens Bromodomain-containing protein 4 Kd nan None 10.1021/acs.jmedchem.1c01119
Homo sapiens Bromodomain testis-specific protein IC50 nan None 10.1021/acs.jmedchem.9b02178
Homo sapiens BT-20 IC50 4794.29 nM 10.6019/CHEMBL1201861
Homo sapiens BT-474 IC50 3633.1 nM 10.6019/CHEMBL1201861
Homo sapiens BT-549 Activity nan None 10.1021/acs.jmedchem.2c01058
Homo sapiens BT-549 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens BT-549 IC50 2300.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens BT-549 IC50 2960.0 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens BT-549 IC50 8670.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens BV-173 IC50 1472.91 nM 10.6019/CHEMBL1201861
Homo sapiens BXPC-3 GI50 5560.0 nM 10.1021/ml400158k
Homo sapiens BXPC-3 IC50 2700.0 nM 10.1021/jm901453q
Homo sapiens BXPC-3 IC50 4740.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens BXPC-3 IC50 5000.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens BXPC-3 IC50 5000.0 nM 10.1021/jm701606b
Homo sapiens BXPC-3 IC50 5000.0 nM 10.1021/jm8002894
Homo sapiens BXPC-3 IC50 5000.0 nM 10.1021/jm901667k
Homo sapiens BXPC-3 IC50 11374.74 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 472.19 nM 10.6019/CHEMBL1201861
Homo sapiens C32 IC50 6130.34 nM 10.6019/CHEMBL1201861
Homo sapiens C-33-A IC50 45325.6 nM 10.6019/CHEMBL1201861
Homo sapiens C3A IC50 7345.2 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 2213.34 nM 10.6019/CHEMBL1201861
Homo sapiens Ca9-22 IC50 1051.07 nM 10.6019/CHEMBL1201861
Homo sapiens Caco-2 Activity nan None 10.1021/jm901561u
Homo sapiens Caco-2 GI 93.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens Caco-2 IC50 3000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Caco-2 IC50 8100.0 nM 10.1021/jm901561u
Homo sapiens Caco-2 IC50 12600.0 nM 10.1021/jm901561u
Homo sapiens Caco-2 IC50 41000.0 nM 10.1021/jm901561u
Homo sapiens Caco-2 Papp 1.7 10'-6 cm/s 10.1016/j.bmcl.2010.04.041
Homo sapiens Caco-2 Papp 1.7 10'-6 cm/s 10.1021/jm2003552
Homo sapiens Caco-2 Papp 1.7 ucm/s 10.1021/jm201496g
Homo sapiens Caco-2 Papp 8.0 10-6 cm s-1 10.1016/j.bmcl.2006.10.045
Homo sapiens Caco-2 Ratio nan None 10.1021/jm201496g
Homo sapiens CAKI-1 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens CAKI-1 GI50 1200.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens CAKI-1 IC50 3890.52 nM 10.6019/CHEMBL1201861
Homo sapiens CAKI-1 IC50 32460.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens CAL-120 IC50 4389.92 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-12T IC50 4131.03 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-27 Activity nan None 10.1021/jm301254q
Homo sapiens CAL-27 FC 21.6 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.2 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.29 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.3 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.31 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.37 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.38 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.39 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.53 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.65 None 10.1021/jm301254q
Homo sapiens CAL-27 FICI 0.93 None 10.1021/jm301254q
Homo sapiens CAL-27 IC50 1500.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens CAL-27 IC50 1706.21 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-27 IC50 1980.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens CAL-27 IC50 1980.0 nM 10.1021/acs.jmedchem.6b01538
Homo sapiens CAL-27 IC50 1990.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens CAL-27 IC50 2080.0 nM 10.1021/jm301254q
Homo sapiens CAL-27 IC50 2640.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens CAL-27 IC50 2640.0 nM 10.1021/jm301254q
Homo sapiens CAL-27 IC50 3200.0 nM 10.1021/jm0703136
Homo sapiens CAL-27 IC50 3200.0 nM 10.1021/jm100665z
Homo sapiens CAL-27 IC50 3720.0 nM 10.1021/jm901453q
Homo sapiens CAL-33 IC50 4230.64 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-39 IC50 2236.26 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-51 IC50 1040.0 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens CAL-51 IC50 2166.99 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-54 IC50 4223.81 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-62 IC50 3545.14 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-72 IC50 88927.19 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-85-1 IC50 13439.94 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-3 IC50 5064.52 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-6 IC50 9375.28 nM 10.6019/CHEMBL1201861
Homo sapiens CAMA-1 IC50 1719.71 nM 10.6019/CHEMBL1201861
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CAPAN-1 IC50 1800.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens CAPAN-1 IC50 1890.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens CAPAN-1 IC50 4423.82 nM 10.6019/CHEMBL1201861
Homo sapiens CAPAN-1 IC50 5400.0 nM 10.1016/j.ejmech.2021.113588
Homo sapiens CAPAN-1 IC50 7300.0 nM 10.1021/jm901453q
Homo sapiens CAPAN-1 TGI 49.0 % 10.1016/j.ejmech.2021.113588
Homo sapiens Capan-2 IC50 3000.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens Capan-2 IC50 62873.89 nM 10.6019/CHEMBL1201861
Homo sapiens CaR-1 IC50 2860.0 nM 10.6019/CHEMBL1201861
Homo sapiens Carbonic anhydrase II Inhibition nan % 10.1021/jm401053m
Homo sapiens CAS-1 IC50 11410.95 nM 10.6019/CHEMBL1201861
Homo sapiens Ca-Ski IC50 3454.3 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM Activity 18.4 % 10.1021/acs.jmedchem.2c01276
Homo sapiens CCRF-CEM CC50 2500.0 nM 10.1021/acs.jmedchem.1c00491
Homo sapiens CCRF-CEM GI50 700.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens CCRF-CEM GI50 800.0 nM 10.1021/jm201496g
Homo sapiens CCRF-CEM IC50 800.0 nM 10.1021/jm0703136
Homo sapiens CCRF-CEM IC50 800.0 nM 10.1021/jm800988r
Homo sapiens CCRF-CEM IC50 950.0 nM 10.1021/jm0703136
Homo sapiens CCRF-CEM IC50 1900.0 nM 10.1021/jm051010j
Homo sapiens CCRF-CEM IC50 1900.0 nM 10.1021/jm7011408
Homo sapiens CCRF-CEM IC50 2530.43 nM 10.6019/CHEMBL1201861
Homo sapiens CDK2/Cyclin A2 IC50 nan None 10.1016/j.bmcl.2019.06.059
Homo sapiens CDK2/Cyclin A2 IC50 nan None 10.1021/acs.jmedchem.1c01311
Homo sapiens CDK2/Cyclin A2 Inhibition 2.9 % 10.1021/acs.jmedchem.1c01311
Homo sapiens CDK2/Cyclin A2 Inhibition nan % 10.1016/j.bmcl.2019.06.059
Homo sapiens CDK4/Cyclin D3 IC50 nan None 10.1021/acs.jmedchem.1c01311
Homo sapiens CDK4/Cyclin D3 Inhibition -5.8 % 10.1021/acs.jmedchem.1c01311
Homo sapiens CDK6/cyclin D3 IC50 nan None 10.1021/acs.jmedchem.1c01311
Homo sapiens CDK6/cyclin D3 Inhibition 0.8 % 10.1021/acs.jmedchem.1c01311
Homo sapiens Cellular tumor antigen p53 Activity nan None 10.1021/acs.jmedchem.5b01052
Homo sapiens Cereblon/Histone deacetylase 1 Activity nan None 10.1016/j.bmcl.2018.05.057
Homo sapiens Cereblon/Histone deacetylase 2 Activity nan None 10.1016/j.bmcl.2018.05.057
Homo sapiens Cereblon/Histone deacetylase 4 Activity nan None 10.1016/j.bmcl.2018.05.057
Homo sapiens Cereblon/Histone deacetylase 6 Activity nan None 10.1016/j.bmcl.2018.05.057
Homo sapiens CFPAC-1 IC50 7362.22 nM 10.6019/CHEMBL1201861
Homo sapiens CGTH-W-1 IC50 1899.46 nM 10.6019/CHEMBL1201861
Homo sapiens ChaGo-K-1 IC50 15835.91 nM 10.6019/CHEMBL1201861
Homo sapiens CHL-1 IC50 642.08 nM 10.6019/CHEMBL1201861
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CHP-134 IC50 1740.0 nM 10.1039/C8MD00454D
Homo sapiens CHP-212 IC50 457.53 nM 10.6019/CHEMBL1201861
Homo sapiens Class 1 histone deacetylase EC50 1600.0 nM 10.1021/acsmedchemlett.0c00302
Homo sapiens Class 1 histone deacetylase IC50 34.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Class 1 histone deacetylase IC50 350.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Class 1 histone deacetylase IC50 950.0 nM 10.1016/j.ejmech.2021.114011
Homo sapiens Class 1 histone deacetylase IC50 1600.0 nM 10.1021/acsmedchemlett.1c00074
Homo sapiens Class 1 histone deacetylase IC50 1900.0 nM 10.1021/acsmedchemlett.1c00074
Homo sapiens Class 1 histone deacetylase IC50 1960.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Class 1 histone deacetylase IC50 2000.0 nM 10.1021/acsmedchemlett.1c00074
Homo sapiens Class 1 histone deacetylase IC50 9390.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1016/j.bmc.2019.115108
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1016/j.ejmech.2020.113095
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.0c01454
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.9b01489
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.9b02161
Homo sapiens Class 1 histone deacetylase Inhibition nan % 10.1021/acsmedchemlett.0c00302
Homo sapiens Class 1 histone deacetylase Ratio IC50 5.0 None 10.1021/acs.jmedchem.9b01489
Homo sapiens Class 1 histone deacetylase Ratio IC50 6.73 None 10.1021/acs.jmedchem.9b01489
Homo sapiens CMK IC50 439.3 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens CMK IC50 490.2 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens CNE-2 IC50 1300.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens COLO 205 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens COLO 205 GI 88.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens COLO 205 GI50 790.0 nM 10.1021/jm201496g
Homo sapiens COLO 205 GI50 4000.0 nM 10.1021/jm201496g
Homo sapiens COLO 205 IC50 1800.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens COLO 205 IC50 2120.0 nM 10.1021/jm2003552
Homo sapiens COLO 205 IC50 2900.0 nM 10.1016/j.bmcl.2009.01.041
Homo sapiens COLO-320-HSR IC50 1881.97 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 5713.2 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-678 IC50 27491.94 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-679 IC50 6002.55 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-680N IC50 7917.3 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 1461.18 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-741 IC50 4559.94 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-792 IC50 5263.56 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 1711.79 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 7728.63 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 3500.73 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L105 IC50 4130.51 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L23 GI50 1100.0 nM 10.1021/jm101177s
Homo sapiens COR-L23 GI50 3300.0 nM 10.1021/jm101177s
Homo sapiens COR-L23 IC50 2585.66 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 1564.24 nM 10.6019/CHEMBL1201861
Homo sapiens CP50-MEL-B IC50 9924.32 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 537.92 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 581.56 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 4190.01 nM 10.6019/CHEMBL1201861
Homo sapiens CWR22R IC50 2592.74 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cystic fibrosis transmembrane conductance regulator Inhibition nan % 10.1038/nchembio.275
Homo sapiens Cytochrome P450 1A2 Inhibition 14.0 % 10.1016/j.bmcl.2006.10.045
Homo sapiens Cytochrome P450 1A2 Inhibition 25.0 % 10.1016/j.ejmech.2015.11.010
Homo sapiens Cytochrome P450 2C19 Inhibition 14.0 % 10.1016/j.bmcl.2006.10.045
Homo sapiens Cytochrome P450 2C19 Inhibition 69.0 % 10.1016/j.ejmech.2015.11.010
Homo sapiens Cytochrome P450 2C9 Inhibition 28.0 % 10.1016/j.bmcl.2006.10.045
Homo sapiens Cytochrome P450 2D6 Inhibition 8.0 % 10.1016/j.bmcl.2006.10.045
Homo sapiens Cytochrome P450 2D6 Inhibition 25.0 % 10.1016/j.ejmech.2015.11.010
Homo sapiens Cytochrome P450 3A4 IC50 10000.0 nM 10.1016/j.bmcl.2011.06.015
Homo sapiens Cytochrome P450 3A4 IC50 12000.0 nM 10.1016/j.bmcl.2006.10.045
Homo sapiens Cytochrome P450 3A4 INH 24.8 uM 10.1021/jm201496g
Homo sapiens Cytochrome P450 3A4 Inhibition 35.0 % 10.1016/j.ejmech.2015.11.010
Homo sapiens D-247MG IC50 11100.88 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 3820.51 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 714.14 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 41844.23 nM 10.6019/CHEMBL1201861
Homo sapiens D-392MG IC50 9257.15 nM 10.6019/CHEMBL1201861
Homo sapiens D-423MG IC50 706.89 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 8769.94 nM 10.6019/CHEMBL1201861
Homo sapiens D-566MG IC50 838.62 nM 10.6019/CHEMBL1201861
Homo sapiens Daoy FC 1.51 None 10.1021/ml400014t
Homo sapiens Daoy IC50 1763.19 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 598.57 nM 10.6019/CHEMBL1201861
Homo sapiens DBTRG-05MG IC50 8875.65 nM 10.6019/CHEMBL1201861
Homo sapiens DEL IC50 1351.62 nM 10.6019/CHEMBL1201861
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Detroit 562 IC50 3650.22 nM 10.6019/CHEMBL1201861
Homo sapiens DG-75 IC50 2100.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens DJM-1 IC50 3376.74 nM 10.6019/CHEMBL1201861
Homo sapiens DK-MG IC50 5184.38 nM 10.6019/CHEMBL1201861
Homo sapiens DLD-1 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens DLD-1 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens DMS-114 GI50 2900.0 nM 10.1021/jm900125m
Homo sapiens DMS-114 IC50 3470.66 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-273 IC50 2148.37 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 5138.83 nM 10.6019/CHEMBL1201861
Homo sapiens DNA (cytosine-5)-methyltransferase 1 IC50 10000.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 7079.5 nM None
Homo sapiens DNA polymerase alpha subunit Inhibition nan % 10.1016/j.ejmech.2021.113971
Homo sapiens DNA polymerase iota Potency 891.3 nM None
Homo sapiens DNA topoisomerase II alpha Inhibition nan % 10.1016/j.bmc.2013.09.023
Homo sapiens DOHH-2 Activity nan None 10.1016/j.bmcl.2022.128825
Homo sapiens DOHH-2 IC50 706.68 nM 10.6019/CHEMBL1201861
Homo sapiens DOK IC50 4265.93 nM 10.6019/CHEMBL1201861
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DoTc2-4510 IC50 2621.85 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 2163.98 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 Activity -51.12 % 10.1021/acs.jmedchem.2c01276
Homo sapiens DU-145 EC50 1600.0 nM 10.1021/jm049207j
Homo sapiens DU-145 EC50 1600.0 nM 10.1021/jm7011408
Homo sapiens DU-145 EC50 2110.0 nM 10.1016/j.bmc.2008.03.050
Homo sapiens DU-145 EC50 2120.0 nM 10.1016/j.bmc.2008.03.050
Homo sapiens DU-145 EC50 2120.0 nM 10.1021/jm801128g
Homo sapiens DU-145 GI50 1050.0 nM 10.1021/jm101177s
Homo sapiens DU-145 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens DU-145 GI50 1360.0 nM 10.1021/ml400175d
Homo sapiens DU-145 GI50 1590.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens DU-145 GI50 6860.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens DU-145 IC50 470.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens DU-145 IC50 790.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens DU-145 IC50 870.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens DU-145 IC50 1200.0 nM 10.1016/j.bmc.2021.116185
Homo sapiens DU-145 IC50 1200.0 nM 10.1021/acs.jmedchem.5b00099
Homo sapiens DU-145 IC50 1800.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens DU-145 IC50 2120.0 nM 10.1016/j.bmcl.2013.03.108
Homo sapiens DU-145 IC50 2120.0 nM 10.1021/jm200799p
Homo sapiens DU-145 IC50 2490.0 nM 10.1016/j.bmcl.2014.08.060
Homo sapiens DU-145 IC50 2490.0 nM 10.1021/jm401225q
Homo sapiens DU-145 IC50 2580.0 nM 10.1021/jm400634n
Homo sapiens DU-145 IC50 3700.0 nM 10.1021/jm400467w
Homo sapiens DU-145 IC50 27200.0 nM 10.1016/j.bmcl.2013.04.067
Homo sapiens DU-145 IC50 748162.35 nM 10.6019/CHEMBL1201861
Homo sapiens DU-4475 IC50 751.91 nM 10.6019/CHEMBL1201861
Homo sapiens EA.hy 926 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens EBC-1 IC50 1300.0 nM 10.1021/acsmedchemlett.7b00172
Homo sapiens ECC10 IC50 945.87 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 3261.53 nM 10.6019/CHEMBL1201861
Homo sapiens EFM-19 IC50 1048.79 nM 10.6019/CHEMBL1201861
Homo sapiens EFO-21 IC50 53975.6 nM 10.6019/CHEMBL1201861
Homo sapiens EFO-27 IC50 1250.43 nM 10.6019/CHEMBL1201861
Homo sapiens EGI-1 IC50 2817.43 nM 10.6019/CHEMBL1201861
Homo sapiens EJ IC50 5460.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens EKVX GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens EKVX IC50 7192.67 nM 10.6019/CHEMBL1201861
Homo sapiens EM-2 IC50 1700.14 nM 10.6019/CHEMBL1201861
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-B AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens EOL1 IC50 454.25 nM 10.6019/CHEMBL1201861
Homo sapiens EOL1 IC50 1000.0 nM 10.1021/jm0703136
Homo sapiens EOL1 IC50 1000.0 nM 10.1021/jm800988r
Homo sapiens Epidermal growth factor receptor erbB1 IC50 12.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Epidermal growth factor receptor erbB1 IC50 900.0 nM 10.1021/acs.jmedchem.0c00491
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmc.2012.05.034
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None 10.1016/j.bmc.2016.10.006
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition nan % 10.1016/j.ejmech.2021.113173
Homo sapiens EPLC-272H IC50 4389.5 nM 10.6019/CHEMBL1201861
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ES1 IC50 724.4 nM 10.6019/CHEMBL1201861
Homo sapiens ES-2 IC50 530.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens ES3 IC50 1826.81 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 1787.41 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 1443.0 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 1936.31 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 1547.73 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 523.53 nM 10.6019/CHEMBL1201861
Homo sapiens ESS-1 IC50 4427.24 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha Activity nan None 10.1016/j.bmc.2018.07.026
Homo sapiens Estrogen receptor alpha IC50 nan None 10.1016/j.bmc.2015.11.005
Homo sapiens ETK-1 IC50 3946.35 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 947.26 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 1360.26 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 3525.1 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 1741.07 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 832.96 nM 10.6019/CHEMBL1201861
Homo sapiens EW-22 IC50 1928.87 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 1465.31 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 1172.12 nM 10.6019/CHEMBL1201861
Homo sapiens FaDu IC50 2471.62 nM 10.6019/CHEMBL1201861
Homo sapiens FHC IC50 2590.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens Fibroblast growth factor receptor 1 IC50 nan None 10.1021/acs.jmedchem.2c01413
Homo sapiens Fibroblast growth factor receptor 1 Inhibition nan % 10.1021/acs.jmedchem.2c01413
Homo sapiens Fibroblast growth factor receptor 2 IC50 nan None 10.1021/acs.jmedchem.2c01413
Homo sapiens Fibroblast growth factor receptor 3 IC50 nan None 10.1021/acs.jmedchem.2c01413
Homo sapiens Fibroblast growth factor receptor 4 IC50 nan None 10.1021/acs.jmedchem.2c01413
Homo sapiens FTC-133 IC50 4792.63 nM 10.6019/CHEMBL1201861
Homo sapiens G-401 CC50 1000.0 nM 10.1021/jm9004303
Homo sapiens G-401 IC50 1000.0 nM 10.1021/jm800079s
Homo sapiens G-401 IC50 3790.85 nM 10.6019/CHEMBL1201861
Homo sapiens G-402 IC50 2704.51 nM 10.6019/CHEMBL1201861
Homo sapiens G55T2 Activity 8.1 % 10.1039/C8MD00454D
Homo sapiens G55T2 Activity 24.8 % 10.1039/C8MD00454D
Homo sapiens G55T2 Activity 28.9 % 10.1039/C8MD00454D
Homo sapiens G55T2 Activity 31.3 % 10.1039/C8MD00454D
Homo sapiens G55T2 IC50 780.0 nM 10.1039/C8MD00454D
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GAK IC50 32261.61 nM 10.6019/CHEMBL1201861
Homo sapiens GAMG IC50 2445.61 nM 10.6019/CHEMBL1201861
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GB-1 IC50 2323.35 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 4774.24 nM 10.6019/CHEMBL1201861
Homo sapiens GCT IC50 2177.7 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 3349.8 nM None
Homo sapiens Geminin Potency 3662.6 nM None
Homo sapiens Geminin Potency 4109.5 nM None
Homo sapiens Geminin Potency 14963.1 nM None
Homo sapiens GES1 IC50 4690.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens GES1 IC50 233000.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GI-1 IC50 2305.43 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 3295.11 nM 10.6019/CHEMBL1201861
Homo sapiens Glucagon receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glycogen synthase kinase-3 beta Inhibition nan % 10.1021/acsmedchemlett.8b00507
Homo sapiens GM15850 Activity nan None 10.1038/nchembio815
Homo sapiens GMS-10 IC50 4428.19 nM 10.6019/CHEMBL1201861
Homo sapiens GOTO IC50 729.12 nM 10.6019/CHEMBL1201861
Homo sapiens GP5d IC50 3729.5 nM 10.6019/CHEMBL1201861
Homo sapiens GR-ST IC50 3221.39 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 3112.83 nM 10.6019/CHEMBL1201861
Homo sapiens H4 EC50 120000.0 nM None
Homo sapiens H4 IC50 1509.12 nM 10.6019/CHEMBL1201861
Homo sapiens H9 IC50 255.04 nM 10.6019/CHEMBL1201861
Homo sapiens HaCaT IC50 1850.0 nM 10.1016/j.ejmech.2021.113961
Homo sapiens HAL-01 IC50 299.0 nM 10.1021/acs.jmedchem.2c01418
Homo sapiens HAL-01 IC50 968.04 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 1598.66 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1395 IC50 8054.52 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1419 IC50 1340.27 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1569 IC50 4884.58 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1806 IC50 4203.12 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1937 IC50 3730.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens HCC1937 IC50 4230.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens HCC1937 IC50 47195.8 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1954 IC50 31366.58 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 958.48 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens HCC 2998 GI50 1900.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens HCC 2998 IC50 9136.81 nM 10.6019/CHEMBL1201861
Homo sapiens HCC38 IC50 10321.96 nM 10.6019/CHEMBL1201861
Homo sapiens HCC70 IC50 14423.34 nM 10.6019/CHEMBL1201861
Homo sapiens HCC827 IC50 1180.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens HCE-4 IC50 3916.63 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 1715.0 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity 0.146 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 1.37 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 1.65 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 1.76 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 2.03 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 2.72 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 Activity 3.2 % 10.1016/j.ejmech.2021.113893
Homo sapiens HCT-116 Activity 4.33 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 Activity 5.05 % 10.1016/j.ejmech.2022.114634
Homo sapiens HCT-116 Activity 5.21 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 Activity 6.34 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 6.59 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 11.02 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 11.37 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 12.27 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 12.87 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 14.0 % 10.1021/jm101177s
Homo sapiens HCT-116 Activity 14.44 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 15.64 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 16.47 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 17.93 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 19.0 % 10.1021/jm101177s
Homo sapiens HCT-116 Activity 19.2 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 26.2 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 29.4 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 30.87 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 32.0 % 10.1021/jm101177s
Homo sapiens HCT-116 Activity 34.3 % 10.1021/acs.jmedchem.5b01052
Homo sapiens HCT-116 Activity 34.9 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 35.0 % 10.1021/jm101177s
Homo sapiens HCT-116 Activity 35.44 % 10.1021/ml500327q
Homo sapiens HCT-116 Activity 36.2 % 10.1016/j.ejmech.2021.113893
Homo sapiens HCT-116 Activity 41.49 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 42.2 % 10.1016/j.ejmech.2016.03.039
Homo sapiens HCT-116 Activity 43.0 % 10.1021/jm200388e
Homo sapiens HCT-116 Activity 44.2 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 57.83 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 58.11 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 58.4 % 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 Activity 62.4 % 10.1016/j.ejmech.2016.03.039
Homo sapiens HCT-116 Activity 67.72 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 67.78 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 77.54 % 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 Activity 87.7 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmc.2017.10.026
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmcl.2010.04.041
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmcl.2022.128846
Homo sapiens HCT-116 Activity nan None 10.1016/j.ejmech.2021.113893
Homo sapiens HCT-116 Activity nan None 10.1016/j.ejmech.2022.114409
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.5b01052
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.9b02178
Homo sapiens HCT-116 Activity nan None 10.1021/jm4012802
Homo sapiens HCT-116 Activity nan None 10.1021/jm401899x
Homo sapiens HCT-116 CC50 1000.0 nM 10.1021/jm9004303
Homo sapiens HCT-116 EC50 570.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens HCT-116 EC50 580.0 nM 10.1021/jm049207j
Homo sapiens HCT-116 EC50 580.0 nM 10.1021/jm7011408
Homo sapiens HCT-116 EC50 1600.0 nM 10.1016/j.bmcl.2008.10.058
Homo sapiens HCT-116 EC50 2000.0 nM 10.1016/j.bmcl.2010.03.091
Homo sapiens HCT-116 Fold change 1.13 None 10.1021/jm701384x
Homo sapiens HCT-116 Fold change 13.24 None 10.1021/jm701384x
Homo sapiens HCT-116 Fold change 30.65 None 10.1021/jm701384x
Homo sapiens HCT-116 Fold change 106.57 None 10.1021/jm701384x
Homo sapiens HCT-116 GI 57.0 % 10.1021/jm200388e
Homo sapiens HCT-116 GI 77.79 % 10.1016/j.ejmech.2020.112073
Homo sapiens HCT-116 GI 86.06 % 10.1016/j.ejmech.2020.112073
Homo sapiens HCT-116 GI50 150.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens HCT-116 GI50 370.0 nM 10.1021/ml400175d
Homo sapiens HCT-116 GI50 400.0 nM 10.1021/jm201496g
Homo sapiens HCT-116 GI50 400.0 nM 10.1021/np400198r
Homo sapiens HCT-116 GI50 410.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HCT-116 GI50 440.0 nM 10.1016/j.bmc.2019.115250
Homo sapiens HCT-116 GI50 550.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens HCT-116 GI50 580.0 nM 10.1021/jm900125m
Homo sapiens HCT-116 GI50 600.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens HCT-116 GI50 600.0 nM 10.1016/j.bmcl.2011.09.042
Homo sapiens HCT-116 GI50 740.0 nM 10.1021/jm101177s
Homo sapiens HCT-116 GI50 750.0 nM 10.1016/j.bmcl.2010.09.016
Homo sapiens HCT-116 GI50 878.0 nM 10.1016/j.bmcl.2013.04.004
Homo sapiens HCT-116 GI50 940.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens HCT-116 GI50 1000.0 nM 10.1016/j.bmcl.2013.03.002
Homo sapiens HCT-116 GI50 2500.0 nM 10.1021/ml400158k
Homo sapiens HCT-116 GI50 2690.0 nM 10.1016/j.bmcl.2009.09.100
Homo sapiens HCT-116 IC50 11.8 nM 10.1016/j.ejmech.2020.112628
Homo sapiens HCT-116 IC50 270.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens HCT-116 IC50 310.0 nM 10.1016/j.ejmech.2008.11.005
Homo sapiens HCT-116 IC50 310.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens HCT-116 IC50 330.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens HCT-116 IC50 340.0 nM 10.1016/j.bmc.2011.06.046
Homo sapiens HCT-116 IC50 490.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens HCT-116 IC50 550.0 nM 10.1016/j.ejmech.2020.112651
Homo sapiens HCT-116 IC50 561.32 nM 10.1016/j.bmc.2018.08.008
Homo sapiens HCT-116 IC50 600.0 nM 10.1016/j.bmcl.2011.02.085
Homo sapiens HCT-116 IC50 600.0 nM 10.1016/j.bmcl.2012.07.067
Homo sapiens HCT-116 IC50 610.0 nM 10.1021/jm401899x
Homo sapiens HCT-116 IC50 670.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens HCT-116 IC50 670.0 nM None
Homo sapiens HCT-116 IC50 700.0 nM 10.1016/j.bmcl.2011.06.046
Homo sapiens HCT-116 IC50 720.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens HCT-116 IC50 757.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens HCT-116 IC50 760.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens HCT-116 IC50 760.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens HCT-116 IC50 797.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens HCT-116 IC50 800.0 nM 10.1016/j.bmc.2013.09.023
Homo sapiens HCT-116 IC50 810.0 nM 10.1016/j.bmcl.2011.06.015
Homo sapiens HCT-116 IC50 810.0 nM 10.1021/jm200388e
Homo sapiens HCT-116 IC50 877.0 nM 10.1016/j.bmc.2017.10.026
Homo sapiens HCT-116 IC50 882.5 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens HCT-116 IC50 890.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens HCT-116 IC50 895.0 nM 10.1016/j.ejmech.2020.112628
Homo sapiens HCT-116 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HCT-116 IC50 900.0 nM 10.1021/jm7011408
Homo sapiens HCT-116 IC50 1000.0 nM 10.1016/j.bmc.2017.10.026
Homo sapiens HCT-116 IC50 1000.0 nM 10.1016/j.bmc.2018.06.016
Homo sapiens HCT-116 IC50 1000.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens HCT-116 IC50 1000.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens HCT-116 IC50 1000.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens HCT-116 IC50 1000.0 nM 10.1021/jm800079s
Homo sapiens HCT-116 IC50 1030.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens HCT-116 IC50 1080.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens HCT-116 IC50 1177.5 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 IC50 1180.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens HCT-116 IC50 1180.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens HCT-116 IC50 1200.0 nM 10.1016/j.bmcl.2007.09.014
Homo sapiens HCT-116 IC50 1200.0 nM 10.1016/j.bmcl.2009.03.101
Homo sapiens HCT-116 IC50 1200.0 nM 10.1016/j.bmcl.2015.09.006
Homo sapiens HCT-116 IC50 1200.0 nM 10.1021/jm101092u
Homo sapiens HCT-116 IC50 1260.0 nM 10.1016/j.ejmech.2020.112073
Homo sapiens HCT-116 IC50 1270.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens HCT-116 IC50 1310.0 nM 10.1016/j.ejmech.2017.01.035
Homo sapiens HCT-116 IC50 1310.0 nM 10.1021/acs.jmedchem.2c00909
Homo sapiens HCT-116 IC50 1390.0 nM 10.1021/jm400634n
Homo sapiens HCT-116 IC50 1400.0 nM 10.1021/acsmedchemlett.7b00172
Homo sapiens HCT-116 IC50 1430.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens HCT-116 IC50 1470.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens HCT-116 IC50 1488.6 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens HCT-116 IC50 1550.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens HCT-116 IC50 1617.76 nM 10.1016/j.bmc.2019.02.046
Homo sapiens HCT-116 IC50 1800.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens HCT-116 IC50 1800.0 nM 10.1021/jm701384x
Homo sapiens HCT-116 IC50 1810.0 nM 10.1016/j.bmc.2015.06.071
Homo sapiens HCT-116 IC50 1810.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens HCT-116 IC50 1850.0 nM 10.1016/j.bmcl.2018.06.037
Homo sapiens HCT-116 IC50 1850.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens HCT-116 IC50 1850.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens HCT-116 IC50 1900.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 IC50 1900.0 nM 10.1021/jm015568c
Homo sapiens HCT-116 IC50 1930.0 nM 10.1016/j.bmcl.2006.07.080
Homo sapiens HCT-116 IC50 1930.0 nM 10.1021/jm030235w
Homo sapiens HCT-116 IC50 2180.0 nM None
Homo sapiens HCT-116 IC50 2200.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens HCT-116 IC50 2350.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens HCT-116 IC50 2410.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens HCT-116 IC50 2520.0 nM 10.1016/j.bmcl.2006.10.045
Homo sapiens HCT-116 IC50 2520.0 nM 10.1016/j.bmcl.2006.10.048
Homo sapiens HCT-116 IC50 2590.0 nM 10.1021/acs.jmedchem.1c00136
Homo sapiens HCT-116 IC50 2700.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens HCT-116 IC50 2800.0 nM 10.1016/j.bmc.2013.11.021
Homo sapiens HCT-116 IC50 2810.0 nM 10.1021/jm401877m
Homo sapiens HCT-116 IC50 2850.0 nM 10.1021/jm2003552
Homo sapiens HCT-116 IC50 3070.0 nM 10.1021/acsmedchemlett.7b00487
Homo sapiens HCT-116 IC50 3100.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens HCT-116 IC50 3590.0 nM 10.1016/j.ejmech.2021.113893
Homo sapiens HCT-116 IC50 3700.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens HCT-116 IC50 3700.0 nM 10.1021/ml500327q
Homo sapiens HCT-116 IC50 3750.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens HCT-116 IC50 4200.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens HCT-116 IC50 4230.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens HCT-116 IC50 4250.0 nM 10.1016/j.bmc.2015.06.015
Homo sapiens HCT-116 IC50 4900.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens HCT-116 IC50 4950.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HCT-116 IC50 4970.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens HCT-116 IC50 5000.0 nM 10.1016/j.bmc.2017.10.026
Homo sapiens HCT-116 IC50 5530.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens HCT-116 IC50 5530.0 nM 10.1039/C6MD00681G
Homo sapiens HCT-116 IC50 5660.0 nM 10.1016/j.bmcl.2023.129305
Homo sapiens HCT-116 IC50 6000.0 nM 10.1021/ml300366t
Homo sapiens HCT-116 IC50 6150.0 nM 10.1016/j.bmc.2015.08.040
Homo sapiens HCT-116 IC50 9600.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens HCT-116 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens HCT-116 IC50 80000.0 nM 10.1016/j.ejmech.2009.06.010
Homo sapiens HCT-116 IC50 790000.0 nM 10.1016/j.bmc.2010.01.060
Homo sapiens HCT-116 IC50 nan None 10.1016/j.bmcl.2011.08.022
Homo sapiens HCT-116 IC50 nan None 10.1021/jm0703136
Homo sapiens HCT-116 Inhibition 43.3 % 10.1016/j.ejmech.2021.113453
Homo sapiens HCT-116 Inhibition 48.0 % 10.1016/j.ejmech.2008.11.005
Homo sapiens HCT-116 Inhibition nan % 10.1016/j.bmcl.2022.128846
Homo sapiens HCT-116 Inhibition nan % 10.1021/ml1001163
Homo sapiens HCT-116 LC50 100000.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens HCT-116 Selectivity index 2.0 None 10.1021/jm060554y
Homo sapiens HCT-116 T/C 49.0 % 10.1021/jm200577a
Homo sapiens HCT-116 T/C 73.0 % 10.1016/j.ejmech.2017.03.069
Homo sapiens HCT-116 TGI 29.0 % 10.1016/j.bmcl.2009.04.011
Homo sapiens HCT-116 TGI 32.0 % 10.1016/j.ejmech.2017.03.069
Homo sapiens HCT-116 TGI 33.0 % 10.1021/acs.jmedchem.7b00467
Homo sapiens HCT-116 TGI 33.0 % 10.1021/acsmedchemlett.7b00414
Homo sapiens HCT-116 TGI 41.0 % 10.1021/jm2003552
Homo sapiens HCT-116 TGI 48.4 % 10.1021/jm401899x
Homo sapiens HCT-116 TGI 53.0 % 10.1016/j.bmcl.2009.01.041
Homo sapiens HCT-116 TGI 53.4 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HCT-116 TGI 54.0 % 10.1021/jm2003552
Homo sapiens HCT-116 TGI 56.0 % 10.1021/jm800079s
Homo sapiens HCT-116 TGI 59.0 % 10.1021/jm2003552
Homo sapiens HCT-116 TGI 65.0 % 10.1021/jm200577a
Homo sapiens HCT-116 TGI 100.0 % 10.1016/j.bmcl.2010.05.020
Homo sapiens HCT-15 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens HCT-15 GI50 820.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens HCT-15 GI50 820.0 nM 10.1021/jm0613828
Homo sapiens HCT-15 GI50 950.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens HCT-15 GI50 2490.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens HCT-15 GI50 2490.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens HCT-15 GI50 2490.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens HCT-15 GI50 2490.0 nM 10.1021/jm3009376
Homo sapiens HCT-15 GI50 2500.0 nM 10.1021/jm201496g
Homo sapiens HCT-15 IC50 3900.0 nM 10.1021/jm0703136
Homo sapiens HCT-8 IC50 350.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens HDAC1/REST corepressor 3 Ki 3.04 nM 10.1016/j.bmcl.2018.02.034
Homo sapiens HDLM-2 IC50 47228.71 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 538.13 nM 10.6019/CHEMBL1201861
Homo sapiens Heat shock protein HSP 90-alpha IC50 1000.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Heat shock protein HSP 90-alpha IC50 1000.0 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Heat shock protein HSP 90-alpha IC50 500000.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens HEC-1 IC50 1953.6 nM 10.6019/CHEMBL1201861
Homo sapiens HEK293 Activity nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens HEK293 CC50 2300.0 nM 10.1021/acs.jmedchem.9b00462
Homo sapiens HEK293 CC50 100000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens HEK293 FC 14.1 None 10.1021/acs.jmedchem.5b00062
Homo sapiens HEK293 FC 35.6 None 10.1021/acs.jmedchem.5b00062
Homo sapiens HEK293 GI50 3380.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens HEK293 GI50 13000.0 nM 10.1021/ml300081u
Homo sapiens HEK293 IC50 183.11 nM None
Homo sapiens HEK293 IC50 2480.0 nM 10.1016/j.ejmech.2021.113588
Homo sapiens HEK293 IC50 5170.0 nM 10.1016/j.ejmech.2018.09.018
Homo sapiens HEK293 IC50 nan None 10.1016/j.ejmech.2016.12.041
Homo sapiens HEK-293T EC50 1000.0 nM 10.1021/acs.jmedchem.0c01704
Homo sapiens HEK-293T IC50 4500.0 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens HEK-293T IC50 8221.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens HEL Activity 0.0 % 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL Activity 2.0 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL Activity 15.83 % 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL Activity 20.02 % 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL Activity 21.3 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL Activity 32.1 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL Activity 44.6 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL Activity 46.97 % 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL Activity 79.98 % 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL Activity nan None 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL Activity nan None 10.1021/acs.jmedchem.8b00393
Homo sapiens HEL CI 0.48 None 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL CI 0.721 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 0.754 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 0.772 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 0.784 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 1.02 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 1.03 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 1.04 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL CI 1.06 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.739 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.797 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.822 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.836 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.838 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.887 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.889 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL FICI 0.908 None 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL GI50 760.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens HEL IC50 20.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens HEL IC50 150.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens HEL IC50 190.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens HEL IC50 210.0 nM 10.1016/j.bmc.2016.12.001
Homo sapiens HEL IC50 250.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens HEL IC50 300.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL IC50 490.0 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens HEL IC50 490.0 nM 10.1021/jm401877m
Homo sapiens HEL IC50 520.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens HEL IC50 650.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL IC50 650.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL IC50 790.0 nM 10.1016/j.bmc.2018.02.033
Homo sapiens HEL IC50 806.08 nM 10.6019/CHEMBL1201861
Homo sapiens HEL IC50 860.0 nM 10.1021/acs.jmedchem.8b00393
Homo sapiens HEL IC50 890.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens HEL IC50 1270.0 nM 10.1016/j.bmc.2015.08.040
Homo sapiens HEL IC50 1740.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens HEL IC50 2420.0 nM 10.1016/j.bmc.2015.06.015
Homo sapiens HEL IC50 2420.0 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL T/C 46.0 % 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL T/C 87.9 % 10.1021/acs.jmedchem.8b00393
Homo sapiens HEL T/C 88.3 % 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL TGI 13.8 % 10.1021/acs.jmedchem.8b00393
Homo sapiens HEL TGI 17.9 % 10.1021/acs.jmedchem.1c02026
Homo sapiens HEL TGI 39.0 % 10.1021/acs.jmedchem.5b00317
Homo sapiens HEL TGI 42.0 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL TGI 57.0 % 10.1021/acs.jmedchem.8b01597
Homo sapiens HEL 92.1.7 IC50 490.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens HEL 92.1.7 IC50 490.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens HeLa Activity 0.61 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 0.654 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 0.957 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 4.1 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 6.56 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 7.6 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 7.84 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 10.2 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 15.1 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 47.1 % 10.1021/acs.jmedchem.0c01454
Homo sapiens HeLa Activity 77.4 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 83.9 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity 85.1 % 10.1039/C5MD00247H
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.0c01454
Homo sapiens HeLa Activity nan None 10.1039/C5MD00247H
Homo sapiens HeLa CC50 460.0 nM 10.1021/jm9004303
Homo sapiens HeLa CC50 2800.0 nM 10.1021/acs.jmedchem.1c00491
Homo sapiens HeLa EC50 4700.0 nM 10.1021/jm2001025
Homo sapiens HeLa EC50 14200.0 nM 10.1021/jm2001025
Homo sapiens HeLa EC50 43000.0 nM 10.1021/jm2001025
Homo sapiens HeLa GI50 1460.0 nM 10.1016/j.bmcl.2010.09.016
Homo sapiens HeLa GI50 2500.0 nM 10.1021/ml300081u
Homo sapiens HeLa GI50 2700.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens HeLa GI50 3200.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens HeLa GI50 3360.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens HeLa GI50 19210.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens HeLa IC50 460.0 nM 10.1016/j.bmcl.2006.09.002
Homo sapiens HeLa IC50 460.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens HeLa IC50 460.0 nM 10.1021/jm800079s
Homo sapiens HeLa IC50 480.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens HeLa IC50 711.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens HeLa IC50 720.0 nM 10.1016/j.bmc.2014.03.019
Homo sapiens HeLa IC50 1170.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens HeLa IC50 1500.0 nM 10.1021/jm100665z
Homo sapiens HeLa IC50 1720.0 nM 10.1016/j.bmc.2016.12.001
Homo sapiens HeLa IC50 1750.0 nM 10.1021/jm0703136
Homo sapiens HeLa IC50 1840.0 nM 10.1016/j.bmc.2018.02.033
Homo sapiens HeLa IC50 1900.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens HeLa IC50 1995.26 nM 10.1016/j.bmcl.2007.06.063
Homo sapiens HeLa IC50 2040.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens HeLa IC50 2060.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens HeLa IC50 2060.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens HeLa IC50 2200.0 nM 10.1021/jm800988r
Homo sapiens HeLa IC50 2410.0 nM 10.1016/j.ejmech.2020.112073
Homo sapiens HeLa IC50 2600.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens HeLa IC50 2600.0 nM 10.1021/np400263f
Homo sapiens HeLa IC50 2650.0 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens HeLa IC50 2700.0 nM 10.1016/j.bmc.2013.11.021
Homo sapiens HeLa IC50 2700.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens HeLa IC50 2700.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens HeLa IC50 2850.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens HeLa IC50 2900.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens HeLa IC50 3100.0 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens HeLa IC50 3550.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens HeLa IC50 3700.0 nM 10.1016/j.ejmech.2015.04.014
Homo sapiens HeLa IC50 3823.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens HeLa IC50 4520.0 nM 10.1016/j.bmc.2022.116626
Homo sapiens HeLa IC50 4520.0 nM 10.1016/j.bmcl.2022.128925
Homo sapiens HeLa IC50 4520.0 nM 10.1016/j.ejmech.2020.113039
Homo sapiens HeLa IC50 4520.0 nM 10.1016/j.ejmech.2022.114375
Homo sapiens HeLa IC50 4610.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens HeLa IC50 4660.0 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens HeLa IC50 5000.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens HeLa IC50 5210.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens HeLa IC50 5450.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens HeLa IC50 6070.0 nM 10.1039/C4MD00203B
Homo sapiens HeLa IC50 7130.0 nM 10.1039/C5MD00247H
Homo sapiens HeLa IC50 8960.0 nM 10.1039/C5MD00247H
Homo sapiens HeLa IC50 9190.0 nM 10.1039/C5MD00247H
Homo sapiens HeLa IC50 9690.0 nM 10.1016/j.bmc.2013.09.021
Homo sapiens HeLa IC50 12280.0 nM 10.1016/j.bmc.2015.06.015
Homo sapiens HeLa IC50 12280.0 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens HeLa IC50 147000.0 nM 10.1021/jm101605z
Homo sapiens HeLa IC50 nan None 10.1021/acsmedchemlett.7b00504
Homo sapiens HeLa Ratio IC50 3.0 None 10.1016/j.bmc.2015.08.040
Homo sapiens H-EMC-SS IC50 13910.36 nM 10.6019/CHEMBL1201861
Homo sapiens Hep 3B2 Activity 3.43 % 10.1021/acs.jmedchem.8b00209
Homo sapiens Hep 3B2 Activity 10.5 % 10.1021/acs.jmedchem.8b00209
Homo sapiens Hep 3B2 Activity 32.8 % 10.1021/acs.jmedchem.8b00209
Homo sapiens Hep 3B2 Activity 53.2 % 10.1021/acs.jmedchem.8b00209
Homo sapiens Hep 3B2 GI50 410.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Hep 3B2 IC50 2300.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens Hep 3B2 IC50 2600.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Hep 3B2 IC50 5580.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens HepaRG Activity 80.0 % 10.1021/acs.jmedchem.8b01090
Homo sapiens Hepatocyte CLH 14.7 uL/min 10.1021/jm5008209
Homo sapiens Hepatocyte GI50 500000.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens Hepatocyte T1/2 0.7917 hr 10.1021/jm5008209
Homo sapiens Hepatocyte growth factor receptor IC50 nan None 10.1016/j.bmcl.2020.127610
Homo sapiens Hepatocyte growth factor receptor IC50 nan None 10.1016/j.ejmech.2020.112651
Homo sapiens Hepatocyte growth factor receptor IC50 nan None 10.1021/acsmedchemlett.7b00172
Homo sapiens Hepatocyte growth factor receptor Inhibition 2.8 % 10.1016/j.ejmech.2020.112651
Homo sapiens Hepatocyte growth factor receptor Inhibition nan % 10.1016/j.bmcl.2020.127610
Homo sapiens HepG2 Activity 5.43 % 10.1021/acs.jmedchem.8b00209
Homo sapiens HepG2 Activity 5.69 % 10.1021/acs.jmedchem.8b00209
Homo sapiens HepG2 Activity 9.3 % 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 Activity 10.7 % 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 Activity 14.0 % 10.1021/acs.jmedchem.8b00209
Homo sapiens HepG2 Activity 26.0 % 10.1021/jm901453q
Homo sapiens HepG2 Activity 29.7 % 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 Activity 33.5 % 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 Activity 34.5 % 10.1039/C6MD00681G
Homo sapiens HepG2 Activity 40.4 % 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 Activity 74.9 % 10.1021/acs.jmedchem.8b00209
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2017.12.061
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2021.113824
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2021.114058
Homo sapiens HepG2 Activity nan None 10.1021/jm2001025
Homo sapiens HepG2 Activity nan None 10.1039/C6MD00681G
Homo sapiens HepG2 CC50 12000.0 nM 10.1021/acs.jmedchem.9b00462
Homo sapiens HepG2 EC50 3800.0 nM 10.1021/jm2001025
Homo sapiens HepG2 EC50 8400.0 nM 10.1021/jm2001025
Homo sapiens HepG2 EC50 12200.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens HepG2 EC50 50000.0 nM 10.1021/jm2001025
Homo sapiens HepG2 GI50 3400.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens HepG2 GI50 3500.0 nM 10.1021/jm201496g
Homo sapiens HepG2 GI50 4600.0 nM 10.1021/jm101177s
Homo sapiens HepG2 GI50 21960.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens HepG2 GI50 63480.0 nM 10.1016/j.bmcl.2009.09.100
Homo sapiens HepG2 IC50 0.0032 ug.mL-1 10.1021/acsmedchemlett.1c00713
Homo sapiens HepG2 IC50 0.18 ug.mL-1 10.1016/j.ejmech.2020.112044
Homo sapiens HepG2 IC50 0.18 ug.mL-1 10.1016/j.ejmech.2020.112679
Homo sapiens HepG2 IC50 0.6 nM 10.1021/jm7011408
Homo sapiens HepG2 IC50 180.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HepG2 IC50 410.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens HepG2 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HepG2 IC50 514.5 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens HepG2 IC50 850.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens HepG2 IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens HepG2 IC50 1180.0 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens HepG2 IC50 1270.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens HepG2 IC50 1430.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens HepG2 IC50 1490.0 nM 10.1016/j.ejmech.2014.05.050
Homo sapiens HepG2 IC50 1540.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens HepG2 IC50 1660.0 nM 10.1021/jm901453q
Homo sapiens HepG2 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens HepG2 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens HepG2 IC50 2000.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens HepG2 IC50 2260.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens HepG2 IC50 2265.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens HepG2 IC50 2400.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens HepG2 IC50 2570.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens HepG2 IC50 2800.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens HepG2 IC50 2900.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens HepG2 IC50 3330.0 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens HepG2 IC50 3400.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens HepG2 IC50 4100.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens HepG2 IC50 4500.0 nM 10.1016/j.bmcl.2018.11.027
Homo sapiens HepG2 IC50 4950.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HepG2 IC50 5750.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens HepG2 IC50 5900.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens HepG2 IC50 5940.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens HepG2 IC50 6000.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens HepG2 IC50 6260.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens HepG2 IC50 6260.0 nM 10.1039/C6MD00681G
Homo sapiens HepG2 IC50 7190.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens HepG2 IC50 7600.0 nM 10.1016/j.ejmech.2020.113065
Homo sapiens HepG2 IC50 8780.0 nM 10.1039/C5MD00247H
Homo sapiens HepG2 IC50 9060.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens HepG2 IC50 9100.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens HepG2 IC50 9300.0 nM 10.1021/jm901561u
Homo sapiens HepG2 IC50 10520.0 nM 10.1039/C5MD00247H
Homo sapiens HepG2 IC50 10770.0 nM 10.1039/C5MD00247H
Homo sapiens HepG2 IC50 13000.0 nM 10.1021/acs.jnatprod.2c00101
Homo sapiens HepG2 IC50 23620.0 nM 10.1016/j.bmc.2015.06.071
Homo sapiens HepG2 IC50 50000.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens HepG2 IC50 3385000.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens HepG2 Potency 6309.6 nM None
Homo sapiens HepG2 TGI 51.0 % 10.1021/acs.jmedchem.7b01465
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 322.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens HERG IC50 30000.0 nM 10.1016/j.bmcl.2011.06.015
Homo sapiens HERG IC50 30000.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens HERG IC50 30000.0 nM 10.1021/jm200388e
Homo sapiens HERG IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens HERG Inhibition 18.0 % 10.1021/jm200388e
Homo sapiens HET-1A IC50 960.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens HFL1 Activity nan None 10.1021/acs.jmedchem.2c00130
Homo sapiens HGC-27 GI90 30.0 uM 10.1021/jm3011838
Homo sapiens HGC-27 IC50 350.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens HGC-27 IC50 872.34 nM 10.6019/CHEMBL1201861
Homo sapiens HGC-27 IC50 5400.0 nM 10.1016/j.bmcl.2013.04.067
Homo sapiens HGC-27 IC50 5790.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens HGC-27 TGI 32.6 % 10.1021/acs.jmedchem.9b00390
Homo sapiens HH EC50 1030.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens HH IC50 860.0 nM 10.1016/j.ejmech.2021.113169
Homo sapiens HH IC50 894.12 nM 10.6019/CHEMBL1201861
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone acetyltransferase KAT8 Inhibition nan % 10.1016/j.ejmech.2018.08.026
Homo sapiens Histone deacetylase AC50 3100.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase Activity 17.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase Activity 26.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase Activity 40.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase Activity 49.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase Activity 54.0 mU 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase Activity 57.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase Activity 75.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase Activity 78.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase Activity 86.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase Activity 97.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase Activity nan None 10.1007/s00044-011-9623-3
Homo sapiens Histone deacetylase Activity nan None 10.1016/j.bmc.2010.03.078
Homo sapiens Histone deacetylase Activity nan None 10.1016/j.bmcl.2008.07.119
Homo sapiens Histone deacetylase Activity nan None 10.1016/j.ejmech.2008.11.005
Homo sapiens Histone deacetylase Activity nan None 10.1021/jm901561u
Homo sapiens Histone deacetylase Activity nan None 10.1038/nchembio815
Homo sapiens Histone deacetylase EC50 180.0 nM 10.1021/acsmedchemlett.7b00504
Homo sapiens Histone deacetylase EC50 550.0 nM 10.1016/j.bmcl.2008.10.058
Homo sapiens Histone deacetylase EC50 1680.0 nM 10.1021/acsmedchemlett.8b00440
Homo sapiens Histone deacetylase EC50 4800.0 nM 10.1021/jm800093c
Homo sapiens Histone deacetylase EC50 6670.0 nM 10.1021/jm0703136
Homo sapiens Histone deacetylase EC50 6700.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase FC 0.73 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 0.8 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase FC 1.2 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 1.43 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 1.48 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 1.5 None 10.1016/j.bmc.2014.02.018
Homo sapiens Histone deacetylase FC 1.64 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 2.0 None 10.1016/j.bmc.2010.05.011
Homo sapiens Histone deacetylase FC 2.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Histone deacetylase FC 2.0 None 10.1021/acs.jnatprod.8b00314
Homo sapiens Histone deacetylase FC 2.0 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase FC 4.03 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 5.36 None 10.1021/ml5000959
Homo sapiens Histone deacetylase FC 10.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Histone deacetylase Flu intensity 36.9 None 10.1016/j.bmc.2014.02.018
Homo sapiens Histone deacetylase Flu intensity 61.7 None 10.1016/j.bmc.2014.02.018
Homo sapiens Histone deacetylase IC50 10.0 nM 10.1016/j.bmcl.2003.09.007
Homo sapiens Histone deacetylase IC50 10.0 nM 10.1016/j.bmcl.2016.04.034
Homo sapiens Histone deacetylase IC50 11.5 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase IC50 12.0 nM 10.1016/j.bmcl.2015.10.006
Homo sapiens Histone deacetylase IC50 12.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase IC50 15.0 nM 10.1016/j.ejmech.2015.12.033
Homo sapiens Histone deacetylase IC50 23.9 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase IC50 25.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens Histone deacetylase IC50 30.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase IC50 37.0 nM 10.1021/jm901561u
Homo sapiens Histone deacetylase IC50 40.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase IC50 40.0 nM 10.1021/jm901453q
Homo sapiens Histone deacetylase IC50 40.0 nM None
Homo sapiens Histone deacetylase IC50 41.7 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens Histone deacetylase IC50 43.13 nM 10.1016/j.bmcl.2021.127829
Homo sapiens Histone deacetylase IC50 45.6 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens Histone deacetylase IC50 50.0 nM 10.1016/j.bmc.2023.117178
Homo sapiens Histone deacetylase IC50 50.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase IC50 50.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase IC50 50.5 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase IC50 53.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens Histone deacetylase IC50 55.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase IC50 55.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase IC50 57.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase IC50 60.2 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens Histone deacetylase IC50 63.0 nM 10.1039/C2MD00317A
Homo sapiens Histone deacetylase IC50 65.0 nM 10.1016/j.bmc.2008.03.050
Homo sapiens Histone deacetylase IC50 65.0 nM 10.1016/j.bmc.2009.10.042
Homo sapiens Histone deacetylase IC50 65.0 nM 10.1016/j.bmcl.2013.03.108
Homo sapiens Histone deacetylase IC50 65.0 nM 10.1021/jm100507q
Homo sapiens Histone deacetylase IC50 67.0 nM 10.1016/j.ejmech.2011.04.027
Homo sapiens Histone deacetylase IC50 67.0 nM 10.1021/jm201496g
Homo sapiens Histone deacetylase IC50 70.0 nM 10.1021/jm0703136
Homo sapiens Histone deacetylase IC50 70.0 nM 10.1021/jm100665z
Homo sapiens Histone deacetylase IC50 73.2 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens Histone deacetylase IC50 73.6 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase IC50 79.0 nM 10.1016/j.bmcl.2011.02.085
Homo sapiens Histone deacetylase IC50 79.0 nM 10.1016/j.bmcl.2011.09.042
Homo sapiens Histone deacetylase IC50 79.0 nM 10.1016/j.bmcl.2012.07.067
Homo sapiens Histone deacetylase IC50 79.0 nM 10.1039/C2MD00317A
Homo sapiens Histone deacetylase IC50 79.43 nM 10.1016/j.bmcl.2007.06.063
Homo sapiens Histone deacetylase IC50 80.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase IC50 80.0 nM 10.1128/aac.00729-08
Homo sapiens Histone deacetylase IC50 80.0 nM None
Homo sapiens Histone deacetylase IC50 83.0 nM 10.1021/jm800093c
Homo sapiens Histone deacetylase IC50 86.0 nM 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase IC50 87.0 nM 10.1016/j.bmcl.2010.09.016
Homo sapiens Histone deacetylase IC50 87.0 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase IC50 87.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase IC50 90.0 nM 10.1016/j.bmcl.2007.01.117
Homo sapiens Histone deacetylase IC50 90.0 nM 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase IC50 96.4 nM 10.1021/jm300197a
Homo sapiens Histone deacetylase IC50 99.4 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase IC50 99.4 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Histone deacetylase IC50 100.0 nM 10.1016/j.bmc.2010.05.011
Homo sapiens Histone deacetylase IC50 100.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Histone deacetylase IC50 102.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens Histone deacetylase IC50 102.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens Histone deacetylase IC50 104.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase IC50 105.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens Histone deacetylase IC50 105.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase IC50 107.0 nM 10.1021/jm101605z
Homo sapiens Histone deacetylase IC50 110.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens Histone deacetylase IC50 110.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens Histone deacetylase IC50 110.0 nM 10.1021/acs.jmedchem.5b00062
Homo sapiens Histone deacetylase IC50 110.0 nM 10.1021/jm0613828
Homo sapiens Histone deacetylase IC50 119.0 nM 10.1016/j.bmc.2023.117213
Homo sapiens Histone deacetylase IC50 120.0 nM 10.1016/j.bmc.2010.10.049
Homo sapiens Histone deacetylase IC50 120.0 nM 10.1016/j.bmc.2013.12.025
Homo sapiens Histone deacetylase IC50 120.0 nM 10.1016/s0960-894x(02)00622-4
Homo sapiens Histone deacetylase IC50 120.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase IC50 120.8 nM 10.1021/jm401877m
Homo sapiens Histone deacetylase IC50 122.0 nM 10.1016/j.bmcl.2013.04.004
Homo sapiens Histone deacetylase IC50 130.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens Histone deacetylase IC50 130.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase IC50 135.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase IC50 137.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase IC50 140.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens Histone deacetylase IC50 140.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens Histone deacetylase IC50 140.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 140.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase IC50 141.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens Histone deacetylase IC50 143.0 nM 10.1016/j.ejmech.2019.111691
Homo sapiens Histone deacetylase IC50 144.8 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens Histone deacetylase IC50 147.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase IC50 156.2 nM 10.1016/j.bmc.2018.02.033
Homo sapiens Histone deacetylase IC50 160.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens Histone deacetylase IC50 168.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase IC50 170.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase IC50 180.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens Histone deacetylase IC50 190.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens Histone deacetylase IC50 190.0 nM 10.1021/ml300366t
Homo sapiens Histone deacetylase IC50 194.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase IC50 194.0 nM 10.1021/jm030235w
Homo sapiens Histone deacetylase IC50 196.0 nM 10.1016/j.bmcl.2009.07.068
Homo sapiens Histone deacetylase IC50 200.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase IC50 200.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase IC50 231.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase IC50 250.0 nM 10.1016/j.ejmech.2020.112953
Homo sapiens Histone deacetylase IC50 260.0 nM 10.1016/j.bmc.2014.03.019
Homo sapiens Histone deacetylase IC50 260.0 nM 10.1016/j.bmcl.2015.12.007
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1016/j.bmcl.2003.09.048
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1016/j.bmcl.2004.03.063
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1016/j.bmcl.2004.10.074
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1021/jm049207j
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 280.0 nM 10.1021/jm900125m
Homo sapiens Histone deacetylase IC50 288.0 nM 10.1021/jm0703800
Homo sapiens Histone deacetylase IC50 330.0 nM 10.1021/jm051010j
Homo sapiens Histone deacetylase IC50 330.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 360.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 410.0 nM 10.1021/jm070864w
Homo sapiens Histone deacetylase IC50 440.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 440.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 480.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase IC50 480.0 nM 10.1021/jm401899x
Homo sapiens Histone deacetylase IC50 480.0 nM 10.1039/C6MD00681G
Homo sapiens Histone deacetylase IC50 500.0 nM 10.1021/jm801529c
Homo sapiens Histone deacetylase IC50 529.0 nM None
Homo sapiens Histone deacetylase IC50 530.0 nM 10.1016/j.ejmech.2021.113961
Homo sapiens Histone deacetylase IC50 530.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 560.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase IC50 590.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase IC50 590.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 600.0 nM 10.1039/C4MD00350K
Homo sapiens Histone deacetylase IC50 610.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 640.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase IC50 700.0 nM 10.1016/j.bmcl.2009.04.102
Homo sapiens Histone deacetylase IC50 700.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 730.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase IC50 770.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase IC50 850.0 nM 10.1021/acs.jmedchem.0c00102
Homo sapiens Histone deacetylase IC50 860.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase IC50 880.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase IC50 910.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase IC50 960.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase IC50 980.0 nM 10.1016/j.bmc.2012.05.034
Homo sapiens Histone deacetylase IC50 980.0 nM 10.1021/acs.jmedchem.0c00491
Homo sapiens Histone deacetylase IC50 1100.0 nM 10.1016/j.bmc.2009.12.005
Homo sapiens Histone deacetylase IC50 1460.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase IC50 1480.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase IC50 1680.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase IC50 2056.0 nM 10.1021/acsmedchemlett.8b00068
Homo sapiens Histone deacetylase IC50 2103.0 nM None
Homo sapiens Histone deacetylase IC50 2590.0 nM 10.1016/j.bmc.2013.09.021
Homo sapiens Histone deacetylase IC50 2800.0 nM 10.1016/j.bmcl.2013.04.067
Homo sapiens Histone deacetylase IC50 4500.0 nM 10.1021/jm800093c
Homo sapiens Histone deacetylase IC50 5044.0 nM 10.1021/acsmedchemlett.8b00068
Homo sapiens Histone deacetylase IC50 5440.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase IC50 7200.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase IC50 98350.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens Histone deacetylase IC50 100000.0 nM 10.1021/acsmedchemlett.8b00068
Homo sapiens Histone deacetylase IC50 nan None 10.1016/j.ejmech.2017.08.041
Homo sapiens Histone deacetylase INH 0.089 uM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase INH 288.0 nM 10.1016/j.bmc.2011.02.024
Homo sapiens Histone deacetylase Inhibition 0.08 uM 10.1016/j.bmcl.2005.01.006
Homo sapiens Histone deacetylase Inhibition 20.0 % 10.1016/j.bmcl.2012.07.067
Homo sapiens Histone deacetylase Inhibition 47.0 % 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase Inhibition 50.0 % 10.1016/j.bmcl.2018.02.034
Homo sapiens Histone deacetylase Inhibition 54.0 % 10.1021/ml1001163
Homo sapiens Histone deacetylase Inhibition 55.0 % 10.1016/j.bmcl.2011.02.085
Homo sapiens Histone deacetylase Inhibition 55.0 % 10.1016/j.bmcl.2011.09.042
Homo sapiens Histone deacetylase Inhibition 55.0 % 10.1016/j.bmcl.2012.07.067
Homo sapiens Histone deacetylase Inhibition 57.89 % 10.1007/s00044-011-9623-3
Homo sapiens Histone deacetylase Inhibition 65.0 % 10.1021/acsmedchemlett.8b00057
Homo sapiens Histone deacetylase Inhibition 71.24 % 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase Inhibition 77.0 % 10.1016/j.bmcl.2009.07.068
Homo sapiens Histone deacetylase Inhibition 81.0 % 10.1016/j.bmcl.2011.02.085
Homo sapiens Histone deacetylase Inhibition 81.0 % 10.1016/j.bmcl.2011.09.042
Homo sapiens Histone deacetylase Inhibition 81.0 % 10.1016/j.bmcl.2012.07.067
Homo sapiens Histone deacetylase Inhibition 85.0 % 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase Inhibition 85.0 % 10.1016/j.ejmech.2013.05.017
Homo sapiens Histone deacetylase Inhibition 85.0 % 10.1016/j.ejmech.2018.09.043
Homo sapiens Histone deacetylase Inhibition 85.44 % 10.1016/j.bmcl.2013.04.004
Homo sapiens Histone deacetylase Inhibition 86.0 % 10.1016/j.bmcl.2011.02.085
Homo sapiens Histone deacetylase Inhibition 86.0 % 10.1016/j.bmcl.2011.09.042
Homo sapiens Histone deacetylase Inhibition 87.5 % 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase Inhibition 87.8 % 10.1016/j.bmc.2013.11.021
Homo sapiens Histone deacetylase Inhibition 89.0 % 10.1016/j.bmcl.2013.09.051
Homo sapiens Histone deacetylase Inhibition 90.75 % 10.1016/j.bmcl.2019.07.045
Homo sapiens Histone deacetylase Inhibition 95.0 % 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase Inhibition 95.36 % 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase Inhibition 97.0 % 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase Inhibition 97.1 % 10.1021/jm900187v
Homo sapiens Histone deacetylase Inhibition 97.48 % 10.1016/j.bmcl.2013.04.004
Homo sapiens Histone deacetylase Inhibition 98.0 % 10.1021/acsmedchemlett.1c00504
Homo sapiens Histone deacetylase Inhibition 99.0 % 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase Inhibition 100.0 % 10.1016/j.bmcl.2003.09.048
Homo sapiens Histone deacetylase Inhibition 100.0 % 10.1016/j.bmcl.2004.10.074
Homo sapiens Histone deacetylase Inhibition 100.0 % 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase Inhibition 100.0 % 10.1021/jm049207j
Homo sapiens Histone deacetylase Inhibition 100.0 % 10.1021/jm701384x
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmc.2015.06.071
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmc.2023.117213
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2013.03.108
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2013.04.067
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2015.12.094
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2021.128207
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2022.128825
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2022.114409
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.2c01413
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.9b00516
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jnatprod.8b00314
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acs.jnatprod.8b00843
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acsmedchemlett.7b00487
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm100244y
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm2001025
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm200799p
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm201496g
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm401899x
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/jm801529c
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/ml300366t
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/ml400158k
Homo sapiens Histone deacetylase Inhibition nan % 10.1038/nchembio.275
Homo sapiens Histone deacetylase Inhibition nan % 10.1039/c4md00401a
Homo sapiens Histone deacetylase Inhibition nan % 10.1039/C8MD00107C
Homo sapiens Histone deacetylase Ki 2470.0 nM 10.1016/j.bmc.2009.05.042
Homo sapiens Histone deacetylase Ratio 0.59 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio 1.52 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase Ratio 1.77 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio 1.91 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase Ratio 2.01 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio 2.8 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase Ratio 2.94 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio 3.5 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio 3.79 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase Ratio IC50 2.41 None 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase Ratio IC50 8.91 None 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase 1 Activity 1.68 % 10.1016/j.bmcl.2009.09.100
Homo sapiens Histone deacetylase 1 Activity 6.7 % 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 1 Activity 8.9 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 1 Activity 8.9 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 1 Activity 12.2 % None
Homo sapiens Histone deacetylase 1 Activity 32.0 % 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 1 Activity 32.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 Activity 34.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 Activity 37.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 Activity 58.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 Activity 80.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 Activity nan None 10.1016/j.bmcl.2003.08.083
Homo sapiens Histone deacetylase 1 Activity nan None 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 1 Activity nan None 10.1016/j.ejmech.2015.04.014
Homo sapiens Histone deacetylase 1 FC 0.6 None 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 FC 0.9 None 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 FC 1.0 None 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 FC 1.2 None 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 FC 1.8 None 10.1021/jm500303u
Homo sapiens Histone deacetylase 1 FC 5.6 None 10.1021/jm500303u
Homo sapiens Histone deacetylase 1 IC50 4.0 nM 10.1016/j.ejmech.2019.02.032
Homo sapiens Histone deacetylase 1 IC50 4.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 1 IC50 4.24 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 1 IC50 4.24 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 1 IC50 5.2 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens Histone deacetylase 1 IC50 5.5 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 1 IC50 7.0 nM 10.1016/j.bmcl.2016.01.022
Homo sapiens Histone deacetylase 1 IC50 7.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 1 IC50 8.9 nM 10.1021/jm300197a
Homo sapiens Histone deacetylase 1 IC50 9.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens Histone deacetylase 1 IC50 9.1 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 1 IC50 9.7 nM 10.1021/jm200620f
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.bmcl.2016.04.090
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.bmcl.2017.07.054
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.ejmech.2019.111691
Homo sapiens Histone deacetylase 1 IC50 10.68 nM 10.1016/j.ejmech.2021.113893
Homo sapiens Histone deacetylase 1 IC50 10.8 nM 10.1016/j.bmc.2016.10.006
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase 1 IC50 11.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 1 IC50 11.11 nM 10.1016/j.ejmech.2017.04.017
Homo sapiens Histone deacetylase 1 IC50 11.34 nM 10.1016/j.bmc.2017.05.058
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens Histone deacetylase 1 IC50 13.0 nM 10.1016/j.bmc.2022.117028
Homo sapiens Histone deacetylase 1 IC50 13.0 nM 10.1016/j.bmcl.2014.06.080
Homo sapiens Histone deacetylase 1 IC50 13.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens Histone deacetylase 1 IC50 13.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens Histone deacetylase 1 IC50 13.0 nM 10.1039/C2MD00317A
Homo sapiens Histone deacetylase 1 IC50 14.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Histone deacetylase 1 IC50 14.0 nM 10.1039/c4md00401a
Homo sapiens Histone deacetylase 1 IC50 14.15 nM 10.1016/j.bmcl.2020.127610
Homo sapiens Histone deacetylase 1 IC50 14.15 nM 10.1016/j.ejmech.2020.112651
Homo sapiens Histone deacetylase 1 IC50 14.3 nM 10.1016/j.bmc.2018.06.016
Homo sapiens Histone deacetylase 1 IC50 14.4 nM 10.1021/acsmedchemlett.7b00487
Homo sapiens Histone deacetylase 1 IC50 14.6 nM 10.1021/acs.jmedchem.1c01155
Homo sapiens Histone deacetylase 1 IC50 15.0 nM 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 IC50 16.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens Histone deacetylase 1 IC50 16.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Histone deacetylase 1 IC50 16.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens Histone deacetylase 1 IC50 17.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens Histone deacetylase 1 IC50 17.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 1 IC50 17.39 nM 10.1016/j.ejmech.2022.114115
Homo sapiens Histone deacetylase 1 IC50 18.0 nM 10.1021/acs.jmedchem.0c01967
Homo sapiens Histone deacetylase 1 IC50 18.55 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase 1 IC50 19.0 nM 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1021/jm0703136
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase 1 IC50 20.9 nM 10.1021/jm400179b
Homo sapiens Histone deacetylase 1 IC50 20.9 nM None
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1016/j.ejmech.2022.114326
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1021/acs.jmedchem.7b00718
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1021/jm100665z
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 1 IC50 22.37 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 1 IC50 22.4 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 22.4 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 1 IC50 22.7 nM 10.1021/acs.jmedchem.0c01763
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.bmcl.2021.128441
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1021/ml500327q
Homo sapiens Histone deacetylase 1 IC50 23.04 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 1 IC50 24.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens Histone deacetylase 1 IC50 25.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 1 IC50 25.0 nM 10.1016/j.ejmech.2021.113946
Homo sapiens Histone deacetylase 1 IC50 25.0 nM 10.1039/C9MD00306A
Homo sapiens Histone deacetylase 1 IC50 25.8 nM 10.1016/j.ejmech.2021.114058
Homo sapiens Histone deacetylase 1 IC50 26.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 1 IC50 26.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 1 IC50 27.0 nM 10.1016/j.bmcl.2006.09.002
Homo sapiens Histone deacetylase 1 IC50 27.0 nM 10.1016/j.bmcl.2009.04.102
Homo sapiens Histone deacetylase 1 IC50 27.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens Histone deacetylase 1 IC50 29.0 nM 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 1 IC50 29.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.bmcl.2008.02.025
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/jm2016182
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 1 IC50 30.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 1 IC50 31.0 nM 10.1016/j.bmcl.2017.01.044
Homo sapiens Histone deacetylase 1 IC50 31.0 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens Histone deacetylase 1 IC50 31.0 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 1 IC50 31.0 nM 10.1021/acsmedchemlett.7b00223
Homo sapiens Histone deacetylase 1 IC50 32.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens Histone deacetylase 1 IC50 32.33 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1016/j.bmcl.2021.128207
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/acs.jmedchem.1c00184
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 1 IC50 33.0 nM 10.1021/jm800093c
Homo sapiens Histone deacetylase 1 IC50 33.5 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens Histone deacetylase 1 IC50 34.0 nM 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 1 IC50 34.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 1 IC50 34.6 nM 10.1021/jm401877m
Homo sapiens Histone deacetylase 1 IC50 35.0 nM 10.1016/j.bmcl.2018.12.052
Homo sapiens Histone deacetylase 1 IC50 37.7 nM 10.1016/j.bmcl.2020.127638
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1016/j.bmcl.2013.03.108
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1016/j.ejmech.2015.04.014
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1016/j.ejmech.2021.113383
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1021/jm200799p
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1021/jm301769u
Homo sapiens Histone deacetylase 1 IC50 38.0 nM 10.1021/jm401225q
Homo sapiens Histone deacetylase 1 IC50 39.8 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens Histone deacetylase 1 IC50 39.91 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 40.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 1 IC50 40.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens Histone deacetylase 1 IC50 40.0 nM 10.1021/acs.jmedchem.8b00393
Homo sapiens Histone deacetylase 1 IC50 41.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 1 IC50 41.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 1 IC50 42.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens Histone deacetylase 1 IC50 42.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens Histone deacetylase 1 IC50 42.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 42.0 nM 10.1021/jm400467w
Homo sapiens Histone deacetylase 1 IC50 42.5 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 1 IC50 42.82 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 43.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 1 IC50 43.76 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 43.76 nM 10.1021/acs.jmedchem.0c00442
Homo sapiens Histone deacetylase 1 IC50 43.9 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 1 IC50 44.0 nM 10.1016/j.ejmech.2011.08.045
Homo sapiens Histone deacetylase 1 IC50 44.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens Histone deacetylase 1 IC50 44.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 1 IC50 44.0 nM 10.1021/acsmedchemlett.7b00172
Homo sapiens Histone deacetylase 1 IC50 45.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens Histone deacetylase 1 IC50 45.0 nM 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 1 IC50 45.0 nM 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 1 IC50 45.5 nM 10.1016/j.ejmech.2021.113526
Homo sapiens Histone deacetylase 1 IC50 46.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 1 IC50 47.0 nM 10.1021/acsmedchemlett.9b00287
Homo sapiens Histone deacetylase 1 IC50 47.4 nM 10.1021/acs.jmedchem.5b00099
Homo sapiens Histone deacetylase 1 IC50 47.95 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 48.0 nM 10.1016/j.bmcl.2007.04.089
Homo sapiens Histone deacetylase 1 IC50 48.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens Histone deacetylase 1 IC50 48.0 nM 10.1021/jm800936s
Homo sapiens Histone deacetylase 1 IC50 49.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 1 IC50 50.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 1 IC50 50.12 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 1 IC50 51.0 nM 10.1039/C4MD00203B
Homo sapiens Histone deacetylase 1 IC50 51.75 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 52.0 nM 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 1 IC50 53.78 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 IC50 54.6 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 1 IC50 56.0 nM 10.1021/acs.jmedchem.0c00102
Homo sapiens Histone deacetylase 1 IC50 56.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 1 IC50 59.0 nM 10.1016/j.bmcl.2017.06.027
Homo sapiens Histone deacetylase 1 IC50 60.7 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 1 IC50 61.0 nM 10.1016/j.ejmech.2019.07.026
Homo sapiens Histone deacetylase 1 IC50 61.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 1 IC50 62.9 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens Histone deacetylase 1 IC50 63.5 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 1 IC50 65.0 nM 10.1016/j.bmcl.2020.127023
Homo sapiens Histone deacetylase 1 IC50 65.2 nM 10.1021/acs.jnatprod.6b00493
Homo sapiens Histone deacetylase 1 IC50 65.4 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens Histone deacetylase 1 IC50 66.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase 1 IC50 68.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 1 IC50 68.1 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 1 IC50 69.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 1 IC50 69.0 nM 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 1 IC50 69.0 nM 10.1021/ml300081u
Homo sapiens Histone deacetylase 1 IC50 70.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens Histone deacetylase 1 IC50 70.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase 1 IC50 71.8 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 1 IC50 73.0 nM 10.1021/acs.jmedchem.0c00931
Homo sapiens Histone deacetylase 1 IC50 75.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens Histone deacetylase 1 IC50 76.0 nM 10.1016/j.bmcl.2010.09.100
Homo sapiens Histone deacetylase 1 IC50 76.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 1 IC50 76.0 nM 10.1021/ml300366t
Homo sapiens Histone deacetylase 1 IC50 77.0 nM 10.1016/j.bmcl.2011.06.015
Homo sapiens Histone deacetylase 1 IC50 79.0 nM 10.1016/j.ejmech.2018.09.018
Homo sapiens Histone deacetylase 1 IC50 80.0 nM 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 1 IC50 81.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 1 IC50 82.0 nM 10.1021/acs.jmedchem.0c00079
Homo sapiens Histone deacetylase 1 IC50 85.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 1 IC50 87.4 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 87.9 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 1 IC50 88.0 nM 10.1021/acs.jmedchem.2c01659
Homo sapiens Histone deacetylase 1 IC50 88.5 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 1 IC50 89.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens Histone deacetylase 1 IC50 89.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 1 IC50 90.0 nM 10.1016/j.bmc.2013.09.023
Homo sapiens Histone deacetylase 1 IC50 90.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 1 IC50 91.0 nM 10.1039/C5MD00247H
Homo sapiens Histone deacetylase 1 IC50 93.34 nM 10.1016/j.bmc.2014.08.030
Homo sapiens Histone deacetylase 1 IC50 93.34 nM 10.1016/j.bmc.2015.06.071
Homo sapiens Histone deacetylase 1 IC50 93.6 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 1 IC50 96.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens Histone deacetylase 1 IC50 96.0 nM 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 1 IC50 96.0 nM 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 1 IC50 96.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 1 IC50 96.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 1 IC50 98.13 nM 10.1016/j.bmc.2021.116510
Homo sapiens Histone deacetylase 1 IC50 98.13 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 99.0 nM 10.1021/acs.jmedchem.2c01418
Homo sapiens Histone deacetylase 1 IC50 100.0 nM 10.1016/j.bmc.2018.08.008
Homo sapiens Histone deacetylase 1 IC50 100.0 nM 10.1016/j.bmcl.2008.11.081
Homo sapiens Histone deacetylase 1 IC50 101.0 nM 10.1039/C8MD00454D
Homo sapiens Histone deacetylase 1 IC50 101.98 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 1 IC50 102.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase 1 IC50 106.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.bmcl.2012.08.006
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.ejmech.2016.06.023
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1016/j.ejmech.2020.113065
Homo sapiens Histone deacetylase 1 IC50 110.0 nM 10.1021/jm401899x
Homo sapiens Histone deacetylase 1 IC50 111.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 1 IC50 117.0 nM 10.1021/acs.jmedchem.5b01478
Homo sapiens Histone deacetylase 1 IC50 117.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 1 IC50 119.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 1 IC50 119.0 nM 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 1 IC50 119.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 1 IC50 119.0 nM 10.1021/jm400385r
Homo sapiens Histone deacetylase 1 IC50 119.0 nM 10.1021/jm901561u
Homo sapiens Histone deacetylase 1 IC50 119.5 nM 10.1021/acsmedchemlett.9b00071
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1016/j.bmc.2013.03.049
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1016/j.bmcl.2009.01.041
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1016/j.bmcl.2011.06.046
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1016/j.bmcl.2015.09.006
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1016/j.ejmech.2021.113745
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1021/acs.jmedchem.1c01119
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1021/acs.jmedchem.9b01888
Homo sapiens Histone deacetylase 1 IC50 120.0 nM 10.1021/jm100244y
Homo sapiens Histone deacetylase 1 IC50 121.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 1 IC50 122.0 nM 10.1021/acs.jmedchem.9b00946
Homo sapiens Histone deacetylase 1 IC50 125.0 nM 10.1016/j.bmcl.2006.10.045
Homo sapiens Histone deacetylase 1 IC50 125.0 nM 10.1016/j.bmcl.2006.10.048
Homo sapiens Histone deacetylase 1 IC50 131.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens Histone deacetylase 1 IC50 131.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 1 IC50 131.5 nM 10.1016/j.bmc.2019.06.036
Homo sapiens Histone deacetylase 1 IC50 131.58 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 1 IC50 132.0 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 1 IC50 136.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 1 IC50 138.5 nM 10.1016/j.ejmech.2021.113870
Homo sapiens Histone deacetylase 1 IC50 140.0 nM 10.1016/j.bmcl.2009.08.010
Homo sapiens Histone deacetylase 1 IC50 140.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens Histone deacetylase 1 IC50 140.0 nM 10.1021/jm8005355
Homo sapiens Histone deacetylase 1 IC50 142.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 1 IC50 142.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Histone deacetylase 1 IC50 142.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens Histone deacetylase 1 IC50 150.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens Histone deacetylase 1 IC50 150.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens Histone deacetylase 1 IC50 150.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 1 IC50 162.7 nM 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 1 IC50 170.0 nM 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase 1 IC50 178.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 1 IC50 180.0 nM 10.1016/j.bmcl.2012.05.123
Homo sapiens Histone deacetylase 1 IC50 180.0 nM 10.1016/j.bmcl.2020.127671
Homo sapiens Histone deacetylase 1 IC50 180.0 nM 10.1016/j.bmcl.2021.127829
Homo sapiens Histone deacetylase 1 IC50 180.0 nM 10.1039/C3MD00285C
Homo sapiens Histone deacetylase 1 IC50 180.3 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 1 IC50 190.0 nM 10.1016/j.bmc.2020.115639
Homo sapiens Histone deacetylase 1 IC50 190.0 nM 10.1016/j.bmcl.2017.08.011
Homo sapiens Histone deacetylase 1 IC50 190.0 nM 10.1016/j.ejmech.2017.08.041
Homo sapiens Histone deacetylase 1 IC50 190.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase 1 IC50 195.0 nM 10.1016/j.ejmech.2017.01.035
Homo sapiens Histone deacetylase 1 IC50 196.0 nM 10.1021/ml300371t
Homo sapiens Histone deacetylase 1 IC50 200.0 nM 10.1021/jm0498497
Homo sapiens Histone deacetylase 1 IC50 200.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 1 IC50 200.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 1 IC50 203.06 nM 10.1016/j.bmc.2015.05.048
Homo sapiens Histone deacetylase 1 IC50 210.98 nM 10.1016/j.ejmech.2016.02.003
Homo sapiens Histone deacetylase 1 IC50 219.3 nM 10.1016/j.ejmech.2022.114582
Homo sapiens Histone deacetylase 1 IC50 220.0 nM 10.1016/j.bmcl.2015.12.007
Homo sapiens Histone deacetylase 1 IC50 236.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 1 IC50 240.0 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 1 IC50 240.0 nM 10.1021/jm502011f
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 1 IC50 258.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 1 IC50 260.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 1 IC50 260.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 1 IC50 260.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 1 IC50 270.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase 1 IC50 290.0 nM 10.1016/j.bmcl.2011.08.022
Homo sapiens Histone deacetylase 1 IC50 300.0 nM 10.1021/jm500303u
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1016/j.bmcl.2018.03.009
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1021/acs.jmedchem.6b00157
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens Histone deacetylase 1 IC50 306.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 1 IC50 310.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 1 IC50 310.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens Histone deacetylase 1 IC50 310.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 1 IC50 320.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 1 IC50 350.0 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 1 IC50 350.0 nM 10.1021/jm900125m
Homo sapiens Histone deacetylase 1 IC50 480.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Histone deacetylase 1 IC50 600.0 nM 10.1016/j.bmcl.2008.11.081
Homo sapiens Histone deacetylase 1 IC50 600.0 nM 10.1021/ml5000959
Homo sapiens Histone deacetylase 1 IC50 775.0 nM 10.1021/jm0703800
Homo sapiens Histone deacetylase 1 IC50 2200.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 1 IC50 33000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 1 IC50 nan None 10.1016/j.bmcl.2019.06.059
Homo sapiens Histone deacetylase 1 IC50 nan None 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 1 Inhibition 25.8 % 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 1 Inhibition 46.0 % 10.1016/j.bmcl.2019.06.059
Homo sapiens Histone deacetylase 1 Inhibition 47.8 % 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 1 Inhibition 50.1 % 10.1016/j.bmcl.2020.127610
Homo sapiens Histone deacetylase 1 Inhibition 52.9 % 10.1021/jm049002a
Homo sapiens Histone deacetylase 1 Inhibition 60.0 % 10.1016/j.bmcl.2018.11.027
Homo sapiens Histone deacetylase 1 Inhibition 68.9 % 10.1021/ml5000959
Homo sapiens Histone deacetylase 1 Inhibition 72.0 % 10.1021/jm8005355
Homo sapiens Histone deacetylase 1 Inhibition 83.6 % 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 1 Inhibition 85.0 % 10.1016/j.ejmech.2018.09.043
Homo sapiens Histone deacetylase 1 Inhibition 88.0 % 10.1039/C1MD00249J
Homo sapiens Histone deacetylase 1 Inhibition 88.4 % 10.1016/j.ejmech.2020.112651
Homo sapiens Histone deacetylase 1 Inhibition 91.4 % 10.1021/jm900187v
Homo sapiens Histone deacetylase 1 Inhibition 92.7 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 1 Inhibition 95.0 % 10.1016/j.bmcl.2019.03.028
Homo sapiens Histone deacetylase 1 Inhibition 96.0 % 10.1016/j.bmcl.2017.07.054
Homo sapiens Histone deacetylase 1 Inhibition 97.9 % 10.1016/j.ejmech.2020.112073
Homo sapiens Histone deacetylase 1 Inhibition 98.0 % 10.1016/j.bmc.2017.12.041
Homo sapiens Histone deacetylase 1 Inhibition 99.0 % 10.1016/j.bmcl.2017.07.054
Homo sapiens Histone deacetylase 1 Inhibition 99.87 % 10.1016/j.ejmech.2019.02.032
Homo sapiens Histone deacetylase 1 Inhibition 100.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 1 Inhibition 100.0 % 10.1016/j.bmc.2017.05.062
Homo sapiens Histone deacetylase 1 Inhibition 100.0 % 10.1016/j.bmcl.2019.06.059
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.bmc.2020.115345
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.bmcl.2019.06.006
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/acs.jmedchem.7b00678
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/acs.jmedchem.8b00209
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/jm100244y
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/jm101177s
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/jm400390r
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/jm401877m
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 1 Kd 40.0 nM 10.1016/j.bmc.2011.11.041
Homo sapiens Histone deacetylase 1 Ki 1.3 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 1 Ki 5.0 nM 10.1021/acs.jmedchem.0c00830
Homo sapiens Histone deacetylase 1 Ki 6.4 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 1 Ki 8.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 1 Ki 8.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 1 Ki 10.0 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 1 Ki 12.0 nM 10.1016/j.bmcl.2018.06.029
Homo sapiens Histone deacetylase 1 Ki 48.0 nM 10.1021/jm7015254
Homo sapiens Histone deacetylase 1 Ki 60.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 1 Ki 63.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 1 Ratio IC50 0.26 None 10.1016/j.bmc.2015.05.048
Homo sapiens Histone deacetylase 1 Ratio IC50 0.85 None 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 1 TIME 0.245 hr 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 10 Activity nan None 10.1021/jm701606b
Homo sapiens Histone deacetylase 10 IC50 27.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 10 IC50 47.5 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 10 IC50 50.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 10 IC50 57.25 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 10 IC50 58.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 10 IC50 64.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 10 IC50 68.4 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 10 IC50 70.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 10 IC50 72.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens Histone deacetylase 10 IC50 72.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 10 IC50 72.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 10 IC50 72.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 10 IC50 77.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 10 IC50 77.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 10 IC50 80.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 10 IC50 88.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 10 IC50 91.8 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 10 IC50 97.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 10 IC50 100.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 10 IC50 150.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 10 IC50 159.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 10 IC50 170.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 10 IC50 170.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 10 IC50 199.53 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 10 IC50 200.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 10 IC50 208.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 10 IC50 210.0 nM 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase 10 IC50 238.1 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 10 IC50 278.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 10 IC50 430.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 10 IC50 430.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 10 IC50 432.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 10 IC50 456.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 10 IC50 460.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 10 IC50 686.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 10 IC50 686.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 10 IC50 982.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 10 IC50 1258.93 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 10 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 10 Inhibition 100.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 10 Inhibition 100.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 10 Ki 40.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 10 Ki 40.0 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 10 Ki 50.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 10 Ki 60.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 10 Ki nan None 10.1021/jm4008449
Homo sapiens Histone deacetylase 11 IC50 34.5 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 11 IC50 51.3 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 11 IC50 61.16 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 11 IC50 90.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 11 IC50 100.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 11 IC50 109.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 11 IC50 133.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 11 IC50 200.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 11 IC50 200.0 nM 10.1016/j.bmcl.2017.05.004
Homo sapiens Histone deacetylase 11 IC50 200.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 11 IC50 200.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 11 IC50 360.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 11 IC50 362.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 11 IC50 370.0 nM 10.1016/j.bmcl.2016.03.116
Homo sapiens Histone deacetylase 11 IC50 480.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 11 IC50 952.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1021/acs.jmedchem.1c00420
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 11 IC50 1000.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 11 IC50 5000.0 nM 10.1016/j.bmc.2022.117028
Homo sapiens Histone deacetylase 11 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 11 IC50 5840.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 11 IC50 8700.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 11 IC50 8700.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 11 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 11 IC50 12542.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 11 IC50 34500.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 11 IC50 40000.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 11 IC50 73770.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 11 IC50 100000.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 11 IC50 nan None 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 11 IC50 nan None 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 11 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 11 Inhibition 10.0 % 10.1016/j.bmcl.2017.05.004
Homo sapiens Histone deacetylase 11 Inhibition 25.0 % 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 11 Inhibition 50.0 % 10.1016/j.bmcl.2017.05.004
Homo sapiens Histone deacetylase 11 Inhibition 50.4 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 11 Inhibition 70.0 % 10.1016/j.bmcl.2016.03.116
Homo sapiens Histone deacetylase 11 Inhibition 90.0 % 10.1016/j.bmcl.2017.05.004
Homo sapiens Histone deacetylase 11 Ki 13.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 11 Ki 13.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 11 Ki 31.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 11 Ki 36.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 11 Ki 60.0 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 1/2/3 EC50 377.48 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase 1/2/3 Inhibition 850.0 % 10.1021/jm5008962
Homo sapiens Histone deacetylase 1/2/3 Inhibition 4030.0 % 10.1021/jm5008962
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acs.jmedchem.6b00157
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 1/2/3 Inhibition nan % 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 1/2/3/6 FC 6.8 None 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 1/2/3/6 FC 8.5 None 10.1021/jm502011f
Homo sapiens Histone deacetylase 1/3/5/8 IC50 110.0 nM 10.1016/j.bmc.2012.06.024
Homo sapiens Histone deacetylase 1/3/5/8 IC50 120.0 nM 10.1016/j.bmc.2013.01.068
Homo sapiens Histone deacetylase 1/3/5/8 IC50 140.0 nM 10.1016/j.bmcl.2013.06.058
Homo sapiens Histone deacetylase 1/6 FC 6.8 None 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 2 Activity 8.3 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 2 Activity 8.3 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 2 Activity 16.8 % None
Homo sapiens Histone deacetylase 2 Activity nan None 10.1021/jm070028m
Homo sapiens Histone deacetylase 2 IC50 1.7 nM 10.1021/jm300197a
Homo sapiens Histone deacetylase 2 IC50 10.0 nM 10.1021/jm401053m
Homo sapiens Histone deacetylase 2 IC50 10.2 nM 10.1016/j.bmcl.2016.01.022
Homo sapiens Histone deacetylase 2 IC50 11.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens Histone deacetylase 2 IC50 11.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens Histone deacetylase 2 IC50 11.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 2 IC50 11.7 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 2 IC50 11.7 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 2 IC50 12.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 2 IC50 12.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens Histone deacetylase 2 IC50 13.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 2 IC50 13.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens Histone deacetylase 2 IC50 15.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens Histone deacetylase 2 IC50 15.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 2 IC50 15.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 2 IC50 16.0 nM 10.1021/jm200620f
Homo sapiens Histone deacetylase 2 IC50 17.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens Histone deacetylase 2 IC50 18.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Histone deacetylase 2 IC50 18.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 2 IC50 18.55 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase 2 IC50 19.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens Histone deacetylase 2 IC50 21.61 nM 10.1016/j.ejmech.2022.114115
Homo sapiens Histone deacetylase 2 IC50 23.8 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens Histone deacetylase 2 IC50 24.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase 2 IC50 26.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Histone deacetylase 2 IC50 27.0 nM 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 2 IC50 28.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 2 IC50 28.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Histone deacetylase 2 IC50 28.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 2 IC50 29.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 2 IC50 31.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 2 IC50 32.0 nM 10.1021/acs.jmedchem.7b00718
Homo sapiens Histone deacetylase 2 IC50 33.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens Histone deacetylase 2 IC50 33.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 2 IC50 35.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 2 IC50 35.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 2 IC50 35.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 2 IC50 35.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 2 IC50 36.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 2 IC50 40.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 2 IC50 48.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase 2 IC50 50.0 nM 10.1016/j.bmcl.2007.09.014
Homo sapiens Histone deacetylase 2 IC50 51.0 nM 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 2 IC50 52.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 2 IC50 56.0 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 2 IC50 66.0 nM 10.1016/j.bmcl.2011.01.134
Homo sapiens Histone deacetylase 2 IC50 66.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 2 IC50 70.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens Histone deacetylase 2 IC50 72.0 nM 10.1016/j.bmcl.2010.03.091
Homo sapiens Histone deacetylase 2 IC50 73.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Histone deacetylase 2 IC50 76.0 nM 10.1016/j.bmcl.2010.03.091
Homo sapiens Histone deacetylase 2 IC50 81.0 nM 10.1016/j.bmc.2016.02.005
Homo sapiens Histone deacetylase 2 IC50 81.0 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens Histone deacetylase 2 IC50 81.28 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 2 IC50 82.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 2 IC50 82.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens Histone deacetylase 2 IC50 82.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 2 IC50 82.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 2 IC50 85.8 nM 10.1021/np400198r
Homo sapiens Histone deacetylase 2 IC50 89.23 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 89.23 nM 10.1021/acs.jmedchem.0c00442
Homo sapiens Histone deacetylase 2 IC50 90.0 nM 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 2 IC50 91.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 2 IC50 91.6 nM 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 2 IC50 93.22 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 93.6 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 2 IC50 98.47 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 100.0 nM 10.1016/j.ejmech.2008.11.005
Homo sapiens Histone deacetylase 2 IC50 100.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 2 IC50 100.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 2 IC50 100.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 2 IC50 100.9 nM 10.1021/jm400179b
Homo sapiens Histone deacetylase 2 IC50 100.9 nM None
Homo sapiens Histone deacetylase 2 IC50 107.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase 2 IC50 110.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 2 IC50 112.5 nM 10.1016/j.ejmech.2021.113526
Homo sapiens Histone deacetylase 2 IC50 114.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 2 IC50 118.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 2 IC50 120.0 nM 10.1016/j.ejmech.2016.06.023
Homo sapiens Histone deacetylase 2 IC50 120.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens Histone deacetylase 2 IC50 120.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 2 IC50 120.5 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 2 IC50 120.75 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 2 IC50 123.7 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 128.9 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens Histone deacetylase 2 IC50 135.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 2 IC50 137.2 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 140.0 nM 10.1016/j.bmcl.2017.06.027
Homo sapiens Histone deacetylase 2 IC50 140.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 2 IC50 140.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 2 IC50 146.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 2 IC50 149.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 2 IC50 150.0 nM 10.1016/j.bmcl.2015.09.006
Homo sapiens Histone deacetylase 2 IC50 153.1 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 2 IC50 154.6 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 IC50 156.0 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 2 IC50 160.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase 2 IC50 163.6 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 2 IC50 164.0 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 2 IC50 164.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 2 IC50 164.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 2 IC50 166.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 2 IC50 167.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens Histone deacetylase 2 IC50 170.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 2 IC50 170.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 2 IC50 170.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 2 IC50 170.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 2 IC50 170.0 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 2 IC50 173.0 nM 10.1016/j.ejmech.2019.07.026
Homo sapiens Histone deacetylase 2 IC50 174.0 nM 10.1021/ml500327q
Homo sapiens Histone deacetylase 2 IC50 174.6 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens Histone deacetylase 2 IC50 176.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 2 IC50 178.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 2 IC50 178.0 nM 10.1021/acs.jmedchem.1c01119
Homo sapiens Histone deacetylase 2 IC50 180.0 nM 10.1016/j.bmcl.2017.08.011
Homo sapiens Histone deacetylase 2 IC50 180.0 nM 10.1016/j.ejmech.2017.08.041
Homo sapiens Histone deacetylase 2 IC50 180.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 2 IC50 180.0 nM 10.1021/ml300081u
Homo sapiens Histone deacetylase 2 IC50 182.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 2 IC50 183.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens Histone deacetylase 2 IC50 184.7 nM 10.1021/jm401877m
Homo sapiens Histone deacetylase 2 IC50 188.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase 2 IC50 193.0 nM 10.1039/C5MD00247H
Homo sapiens Histone deacetylase 2 IC50 197.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens Histone deacetylase 2 IC50 197.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1016/j.bmcl.2009.08.010
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 2 IC50 200.0 nM 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 2 IC50 210.0 nM 10.1016/j.bmc.2010.03.078
Homo sapiens Histone deacetylase 2 IC50 213.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 2 IC50 214.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 2 IC50 220.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase 2 IC50 220.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 2 IC50 220.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 2 IC50 220.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 2 IC50 230.0 nM 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 2 IC50 232.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 2 IC50 240.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 2 IC50 240.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens Histone deacetylase 2 IC50 240.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 2 IC50 240.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 2 IC50 250.0 nM 10.1021/jm900125m
Homo sapiens Histone deacetylase 2 IC50 256.0 nM 10.1021/ml300366t
Homo sapiens Histone deacetylase 2 IC50 260.0 nM 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 2 IC50 280.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens Histone deacetylase 2 IC50 280.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens Histone deacetylase 2 IC50 282.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens Histone deacetylase 2 IC50 282.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 2 IC50 282.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 2 IC50 332.65 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 2 IC50 362.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 2 IC50 390.0 nM 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase 2 IC50 398.11 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 2 IC50 400.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 2 IC50 410.0 nM 10.1021/jm401899x
Homo sapiens Histone deacetylase 2 IC50 411.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 2 IC50 454.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 2 IC50 537.0 nM 10.1021/ml300371t
Homo sapiens Histone deacetylase 2 IC50 550.0 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 2 IC50 760.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 2 IC50 780.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase 2 IC50 920.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 2 IC50 920.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 2 IC50 920.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 2 IC50 920.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 2 IC50 920.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 2 IC50 921.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 2 IC50 921.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 2 IC50 921.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 2 IC50 921.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 2 IC50 921.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 2 IC50 96000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 2 IC50 nan None 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 2 IC50 nan None 10.1021/jm7011408
Homo sapiens Histone deacetylase 2 Inhibition 83.2 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 2 Inhibition 99.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 2 Inhibition 100.0 % 10.1016/j.bmc.2017.05.062
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1016/j.bmcl.2019.06.006
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/acsmedchemlett.9b00287
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/jm400390r
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/jm401053m
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/jm401877m
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/ml300366t
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 2 Ki 1.6 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 2 Ki 4.2 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 2 Ki 7.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 2 Ki 7.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 2 Ki 8.0 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 2 Ki 40.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 2 Ki 42.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 2 Ki 90.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase 2 Ki 100.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase 2 Ratio IC50 0.77 None 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 2 Ratio IC50 nan None 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 3 Activity 14.0 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 3 Activity 14.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 3 Activity 21.0 % None
Homo sapiens Histone deacetylase 3 Activity 34.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 Activity 44.0 % 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 3 Activity 44.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 Activity 56.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 Activity 73.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 Activity 80.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 Activity nan None 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 3 Activity nan None 10.1021/jm070028m
Homo sapiens Histone deacetylase 3 IC50 1.4 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 3 IC50 3.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 3 IC50 3.05 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 3 IC50 3.05 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 3 IC50 4.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 3 IC50 6.57 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens Histone deacetylase 3 IC50 6.57 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 3 IC50 6.8 nM 10.1021/acs.jmedchem.1c00420
Homo sapiens Histone deacetylase 3 IC50 12.6 nM 10.1016/j.ejmech.2021.114058
Homo sapiens Histone deacetylase 3 IC50 17.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens Histone deacetylase 3 IC50 17.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 3 IC50 17.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 3 IC50 18.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens Histone deacetylase 3 IC50 18.06 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 3 IC50 18.6 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 3 IC50 19.1 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1016/j.bmcl.2016.04.090
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1016/j.ejmech.2019.111691
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 3 IC50 21.0 nM 10.1016/j.bmcl.2016.01.022
Homo sapiens Histone deacetylase 3 IC50 21.8 nM 10.1021/jm200620f
Homo sapiens Histone deacetylase 3 IC50 26.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 3 IC50 27.8 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens Histone deacetylase 3 IC50 28.0 nM 10.1021/ml300366t
Homo sapiens Histone deacetylase 3 IC50 28.1 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 3 IC50 29.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 3 IC50 29.0 nM 10.1021/acsmedchemlett.1c00074
Homo sapiens Histone deacetylase 3 IC50 29.5 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 3 IC50 29.7 nM 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 3 IC50 31.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 3 IC50 33.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 3 IC50 33.1 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 3 IC50 33.8 nM None
Homo sapiens Histone deacetylase 3 IC50 34.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 3 IC50 35.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase 3 IC50 35.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 3 IC50 37.0 nM 10.1021/jm100665z
Homo sapiens Histone deacetylase 3 IC50 37.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 3 IC50 38.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 3 IC50 39.6 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 3 IC50 40.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase 3 IC50 40.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 3 IC50 40.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 3 IC50 41.0 nM 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 3 IC50 45.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 3 IC50 46.0 nM 10.1016/j.bmcl.2017.06.027
Homo sapiens Histone deacetylase 3 IC50 47.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase 3 IC50 48.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 3 IC50 49.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 3 IC50 50.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 3 IC50 51.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Histone deacetylase 3 IC50 52.99 nM 10.1016/j.bmc.2015.05.048
Homo sapiens Histone deacetylase 3 IC50 55.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens Histone deacetylase 3 IC50 55.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens Histone deacetylase 3 IC50 56.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 3 IC50 56.56 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 56.8 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1016/j.bmcl.2008.02.025
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 3 IC50 57.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 3 IC50 58.5 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 3 IC50 62.0 nM 10.1016/j.ejmech.2019.07.026
Homo sapiens Histone deacetylase 3 IC50 65.18 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 67.0 nM 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 3 IC50 67.1 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 3 IC50 70.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 3 IC50 74.4 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 81.76 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 84.75 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase 3 IC50 87.95 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 90.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens Histone deacetylase 3 IC50 90.1 nM 10.1021/jm401877m
Homo sapiens Histone deacetylase 3 IC50 100.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 3 IC50 100.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 3 IC50 100.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 3 IC50 100.0 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 3 IC50 106.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 3 IC50 106.0 nM 10.1021/jm400385r
Homo sapiens Histone deacetylase 3 IC50 107.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 3 IC50 107.2 nM 10.1016/j.ejmech.2022.114582
Homo sapiens Histone deacetylase 3 IC50 108.0 nM 10.1021/acs.jmedchem.1c01119
Homo sapiens Histone deacetylase 3 IC50 110.0 nM 10.1016/j.bmc.2013.09.023
Homo sapiens Histone deacetylase 3 IC50 110.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 3 IC50 110.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 3 IC50 110.0 nM 10.1021/ml300371t
Homo sapiens Histone deacetylase 3 IC50 120.0 nM 10.1016/j.bmc.2018.08.008
Homo sapiens Histone deacetylase 3 IC50 126.0 nM 10.1039/C5MD00247H
Homo sapiens Histone deacetylase 3 IC50 130.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 3 IC50 130.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 3 IC50 132.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 3 IC50 136.0 nM 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 3 IC50 140.0 nM 10.1016/j.bmcl.2012.05.123
Homo sapiens Histone deacetylase 3 IC50 140.0 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 3 IC50 144.7 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 IC50 146.0 nM 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 3 IC50 147.0 nM 10.1021/jm901561u
Homo sapiens Histone deacetylase 3 IC50 150.0 nM 10.1016/j.bmc.2010.03.078
Homo sapiens Histone deacetylase 3 IC50 150.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase 3 IC50 153.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 3 IC50 153.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Histone deacetylase 3 IC50 153.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens Histone deacetylase 3 IC50 158.17 nM 10.1016/j.bmc.2014.08.030
Homo sapiens Histone deacetylase 3 IC50 158.17 nM 10.1016/j.bmc.2015.06.071
Homo sapiens Histone deacetylase 3 IC50 170.0 nM 10.1016/j.bmc.2013.03.049
Homo sapiens Histone deacetylase 3 IC50 170.0 nM 10.1016/j.bmc.2015.11.005
Homo sapiens Histone deacetylase 3 IC50 170.0 nM 10.1016/j.bmcl.2011.06.046
Homo sapiens Histone deacetylase 3 IC50 181.05 nM 10.1016/j.ejmech.2017.01.035
Homo sapiens Histone deacetylase 3 IC50 182.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 3 IC50 190.0 nM 10.1016/j.bmc.2020.115639
Homo sapiens Histone deacetylase 3 IC50 200.0 nM 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase 3 IC50 200.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 3 IC50 232.08 nM 10.1016/j.ejmech.2016.02.003
Homo sapiens Histone deacetylase 3 IC50 250.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 3 IC50 250.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 3 IC50 261.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 3 IC50 323.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 3 IC50 350.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 3 IC50 460.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 3 IC50 517.0 nM 10.1016/j.bmc.2018.10.022
Homo sapiens Histone deacetylase 3 IC50 20000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 3 IC50 nan None 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 3 Inhibition 97.0 % 10.1021/jm900187v
Homo sapiens Histone deacetylase 3 Inhibition 97.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 3 Inhibition 100.0 % 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1016/j.bmc.2018.07.026
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1016/j.bmcl.2019.06.006
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1021/acs.jmedchem.6b01385
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1021/jm400390r
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1021/jm401877m
Homo sapiens Histone deacetylase 3 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 3 Ki 5.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 3 Ki 8.0 nM 10.1021/acs.jmedchem.0c00830
Homo sapiens Histone deacetylase 3 Ki 12.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 3 Ki 29.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 3 Ki 36.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 3 Ratio 1.0 None 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 3/NCoR1 IC50 9.8 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 3/NCoR1 IC50 51.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 3/NCoR1 IC50 53.89 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 3/NCoR1 Ki 9.9 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 3/NCoR1 Ki 12.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 9.7 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 10.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 13.0 nM 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 18.8 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 19.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 27.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 27.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 30.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 32.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 33.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 34.0 nM 10.1016/j.bmcl.2011.01.134
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 34.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 39.81 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 41.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 43.0 nM 10.1021/ml300081u
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 49.0 nM 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 56.0 nM 10.1021/ml500327q
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 63.9 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 72.8 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 83.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 89.7 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 89.7 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 90.0 nM 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 105.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 110.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 144.7 nM 10.1021/acs.jmedchem.0c00442
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 350.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 350.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 350.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 350.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibition 99.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibition nan % 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Inhibition nan % 10.1021/acsmedchemlett.9b00287
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Ki 2.0 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Ki 5.42 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Ki 22.0 nM 10.1039/C4MD00252K
Homo sapiens Histone deacetylase 4 Activity 0.49 % 10.1016/j.bmcl.2009.09.100
Homo sapiens Histone deacetylase 4 Activity 61.7 % 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 4 Activity nan None 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 4 IC50 0.047 ug.mL-1 10.1016/j.bmcl.2006.12.028
Homo sapiens Histone deacetylase 4 IC50 1.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 4 IC50 18.06 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 4 IC50 40.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 4 IC50 54.3 nM 10.1016/j.ejmech.2021.113870
Homo sapiens Histone deacetylase 4 IC50 63.2 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 4 IC50 91.1 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens Histone deacetylase 4 IC50 100.0 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 4 IC50 100.9 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 4 IC50 113.0 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 4 IC50 150.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 4 IC50 150.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 4 IC50 200.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 4 IC50 210.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 4 IC50 300.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase 4 IC50 300.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 4 IC50 340.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 4 IC50 353.78 nM 10.1016/j.ejmech.2016.02.003
Homo sapiens Histone deacetylase 4 IC50 490.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 4 IC50 490.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 4 IC50 493.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 4 IC50 493.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 4 IC50 493.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 4 IC50 493.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 4 IC50 540.0 nM 10.1016/j.bmcl.2008.02.025
Homo sapiens Histone deacetylase 4 IC50 540.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 4 IC50 1000.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens Histone deacetylase 4 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 4 IC50 1000.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 4 IC50 1000.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens Histone deacetylase 4 IC50 1140.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase 4 IC50 1600.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 4 IC50 1600.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 4 IC50 2139.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 4 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 4 IC50 6200.0 nM 10.1021/jm100244y
Homo sapiens Histone deacetylase 4 IC50 6860.1 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 4 IC50 7800.0 nM 10.1021/ml5000959
Homo sapiens Histone deacetylase 4 IC50 8800.0 nM 10.1021/jm500303u
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.bmcl.2009.08.010
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 4 IC50 10000.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 4 IC50 12000.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 4 IC50 15056.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 4 IC50 30710.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 4 IC50 33000.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 4 IC50 33040.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 4 IC50 33330.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 4 IC50 37090.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 4 IC50 41000.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 4 IC50 42200.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 4 IC50 47800.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase 4 IC50 48300.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 4 IC50 50000.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 4 IC50 74000.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 4 IC50 76000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 4 IC50 76000.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 4 IC50 76000.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 4 IC50 100000.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 4 IC50 100000.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 4 IC50 100000.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 4 IC50 100000.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 4 IC50 12000000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/jm7011408
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/ml200136e
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 4 Inhibition 0.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 4 Inhibition 13.0 % 10.1016/j.bmcl.2008.02.025
Homo sapiens Histone deacetylase 4 Inhibition 21.5 % 10.1021/ml5000959
Homo sapiens Histone deacetylase 4 Inhibition 29.0 % 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 4 Inhibition 31.4 % 10.1016/j.bmcl.2008.03.055
Homo sapiens Histone deacetylase 4 Inhibition 37.2 % 10.1021/jm049002a
Homo sapiens Histone deacetylase 4 Inhibition 49.0 % 10.1039/C1MD00249J
Homo sapiens Histone deacetylase 4 Inhibition 50.0 % 10.1021/jm4008449
Homo sapiens Histone deacetylase 4 Inhibition nan % 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 4 Inhibition nan % 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 4 Inhibition nan % 10.1021/jm100244y
Homo sapiens Histone deacetylase 4 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 4 Ki 16.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 4 Ki 20.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 4 Ki 14000.0 nM 10.1016/j.bmcl.2017.02.050
Homo sapiens Histone deacetylase 4 Ki 28400.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase 4 Ki 30100.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase 4 Ki nan None 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 5 IC50 1.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 5 IC50 107.3 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 5 IC50 150.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 5 IC50 163.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 5 IC50 200.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 5 IC50 378.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 5 IC50 378.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 5 IC50 378.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 5 IC50 378.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 5 IC50 380.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 5 IC50 380.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 5 IC50 380.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 5 IC50 400.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 5 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 5 IC50 1000.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 5 IC50 1100.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 5 IC50 1100.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 5 IC50 1300.0 nM 10.1016/j.bmcl.2009.08.010
Homo sapiens Histone deacetylase 5 IC50 2180.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 5 IC50 2480.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 5 IC50 2580.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 5 IC50 3000.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase 5 IC50 4600.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 5 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 5 IC50 8750.0 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 5 IC50 8750.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 5 IC50 8750.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 5 IC50 10000.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 5 IC50 10510.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 5 IC50 11000.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 5 IC50 13800.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 5 IC50 15000.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 5 IC50 18440.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 5 IC50 20000.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 5 IC50 27000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 5 IC50 27200.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 5 IC50 27200.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 5 IC50 30000.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 5 IC50 33768.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 5 IC50 41500.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/jm7011408
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 5 Inhibition 0.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 5 Inhibition 40.0 % 10.1021/jm800079s
Homo sapiens Histone deacetylase 5 Inhibition 50.0 % 10.1021/jm4008449
Homo sapiens Histone deacetylase 5 Inhibition nan % 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 5 Ki 33.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 5 Ki 36.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 5 Ki 3600.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 5 Ki 12000.0 nM 10.1016/j.bmcl.2017.02.050
Homo sapiens Histone deacetylase 6 Activity 7.9 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 6 Activity 7.9 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 6 Activity 11.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 Activity 32.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 Activity 34.0 % 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 6 Activity 34.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 Activity 62.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 Activity 72.0 % 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 Activity 130.0 % 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 6 Activity nan None 10.1016/j.bmcl.2011.05.098
Homo sapiens Histone deacetylase 6 Activity nan None 10.1016/j.ejmech.2008.11.005
Homo sapiens Histone deacetylase 6 Activity nan None 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 6 Activity nan None 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 6 Activity nan None 10.1021/acs.jmedchem.9b00516
Homo sapiens Histone deacetylase 6 Activity nan None 10.1021/acsmedchemlett.8b00440
Homo sapiens Histone deacetylase 6 EC50 21.7 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 6 EC50 399.25 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase 6 EC50 430.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 6 EC50 1000.0 nM 10.1021/jm502011f
Homo sapiens Histone deacetylase 6 EC50 1030.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 6 FC 0.9 None 10.1016/j.ejmech.2021.113383
Homo sapiens Histone deacetylase 6 FC 1.3 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 6 FC 1.4 None 10.1021/jm500303u
Homo sapiens Histone deacetylase 6 FC 1.5 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 6 FC 1.61 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 1.62 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 1.71 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 1.72 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 1.9 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 FC 1.94 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 FC 2.06 None 10.1021/ml5000959
Homo sapiens Histone deacetylase 6 FC 2.07 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 2.07 None 10.1021/ml5000959
Homo sapiens Histone deacetylase 6 FC 3.64 None 10.1016/j.ejmech.2018.07.069
Homo sapiens Histone deacetylase 6 FC 5.0 None 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 FC 5.0 None 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 FC 11.9 None 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 FC 11.9 None 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 FC 27.6 None 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 FC 27.6 None 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 IC50 1.4 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 6 IC50 2.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 6 IC50 2.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 6 IC50 2.71 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 6 IC50 2.8 nM 10.1021/acsmedchemlett.7b00223
Homo sapiens Histone deacetylase 6 IC50 3.9 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 6 IC50 4.87 nM 10.1016/j.ejmech.2021.113893
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1021/acs.jmedchem.0c00079
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1021/acs.jmedchem.1c00420
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1021/jm300197a
Homo sapiens Histone deacetylase 6 IC50 5.8 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens Histone deacetylase 6 IC50 5.8 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 6 IC50 6.7 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 6 IC50 6.9 nM 10.1016/j.bmc.2018.06.016
Homo sapiens Histone deacetylase 6 IC50 7.1 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 6 IC50 7.1 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 6 IC50 7.25 nM 10.1016/j.ejmech.2022.114115
Homo sapiens Histone deacetylase 6 IC50 7.7 nM 10.1016/j.bmc.2017.05.058
Homo sapiens Histone deacetylase 6 IC50 7.76 nM 10.1016/j.ejmech.2017.04.017
Homo sapiens Histone deacetylase 6 IC50 7.9 nM 10.1016/j.bmc.2021.116510
Homo sapiens Histone deacetylase 6 IC50 7.9 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 8.8 nM 10.1016/j.bmc.2017.12.041
Homo sapiens Histone deacetylase 6 IC50 9.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 6 IC50 9.1 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 6 IC50 9.2 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Histone deacetylase 6 IC50 9.3 nM 10.1016/j.ejmech.2010.06.035
Homo sapiens Histone deacetylase 6 IC50 9.4 nM 10.1021/jm401899x
Homo sapiens Histone deacetylase 6 IC50 9.44 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 6 IC50 10.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens Histone deacetylase 6 IC50 10.8 nM 10.1016/j.bmc.2016.10.006
Homo sapiens Histone deacetylase 6 IC50 11.0 nM 10.1016/j.bmcl.2017.01.044
Homo sapiens Histone deacetylase 6 IC50 11.0 nM 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 6 IC50 11.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 6 IC50 12.0 nM 10.1016/j.ejmech.2021.113383
Homo sapiens Histone deacetylase 6 IC50 12.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 6 IC50 12.6 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 6 IC50 13.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens Histone deacetylase 6 IC50 13.0 nM 10.1016/j.bmcl.2018.12.052
Homo sapiens Histone deacetylase 6 IC50 13.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens Histone deacetylase 6 IC50 13.5 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens Histone deacetylase 6 IC50 14.0 nM 10.1016/j.bmc.2021.116185
Homo sapiens Histone deacetylase 6 IC50 14.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens Histone deacetylase 6 IC50 14.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 6 IC50 14.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 6 IC50 14.5 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 6 IC50 15.1 nM 10.1016/j.ejmech.2021.113870
Homo sapiens Histone deacetylase 6 IC50 16.0 nM 10.1021/acsmedchemlett.8b00487
Homo sapiens Histone deacetylase 6 IC50 16.3 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 6 IC50 17.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase 6 IC50 17.2 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 6 IC50 17.4 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 18.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 6 IC50 18.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 6 IC50 18.0 nM 10.1021/ml300081u
Homo sapiens Histone deacetylase 6 IC50 18.5 nM 10.1021/acs.jmedchem.1c01155
Homo sapiens Histone deacetylase 6 IC50 18.55 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase 6 IC50 18.95 nM 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 IC50 19.0 nM 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 6 IC50 19.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens Histone deacetylase 6 IC50 19.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens Histone deacetylase 6 IC50 19.0 nM 10.1021/jm800093c
Homo sapiens Histone deacetylase 6 IC50 19.4 nM 10.1021/jm400179b
Homo sapiens Histone deacetylase 6 IC50 19.4 nM None
Homo sapiens Histone deacetylase 6 IC50 19.8 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens Histone deacetylase 6 IC50 19.8 nM 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 6 IC50 19.8 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.bmcl.2018.03.009
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1021/acs.jmedchem.6b00157
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 6 IC50 20.2 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 6 IC50 21.0 nM 10.1016/j.bmcl.2020.127023
Homo sapiens Histone deacetylase 6 IC50 21.0 nM 10.1016/j.ejmech.2019.07.026
Homo sapiens Histone deacetylase 6 IC50 21.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 6 IC50 21.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 6 IC50 21.5 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 6 IC50 21.6 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 6 IC50 23.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 6 IC50 23.0 nM 10.1021/ml500327q
Homo sapiens Histone deacetylase 6 IC50 24.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase 6 IC50 24.0 nM 10.1021/acs.jmedchem.0c00102
Homo sapiens Histone deacetylase 6 IC50 24.2 nM 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 6 IC50 24.25 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Histone deacetylase 6 IC50 24.4 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens Histone deacetylase 6 IC50 25.0 nM 10.1016/j.bmc.2018.10.022
Homo sapiens Histone deacetylase 6 IC50 25.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 6 IC50 25.0 nM 10.1021/jm100665z
Homo sapiens Histone deacetylase 6 IC50 25.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 6 IC50 25.6 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 6 IC50 26.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 6 IC50 26.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase 6 IC50 26.9 nM 10.1016/j.ejmech.2021.113526
Homo sapiens Histone deacetylase 6 IC50 27.0 nM 10.1016/j.bmcl.2013.03.108
Homo sapiens Histone deacetylase 6 IC50 27.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 6 IC50 27.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 6 IC50 27.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens Histone deacetylase 6 IC50 27.0 nM 10.1021/jm200799p
Homo sapiens Histone deacetylase 6 IC50 28.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens Histone deacetylase 6 IC50 28.0 nM 10.1021/acs.jmedchem.0c01763
Homo sapiens Histone deacetylase 6 IC50 28.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens Histone deacetylase 6 IC50 28.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 6 IC50 28.0 nM 10.1021/jm900125m
Homo sapiens Histone deacetylase 6 IC50 28.6 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 6 IC50 28.6 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 6 IC50 28.9 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 6 IC50 29.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 6 IC50 29.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 6 IC50 29.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens Histone deacetylase 6 IC50 29.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 6 IC50 29.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 6 IC50 29.7 nM 10.1021/acs.jmedchem.5b00099
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1016/j.bmcl.2017.08.011
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1016/j.ejmech.2017.08.041
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1021/jm101177s
Homo sapiens Histone deacetylase 6 IC50 30.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 6 IC50 31.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 6 IC50 31.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 6 IC50 32.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 6 IC50 32.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 32.0 nM 10.1039/C4MD00203B
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1016/j.bmcl.2021.128207
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1016/j.ejmech.2021.113874
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1021/acs.jmedchem.1c00184
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 6 IC50 33.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens Histone deacetylase 6 IC50 33.1 nM 10.1016/j.bmcl.2020.127638
Homo sapiens Histone deacetylase 6 IC50 33.1 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 6 IC50 33.4 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens Histone deacetylase 6 IC50 34.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens Histone deacetylase 6 IC50 34.0 nM 10.1016/j.bmcl.2011.06.046
Homo sapiens Histone deacetylase 6 IC50 34.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 34.0 nM 10.1021/jm400467w
Homo sapiens Histone deacetylase 6 IC50 34.3 nM 10.1039/C8MD00454D
Homo sapiens Histone deacetylase 6 IC50 35.0 nM 10.1016/j.bmcl.2017.06.027
Homo sapiens Histone deacetylase 6 IC50 35.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 6 IC50 36.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens Histone deacetylase 6 IC50 36.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 IC50 38.0 nM None
Homo sapiens Histone deacetylase 6 IC50 38.9 nM 10.1021/np400198r
Homo sapiens Histone deacetylase 6 IC50 39.0 nM 10.1016/j.bmc.2022.117028
Homo sapiens Histone deacetylase 6 IC50 39.9 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 6 IC50 40.0 nM 10.1016/j.ejmech.2021.113745
Homo sapiens Histone deacetylase 6 IC50 40.0 nM 10.1021/acs.jmedchem.9b01888
Homo sapiens Histone deacetylase 6 IC50 41.9 nM 10.1021/acsmedchemlett.9b00071
Homo sapiens Histone deacetylase 6 IC50 42.0 nM 10.1021/acs.jmedchem.2c01418
Homo sapiens Histone deacetylase 6 IC50 42.0 nM 10.1021/acs.jmedchem.5b01478
Homo sapiens Histone deacetylase 6 IC50 43.0 nM 10.1016/j.bmcl.2008.02.025
Homo sapiens Histone deacetylase 6 IC50 43.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 6 IC50 43.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens Histone deacetylase 6 IC50 43.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 6 IC50 43.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 6 IC50 46.48 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 6 IC50 47.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 6 IC50 49.0 nM 10.1016/j.ejmech.2022.114582
Homo sapiens Histone deacetylase 6 IC50 50.0 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 6 IC50 50.0 nM 10.1016/j.ejmech.2020.113065
Homo sapiens Histone deacetylase 6 IC50 50.0 nM 10.1039/C3MD00285C
Homo sapiens Histone deacetylase 6 IC50 51.0 nM 10.1021/acs.jmedchem.1c01119
Homo sapiens Histone deacetylase 6 IC50 52.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 6 IC50 52.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase 6 IC50 53.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 6 IC50 53.0 nM 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 IC50 54.0 nM 10.1021/jm502011f
Homo sapiens Histone deacetylase 6 IC50 55.0 nM 10.1016/j.ejmech.2018.09.018
Homo sapiens Histone deacetylase 6 IC50 57.3 nM 10.1021/jm200620f
Homo sapiens Histone deacetylase 6 IC50 59.3 nM 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 6 IC50 60.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens Histone deacetylase 6 IC50 60.0 nM 10.1021/jm500303u
Homo sapiens Histone deacetylase 6 IC50 63.0 nM 10.1021/jm401877m
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens Histone deacetylase 6 IC50 70.0 nM 10.1016/j.bmc.2013.09.023
Homo sapiens Histone deacetylase 6 IC50 70.0 nM 10.1016/j.bmcl.2015.09.006
Homo sapiens Histone deacetylase 6 IC50 70.0 nM 10.1016/j.bmcl.2015.12.007
Homo sapiens Histone deacetylase 6 IC50 70.8 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 6 IC50 70.83 nM 10.1016/j.bmc.2019.06.036
Homo sapiens Histone deacetylase 6 IC50 70.83 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 6 IC50 71.0 nM 10.1016/j.bmc.2022.117067
Homo sapiens Histone deacetylase 6 IC50 72.34 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 6 IC50 72.42 nM 10.1016/j.bmcl.2023.129305
Homo sapiens Histone deacetylase 6 IC50 74.0 nM 10.1016/j.bmcl.2011.08.027
Homo sapiens Histone deacetylase 6 IC50 74.0 nM 10.1016/j.bmcl.2012.09.093
Homo sapiens Histone deacetylase 6 IC50 74.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens Histone deacetylase 6 IC50 75.9 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 6 IC50 76.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase 6 IC50 78.3 nM 10.1021/acs.jmedchem.0c00442
Homo sapiens Histone deacetylase 6 IC50 78.98 nM 10.1016/j.bmc.2014.08.030
Homo sapiens Histone deacetylase 6 IC50 78.98 nM 10.1016/j.bmc.2015.06.071
Homo sapiens Histone deacetylase 6 IC50 82.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 6 IC50 83.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 6 IC50 85.0 nM 10.1016/j.bmcl.2010.09.100
Homo sapiens Histone deacetylase 6 IC50 85.5 nM 10.1021/jm100507q
Homo sapiens Histone deacetylase 6 IC50 85.5 nM 10.1021/jm801128g
Homo sapiens Histone deacetylase 6 IC50 88.0 nM 10.1021/acs.jmedchem.2c01659
Homo sapiens Histone deacetylase 6 IC50 90.0 nM 10.1016/j.bmc.2013.03.049
Homo sapiens Histone deacetylase 6 IC50 90.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 6 IC50 90.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase 6 IC50 90.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 6 IC50 90.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 6 IC50 91.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 6 IC50 96.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 6 IC50 98.0 nM 10.1039/C5MD00247H
Homo sapiens Histone deacetylase 6 IC50 100.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Histone deacetylase 6 IC50 100.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens Histone deacetylase 6 IC50 100.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 6 IC50 100.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 6 IC50 102.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 6 IC50 102.0 nM 10.1021/acsmedchemlett.9b00287
Homo sapiens Histone deacetylase 6 IC50 104.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 IC50 105.1 nM 10.1016/j.ejmech.2017.01.035
Homo sapiens Histone deacetylase 6 IC50 108.0 nM 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 6 IC50 108.0 nM 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 6 IC50 109.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens Histone deacetylase 6 IC50 110.0 nM 10.1016/j.ejmech.2016.06.023
Homo sapiens Histone deacetylase 6 IC50 110.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens Histone deacetylase 6 IC50 110.6 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 6 IC50 118.0 nM 10.1021/ml300366t
Homo sapiens Histone deacetylase 6 IC50 120.0 nM 10.1016/j.bmcl.2012.05.123
Homo sapiens Histone deacetylase 6 IC50 130.0 nM 10.1016/j.bmc.2018.08.008
Homo sapiens Histone deacetylase 6 IC50 140.0 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 6 IC50 144.0 nM 10.1016/j.ejmech.2015.04.014
Homo sapiens Histone deacetylase 6 IC50 144.0 nM 10.1021/jm301769u
Homo sapiens Histone deacetylase 6 IC50 144.0 nM 10.1021/jm401225q
Homo sapiens Histone deacetylase 6 IC50 150.0 nM 10.1016/j.bmc.2020.115639
Homo sapiens Histone deacetylase 6 IC50 154.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 160.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 160.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 6 IC50 169.5 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 6 IC50 179.62 nM 10.1016/j.ejmech.2016.02.003
Homo sapiens Histone deacetylase 6 IC50 195.0 nM 10.1021/jm101605z
Homo sapiens Histone deacetylase 6 IC50 196.0 nM 10.1021/jm0703800
Homo sapiens Histone deacetylase 6 IC50 200.0 nM 10.1016/j.bmcl.2008.11.081
Homo sapiens Histone deacetylase 6 IC50 200.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 6 IC50 202.11 nM 10.1016/j.bmc.2015.05.048
Homo sapiens Histone deacetylase 6 IC50 210.0 nM 10.1021/jm2016182
Homo sapiens Histone deacetylase 6 IC50 210.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase 6 IC50 226.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 6 IC50 241.0 nM 10.1021/acs.jmedchem.9b00946
Homo sapiens Histone deacetylase 6 IC50 250.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 6 IC50 270.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase 6 IC50 340.0 nM 10.1021/acs.jmedchem.0c00931
Homo sapiens Histone deacetylase 6 IC50 350.0 nM 10.1016/j.bmc.2010.03.078
Homo sapiens Histone deacetylase 6 IC50 350.0 nM 10.1016/j.bmc.2015.11.005
Homo sapiens Histone deacetylase 6 IC50 400.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 6 IC50 400.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 6 IC50 580.0 nM None
Homo sapiens Histone deacetylase 6 IC50 800.0 nM 10.1016/j.bmcl.2009.10.028
Homo sapiens Histone deacetylase 6 IC50 860.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase 6 IC50 2310.0 nM 10.1016/j.bmcl.2014.08.060
Homo sapiens Histone deacetylase 6 IC50 5600.0 nM 10.1021/ml5000959
Homo sapiens Histone deacetylase 6 IC50 5800.0 nM 10.1021/acs.jmedchem.0c01922
Homo sapiens Histone deacetylase 6 IC50 33000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 6 IC50 nan None 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 6 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 6 IC50 nan None 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 6 Inhibition 40.7 % 10.1021/ml5000959
Homo sapiens Histone deacetylase 6 Inhibition 54.0 % 10.1016/j.bmc.2022.117067
Homo sapiens Histone deacetylase 6 Inhibition 80.2 % 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 6 Inhibition 88.4 % 10.1016/j.ejmech.2021.113870
Homo sapiens Histone deacetylase 6 Inhibition 91.0 % 10.1016/j.bmc.2017.12.041
Homo sapiens Histone deacetylase 6 Inhibition 97.2 % 10.1021/jm900187v
Homo sapiens Histone deacetylase 6 Inhibition 97.46 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 97.7 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 6 Inhibition 98.05 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 99.0 % 10.1021/acsmedchemlett.1c00504
Homo sapiens Histone deacetylase 6 Inhibition 99.6 % 10.1016/j.ejmech.2021.113870
Homo sapiens Histone deacetylase 6 Inhibition 100.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 6 Inhibition 100.0 % 10.1016/j.bmc.2017.05.062
Homo sapiens Histone deacetylase 6 Inhibition 104.39 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2016.12.032
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2018.07.026
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2020.115345
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2020.115639
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmcl.2016.09.058
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmcl.2019.06.006
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2017.01.035
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2017.10.022
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2021.113383
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.ejmech.2021.113971
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.2c00853
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b00157
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b00579
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b00772
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b00908
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.7b00678
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acsmedchemlett.8b00507
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm101177s
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm301769u
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm400390r
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm401225q
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm401899x
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm502011f
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/ml300366t
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 6 Kd 300.0 nM 10.1016/j.bmc.2011.11.041
Homo sapiens Histone deacetylase 6 Ki 1.0 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 6 Ki 1.6 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 6 Ki 17.7 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 6 Ki 18.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 6 Ki 20.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase 6 Ki 21.0 nM 10.1021/jm7015254
Homo sapiens Histone deacetylase 6 Ki 22.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 6 Ki 22.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 6 Ki 29.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 6 Ki 35.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 6 Ki 40.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase 6 Ki 126.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 6 Ratio 1.12 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 1.89 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 2.57 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 2.59 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 2.78 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 3.36 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 3.79 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 Ratio 5.1 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 5.73 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 6.21 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 6.89 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 8.78 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 9.52 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 Ratio 9.97 None 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 6 Ratio 10.09 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 14.23 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 18.36 None 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 6 Ratio 68.15 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 78.8 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 146.1 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 Ratio 309.78 None 10.1016/j.ejmech.2020.112338
Homo sapiens Histone deacetylase 6 TIME 0.7 hr 10.1021/acs.jmedchem.1c01585
Homo sapiens Histone deacetylase 7 Activity nan None 10.1021/ml200136e
Homo sapiens Histone deacetylase 7 FC 2.0 None 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 FC 2.5 None 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 FC 6.0 None 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 IC50 1.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 7 IC50 21.6 nM 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 7 IC50 34.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 7 IC50 34.4 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 7 IC50 75.2 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 7 IC50 102.4 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 7 IC50 200.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 7 IC50 344.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 7 IC50 344.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 7 IC50 344.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 7 IC50 500.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 IC50 800.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 7 IC50 800.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 7 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 7 IC50 1000.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 7 IC50 2480.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 7 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 7 IC50 6110.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 7 IC50 8200.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 7 IC50 9600.0 nM 10.1021/acs.jmedchem.0c01967
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1016/j.bmcl.2009.08.010
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 7 IC50 10000.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 7 IC50 12522.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 7 IC50 21000.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 7 IC50 29290.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 7 IC50 29760.0 nM 10.1039/C3MD00285C
Homo sapiens Histone deacetylase 7 IC50 30000.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 7 IC50 33000.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 7 IC50 33330.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 7 IC50 35160.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 7 IC50 38900.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens Histone deacetylase 7 IC50 38900.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 7 IC50 40000.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 7 IC50 41000.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 7 IC50 41800.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 7 IC50 54910.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 7 IC50 61020.0 nM 10.1016/j.ejmech.2022.114582
Homo sapiens Histone deacetylase 7 IC50 105000.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 7 IC50 105000.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 7 IC50 110000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1021/jm7011408
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 7 Inhibition 2.9 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 7 Inhibition 34.0 % 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 7 Inhibition 50.0 % 10.1021/jm4008449
Homo sapiens Histone deacetylase 7 Inhibition nan % 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 7 Inhibition nan % 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 Kd 36000.0 nM 10.1016/j.bmc.2011.11.041
Homo sapiens Histone deacetylase 7 Ki 129.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 7 Ki nan None 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 8 Activity 63.3 % None
Homo sapiens Histone deacetylase 8 Activity nan None 10.1021/jm8005355
Homo sapiens Histone deacetylase 8 IC50 1.0 nM 10.1016/j.bmcl.2008.09.003
Homo sapiens Histone deacetylase 8 IC50 5.5 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase 8 IC50 8.8 nM 10.1021/ml500327q
Homo sapiens Histone deacetylase 8 IC50 10.0 nM 10.1016/j.bmc.2021.116185
Homo sapiens Histone deacetylase 8 IC50 18.55 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Histone deacetylase 8 IC50 44.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens Histone deacetylase 8 IC50 45.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens Histone deacetylase 8 IC50 82.96 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 8 IC50 83.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 8 IC50 110.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 8 IC50 110.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 8 IC50 119.0 nM 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 8 IC50 161.0 nM 10.1016/j.bmc.2022.117028
Homo sapiens Histone deacetylase 8 IC50 172.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 8 IC50 172.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 8 IC50 180.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 8 IC50 188.0 nM 10.1016/j.ejmech.2021.113363
Homo sapiens Histone deacetylase 8 IC50 191.5 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens Histone deacetylase 8 IC50 193.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens Histone deacetylase 8 IC50 195.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 8 IC50 205.2 nM 10.1016/j.ejmech.2020.112868
Homo sapiens Histone deacetylase 8 IC50 230.0 nM 10.1016/j.bmcl.2017.06.027
Homo sapiens Histone deacetylase 8 IC50 230.0 nM 10.1039/C4MD00203B
Homo sapiens Histone deacetylase 8 IC50 232.0 nM 10.1016/j.ejmech.2015.04.014
Homo sapiens Histone deacetylase 8 IC50 232.0 nM 10.1021/jm301769u
Homo sapiens Histone deacetylase 8 IC50 232.0 nM 10.1021/jm401225q
Homo sapiens Histone deacetylase 8 IC50 232.0 nM None
Homo sapiens Histone deacetylase 8 IC50 239.0 nM 10.1016/j.ejmech.2022.114228
Homo sapiens Histone deacetylase 8 IC50 240.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 8 IC50 240.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Histone deacetylase 8 IC50 240.0 nM 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1016/j.bmcl.2013.11.072
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1016/j.ejmech.2014.01.056
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 8 IC50 243.0 nM 10.1021/jm5008209
Homo sapiens Histone deacetylase 8 IC50 250.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens Histone deacetylase 8 IC50 261.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Histone deacetylase 8 IC50 272.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 8 IC50 290.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Histone deacetylase 8 IC50 300.0 nM 10.1016/j.ejmech.2016.06.023
Homo sapiens Histone deacetylase 8 IC50 300.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 8 IC50 300.0 nM 10.1021/np4005745
Homo sapiens Histone deacetylase 8 IC50 300.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 8 IC50 302.6 nM 10.1021/acs.jmedchem.1c01993
Homo sapiens Histone deacetylase 8 IC50 306.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 8 IC50 310.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 8 IC50 310.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 8 IC50 328.0 nM 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 8 IC50 330.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Histone deacetylase 8 IC50 330.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens Histone deacetylase 8 IC50 370.0 nM 10.1016/j.ejmech.2018.12.039
Homo sapiens Histone deacetylase 8 IC50 400.0 nM 10.1016/j.ejmech.2021.113745
Homo sapiens Histone deacetylase 8 IC50 400.0 nM 10.1021/acs.jmedchem.5b01478
Homo sapiens Histone deacetylase 8 IC50 400.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens Histone deacetylase 8 IC50 410.0 nM 10.1016/j.bmcl.2007.11.047
Homo sapiens Histone deacetylase 8 IC50 425.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Histone deacetylase 8 IC50 425.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens Histone deacetylase 8 IC50 425.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens Histone deacetylase 8 IC50 440.0 nM 10.1016/j.bmcl.2012.08.104
Homo sapiens Histone deacetylase 8 IC50 440.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 440.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 8 IC50 440.0 nM 10.1021/jm9005077
Homo sapiens Histone deacetylase 8 IC50 442.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens Histone deacetylase 8 IC50 442.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens Histone deacetylase 8 IC50 497.0 nM 10.1021/acs.jmedchem.1c00420
Homo sapiens Histone deacetylase 8 IC50 497.0 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens Histone deacetylase 8 IC50 497.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 8 IC50 500.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens Histone deacetylase 8 IC50 500.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 8 IC50 540.0 nM 10.1016/j.bmcl.2017.06.033
Homo sapiens Histone deacetylase 8 IC50 540.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens Histone deacetylase 8 IC50 540.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 8 IC50 540.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 8 IC50 540.0 nM 10.1021/acsmedchemlett.6b00124
Homo sapiens Histone deacetylase 8 IC50 543.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens Histone deacetylase 8 IC50 640.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 8 IC50 645.0 nM 10.1016/j.ejmech.2021.113392
Homo sapiens Histone deacetylase 8 IC50 646.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Histone deacetylase 8 IC50 660.0 nM 10.1021/jm502011f
Homo sapiens Histone deacetylase 8 IC50 669.0 nM 10.1021/acsmedchemlett.8b00487
Homo sapiens Histone deacetylase 8 IC50 682.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 8 IC50 700.0 nM 10.1016/j.ejmech.2011.08.045
Homo sapiens Histone deacetylase 8 IC50 776.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens Histone deacetylase 8 IC50 780.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens Histone deacetylase 8 IC50 780.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 8 IC50 780.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 794.33 nM 10.1021/acs.jmedchem.8b01936
Homo sapiens Histone deacetylase 8 IC50 820.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 8 IC50 827.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 8 IC50 960.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 8 IC50 980.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 8 IC50 1000.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens Histone deacetylase 8 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 8 IC50 1000.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 8 IC50 1020.0 nM 10.1016/j.bmcl.2023.129148
Homo sapiens Histone deacetylase 8 IC50 1020.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 8 IC50 1020.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 8 IC50 1020.0 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 8 IC50 1030.0 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 8 IC50 1069.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 8 IC50 1100.0 nM 10.1016/j.bmcl.2011.01.134
Homo sapiens Histone deacetylase 8 IC50 1140.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 8 IC50 1152.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens Histone deacetylase 8 IC50 1200.0 nM 10.1021/jm100665z
Homo sapiens Histone deacetylase 8 IC50 1200.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase 8 IC50 1260.0 nM 10.1021/acs.jmedchem.6b01538
Homo sapiens Histone deacetylase 8 IC50 1260.0 nM 10.1021/acs.jmedchem.7b00197
Homo sapiens Histone deacetylase 8 IC50 1279.3 nM 10.1016/j.ejmech.2021.113526
Homo sapiens Histone deacetylase 8 IC50 1320.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Histone deacetylase 8 IC50 1337.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 8 IC50 1350.0 nM 10.1016/j.bmcl.2013.03.084
Homo sapiens Histone deacetylase 8 IC50 1374.7 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 8 IC50 1410.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 1480.0 nM 10.1007/s00044-010-9519-7
Homo sapiens Histone deacetylase 8 IC50 1480.0 nM 10.1016/j.bmc.2010.01.060
Homo sapiens Histone deacetylase 8 IC50 1480.0 nM 10.1016/j.bmc.2016.09.022
Homo sapiens Histone deacetylase 8 IC50 1500.0 nM 10.1016/j.bmcl.2014.10.022
Homo sapiens Histone deacetylase 8 IC50 1500.0 nM 10.1021/jm300837y
Homo sapiens Histone deacetylase 8 IC50 1524.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 8 IC50 1532.0 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 8 IC50 1600.0 nM 10.1016/j.bmc.2012.08.014
Homo sapiens Histone deacetylase 8 IC50 1680.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens Histone deacetylase 8 IC50 1680.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens Histone deacetylase 8 IC50 1700.0 nM 10.1016/j.bmcl.2009.04.011
Homo sapiens Histone deacetylase 8 IC50 1700.0 nM 10.1021/jm800079s
Homo sapiens Histone deacetylase 8 IC50 1700.0 nM 10.1021/jm900125m
Homo sapiens Histone deacetylase 8 IC50 1700.0 nM 10.1021/jm9004303
Homo sapiens Histone deacetylase 8 IC50 1800.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 8 IC50 1860.0 nM 10.1021/jm100507q
Homo sapiens Histone deacetylase 8 IC50 1860.0 nM 10.1021/jm801128g
Homo sapiens Histone deacetylase 8 IC50 1890.0 nM 10.1021/acs.jmedchem.5b01493
Homo sapiens Histone deacetylase 8 IC50 1989.0 nM 10.1016/j.bmcl.2013.03.108
Homo sapiens Histone deacetylase 8 IC50 1989.0 nM 10.1021/jm200799p
Homo sapiens Histone deacetylase 8 IC50 2000.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 8 IC50 2000.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens Histone deacetylase 8 IC50 2000.0 nM 10.1021/acsmedchemlett.6b00239
Homo sapiens Histone deacetylase 8 IC50 2000.0 nM 10.1021/ml200136e
Homo sapiens Histone deacetylase 8 IC50 2139.0 nM 10.1016/j.bmc.2017.08.029
Homo sapiens Histone deacetylase 8 IC50 2185.0 nM 10.1016/j.bmcl.2009.10.028
Homo sapiens Histone deacetylase 8 IC50 2260.0 nM 10.1016/j.ejmech.2020.113095
Homo sapiens Histone deacetylase 8 IC50 2290.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 2290.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 8 IC50 2736.9 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens Histone deacetylase 8 IC50 2800.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens Histone deacetylase 8 IC50 2800.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 2800.0 nM 10.1021/jm400467w
Homo sapiens Histone deacetylase 8 IC50 2880.0 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 8 IC50 3295.01 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens Histone deacetylase 8 IC50 3344.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Histone deacetylase 8 IC50 3400.1 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 8 IC50 3700.0 nM 10.1016/j.bmc.2016.02.005
Homo sapiens Histone deacetylase 8 IC50 3899.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens Histone deacetylase 8 IC50 3970.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens Histone deacetylase 8 IC50 4300.0 nM 10.1016/j.ejmech.2019.07.026
Homo sapiens Histone deacetylase 8 IC50 4800.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens Histone deacetylase 8 IC50 4890.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 8 IC50 4890.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 8 IC50 5000.0 nM 10.1016/j.bmcl.2020.127638
Homo sapiens Histone deacetylase 8 IC50 5000.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase 8 IC50 5000.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens Histone deacetylase 8 IC50 5120.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens Histone deacetylase 8 IC50 5150.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens Histone deacetylase 8 IC50 5300.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens Histone deacetylase 8 IC50 5600.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens Histone deacetylase 8 IC50 7300.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens Histone deacetylase 8 IC50 7300.0 nM 10.1021/acsmedchemlett.7b00414
Homo sapiens Histone deacetylase 8 IC50 7468.5 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens Histone deacetylase 8 IC50 9590.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase 8 IC50 10000.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens Histone deacetylase 8 IC50 11900.0 nM 10.1021/acs.jmedchem.9b01489
Homo sapiens Histone deacetylase 8 IC50 540000.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens Histone deacetylase 8 IC50 nan None 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 8 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 8 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 8 IC50 nan None 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 8 Inhibition 10.7 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 8 Inhibition 31.9 % 10.1021/jm300837y
Homo sapiens Histone deacetylase 8 Inhibition 35.0 % 10.1021/jm300837y
Homo sapiens Histone deacetylase 8 Inhibition 78.0 % 10.1016/j.bmc.2017.12.041
Homo sapiens Histone deacetylase 8 Inhibition 94.2 % 10.1021/jm900187v
Homo sapiens Histone deacetylase 8 Inhibition 100.0 % 10.1016/j.bmcl.2012.06.017
Homo sapiens Histone deacetylase 8 Inhibition nan % 10.1016/j.ejmech.2019.111672
Homo sapiens Histone deacetylase 8 Inhibition nan % 10.1021/acs.jmedchem.5b00539
Homo sapiens Histone deacetylase 8 Inhibition nan % 10.1021/acsmedchemlett.1c00504
Homo sapiens Histone deacetylase 8 Inhibition nan % 10.1039/C6MD00681G
Homo sapiens Histone deacetylase 8 Ka 1.72 10'3/M 10.1039/c4md00401a
Homo sapiens Histone deacetylase 8 Kd 580.0 nM 10.1039/c4md00401a
Homo sapiens Histone deacetylase 8 Kd 2900.0 nM 10.1016/j.bmc.2011.11.041
Homo sapiens Histone deacetylase 8 Ki 173.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 8 Ki 205.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 8 Ki 230.0 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 8 Ki 396.0 nM 10.1021/jm9005077
Homo sapiens Histone deacetylase 8 Ki 480.0 nM 10.1016/j.ejmech.2017.09.075
Homo sapiens Histone deacetylase 8 Ki 480.0 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 8 Ki 480.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 8 Ki 700.0 nM 10.1021/jm4008449
Homo sapiens Histone deacetylase 8 Ki 700.0 nM 10.1021/jm501399d
Homo sapiens Histone deacetylase 8 Ki 5330.0 nM 10.1016/j.bmc.2019.115108
Homo sapiens Histone deacetylase 8 Ki 15700.0 nM 10.1016/j.bmc.2019.07.052
Homo sapiens Histone deacetylase 9 IC50 20.0 nM 10.1021/jm101373a
Homo sapiens Histone deacetylase 9 IC50 38.0 nM 10.1016/j.bmc.2014.05.001
Homo sapiens Histone deacetylase 9 IC50 38.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 9 IC50 78.0 nM 10.1016/j.ejmech.2020.112887
Homo sapiens Histone deacetylase 9 IC50 107.2 nM 10.1016/j.ejmech.2008.06.020
Homo sapiens Histone deacetylase 9 IC50 200.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens Histone deacetylase 9 IC50 200.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 9 IC50 316.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 9 IC50 316.0 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 9 IC50 316.0 nM 10.1021/jm401536b
Homo sapiens Histone deacetylase 9 IC50 320.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens Histone deacetylase 9 IC50 1000.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens Histone deacetylase 9 IC50 1000.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Histone deacetylase 9 IC50 3100.0 nM 10.1016/j.ejmech.2016.05.047
Homo sapiens Histone deacetylase 9 IC50 3100.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 9 IC50 3570.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens Histone deacetylase 9 IC50 5000.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens Histone deacetylase 9 IC50 7372.8 nM 10.1016/j.bmcl.2022.128797
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Histone deacetylase 9 IC50 10000.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens Histone deacetylase 9 IC50 15600.0 nM 10.1021/ml300371t
Homo sapiens Histone deacetylase 9 IC50 15830.0 nM 10.1016/j.ejmech.2021.113419
Homo sapiens Histone deacetylase 9 IC50 22800.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens Histone deacetylase 9 IC50 32260.0 nM 10.1016/j.ejmech.2020.112193
Homo sapiens Histone deacetylase 9 IC50 33000.0 nM 10.1021/jm400390r
Homo sapiens Histone deacetylase 9 IC50 33330.0 nM 10.1021/jm301355j
Homo sapiens Histone deacetylase 9 IC50 49000.0 nM 10.1021/jm4011884
Homo sapiens Histone deacetylase 9 IC50 51290.0 nM 10.1016/j.ejmech.2018.12.056
Homo sapiens Histone deacetylase 9 IC50 64000.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens Histone deacetylase 9 IC50 80030.0 nM 10.1039/C3MD00285C
Homo sapiens Histone deacetylase 9 IC50 140000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 9 IC50 141000.0 nM 10.1021/jm5008962
Homo sapiens Histone deacetylase 9 IC50 141000.0 nM 10.1021/ml400175d
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/acs.jmedchem.0c02161
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/acs.jmedchem.8b00189
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/jm7011408
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/ml200136e
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1039/C4MD00211C
Homo sapiens Histone deacetylase 9 Inhibition 14.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 9 Inhibition 25.0 % 10.1016/j.ejmech.2015.11.014
Homo sapiens Histone deacetylase 9 Inhibition 50.0 % 10.1021/jm4008449
Homo sapiens Histone deacetylase 9 Inhibition nan % 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 9 Ki 49.0 nM 10.1021/jm2003552
Homo sapiens Histone deacetylase 9 Ki 65.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens Histone deacetylase 9 Ki 2000.0 nM 10.1021/jm7015254
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 10.0 nM 10.1016/s0960-894x(02)00754-0
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 11.0 nM 10.1016/j.bmcl.2016.08.073
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 49.0 nM 10.1016/j.bmcl.2009.10.028
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 65.0 nM 10.1021/jm200799p
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 65.0 nM 10.1021/jm801128g
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 91.0 nM 10.1016/j.bmc.2016.02.005
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 107.8 nM 10.1016/j.bmc.2015.06.015
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 110.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 110.0 nM 10.1021/acs.jmedchem.5b00317
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 120.0 nM 10.1016/j.ejmech.2015.11.021
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 121.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 130.0 nM 10.1016/j.bmc.2014.01.045
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 138.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 140.0 nM 10.1016/j.bmcl.2003.07.012
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 140.0 nM 10.1039/C4MD00203B
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 143.0 nM 10.1016/s0960-894x(03)00301-9
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 159.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 161.0 nM 10.1016/j.bmc.2015.06.024
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 190.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 193.0 nM 10.1016/j.bmc.2015.07.008
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 213.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 416.0 nM 10.1016/j.bmc.2014.09.039
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 500.0 nM 10.1016/j.ejmech.2009.06.010
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) IC50 176600.0 nM 10.1016/j.bmc.2015.09.013
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) Inhibition 88.0 % 10.1039/C4MD00203B
Homo sapiens Histone deacetylase (HDAC1 and HDAC2) Inhibition nan % 10.1016/j.ejmech.2021.113971
Homo sapiens Histone-lysine N-methyltransferase EZH2 FC 0.4 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone-lysine N-methyltransferase EZH2 FC 0.7 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone-lysine N-methyltransferase EZH2 FC 1.2 None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone-lysine N-methyltransferase EZH2 IC50 nan None 10.1021/acsmedchemlett.0c00014
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 IC50 10000.0 nM 10.1021/acs.jmedchem.0c02255
Homo sapiens HL-60 Activity 1.94 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 2.07 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 2.36 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 2.41 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 2.42 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 4.0 % 10.1016/j.bmcl.2014.08.007
Homo sapiens HL-60 Activity 5.02 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 5.34 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 5.87 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 8.95 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 12.9 % 10.1021/acs.jmedchem.7b00322
Homo sapiens HL-60 Activity 12.96 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 21.0 % 10.1021/jm00008a020
Homo sapiens HL-60 Activity 39.71 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 43.31 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 49.4 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 75.6 % 10.1021/acs.jmedchem.7b00322
Homo sapiens HL-60 Activity 82.27 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 86.69 % 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 Activity 96.0 % 10.1016/j.bmcl.2014.08.007
Homo sapiens HL-60 Activity nan None 10.1021/acs.jmedchem.1c01119
Homo sapiens HL-60 Activity nan None 10.1021/acs.jmedchem.8b01090
Homo sapiens HL-60 Activity nan None 10.1021/acsmedchemlett.9b00084
Homo sapiens HL-60 EC50 1200.0 nM 10.1021/jm901358y
Homo sapiens HL-60 EC50 1300.0 nM 10.1016/j.bmc.2017.04.043
Homo sapiens HL-60 GC50 0.39 uM 10.1016/j.bmc.2017.04.043
Homo sapiens HL-60 GI 93.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens HL-60 GI50 930.0 nM 10.1021/ml300081u
Homo sapiens HL-60 GI50 1740.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens HL-60 IC50 0.18 ug.mL-1 10.1016/j.ejmech.2020.112044
Homo sapiens HL-60 IC50 0.18 ug.mL-1 10.1016/j.ejmech.2020.112679
Homo sapiens HL-60 IC50 220.0 nM 10.1021/acs.jmedchem.2c01418
Homo sapiens HL-60 IC50 420.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens HL-60 IC50 480.0 nM 10.1016/j.ejmech.2021.113169
Homo sapiens HL-60 IC50 520.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens HL-60 IC50 540.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens HL-60 IC50 570.5 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens HL-60 IC50 690.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HL-60 IC50 729.0 nM 10.1039/C3MD00285C
Homo sapiens HL-60 IC50 900.0 nM 10.1021/acs.jmedchem.1c00821
Homo sapiens HL-60 IC50 930.0 nM 10.1016/j.ejmech.2021.113893
Homo sapiens HL-60 IC50 1000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens HL-60 IC50 1331.0 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens HL-60 IC50 1500.0 nM 10.1021/acs.jmedchem.8b00393
Homo sapiens HL-60 IC50 1520.0 nM 10.1016/j.bmc.2022.117067
Homo sapiens HL-60 IC50 1939.02 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 IC50 2280.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens HL-60 IC50 3040.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens HL-60 IC50 4260.0 nM 10.1021/jm401877m
Homo sapiens HL-60 IC50 76500.0 nM 10.1016/j.bmc.2012.05.034
Homo sapiens HL-60 IC50 200000.0 nM 10.1021/jm101605z
Homo sapiens HL-60 IC50 3780000.0 nM 10.1016/j.bmc.2010.01.060
Homo sapiens HL-60 Inhibition 55.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens HL-60 Inhibition 95.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens HL-60 Inhibition 98.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens HL-60(TB) GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens HLE IC50 2085.29 nM 10.6019/CHEMBL1201861
Homo sapiens HMEC EC50 10000.0 nM 10.1021/jm801128g
Homo sapiens HMEC GI50 5800.0 nM 10.1021/ml400175d
Homo sapiens HMEC IC50 1300.0 nM 10.1021/jm8002894
Homo sapiens HMEC IC50 10700.0 nM 10.1021/acsmedchemlett.2c00126
Homo sapiens HMG-CoA reductase IC50 10000.0 nM 10.1021/jm400179b
Homo sapiens HMG-CoA reductase IC50 10000.0 nM None
Homo sapiens HMG-CoA reductase IC50 nan None 10.1021/jm400179b
Homo sapiens HMV-2 cell line IC50 4517.3 nM 10.6019/CHEMBL1201861
Homo sapiens HN IC50 1887.25 nM 10.6019/CHEMBL1201861
Homo sapiens HO-1-N-1 IC50 1238.35 nM 10.6019/CHEMBL1201861
Homo sapiens Homo sapiens Cp 1.58 uM 10.1021/jm200388e
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens EC50 500000.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Homo sapiens T1/2 2.0 hr 10.1039/C5MD00247H
Homo sapiens HOP-62 GI50 1600.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens HOP-62 IC50 2910.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens HOP-92 GI50 2900.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens HOP-92 GI50 4000.0 nM 10.1021/jm201496g
Homo sapiens HOP-92 IC50 1940.65 nM 10.6019/CHEMBL1201861
Homo sapiens HOS IC50 2076.53 nM 10.6019/CHEMBL1201861
Homo sapiens HPAF-II IC50 6354.8 nM 10.6019/CHEMBL1201861
Homo sapiens Hs-578T GI50 3600.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Hs-578T GI50 4830.0 nM 10.1021/ml400175d
Homo sapiens Hs-578T IC50 4776.55 nM 10.6019/CHEMBL1201861
Homo sapiens Hs68 IC50 4600.0 nM 10.1021/jm400179b
Homo sapiens Hs 683 Activity nan None 10.1021/acs.jmedchem.7b00533
Homo sapiens HSC-2 IC50 2128.98 nM 10.6019/CHEMBL1201861
Homo sapiens HSC-3 IC50 2445.09 nM 10.6019/CHEMBL1201861
Homo sapiens HSC-4 IC50 846.51 nM 10.6019/CHEMBL1201861
Homo sapiens HT IC50 1889.47 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 GI50 4870.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens HT-1080 IC50 2.4 nM 10.1021/jm7011408
Homo sapiens HT-1080 IC50 24.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens HT-1080 IC50 2400.0 nM 10.1016/j.bmcl.2003.07.012
Homo sapiens HT-1080 IC50 2400.0 nM 10.1016/s0960-894x(02)00622-4
Homo sapiens HT-1080 IC50 2400.0 nM 10.1016/s0960-894x(03)00301-9
Homo sapiens HT-1080 IC50 2400.0 nM 10.1021/jm0303094
Homo sapiens HT-1080 IC50 2448.64 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 IC50 2540.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens HT-1080 IC50 3560.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens HT-1080 IC50 7500.0 nM 10.1016/j.bmc.2013.07.039
Homo sapiens HT1197 IC50 19922.66 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1376 IC50 5780.52 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 5249.87 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens HT-29 EC50 2000.0 nM 10.1021/jm901358y
Homo sapiens HT-29 GI50 790.0 nM 10.1021/jm201496g
Homo sapiens HT-29 GI50 2880.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens HT-29 IC50 560.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens HT-29 IC50 720.0 nM 10.1021/jm401899x
Homo sapiens HT-29 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens HT-29 IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens HT-29 IC50 1510.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens HT-29 IC50 1780.0 nM 10.1021/acsmedchemlett.7b00487
Homo sapiens HT-29 IC50 2200.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens HT-29 IC50 2370.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens HT-29 IC50 3266.14 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 IC50 nan None 10.1016/j.ejmech.2016.02.001
Homo sapiens HT-29 T/C 66.0 % 10.1021/acs.jmedchem.8b00384
Homo sapiens HT-29 TGI 39.0 % 10.1021/acs.jmedchem.8b00384
Homo sapiens HT-3 IC50 2495.35 nM 10.6019/CHEMBL1201861
Homo sapiens HT55 IC50 1651.31 nM 10.6019/CHEMBL1201861
Homo sapiens HTC-C3 IC50 2268.5 nM 10.6019/CHEMBL1201861
Homo sapiens HuCCT-1 IC50 5238.56 nM 10.6019/CHEMBL1201861
Homo sapiens Huh-7 Activity 6.4 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 7.16 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 9.35 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 18.46 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 25.97 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 37.0 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 46.95 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 Activity 47.2 % 10.1016/j.bmc.2023.117213
Homo sapiens Huh-7 CC50 640.0 nM 10.1016/j.bmcl.2019.06.006
Homo sapiens Huh-7 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Huh-7 IC50 1200.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens Huh-7 IC50 1950.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Huh-7 IC50 2306.37 nM 10.6019/CHEMBL1201861
Homo sapiens Huh-7 IC50 3880.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Huh-7 IC50 4300.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens Huh-7 IC50 4950.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens Huh-7 IC50 5100.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens HuO-3N1 IC50 1593.85 nM 10.6019/CHEMBL1201861
Homo sapiens HuO9 IC50 1453.62 nM 10.6019/CHEMBL1201861
Homo sapiens HuP-T3 IC50 800.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens HuP-T3 IC50 800.0 nM 10.1021/jm8002894
Homo sapiens HuP-T3 IC50 800.0 nM 10.1021/jm901667k
Homo sapiens HuP-T3 IC50 5886.77 nM 10.6019/CHEMBL1201861
Homo sapiens HuP-T4 IC50 1493.0 nM 10.6019/CHEMBL1201861
Homo sapiens HuT78 EC50 290.0 nM 10.1016/j.bmcl.2018.06.029
Homo sapiens HuT78 GI50 295.0 nM 10.1021/jm101177s
Homo sapiens HuT78 GI50 300.0 nM 10.1016/j.bmcl.2010.09.016
Homo sapiens HuT78 GI50 2100.0 nM 10.1021/ml400158k
Homo sapiens HuT78 GI50 3000.0 nM 10.1021/np400198r
Homo sapiens HuT78 IC50 710.0 nM 10.1016/j.ejmech.2021.113169
Homo sapiens HUVEC Activity nan None 10.1016/j.bmc.2022.117085
Homo sapiens HUVEC Activity nan None 10.1021/acs.jmedchem.2c00681
Homo sapiens HUVEC GI50 8130.0 nM 10.1016/j.bmcl.2013.03.102
Homo sapiens HUVEC IC50 2720.0 nM 10.1016/j.bmcl.2023.129305
Homo sapiens HUVEC IC50 2840.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens HUVEC IC50 3610.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens HUVEC IC50 8580.0 nM 10.1016/j.bmc.2022.117028
Homo sapiens HUVEC IC50 26400.0 nM 10.1016/j.bmcl.2022.128925
Homo sapiens HUVEC IC50 50000.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens IA-LM IC50 1692.78 nM 10.6019/CHEMBL1201861
Homo sapiens IGR-1 IC50 20311.66 nM 10.6019/CHEMBL1201861
Homo sapiens IGROV-1 Activity 15.0 % 10.1016/j.ejmech.2008.11.005
Homo sapiens IGROV-1 Activity 23.7 % 10.1021/acs.jmedchem.2c01276
Homo sapiens IGROV-1 Activity 37.0 % 10.1016/j.ejmech.2014.04.021
Homo sapiens IGROV-1 Activity 45.0 % 10.1016/j.ejmech.2008.11.005
Homo sapiens IGROV-1 Activity nan None 10.1016/j.ejmech.2008.11.005
Homo sapiens IGROV-1 GI50 1100.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens IGROV-1 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens IGROV-1 IC50 2200.0 nM 10.1016/j.bmcl.2015.09.006
Homo sapiens IGROV-1 IC50 2200.0 nM 10.1016/j.ejmech.2008.11.005
Homo sapiens IGROV-1 IC50 2200.0 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens IMR-32 IC50 620.0 nM 10.1039/C8MD00454D
Homo sapiens Indoleamine 2,3-dioxygenase IC50 nan None 10.1021/acsmedchemlett.7b00487
Homo sapiens Indoleamine 2,3-dioxygenase Inhibition nan % 10.1021/acsmedchemlett.7b00487
Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 EC50 nan None 10.1021/acs.jmedchem.0c01454
Homo sapiens Inosine-5'-monophosphate dehydrogenase 1 Activity nan None 10.1021/jm070864w
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Activity nan None 10.1021/jm070864w
Homo sapiens IST-MEL1 IC50 6896.69 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 9516.44 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 2168.44 nM 10.6019/CHEMBL1201861
Homo sapiens J82 IC50 3505.7 nM 10.6019/CHEMBL1201861
Homo sapiens Janus Kinase (JAK) Activity nan None 10.1021/acs.jmedchem.8b01597
Homo sapiens Janus Kinase (JAK) Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens JAR IC50 2319.87 nM 10.6019/CHEMBL1201861
Homo sapiens JEG-3 IC50 8786.18 nM 10.6019/CHEMBL1201861
Homo sapiens JeKo-1 IC50 638.6 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens JeKo-1 IC50 3500.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens J-RT3-T3-5 IC50 910.49 nM 10.6019/CHEMBL1201861
Homo sapiens Jurkat Activity 0.4 % 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat Activity 0.412 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 1.03 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 5.0 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Jurkat Activity 5.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Jurkat Activity 6.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 7.46 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 8.26 % 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat Activity 11.0 % 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat Activity 12.3 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 14.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 15.6 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 19.7 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 19.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 20.4 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 25.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 31.6 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 35.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 48.9 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 49.0 % 10.1016/j.bmcl.2017.06.033
Homo sapiens Jurkat Activity 49.0 % 10.1016/j.ejmech.2017.10.076
Homo sapiens Jurkat Activity 60.8 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 62.6 % 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat Activity 79.5 % 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat EC50 870.0 nM 10.1021/jm901358y
Homo sapiens Jurkat EC50 1660.0 nM 10.1021/acs.jmedchem.5b00539
Homo sapiens Jurkat EC50 2300.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens Jurkat FC 3.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat FC 100.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat FC 300.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat GI50 900.0 nM 10.1021/ml400158k
Homo sapiens Jurkat GI50 1100.0 nM 10.1021/ml300081u
Homo sapiens Jurkat IC50 100.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat IC50 270.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens Jurkat IC50 300.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens Jurkat IC50 350.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens Jurkat IC50 470.0 nM 10.1021/acs.jmedchem.2c01418
Homo sapiens Jurkat IC50 590.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens Jurkat IC50 590.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens Jurkat IC50 700.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat IC50 1180.0 nM 10.1016/j.bmc.2018.02.033
Homo sapiens Jurkat IC50 1490.0 nM 10.1016/j.bmcl.2014.08.060
Homo sapiens Jurkat IC50 1490.0 nM 10.1021/jm301769u
Homo sapiens Jurkat IC50 1490.0 nM 10.1021/jm401225q
Homo sapiens Jurkat IC50 3620.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens Jurkat IC50 30000.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens Jurkat IC50 32000.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens Jurkat RLU 53518.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat RLU 95463.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat RLU 125484.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens Jurkat RLU 157988.0 None 10.1016/j.bmc.2014.02.018
Homo sapiens JVM-2 IC50 116729.93 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 1854.51 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 2078.11 nM 10.6019/CHEMBL1201861
Homo sapiens K562 AC50 10000.0 nM 10.1021/ml5000959
Homo sapiens K562 Activity 0.05 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 0.06 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 0.73 % 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 Activity 2.99 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 4.04 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 6.1 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 6.97 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 14.5 % 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 Activity 17.3 % 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 Activity 47.4 % 10.1021/jm070864w
Homo sapiens K562 Activity 67.6 % 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 Activity 88.9 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity 90.8 % 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity nan None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Activity nan None 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 Activity nan None 10.1016/j.ejmech.2020.112291
Homo sapiens K562 Activity nan None 10.1021/ml5000959
Homo sapiens K562 CI 0.1179 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 CI 0.1204 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 CI 0.8011 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 CI 0.97 None 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 CI 0.9881 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 CI 1.509 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 CI 1.742 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 EC50 2200.0 nM 10.1021/jm901358y
Homo sapiens K562 ED50 0.4579 uM 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 ED50 1.248 uM 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 GC50 0.8 uM 10.1016/j.bmc.2017.04.043
Homo sapiens K562 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens K562 GI50 520.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens K562 GI50 900.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens K562 GI50 1970.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens K562 GI50 3660.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens K562 IC50 110.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens K562 IC50 170.0 nM 10.1016/j.bmcl.2016.04.034
Homo sapiens K562 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens K562 IC50 444.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens K562 IC50 520.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens K562 IC50 560.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens K562 IC50 640.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens K562 IC50 645.0 nM 10.1016/j.ejmech.2013.03.061
Homo sapiens K562 IC50 645.0 nM 10.1016/j.ejmech.2015.11.010
Homo sapiens K562 IC50 650.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens K562 IC50 670.0 nM 10.1021/jm0703136
Homo sapiens K562 IC50 670.0 nM 10.1021/jm800988r
Homo sapiens K562 IC50 680.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens K562 IC50 680.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens K562 IC50 750.0 nM 10.1021/jm070864w
Homo sapiens K562 IC50 900.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens K562 IC50 980.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens K562 IC50 1000.0 nM 10.1021/ml5000959
Homo sapiens K562 IC50 1020.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens K562 IC50 1030.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 IC50 1110.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens K562 IC50 1170.0 nM 10.1016/j.bmc.2022.117067
Homo sapiens K562 IC50 1350.0 nM 10.1016/j.bmcl.2020.127638
Homo sapiens K562 IC50 1350.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens K562 IC50 1391.0 nM 10.1021/acs.jmedchem.2c00681
Homo sapiens K562 IC50 1440.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens K562 IC50 1450.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens K562 IC50 1490.0 nM 10.1016/j.bmc.2016.12.001
Homo sapiens K562 IC50 1510.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens K562 IC50 1520.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens K562 IC50 1610.0 nM 10.1016/j.bmc.2014.09.039
Homo sapiens K562 IC50 1910.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens K562 IC50 1910.0 nM 10.1016/j.ejmech.2017.04.017
Homo sapiens K562 IC50 1950.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens K562 IC50 2000.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens K562 IC50 2240.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens K562 IC50 2900.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens K562 IC50 3240.0 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens K562 IC50 3240.0 nM 10.1021/jm401877m
Homo sapiens K562 IC50 3320.0 nM 10.1021/jm101605z
Homo sapiens K562 IC50 3770.0 nM 10.1016/j.bmc.2014.01.045
Homo sapiens K562 IC50 3880.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens K562 IC50 3890.0 nM 10.1016/j.bmc.2015.08.040
Homo sapiens K562 IC50 3940.0 nM 10.1016/j.bmc.2015.06.024
Homo sapiens K562 IC50 4950.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens K562 IC50 7700.0 nM 10.1021/acs.jmedchem.8b00393
Homo sapiens K562 IC50 10000.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens K562 IC50 18631.69 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 38000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens K562 Ratio 0.1338 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 0.152 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 0.326 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 0.9864 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 0.9917 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 0.9943 None 10.1016/j.bmcl.2016.04.090
Homo sapiens K562 Ratio 3.61 None 10.1021/jm901502p
Homo sapiens K562 Ratio IC50 0.03 None 10.1016/j.bmcl.2015.07.065
Homo sapiens K562/A02 IC50 3130.0 nM 10.1016/j.bmcl.2020.127638
Homo sapiens KALS-1 IC50 8509.28 nM 10.6019/CHEMBL1201861
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens KARPAS-299 IC50 730568.5 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 173.89 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 99.17 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 620.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens KB GI 22.93 % 10.1016/j.bmcl.2010.03.112
Homo sapiens KB GI 51.23 % 10.1016/j.bmcl.2010.03.112
Homo sapiens KB GI 57.71 % 10.1016/j.bmcl.2010.03.112
Homo sapiens KB GI 64.6 % 10.1007/s00044-011-9879-7
Homo sapiens KB GI 64.6 % 10.1016/j.bmcl.2010.03.112
Homo sapiens KB IC50 750.0 nM 10.1021/jm401899x
Homo sapiens KB IC50 1800.0 nM 10.1016/j.ejmech.2015.04.014
Homo sapiens KB-V1 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens KE-37 IC50 894.62 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 Activity 18.2 % 10.1021/acs.jmedchem.1c02225
Homo sapiens KG-1 Activity nan None 10.1016/j.ejmech.2020.112291
Homo sapiens KG-1 IC50 70.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens KG-1 IC50 590.0 nM 10.1016/j.ejmech.2021.113169
Homo sapiens KG-1 IC50 775.45 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 1520.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens KG-1 IC50 1590.0 nM 10.1016/j.ejmech.2020.112831
Homo sapiens KG-1 IC50 nan None 10.1021/acs.jmedchem.7b00678
Homo sapiens KGN IC50 12290.11 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 6261.52 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 9322.32 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens KM12 GI50 800.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens KM12 GI50 1880.0 nM 10.1021/ml400175d
Homo sapiens KM12 GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens KM12 IC50 6240.99 nM 10.6019/CHEMBL1201861
Homo sapiens KM3/BTZ Activity 0.27 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 0.37 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 1.5 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 1.86 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 3.68 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 5.34 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 10.6 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 43.3 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 45.5 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 92.5 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ Activity 94.5 % 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ CI 0.62 None 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ IC50 78.2 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens KM3/BTZ IC50 860.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens KM-H2 IC50 1540.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens KM-H2 IC50 3826.24 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 1094.22 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-BM Activity nan None 10.1016/j.ejmech.2019.111755
Homo sapiens KMS-12-BM EC50 940.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens KMS-12-BM IC50 940.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens KMS-12-BM IC50 940.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens KNS-42 IC50 16658.94 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-62 IC50 2450.61 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 14704.52 nM 10.6019/CHEMBL1201861
Homo sapiens KOSC-2 IC50 2560.76 nM 10.6019/CHEMBL1201861
Homo sapiens KP-4 IC50 1370.85 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YN IC50 4209.27 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 2326.15 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 5988.36 nM 10.6019/CHEMBL1201861
Homo sapiens KU-19-19 IC50 2535.13 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 813.1 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 28125.96 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 563.25 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-140 IC50 7440.61 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-150 cell line IC50 11038.75 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-180 IC50 3633.72 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-270 IC50 5660.31 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-410 IC50 6306.45 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-450 IC50 3685.82 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-510 Activity nan None 10.1021/jm301254q
Homo sapiens KYSE-510 FC 18.8 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.23 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.24 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.27 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.42 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.44 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.46 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.47 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.5 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.51 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.52 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.55 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.56 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.6 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.66 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.67 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.68 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.71 None 10.1021/jm301254q
Homo sapiens KYSE-510 FICI 0.75 None 10.1021/jm301254q
Homo sapiens KYSE-510 IC50 3721.81 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-510 IC50 4620.0 nM 10.1021/jm301254q
Homo sapiens KYSE-510 IC50 4660.0 nM 10.1021/jm301254q
Homo sapiens KYSE-520 cell line IC50 2810.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens KYSE-520 cell line IC50 14927.02 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-70 cell line IC50 4293.4 nM 10.6019/CHEMBL1201861
Homo sapiens L02 Activity 26.0 % 10.1021/acs.jmedchem.1c00136
Homo sapiens L02 Activity 92.5 % 10.1021/acs.jnatprod.2c00101
Homo sapiens L02 Activity nan None 10.1016/j.bmc.2022.117085
Homo sapiens L02 Activity nan None 10.1021/acs.jmedchem.2c00130
Homo sapiens L02 IC50 948.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens L02 IC50 1350.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens L02 IC50 5450.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens L02 IC50 10000.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens L02 IC50 27400.0 nM 10.1021/acs.jmedchem.0c01454
Homo sapiens L02 IC50 50000.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens L02 IC50 50000.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens L02 IC50 nan None 10.1016/j.bmcl.2022.128663
Homo sapiens L02 IC50 nan None 10.1016/j.bmcl.2022.128846
Homo sapiens L-363 IC50 503.1 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 870.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens L-428 IC50 2300.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens L-428 IC50 3400.45 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 1439.45 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 6496.31 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 1183.12 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 1982.31 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 3223.98 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 14418.96 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 9451.71 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 8219.37 nM 10.6019/CHEMBL1201861
Homo sapiens LCLC-103H cell line IC50 2904.38 nM 10.6019/CHEMBL1201861
Homo sapiens LCLC-97TM1 IC50 2145.83 nM 10.6019/CHEMBL1201861
Homo sapiens Leukemia cell IC50 nan None 10.1016/j.ejmech.2019.05.089
Homo sapiens Leukemia cell Inhibition 0.0 % 10.1021/jm8005355
Homo sapiens Leukotriene A4 hydrolase Delta Tm 1.47 degrees C 10.1021/acs.jmedchem.6b01507
Homo sapiens Leukotriene A4 hydrolase IC50 1670.0 nM 10.1021/acs.jmedchem.6b01507
Homo sapiens Leukotriene A4 hydrolase IC50 7650.0 nM 10.1021/acs.jmedchem.6b01507
Homo sapiens Leukotriene A4 hydrolase Inhibition 50.0 % 10.1021/acs.jmedchem.6b01507
Homo sapiens Liver microsome CL 0.1 mL.min-1.kg-1 10.1021/jm502011f
Homo sapiens Liver microsome Stability 93.0 % 10.1016/j.ejmech.2015.11.010
Homo sapiens Liver microsomes T1/2 1.0 hr 10.1016/j.bmcl.2010.04.041
Homo sapiens Liver microsomes T1/2 1.0 hr 10.1021/jm2003552
Homo sapiens Liver microsomes T1/2 1.0 hr 10.1021/jm901502p
Homo sapiens Liver microsomes T1/2 6.75 hr 10.1016/j.bmcl.2011.06.015
Homo sapiens LK-2 IC50 10420.83 nM 10.6019/CHEMBL1201861
Homo sapiens LN-405 IC50 5730.85 nM 10.6019/CHEMBL1201861
Homo sapiens LNCaP Activity -4.88 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 0.0 % 10.1016/j.bmc.2007.12.007
Homo sapiens LNCaP Activity 0.31 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 0.69 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 18.1 % 10.1016/j.bmc.2007.12.007
Homo sapiens LNCaP Activity 18.4 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 81.9 % 10.1016/j.bmc.2007.12.007
Homo sapiens LNCaP Activity 85.6 % 10.1016/j.bmc.2016.12.032
Homo sapiens LNCaP Activity 97.1 % 10.1016/j.bmc.2007.12.007
Homo sapiens LNCaP Activity nan None 10.1021/jm4012802
Homo sapiens LNCaP Growth inhibition 1.0 uM 10.1021/jm058214k
Homo sapiens LNCaP IC50 580.0 nM 10.1021/jm901453q
Homo sapiens LNCaP IC50 690.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens LNCaP IC50 1000.0 nM 10.1016/j.bmc.2007.12.007
Homo sapiens LNCaP IC50 1000.0 nM 10.1021/jm058214k
Homo sapiens LNCaP IC50 1800.0 nM 10.1016/j.bmcl.2017.01.044
Homo sapiens LNCaP IC50 2310.0 nM 10.1016/j.bmcl.2014.08.060
Homo sapiens LNCaP IC50 2310.0 nM 10.1021/jm301769u
Homo sapiens LNCaP IC50 2310.0 nM 10.1021/jm401225q
Homo sapiens LNCaP-Clone-FGC IC50 6804.03 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo GI50 1700.0 nM 10.1021/jm101177s
Homo sapiens LoVo IC50 1898.1 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo IC50 2150.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens LoVo IC50 3700.0 nM 10.1016/j.ejmech.2016.02.001
Homo sapiens LoVo IC50 4950.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens LoVo IC50 6750.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens LoVo IC50 6750.0 nM 10.1039/C6MD00681G
Homo sapiens LOX IMVI Activity -3.4 % 10.1021/acs.jmedchem.2c01276
Homo sapiens LOX IMVI EC50 1300.0 nM 10.1021/jm049207j
Homo sapiens LOX IMVI EC50 1300.0 nM 10.1021/jm7011408
Homo sapiens LOX IMVI GI50 1000.0 nM 10.1021/jm201496g
Homo sapiens LOX IMVI GI50 1200.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens LOX IMVI GI50 1300.0 nM 10.1021/jm900125m
Homo sapiens LOX IMVI GI50 1390.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens LOX IMVI GI50 1390.0 nM 10.1021/jm0613828
Homo sapiens LOX IMVI GI50 1600.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens LOX IMVI IC50 1721.1 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 1390.0 nM 10.1016/j.ejmech.2016.02.003
Homo sapiens LS-1034 IC50 8574.37 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 3879.09 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 2823.3 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 4421.98 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 2470.08 nM 10.6019/CHEMBL1201861
Homo sapiens LU-135 IC50 19263.56 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 822.86 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 4076.33 nM 10.6019/CHEMBL1201861
Homo sapiens LU-99A IC50 6559.89 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 1352.4 nM 10.6019/CHEMBL1201861
Homo sapiens Lysine-specific demethylase 4D-like IC50 14000.0 nM 10.1016/j.bmc.2011.01.046
Homo sapiens Lysine-specific demethylase 4D-like IC50 14000.0 nM 10.1021/acs.jmedchem.2c00680
Homo sapiens Lysine-specific demethylase 4D-like IC50 540000.0 nM 10.1016/j.bmc.2011.01.046
Homo sapiens Lysine-specific histone demethylase 1 IC50 100000.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Lysine-specific histone demethylase 1 IC50 100000.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens Lysine-specific histone demethylase 1 IC50 nan None 10.1021/acsmedchemlett.2c00126
Homo sapiens Lysine-specific histone demethylase 1A/REST corepressor IC50 nan None 10.1016/j.bmcl.2018.02.034
Homo sapiens M059J IC50 5257.6 nM 10.6019/CHEMBL1201861
Homo sapiens M14 GI50 1300.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens M14 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens M14 IC50 2669.93 nM 10.6019/CHEMBL1201861
Homo sapiens Malme-3M GI50 320.0 nM 10.1021/jm201496g
Homo sapiens Malme-3M GI50 370.0 nM 10.1021/ml400175d
Homo sapiens Matrix metalloproteinase 12 Inhibition 25.0 % 10.1021/jm401053m
Homo sapiens Matrix metalloproteinase-2 IC50 nan None 10.1016/j.bmc.2013.12.025
Homo sapiens Matrix metalloproteinase-2 IC50 nan None 10.1016/j.bmc.2015.09.013
Homo sapiens Matrix metalloproteinase-2 Inhibition 25.0 % 10.1021/jm401053m
Homo sapiens Matrix metalloproteinase-2 Inhibition nan % 10.1016/j.bmc.2015.09.013
Homo sapiens Matrix metalloproteinase-2 Inhibition nan % 10.1021/jm200577a
Homo sapiens Matrix metalloproteinase 9 IC50 nan None 10.1016/j.bmc.2015.09.013
Homo sapiens Matrix metalloproteinase 9 Inhibition nan % 10.1016/j.bmc.2015.09.013
Homo sapiens MC116 IC50 1136.21 nM 10.6019/CHEMBL1201861
Homo sapiens MCF-10A Activity 24.0 % 10.1021/acs.jmedchem.1c00136
Homo sapiens MCF-10A Activity nan None 10.1016/j.bmc.2022.117085
Homo sapiens MCF-10A Activity nan None 10.1021/acs.jmedchem.6b00772
Homo sapiens MCF-10A GI50 9600.0 nM 10.1021/jm201496g
Homo sapiens MCF-10A IC50 420.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MCF-10A IC50 1100.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MCF-10A IC50 2110.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens MCF-10A IC50 28000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens MCF-10A IC50 31000.0 nM 10.1021/jm900187v
Homo sapiens MCF-10A IC50 50000.0 nM 10.1039/C9MD00306A
Homo sapiens MCF7 Activity 20.8 % 10.1016/j.bmcl.2018.02.034
Homo sapiens MCF7 Activity 49.3 % 10.1016/j.bmcl.2018.02.034
Homo sapiens MCF7 Activity 52.0 % 10.1016/j.bmcl.2015.11.086
Homo sapiens MCF7 Activity 56.6 % 10.1016/j.bmcl.2018.02.034
Homo sapiens MCF7 Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens MCF7 Activity nan None 10.1016/j.bmc.2021.116251
Homo sapiens MCF7 Activity nan None 10.1016/j.bmcl.2018.02.034
Homo sapiens MCF7 Activity nan None 10.1021/acs.jmedchem.8b01090
Homo sapiens MCF7 Activity nan None 10.1021/jm700972e
Homo sapiens MCF7 Activity nan None 10.1021/ml5000959
Homo sapiens MCF7 CC50 3000.0 nM 10.1021/jm9004303
Homo sapiens MCF7 EC50 10.0 nM 10.1021/acs.jmedchem.1c01215
Homo sapiens MCF7 EC50 650.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens MCF7 GC50 4.6 uM 10.1016/j.bmc.2017.04.043
Homo sapiens MCF7 GI 89.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens MCF7 GI50 450.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens MCF7 GI50 610.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens MCF7 GI50 689.0 nM 10.1016/j.bmcl.2013.04.004
Homo sapiens MCF7 GI50 1250.0 nM 10.1016/j.ejmech.2021.113870
Homo sapiens MCF7 GI50 1340.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens MCF7 GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens MCF7 GI50 2190.0 nM 10.1021/ml400175d
Homo sapiens MCF7 GI50 2200.0 nM 10.1016/j.ejmech.2014.09.024
Homo sapiens MCF7 GI50 2600.0 nM 10.1016/j.ejmech.2021.113799
Homo sapiens MCF7 GI50 8600.0 nM 10.1021/ml300081u
Homo sapiens MCF7 GI50 17900.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens MCF7 GI50 29100.0 nM 10.1016/j.bmc.2016.08.040
Homo sapiens MCF7 IC50 0.13 ug.mL-1 10.1016/j.bmcl.2011.07.124
Homo sapiens MCF7 IC50 0.18 ug.mL-1 10.1016/j.ejmech.2020.112044
Homo sapiens MCF7 IC50 160.0 nM 10.1021/acs.jmedchem.1c02026
Homo sapiens MCF7 IC50 320.0 nM 10.1016/j.bmc.2015.11.005
Homo sapiens MCF7 IC50 354.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens MCF7 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MCF7 IC50 450.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MCF7 IC50 500.0 nM 10.1021/jm0703800
Homo sapiens MCF7 IC50 580.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens MCF7 IC50 637.2 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens MCF7 IC50 650.0 nM 10.1016/j.bmcl.2018.06.037
Homo sapiens MCF7 IC50 650.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens MCF7 IC50 800.0 nM 10.1016/j.ejmech.2020.112189
Homo sapiens MCF7 IC50 810.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens MCF7 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MCF7 IC50 900.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens MCF7 IC50 939.97 nM 10.1016/j.bmc.2019.02.046
Homo sapiens MCF7 IC50 950.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MCF7 IC50 1040.0 nM 10.1016/j.bmcl.2020.127610
Homo sapiens MCF7 IC50 1100.0 nM 10.1021/jm401899x
Homo sapiens MCF7 IC50 1110.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens MCF7 IC50 1150.0 nM 10.1016/j.ejmech.2011.08.045
Homo sapiens MCF7 IC50 1260.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens MCF7 IC50 1500.0 nM 10.1016/j.bmcl.2006.10.045
Homo sapiens MCF7 IC50 1500.0 nM 10.1016/j.bmcl.2006.10.048
Homo sapiens MCF7 IC50 1600.0 nM 10.1016/j.bmc.2013.11.021
Homo sapiens MCF7 IC50 1600.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens MCF7 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens MCF7 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens MCF7 IC50 2000.0 nM 10.1016/j.ejmech.2020.112651
Homo sapiens MCF7 IC50 2180.0 nM 10.1016/j.ejmech.2018.01.021
Homo sapiens MCF7 IC50 2290.0 nM 10.1021/jm400634n
Homo sapiens MCF7 IC50 2360.0 nM 10.1021/acs.jmedchem.1c01863
Homo sapiens MCF7 IC50 2500.0 nM 10.1016/j.bmc.2021.116185
Homo sapiens MCF7 IC50 2500.0 nM 10.1016/j.bmcl.2015.12.036
Homo sapiens MCF7 IC50 2500.0 nM 10.1021/acs.jmedchem.5b00099
Homo sapiens MCF7 IC50 2500.0 nM 10.1021/jm200799p
Homo sapiens MCF7 IC50 2600.0 nM 10.1021/acs.jmedchem.1c01311
Homo sapiens MCF7 IC50 2700.0 nM 10.1016/j.bmc.2017.12.041
Homo sapiens MCF7 IC50 2700.0 nM 10.1021/acs.jmedchem.0c00491
Homo sapiens MCF7 IC50 2800.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MCF7 IC50 2800.0 nM 10.1021/jm901453q
Homo sapiens MCF7 IC50 2810.0 nM 10.1021/jm200577a
Homo sapiens MCF7 IC50 2900.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens MCF7 IC50 3260.0 nM 10.1039/C4MD00203B
Homo sapiens MCF7 IC50 3270.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens MCF7 IC50 3470.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens MCF7 IC50 3490.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens MCF7 IC50 3780.0 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens MCF7 IC50 3780.0 nM 10.1021/jm401877m
Homo sapiens MCF7 IC50 4100.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens MCF7 IC50 4200.0 nM 10.1016/j.ejmech.2015.12.033
Homo sapiens MCF7 IC50 4200.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens MCF7 IC50 4200.0 nM 10.1021/acs.jmedchem.0c00491
Homo sapiens MCF7 IC50 4220.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens MCF7 IC50 4339.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens MCF7 IC50 4400.0 nM 10.1021/jm400467w
Homo sapiens MCF7 IC50 4480.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens MCF7 IC50 4500.0 nM 10.1016/j.bmcl.2015.10.006
Homo sapiens MCF7 IC50 4690.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens MCF7 IC50 4780.0 nM 10.1016/j.bmcl.2023.129305
Homo sapiens MCF7 IC50 4830.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens MCF7 IC50 5007.38 nM 10.6019/CHEMBL1201861
Homo sapiens MCF7 IC50 5150.0 nM 10.1016/j.bmcl.2022.128663
Homo sapiens MCF7 IC50 5150.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens MCF7 IC50 5430.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens MCF7 IC50 6170.0 nM 10.1039/C9MD00306A
Homo sapiens MCF7 IC50 6420.0 nM 10.1016/j.ejmech.2013.10.045
Homo sapiens MCF7 IC50 6500.0 nM 10.1021/acs.jnatprod.2c00101
Homo sapiens MCF7 IC50 6700.0 nM 10.1021/jm0703136
Homo sapiens MCF7 IC50 7110.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens MCF7 IC50 8500.0 nM 10.1021/jm900187v
Homo sapiens MCF7 IC50 8500.0 nM 10.1039/c1md00220a
Homo sapiens MCF7 IC50 9590.0 nM 10.1039/C5MD00247H
Homo sapiens MCF7 IC50 9798.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.bmc.2021.116251
Homo sapiens MCF7 IC50 28660.0 nM 10.1039/C5MD00247H
Homo sapiens MCF7 IC50 38200.0 nM 10.1016/j.bmcl.2018.02.034
Homo sapiens MCF7 IC50 50000.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens MCF7 IC50 54550.0 nM 10.1039/C5MD00247H
Homo sapiens MCF7 IC50 60200.0 nM 10.1016/j.bmc.2013.09.021
Homo sapiens MCF7 IC50 100000.0 nM 10.1021/jm7011408
Homo sapiens MCF7 IC50 150000.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens MCF7 IC50 nan None 10.1021/acsmedchemlett.7b00504
Homo sapiens MCF7 TGI 46.0 % 10.1016/j.ejmech.2021.113870
Homo sapiens MC-IXC IC50 1178.81 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-157 IC50 300893.39 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-175-VII IC50 5640.41 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 Activity 0.356 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 2.33 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 2.72 % 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-231 Activity 3.32 % 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 Activity 3.74 % 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-231 Activity 3.83 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 7.1 % 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 Activity 7.66 % 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 Activity 8.0 % 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 Activity 8.32 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 8.92 % 10.1016/j.bmc.2020.115345
Homo sapiens MDA-MB-231 Activity 8.93 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 11.32 % 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 Activity 16.1 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 16.4 % 10.1021/acs.jmedchem.2c01276
Homo sapiens MDA-MB-231 Activity 18.2 % 10.1016/j.bmc.2020.115345
Homo sapiens MDA-MB-231 Activity 18.69 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 18.7 % 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-231 Activity 20.1 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 25.8 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 25.8 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 30.0 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 40.0 % 10.1016/j.ejmech.2020.112679
Homo sapiens MDA-MB-231 Activity 53.8 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 55.8 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 57.3 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 Activity 65.1 % 10.1016/j.bmc.2020.115345
Homo sapiens MDA-MB-231 Activity 72.99 % 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity 74.8 % 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-231 Activity 100.0 % 10.1016/j.bmcl.2007.09.034
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.ejmech.2020.112648
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.2c01058
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.8b01090
Homo sapiens MDA-MB-231 Activity nan None 10.1021/jm101605z
Homo sapiens MDA-MB-231 Activity nan None 10.1021/jm200577a
Homo sapiens MDA-MB-231 Activity nan None 10.1021/jm301254q
Homo sapiens MDA-MB-231 EC50 1200.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens MDA-MB-231 EC50 1500.0 nM 10.1021/jm049207j
Homo sapiens MDA-MB-231 EC50 1500.0 nM 10.1021/jm7011408
Homo sapiens MDA-MB-231 FC 3.53 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.2 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.83 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.84 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.88 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.91 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.92 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 0.93 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 FICI 1.0 None 10.1021/jm301254q
Homo sapiens MDA-MB-231 GC50 2.7 uM 10.1016/j.bmc.2017.04.043
Homo sapiens MDA-MB-231 GI50 660.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens MDA-MB-231 GI50 660.0 nM 10.1021/jm0613828
Homo sapiens MDA-MB-231 GI50 890.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens MDA-MB-231 GI50 970.0 nM 10.1021/jm300197a
Homo sapiens MDA-MB-231 GI50 1000.0 nM 10.1021/jm201496g
Homo sapiens MDA-MB-231 GI50 1810.0 nM 10.1016/j.ejmech.2016.01.013
Homo sapiens MDA-MB-231 GI50 2000.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens MDA-MB-231 GI50 2000.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens MDA-MB-231 GI50 2000.0 nM 10.1021/acs.jmedchem.5b00062
Homo sapiens MDA-MB-231 GI50 2000.0 nM 10.1021/jm3009376
Homo sapiens MDA-MB-231 GI50 2320.0 nM 10.1021/ml400175d
Homo sapiens MDA-MB-231 GI50 2500.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens MDA-MB-231 GI50 2500.0 nM 10.1021/jm201496g
Homo sapiens MDA-MB-231 GI50 2670.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens MDA-MB-231 GI50 2730.0 nM 10.1021/acsmedchemlett.2c00126
Homo sapiens MDA-MB-231 IC50 160.0 nM 10.1016/j.bmc.2013.09.021
Homo sapiens MDA-MB-231 IC50 201.0 nM 10.1021/acsmedchemlett.7b00504
Homo sapiens MDA-MB-231 IC50 411.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MDA-MB-231 IC50 430.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens MDA-MB-231 IC50 610.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MDA-MB-231 IC50 610.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens MDA-MB-231 IC50 960.0 nM 10.1016/j.bmc.2015.11.005
Homo sapiens MDA-MB-231 IC50 970.0 nM 10.1016/j.bmc.2018.07.026
Homo sapiens MDA-MB-231 IC50 1090.0 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 IC50 1110.0 nM 10.1039/C4MD00203B
Homo sapiens MDA-MB-231 IC50 1180.0 nM 10.1016/j.bmc.2011.06.046
Homo sapiens MDA-MB-231 IC50 1190.0 nM 10.1016/j.bmcl.2018.06.037
Homo sapiens MDA-MB-231 IC50 1190.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens MDA-MB-231 IC50 1290.0 nM 10.1016/j.bmc.2014.03.019
Homo sapiens MDA-MB-231 IC50 1300.0 nM 10.1016/j.bmcl.2013.07.001
Homo sapiens MDA-MB-231 IC50 1310.0 nM 10.1021/jm101605z
Homo sapiens MDA-MB-231 IC50 1350.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MDA-MB-231 IC50 1450.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens MDA-MB-231 IC50 1490.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens MDA-MB-231 IC50 1540.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens MDA-MB-231 IC50 1660.0 nM 10.1021/jm301254q
Homo sapiens MDA-MB-231 IC50 1710.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens MDA-MB-231 IC50 1720.0 nM 10.1016/j.ejmech.2014.10.077
Homo sapiens MDA-MB-231 IC50 1720.0 nM 10.1021/jm401877m
Homo sapiens MDA-MB-231 IC50 1730.0 nM 10.1016/j.bmc.2016.02.005
Homo sapiens MDA-MB-231 IC50 1770.0 nM 10.1021/acs.jmedchem.1c00136
Homo sapiens MDA-MB-231 IC50 1800.0 nM 10.1039/C4MD00211C
Homo sapiens MDA-MB-231 IC50 1910.0 nM 10.1016/j.ejmech.2011.08.045
Homo sapiens MDA-MB-231 IC50 1980.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens MDA-MB-231 IC50 2000.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens MDA-MB-231 IC50 2020.0 nM 10.1016/j.bmc.2015.06.024
Homo sapiens MDA-MB-231 IC50 2030.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens MDA-MB-231 IC50 2110.0 nM 10.1021/jm901453q
Homo sapiens MDA-MB-231 IC50 2140.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens MDA-MB-231 IC50 2200.0 nM 10.1021/jm0703136
Homo sapiens MDA-MB-231 IC50 2230.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens MDA-MB-231 IC50 2290.0 nM 10.1016/j.bmc.2014.09.039
Homo sapiens MDA-MB-231 IC50 2360.0 nM 10.1016/j.bmc.2021.116524
Homo sapiens MDA-MB-231 IC50 2590.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-231 IC50 2690.0 nM 10.1021/jm301254q
Homo sapiens MDA-MB-231 IC50 2800.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens MDA-MB-231 IC50 3000.0 nM 10.1016/j.bmcl.2022.128821
Homo sapiens MDA-MB-231 IC50 3020.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens MDA-MB-231 IC50 3070.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens MDA-MB-231 IC50 3300.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens MDA-MB-231 IC50 3300.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens MDA-MB-231 IC50 3310.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens MDA-MB-231 IC50 3400.0 nM 10.1016/j.bmc.2020.115345
Homo sapiens MDA-MB-231 IC50 3400.0 nM 10.1021/jm400467w
Homo sapiens MDA-MB-231 IC50 3520.0 nM 10.1016/j.bmc.2022.116626
Homo sapiens MDA-MB-231 IC50 3520.0 nM 10.1016/j.bmcl.2022.128925
Homo sapiens MDA-MB-231 IC50 3520.0 nM 10.1016/j.ejmech.2020.113039
Homo sapiens MDA-MB-231 IC50 3960.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens MDA-MB-231 IC50 4530.0 nM 10.1016/j.bmc.2017.06.039
Homo sapiens MDA-MB-231 IC50 4585.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-231 IC50 4610.0 nM 10.1016/j.bmc.2014.01.045
Homo sapiens MDA-MB-231 IC50 4610.0 nM 10.1016/j.bmc.2015.07.008
Homo sapiens MDA-MB-231 IC50 4660.0 nM 10.1039/C9MD00306A
Homo sapiens MDA-MB-231 IC50 4702.43 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 IC50 4930.0 nM 10.1016/j.bmc.2018.06.016
Homo sapiens MDA-MB-231 IC50 5520.0 nM 10.1016/j.ejmech.2022.114375
Homo sapiens MDA-MB-231 IC50 5600.0 nM 10.1021/ml300366t
Homo sapiens MDA-MB-231 IC50 5800.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens MDA-MB-231 IC50 6040.0 nM 10.1016/j.ejmech.2021.113870
Homo sapiens MDA-MB-231 IC50 7400.0 nM 10.1021/ml500327q
Homo sapiens MDA-MB-231 IC50 8140.0 nM 10.1016/j.ejmech.2020.112648
Homo sapiens MDA-MB-231 IC50 8250.0 nM 10.1016/j.ejmech.2021.113893
Homo sapiens MDA-MB-231 IC50 12300.0 nM 10.1016/j.bmcl.2006.10.045
Homo sapiens MDA-MB-231 IC50 12300.0 nM 10.1016/j.bmcl.2006.10.048
Homo sapiens MDA-MB-231 IC50 13480.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens MDA-MB-231 IC50 100000.0 nM 10.1021/acs.jmedchem.7b00467
Homo sapiens MDA-MB-231 Inhibition 39.0 % 10.1016/j.bmcl.2007.09.034
Homo sapiens MDA-MB-231 Inhibition 39.0 % 10.1021/jm0613828
Homo sapiens MDA-MB-231 T/C 39.3 % 10.1021/acs.jmedchem.2c01058
Homo sapiens MDA-MB-231 T/C 57.0 % 10.1021/jm200577a
Homo sapiens MDA-MB-231 T/C 58.0 % 10.1021/jm200577a
Homo sapiens MDA-MB-231 T/C 64.0 % 10.1021/jm101605z
Homo sapiens MDA-MB-231 TGI 26.0 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 TGI 32.0 % 10.1016/j.ejmech.2020.112679
Homo sapiens MDA-MB-231 TGI 33.0 % 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-231 TGI 43.0 % 10.1021/jm200577a
Homo sapiens MDA-MB-231 TGI 44.0 % 10.1021/jm200577a
Homo sapiens MDA-MB-231 TGI 76.6 % 10.1021/acs.jmedchem.2c01058
Homo sapiens MDA-MB-231 TGI nan None 10.1016/j.ejmech.2020.112648
Homo sapiens MDA-MB-231 TGI nan None 10.1016/j.ejmech.2020.112677
Homo sapiens MDA-MB-361 IC50 1731.57 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-415 IC50 5921.39 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-435 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens MDA-MB-435 GI50 880.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens MDA-MB-435 GI50 1180.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens MDA-MB-435 IC50 1900.0 nM 10.1016/s0960-894x(03)00301-9
Homo sapiens MDA-MB-435 IC50 1900.0 nM 10.1021/jm0303094
Homo sapiens MDA-MB-436 IC50 3900.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens MDA-MB-453 IC50 370.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens MDA-MB-453 IC50 2242.75 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-468 GI50 630.0 nM 10.1021/jm201496g
Homo sapiens MDA-MB-468 IC50 950.0 nM 10.1016/j.ejmech.2020.112831
Homo sapiens MDA-MB-468 IC50 1300.0 nM 10.1021/jm0703136
Homo sapiens MDA-MB-468 IC50 2300.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens MDA-MB-468 IC50 2690.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens MDA-MB-468 IC50 2750.0 nM 10.1021/acs.jmedchem.0c02111
Homo sapiens MDA-MB-468 IC50 2850.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens MDA-MB-468 IC50 5000.0 nM 10.1021/jm901453q
Homo sapiens MDA-MB-468 IC50 10030.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens ME-180 IC50 9067.25 nM 10.6019/CHEMBL1201861
Homo sapiens MEG-01 IC50 3061.64 nM 10.6019/CHEMBL1201861
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanoma cell Inhibition -18.0 % 10.1021/jm8005355
Homo sapiens MEL-HO IC50 1005.82 nM 10.6019/CHEMBL1201861
Homo sapiens MEL-JUSO IC50 3891.53 nM 10.6019/CHEMBL1201861
Homo sapiens MeWo IC50 4817.47 nM 10.6019/CHEMBL1201861
Homo sapiens MFE-280 IC50 9727.85 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 59803.31 nM 10.6019/CHEMBL1201861
Homo sapiens MG-63 GI50 10000.0 nM 10.1021/jm101177s
Homo sapiens MG-63 IC50 7418.49 nM 10.6019/CHEMBL1201861
Homo sapiens MGC-803 Activity 73.8 % 10.1016/j.ejmech.2021.113453
Homo sapiens MGC-803 GI90 10.8 uM 10.1021/jm3011838
Homo sapiens MGC-803 IC50 1540.0 nM 10.1016/j.ejmech.2021.113453
Homo sapiens MGC-803 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens MGC-803 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens MGC-803 IC50 2678.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens MGC-803 IC50 3510.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens MGC-803 IC50 8670.0 nM 10.1016/j.ejmech.2021.113392
Homo sapiens MGC-803 IC50 8750.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens MGC-803 IC50 9740.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens MHH-ES-1 IC50 1704.35 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 1283.29 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 294.53 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 GI 86.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens MIA PaCa-2 GI50 3500.0 nM 10.1021/jm101177s
Homo sapiens MIA PaCa-2 IC50 949.12 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 IC50 1000.0 nM 10.1016/j.bmcl.2009.04.058
Homo sapiens MIA PaCa-2 IC50 1000.0 nM 10.1021/jm8002894
Homo sapiens MIA PaCa-2 IC50 1100.0 nM 10.1021/jm701606b
Homo sapiens MIA PaCa-2 IC50 1100.0 nM 10.1021/jm901667k
Homo sapiens MIA PaCa-2 IC50 2200.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens Mitogen-activated protein kinase; ERK1/ERK2 Inhibition nan % 10.1016/j.ejmech.2017.12.061
Homo sapiens MKN-1 IC50 90812.51 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-28 IC50 2590.37 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-45 GI50 7300.0 nM 10.1021/jm900125m
Homo sapiens MKN-45 IC50 4577.32 nM 10.6019/CHEMBL1201861
Homo sapiens MKN-7 IC50 5988.0 nM 10.6019/CHEMBL1201861
Homo sapiens ML-2 IC50 1004.07 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 2967.17 nM 10.6019/CHEMBL1201861
Homo sapiens MM1.S Activity 1.74 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 3.04 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 9.68 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 11.8 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 15.0 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 29.7 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 53.6 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S Activity 75.4 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S IC50 573.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S IC50 590.3 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens MM1.S IC50 1540.0 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens MM1.S IC50 2844.0 nM 10.1021/acsmedchemlett.8b00125
Homo sapiens MM1.S TGI 32.5 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM1.S TGI 73.8 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MM473 Activity nan None 10.1016/j.ejmech.2021.113971
Homo sapiens MM473 IC50 8200.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens MM473 IC50 10000.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens MM96L EC50 10.0 nM 10.1021/acs.jmedchem.1c01215
Homo sapiens MMAC-SF IC50 4268.59 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 1026.8 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 2509.27 nM 10.6019/CHEMBL1201861
Homo sapiens MOLM-13 IC50 345.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens MOLM-13 IC50 984.9 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens MOLM-14 EC50 540.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens MOLM-14 IC50 nan None 10.1021/acs.jmedchem.7b00678
Homo sapiens MOLT-13 IC50 738.98 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 1297.97 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 Activity 28.4 % 10.1021/acs.jmedchem.7b00322
Homo sapiens MOLT-4 Activity 29.58 % 10.1016/j.bmcl.2020.127128
Homo sapiens MOLT-4 Activity 71.6 % 10.1021/acs.jmedchem.7b00322
Homo sapiens MOLT-4 Activity nan None 10.1021/acs.jmedchem.1c01119
Homo sapiens MOLT-4 GI 90.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens MOLT-4 GI50 400.0 nM 10.1021/jm201496g
Homo sapiens MOLT-4 GI50 670.0 nM 10.1021/jm101177s
Homo sapiens MOLT-4 IC50 330.0 nM 10.1016/j.bmc.2016.12.001
Homo sapiens MOLT-4 IC50 360.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens MOLT-4 IC50 380.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens MOLT-4 IC50 400.0 nM 10.1021/acs.jmedchem.8b01597
Homo sapiens MOLT-4 IC50 410.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens MOLT-4 IC50 410.0 nM 10.1016/j.ejmech.2022.114634
Homo sapiens MOLT-4 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens MOLT-4 IC50 520.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens MOLT-4 IC50 560.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens MOLT-4 IC50 700.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens MOLT-4 IC50 787.46 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 1080.0 nM 10.1016/j.bmc.2018.02.033
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 100000.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Monoamine oxidase B IC50 100000.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 3162.3 nM None
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MPP-89 IC50 7597.29 nM 10.6019/CHEMBL1201861
Homo sapiens MRC5 IC50 68700.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens MS-1 IC50 1006.17 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 6722.33 nM 10.6019/CHEMBL1201861
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MV4-11 Activity 0.0 % 10.1021/acs.jmedchem.5b01342
Homo sapiens MV4-11 Activity 0.0 % 10.1021/acs.jmedchem.6b00579
Homo sapiens MV4-11 Activity 0.93 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 3.48 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 3.51 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 5.62 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 9.99 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 11.46 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 12.72 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 12.9 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 15.37 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 17.1 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 18.6 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 19.79 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 20.0 % 10.1016/j.ejmech.2020.112670
Homo sapiens MV4-11 Activity 20.37 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 24.13 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 24.22 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 26.52 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 27.29 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 28.6 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 28.82 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 30.07 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 35.44 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 35.72 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 37.0 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 37.9 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 38.87 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 40.0 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 42.4 % 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 Activity 43.2 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity 51.83 % 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 Activity 57.44 % 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 Activity 76.1 % 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 Activity nan None 10.1016/j.ejmech.2020.112868
Homo sapiens MV4-11 Activity nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens MV4-11 Activity nan None 10.1021/acs.jmedchem.0c00442
Homo sapiens MV4-11 Activity nan None 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 Activity nan None 10.1021/acs.jmedchem.8b00136
Homo sapiens MV4-11 Activity nan None 10.1021/acsmedchemlett.8b00057
Homo sapiens MV4-11 Activity nan None 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 CI 0.87 None 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 EC50 30.0 nM 10.1021/acs.jmedchem.6b01385
Homo sapiens MV4-11 EC50 418.1 nM 10.1021/acs.jmedchem.0c00442
Homo sapiens MV4-11 EC50 530.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens MV4-11 EC50 900.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens MV4-11 GI50 590.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens MV4-11 IC50 85.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens MV4-11 IC50 220.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens MV4-11 IC50 230.0 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens MV4-11 IC50 240.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 IC50 260.0 nM 10.1016/j.ejmech.2020.112868
Homo sapiens MV4-11 IC50 290.0 nM 10.1021/acs.jmedchem.1c01585
Homo sapiens MV4-11 IC50 310.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens MV4-11 IC50 380.0 nM 10.1021/acs.jmedchem.1c00420
Homo sapiens MV4-11 IC50 430.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens MV4-11 IC50 439.0 nM 10.1039/C3MD00285C
Homo sapiens MV4-11 IC50 471.4 nM 10.1016/j.bmcl.2022.128797
Homo sapiens MV4-11 IC50 496.1 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens MV4-11 IC50 500.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 IC50 500.0 nM 10.1021/acsmedchemlett.8b00057
Homo sapiens MV4-11 IC50 649.1 nM 10.6019/CHEMBL1201861
Homo sapiens MV4-11 IC50 680.0 nM 10.1016/j.bmc.2022.117067
Homo sapiens MV4-11 IC50 720.0 nM 10.1016/j.bmcl.2016.04.034
Homo sapiens MV4-11 IC50 850.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens MV4-11 IC50 980.0 nM 10.1016/j.bmcl.2017.07.054
Homo sapiens MV4-11 IC50 8440.0 nM 10.1016/j.bmcl.2021.128286
Homo sapiens MV4-11 IC50 nan None 10.1021/acs.jmedchem.7b00678
Homo sapiens MV4-11 TGI 24.0 % 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 TGI 37.0 % 10.1021/acs.jmedchem.2c00866
Homo sapiens MV4-11 TGI 68.5 % 10.1021/acs.jmedchem.2c00673
Homo sapiens MZ1-PC IC50 24675.92 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 3476.81 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 143318.58 nM 10.6019/CHEMBL1201861
Homo sapiens NAD-dependent deacetylase sirtuin 1 FC 1.3 None 10.1021/acs.jmedchem.9b00255
Homo sapiens NAD-dependent deacetylase sirtuin 1 FC 7.9 None 10.1021/acs.jmedchem.7b00533
Homo sapiens NAD-dependent deacetylase sirtuin 1 FC 12.6 None 10.1021/acs.jmedchem.7b00533
Homo sapiens NAD-dependent deacetylase sirtuin 2 FC 1.61 None 10.1021/acs.jmedchem.9b00255
Homo sapiens NAD-dependent deacetylase sirtuin 2 FC 18.6 None 10.1021/acs.jmedchem.7b00533
Homo sapiens NAD-dependent deacetylase sirtuin 2 FC 18.7 None 10.1021/acs.jmedchem.7b00533
Homo sapiens NAD-dependent deacetylase sirtuin 2 IC50 nan None 10.1021/acs.jmedchem.1c01311
Homo sapiens NAD-dependent protein deacylase sirtuin-5, mitochondrial IC50 100000.0 nM 10.1021/jm300526r
Homo sapiens NAD-dependent protein deacylase sirtuin-5, mitochondrial IC50 nan None 10.1021/acs.jmedchem.1c01311
Homo sapiens NALM-6 IC50 1200.0 nM 10.1016/j.bmc.2022.117085
Homo sapiens NAMALVA Activity 1.17 % 10.1016/j.bmc.2021.116085
Homo sapiens NAMALVA Activity 10.2 % 10.1016/j.bmc.2021.116085
Homo sapiens NAMALVA Activity 39.2 % 10.1016/j.bmc.2021.116085
Homo sapiens NAMALVA Activity 49.5 % 10.1016/j.bmc.2021.116085
Homo sapiens NAMALVA IC50 110.0 nM 10.1016/j.bmc.2021.116085
Homo sapiens NB1 IC50 2710.0 nM 10.1039/C8MD00454D
Homo sapiens NB10 IC50 751.92 nM 10.6019/CHEMBL1201861
Homo sapiens NB12 IC50 2717.1 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 1055.01 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 696.95 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 2382.43 nM 10.6019/CHEMBL1201861
Homo sapiens NB-4 Activity nan None 10.1016/j.ejmech.2018.07.069
Homo sapiens NB-4 Activity nan None 10.1021/jm100244y
Homo sapiens NB-4 IC50 600.0 nM 10.1016/j.bmcl.2008.07.119
Homo sapiens NB-4 IC50 700.0 nM 10.1016/j.bmcl.2007.09.014
Homo sapiens NB-4 IC50 700.0 nM 10.1016/j.ejmech.2008.11.005
Homo sapiens NB-4 IC50 880.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens NB-4 IC50 980.0 nM 10.1016/j.ejmech.2013.05.017
Homo sapiens NB-4 IC50 1200.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens NB-4 IC50 1520.0 nM 10.1021/jm101605z
Homo sapiens NB-4 IC50 3300.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens NB5 IC50 1198.56 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 1912.98 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 411.71 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 345.74 nM 10.6019/CHEMBL1201861
Homo sapiens NBsusSR IC50 1051.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI/ADR-RES Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens NCI/ADR-RES IC50 1413.4 nM 10.1016/j.bmc.2019.02.046
Homo sapiens NCI-H1048 IC50 2550.25 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 1154.06 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 2367.25 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 IC50 550.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H1299 IC50 3460.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H1299 IC50 4920.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens NCI-H1299 IC50 5100.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens NCI-H1299 IC50 5463.35 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 IC50 5530.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens NCI-H1299 IC50 7020.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens NCI-H1299 IC50 7240.0 nM 10.1021/jm030235w
Homo sapiens NCI-H1304 IC50 20750.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 3007.96 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 10178.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1437 IC50 2418.73 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1563 IC50 3330.18 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1573 IC50 9105.32 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 2501.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens NCI-H1581 IC50 3844.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1623 IC50 7140.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 4722.73 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 30192.39 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1651 IC50 3246.44 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1666 IC50 2281.11 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1693 IC50 12581.64 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1703 IC50 5358.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1755 IC50 16572.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 1485.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1792 IC50 4761.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1793 IC50 53349.89 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 8257.81 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1975 GI50 980.0 nM 10.1016/j.ejmech.2020.112086
Homo sapiens NCI-H1975 GI50 1410.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens NCI-H1975 GI50 2610.0 nM 10.1016/j.ejmech.2019.111725
Homo sapiens NCI-H1975 IC50 2040.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens NCI-H1993 IC50 958329.82 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2029 IC50 19602.05 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2030 IC50 6912.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2052 IC50 10188.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2087 IC50 9673.52 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 729.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2122 IC50 3413.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2122 IC50 7500.0 nM 10.1021/jm901453q
Homo sapiens NCI-H2126 IC50 1319.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H2126 IC50 2609.84 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2170 IC50 2505.49 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2228 IC50 34360.55 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2228 IC50 nan None 10.1016/j.ejmech.2021.113672
Homo sapiens NCI-H226 EC50 2600.0 nM 10.1021/jm049207j
Homo sapiens NCI-H226 EC50 2600.0 nM 10.1021/jm7011408
Homo sapiens NCI-H226 GI50 4000.0 nM 10.1021/jm201496g
Homo sapiens NCI-H226 IC50 3480.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H226 IC50 8330.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens NCI-H226 IC50 17934.5 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2291 IC50 49830.14 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 Activity 3.3 % 10.1021/acs.jmedchem.2c01276
Homo sapiens NCI-H23 GI50 920.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens NCI-H23 GI50 920.0 nM 10.1021/jm0613828
Homo sapiens NCI-H23 GI50 1000.0 nM 10.1021/jm201496g
Homo sapiens NCI-H23 GI50 1340.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens NCI-H23 GI50 2000.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens NCI-H23 GI50 2340.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens NCI-H23 GI50 2340.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens NCI-H23 GI50 2340.0 nM 10.1021/acs.jmedchem.5b00062
Homo sapiens NCI-H23 GI50 2340.0 nM 10.1021/jm3009376
Homo sapiens NCI-H23 IC50 383.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H23 IC50 1440.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens NCI-H23 IC50 1546.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 2800.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens NCI-H23 IC50 3200.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens NCI-H2342 IC50 66607.35 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2347 IC50 23267.42 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2405 IC50 12203.64 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2452 IC50 10159.98 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H28 IC50 8059.63 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H292 IC50 1110.0 nM 10.1016/j.bmcl.2017.01.025
Homo sapiens NCI-H292 IC50 2010.0 nM 10.1016/j.bmcl.2017.01.025
Homo sapiens NCI-H292 IC50 2865.96 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H292 IC50 4610.0 nM 10.1016/j.bmcl.2017.01.025
Homo sapiens NCI-H292 IC50 5150.0 nM 10.1016/j.bmcl.2017.01.025
Homo sapiens NCI-H322M GI50 790.0 nM 10.1021/jm201496g
Homo sapiens NCI-H358 IC50 2500.0 nM 10.1021/jm901453q
Homo sapiens NCI-H358 IC50 66551.89 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H441 IC50 16003.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 2045.99 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 Activity 1.8 % 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 Activity 2.2 % 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H460 Activity 4.81 % 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H460 Activity 6.4 % 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H460 Activity 11.7 % 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 Activity 23.1 % 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 Activity 65.2 % 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 Activity 86.6 % 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H460 Activity nan None 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 GI 15.12 % 10.1016/j.bmcl.2010.03.112
Homo sapiens NCI-H460 GI 26.05 % 10.1016/j.ejmech.2020.112073
Homo sapiens NCI-H460 GI 40.85 % 10.1016/j.bmcl.2010.03.112
Homo sapiens NCI-H460 GI 54.93 % 10.1016/j.bmcl.2010.03.112
Homo sapiens NCI-H460 GI 61.06 % 10.1007/s00044-011-9879-7
Homo sapiens NCI-H460 GI 61.06 % 10.1016/j.bmcl.2010.03.112
Homo sapiens NCI-H460 GI 68.66 % 10.1016/j.ejmech.2020.112073
Homo sapiens NCI-H460 GI50 790.0 nM 10.1021/jm201496g
Homo sapiens NCI-H460 GI50 850.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens NCI-H460 GI50 850.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens NCI-H460 GI50 1000.0 nM 10.1016/j.bmcl.2013.03.002
Homo sapiens NCI-H460 GI50 8000.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens NCI-H460 IC50 0.68 ug.mL-1 10.1016/j.bmcl.2011.07.124
Homo sapiens NCI-H460 IC50 425.0 nM 10.1021/acsmedchemlett.7b00504
Homo sapiens NCI-H460 IC50 1000.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens NCI-H460 IC50 1000.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens NCI-H460 IC50 1200.0 nM 10.1021/jm0703136
Homo sapiens NCI-H460 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens NCI-H460 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens NCI-H460 IC50 1700.0 nM 10.1021/jm901453q
Homo sapiens NCI-H460 IC50 2770.0 nM 10.1016/j.ejmech.2013.10.045
Homo sapiens NCI-H460 IC50 3040.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens NCI-H460 IC50 3400.0 nM 10.1016/j.bmcl.2007.09.014
Homo sapiens NCI-H460 IC50 3400.0 nM 10.1016/j.bmcl.2009.03.101
Homo sapiens NCI-H460 IC50 3400.0 nM 10.1016/j.bmcl.2014.12.051
Homo sapiens NCI-H460 IC50 3400.0 nM 10.1016/j.ejmech.2008.11.005
Homo sapiens NCI-H460 IC50 3400.0 nM 10.1021/jm101092u
Homo sapiens NCI-H460 IC50 3448.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H460 IC50 4136.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens NCI-H460 IC50 4200.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens NCI-H460 IC50 5460.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens NCI-H460 IC50 6290.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens NCI-H460 IC50 11920.0 nM 10.1016/j.ejmech.2020.112073
Homo sapiens NCI-H460 IC50 100000.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens NCI-H460 Inhibition 34.0 % 10.1016/j.ejmech.2008.11.005
Homo sapiens NCI-H460 LC50 100000.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens NCI-H460 TGI 100.0 % 10.1016/j.bmcl.2010.05.020
Homo sapiens NCI-H510A IC50 2644.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H520 IC50 22761.08 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H522 Activity 30.0 % 10.1021/acs.jmedchem.2c01276
Homo sapiens NCI-H522 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens NCI-H522 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens NCI-H522 IC50 832.0 nM 10.1016/j.bmcl.2010.08.113
Homo sapiens NCI-H522 IC50 1720.0 nM 10.1021/acs.jmedchem.2c00909
Homo sapiens NCI-H522 IC50 2380.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens NCI-H526 GI50 481.0 nM 10.1021/acsmedchemlett.2c00126
Homo sapiens NCI-H526 IC50 1082.91 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H596 IC50 23905.51 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H630 IC50 4780.81 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H650 IC50 3642.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H661 IC50 130.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens NCI-H661 IC50 130.0 nM 10.1016/j.ejmech.2015.04.002
Homo sapiens NCI-H661 IC50 2640.85 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 EC50 2060.0 nM 10.1021/jm801128g
Homo sapiens NCI-H69 IC50 600.0 nM 10.1016/j.bmcl.2013.07.001
Homo sapiens NCI-H69 IC50 1341.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 560.18 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 IC50 1370.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens NCI-H727 IC50 47245.06 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H747 IC50 10874.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H810 IC50 3048.23 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 26428.79 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H838 IC50 5180.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens NCI-H929 EC50 1400.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens NCI-N87 IC50 4508.68 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 289.38 nM 10.6019/CHEMBL1201861
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NFF IC50 5170.0 nM 10.1016/j.ejmech.2018.09.018
Homo sapiens NH-12 IC50 1726.91 nM 10.6019/CHEMBL1201861
Homo sapiens Nicotinamide phosphoribosyltransferase IC50 nan None 10.1021/acs.jmedchem.7b00467
Homo sapiens Nicotinamide phosphoribosyltransferase IC50 nan None 10.1021/acsmedchemlett.7b00414
Homo sapiens NKM-1 IC50 544.27 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 37052.91 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 12121.75 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 9260.28 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 2193.17 nM 10.6019/CHEMBL1201861
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NOS-1 IC50 1411.94 nM 10.6019/CHEMBL1201861
Homo sapiens NTERA-2-cl-D1 IC50 1317.61 nM 10.6019/CHEMBL1201861
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 2310.9 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 4466.8 nM None
Homo sapiens Nuclear receptor subfamily 0 group B member 1 IC50 747.17 nM None
Homo sapiens Nuclear receptor subfamily 0 group B member 1 IC50 67642.0 nM None
Homo sapiens NUGC-3 GI50 2790.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens NUGC-3 GI50 2940.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens NUGC-3 GI50 2940.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens NUGC-3 GI50 2940.0 nM 10.1021/jm3009376
Homo sapiens NUGC-3 IC50 4255.05 nM 10.6019/CHEMBL1201861
Homo sapiens NY IC50 49390.84 nM 10.6019/CHEMBL1201861
Homo sapiens OAW-28 IC50 4583.98 nM 10.6019/CHEMBL1201861
Homo sapiens OAW-42 IC50 2334.16 nM 10.6019/CHEMBL1201861
Homo sapiens OC-314 IC50 2232.59 nM 10.6019/CHEMBL1201861
Homo sapiens OCI-AML2 IC50 390.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens OCI-AML2 IC50 780.0 nM 10.1016/j.bmcl.2017.07.054
Homo sapiens OCI-AML2 IC50 4652.38 nM 10.6019/CHEMBL1201861
Homo sapiens OCI-AML-3 IC50 300.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens OCI-AML-3 IC50 850.0 nM 10.1016/j.bmcl.2017.07.054
Homo sapiens OCI-AML-3 IC50 1365.0 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens OCI-Ly3 Activity nan None 10.1016/j.bmcl.2022.128825
Homo sapiens OCI-Ly3 IC50 2200.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens OCUB-M IC50 3546.65 nM 10.6019/CHEMBL1201861
Homo sapiens OE19 GI50 1420.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens OE19 IC50 8762.62 nM 10.6019/CHEMBL1201861
Homo sapiens OE33 GI50 1120.0 nM 10.1016/j.bmc.2019.07.055
Homo sapiens OE33 IC50 4877.13 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 6854.02 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 1828.97 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 2040.0 nM 10.1021/acs.jmedchem.6b01538
Homo sapiens OPM-2 EC50 2900.0 nM 10.1016/j.ejmech.2019.111755
Homo sapiens OPM-2 IC50 2910.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens OS-RC-2 IC50 1871.51 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-3 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens OVCAR-3 GI50 1400.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens OVCAR-3 GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens OVCAR-3 IC50 7211.33 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 GI50 4000.0 nM 10.1021/jm201496g
Homo sapiens OVCAR-4 IC50 3928.89 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-5 GC50 0.99 uM 10.1016/j.bmc.2017.04.043
Homo sapiens OVCAR-5 GI50 790.0 nM 10.1021/jm201496g
Homo sapiens OVCAR-5 GI50 1780.0 nM 10.1016/j.bmcl.2013.09.051
Homo sapiens OVCAR-5 IC50 576.11 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-8 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens OVCAR-8 IC50 1544.77 nM 10.6019/CHEMBL1201861
Homo sapiens P12-Ichikawa IC50 596.51 nM 10.6019/CHEMBL1201861
Homo sapiens P30-OHK IC50 835.7 nM 10.6019/CHEMBL1201861
Homo sapiens p53-binding protein Mdm-2 Ki 20000.0 nM 10.1021/acs.jmedchem.8b00664
Homo sapiens PA-1 IC50 286.26 nM 10.6019/CHEMBL1201861
Homo sapiens Paired box protein Pax-8 AC50 4580.0 nM None
Homo sapiens PANC-03-27 IC50 4999.62 nM 10.6019/CHEMBL1201861
Homo sapiens PANC-08-13 IC50 3796.02 nM 10.6019/CHEMBL1201861
Homo sapiens PANC-1 Activity nan None 10.1016/j.bmcl.2007.06.038
Homo sapiens PANC-1 IC50 450.0 nM 10.1016/j.bmcl.2007.06.038
Homo sapiens PANC-1 IC50 900.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens PANC-1 IC50 3140.0 nM 10.1016/j.bmcl.2023.129305
Homo sapiens PANC-1 IC50 10000.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens Panc1005 IC50 8370.47 nM 10.6019/CHEMBL1201861
Homo sapiens PBMC Activity nan None 10.1021/acsmedchemlett.8b00057
Homo sapiens PBMC IC50 229.0 nM 10.1039/C3MD00285C
Homo sapiens PBMC IC50 955.0 nM 10.1039/C3MD00285C
Homo sapiens PBMC IC50 3500.0 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens PC-14 IC50 2805.1 nM 10.6019/CHEMBL1201861
Homo sapiens PC-3 Activity 10.4 % 10.1021/acs.jmedchem.2c01276
Homo sapiens PC-3 Activity nan None 10.1016/j.ejmech.2017.11.092
Homo sapiens PC-3 EC50 166670.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens PC-3 GI 88.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens PC-3 GI50 410.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens PC-3 GI50 600.0 nM 10.1016/j.ejmech.2017.03.079
Homo sapiens PC-3 GI50 710.0 nM 10.1016/j.bmcl.2007.06.060
Homo sapiens PC-3 GI50 890.0 nM 10.1016/j.bmcl.2006.04.091
Homo sapiens PC-3 GI50 890.0 nM 10.1021/jm0613828
Homo sapiens PC-3 GI50 1020.0 nM 10.1016/j.ejmech.2011.06.002
Homo sapiens PC-3 GI50 1210.0 nM 10.1021/jm300197a
Homo sapiens PC-3 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens PC-3 GI50 2000.0 nM 10.1021/jm101177s
Homo sapiens PC-3 GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens PC-3 GI50 2690.0 nM 10.1016/j.bmcl.2007.09.034
Homo sapiens PC-3 GI50 2690.0 nM 10.1016/j.ejmech.2016.11.055
Homo sapiens PC-3 GI50 2690.0 nM 10.1021/jm3009376
Homo sapiens PC-3 GI50 4600.0 nM 10.1021/jm900125m
Homo sapiens PC-3 GI50 5000.0 nM 10.1016/j.ejmech.2019.02.022
Homo sapiens PC-3 GI50 8170.0 nM 10.1016/j.bmcl.2009.09.100
Homo sapiens PC-3 GI50 18830.0 nM 10.1016/j.bmc.2017.05.062
Homo sapiens PC-3 IC50 0.94 ug.mL-1 10.1016/j.bmcl.2011.07.124
Homo sapiens PC-3 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens PC-3 IC50 447.6 nM 10.1016/j.bmc.2015.08.040
Homo sapiens PC-3 IC50 850.0 nM 10.1016/j.bmcl.2018.06.037
Homo sapiens PC-3 IC50 850.0 nM 10.1021/acs.jmedchem.7b00678
Homo sapiens PC-3 IC50 873.26 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens PC-3 IC50 1000.0 nM 10.1016/j.ejmech.2018.09.024
Homo sapiens PC-3 IC50 1140.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens PC-3 IC50 1210.0 nM 10.1016/j.bmcl.2010.04.041
Homo sapiens PC-3 IC50 1210.0 nM 10.1021/jm2003552
Homo sapiens PC-3 IC50 1330.0 nM 10.1021/jm200577a
Homo sapiens PC-3 IC50 1350.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens PC-3 IC50 1420.0 nM 10.1039/C4MD00203B
Homo sapiens PC-3 IC50 1500.0 nM 10.1016/j.ejmech.2017.11.092
Homo sapiens PC-3 IC50 1560.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens PC-3 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens PC-3 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens PC-3 IC50 1740.0 nM 10.1021/jm401899x
Homo sapiens PC-3 IC50 1810.0 nM 10.1016/j.ejmech.2019.111991
Homo sapiens PC-3 IC50 1820.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens PC-3 IC50 1860.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens PC-3 IC50 1900.0 nM 10.1021/acs.jmedchem.1c02225
Homo sapiens PC-3 IC50 1900.0 nM 10.1021/jm0703136
Homo sapiens PC-3 IC50 1920.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens PC-3 IC50 1980.0 nM 10.1016/j.ejmech.2011.08.045
Homo sapiens PC-3 IC50 2030.0 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens PC-3 IC50 2459.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens PC-3 IC50 2580.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens PC-3 IC50 2690.0 nM 10.1016/j.bmcl.2010.08.117
Homo sapiens PC-3 IC50 2780.0 nM 10.1016/j.bmc.2015.06.015
Homo sapiens PC-3 IC50 2900.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens PC-3 IC50 2920.0 nM 10.1016/j.bmcl.2017.09.036
Homo sapiens PC-3 IC50 3000.0 nM 10.1016/j.bmc.2021.116454
Homo sapiens PC-3 IC50 3000.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens PC-3 IC50 3038.74 nM 10.6019/CHEMBL1201861
Homo sapiens PC-3 IC50 3052.4 nM 10.1016/j.bmc.2015.08.040
Homo sapiens PC-3 IC50 3070.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens PC-3 IC50 3110.0 nM 10.1016/j.bmcl.2006.10.048
Homo sapiens PC-3 IC50 3200.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens PC-3 IC50 3220.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens PC-3 IC50 3310.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens PC-3 IC50 3460.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens PC-3 IC50 3570.0 nM 10.1021/jm401877m
Homo sapiens PC-3 IC50 3600.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens PC-3 IC50 4310.0 nM 10.1016/j.ejmech.2013.10.045
Homo sapiens PC-3 IC50 5000.0 nM 10.1021/acs.jmedchem.8b00384
Homo sapiens PC-3 IC50 5360.0 nM 10.1016/j.bmc.2015.08.040
Homo sapiens PC-3 IC50 6500.0 nM 10.1016/j.bmcl.2010.03.112
Homo sapiens PC-3 IC50 6500.0 nM 10.1021/jm058214k
Homo sapiens PC-3 IC50 6700.0 nM 10.1016/j.ejmech.2018.03.002
Homo sapiens PC-3 IC50 7300.0 nM 10.1016/j.bmc.2015.06.024
Homo sapiens PC-3 IC50 9790.0 nM 10.1016/j.bmc.2014.01.045
Homo sapiens PC-3 IC50 9900.0 nM 10.1021/ml300366t
Homo sapiens PC-3 IC50 10400.0 nM 10.1016/j.bmc.2015.07.008
Homo sapiens PC-3 IC50 13910.0 nM 10.1016/j.ejmech.2017.03.064
Homo sapiens PC-3 IC50 16280.0 nM 10.1016/j.bmc.2016.12.001
Homo sapiens PC-3 IC50 60800.0 nM 10.1016/j.bmcl.2020.127128
Homo sapiens PC-3 IC50 12999899.65 nM 10.1016/j.bmcl.2003.11.062
Homo sapiens PC-3 TGI 35.0 % 10.1016/j.bmcl.2010.04.041
Homo sapiens Peroxisome proliferator-activated receptor gamma AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens PFSK-1 IC50 1803.7 nM 10.6019/CHEMBL1201861
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A FC nan None 10.1021/acs.jmedchem.6b00908
Homo sapiens PI3-kinase p110-alpha/p85-alpha IC50 10000.0 nM 10.1021/acs.jmedchem.6b00579
Homo sapiens PI3-kinase p110-alpha/p85-alpha IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens PI3-kinase p110-alpha subunit IC50 nan None 10.1016/j.bmc.2022.117067
Homo sapiens PI3-kinase p110-alpha subunit Inhibition nan % 10.1016/j.bmc.2022.117067
Homo sapiens PI3-kinase p110-delta subunit IC50 nan None 10.1016/j.bmc.2022.117028
Homo sapiens Plasma Cp 0.01 uM 10.1021/acs.jmedchem.6b01507
Homo sapiens Plasma Drug degradation 45.0 % 10.1021/acs.jmedchem.5b00539
Homo sapiens Plasma Stability 55.0 % 10.1021/acs.jmedchem.5b00539
Homo sapiens Plasma Stability 72.0 % 10.1021/acs.jmedchem.5b00539
Homo sapiens PLC IC50 1534.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens PLC-PRF-5 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens PLC-PRF-5 IC50 1870.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens PLC-PRF-5 IC50 2220.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens Poly [ADP-ribose] polymerase-1 IC50 nan None 10.1016/j.bmcl.2022.128821
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor Activity nan None 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor EC50 25100.0 nM 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor EC50 35500.0 nM 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor Efficacy 55.1 % 10.1124/dmd.110.035105
Homo sapiens Pregnane X receptor Efficacy 82.7 % 10.1124/dmd.110.035105
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Proteasome Macropain subunit MB1 IC50 25000.0 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Protein-tyrosine phosphatase 2C IC50 nan None 10.1021/acs.jmedchem.2c00866
Homo sapiens Protein-tyrosine phosphatase 2C Inhibition nan % 10.1021/acs.jmedchem.2c00866
Homo sapiens PSN1 IC50 2289.13 nM 10.6019/CHEMBL1201861
Homo sapiens PT-45 IC50 4000.0 nM 10.1016/j.bmcl.2007.06.038
Homo sapiens QIMR-WIL IC50 862.03 nM 10.6019/CHEMBL1201861
Homo sapiens quadruplex DNA Activity nan None 10.1021/acs.jmedchem.2c01058
Homo sapiens quadruplex DNA Delta Tm 0.1 degrees C 10.1021/acs.jmedchem.2c01058
Homo sapiens Raji IC50 0.97 nM 10.1016/j.bmcl.2017.03.020
Homo sapiens Raji IC50 196.0 nM 10.1021/acs.jmedchem.8b01825
Homo sapiens Raji IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Raji IC50 867.4 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Raji IC50 970.0 nM 10.1016/j.bmc.2018.03.002
Homo sapiens Raji IC50 1110.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Raji IC50 9440.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens Ramos IC50 0.52 nM 10.1016/j.bmcl.2017.03.020
Homo sapiens Ramos IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens Ramos IC50 514.6 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens Ramos IC50 520.0 nM 10.1016/j.bmc.2018.03.002
Homo sapiens Ramos IC50 620.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Ramos IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
Homo sapiens Ramos IC50 3900.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens Ramos-2G6-4C10 IC50 1994.93 nM 10.6019/CHEMBL1201861
Homo sapiens RCC10RGB IC50 21282.88 nM 10.6019/CHEMBL1201861
Homo sapiens RCM-1 IC50 1121.02 nM 10.6019/CHEMBL1201861
Homo sapiens RD IC50 974.45 nM 10.6019/CHEMBL1201861
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None 10.1016/j.bmc.2016.10.006
Homo sapiens RERF-LC-MS IC50 5069.03 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 3102.78 nM 10.6019/CHEMBL1201861
Homo sapiens RH-18 IC50 2350.22 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 3307.57 nM 10.6019/CHEMBL1201861
Homo sapiens RMG-I IC50 3025.92 nM 10.6019/CHEMBL1201861
Homo sapiens RO82-W-1 IC50 13064.94 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-2650 IC50 2641.43 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-7951 IC50 3747.23 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 Activity 8.3 % 10.1016/j.ejmech.2016.02.003
Homo sapiens RPMI-8226 Activity 9.0 % 10.1016/j.ejmech.2016.02.003
Homo sapiens RPMI-8226 Activity 22.0 % 10.1021/acs.jmedchem.9b02161
Homo sapiens RPMI-8226 Activity 30.6 % 10.1021/acs.jmedchem.9b02161
Homo sapiens RPMI-8226 Activity 39.8 % 10.1016/j.ejmech.2016.02.003
Homo sapiens RPMI-8226 Activity 42.9 % 10.1016/j.ejmech.2016.02.003
Homo sapiens RPMI-8226 Activity 45.3 % 10.1021/acs.jmedchem.9b02161
Homo sapiens RPMI-8226 Activity nan None 10.1021/acs.jmedchem.9b02161
Homo sapiens RPMI-8226 GI50 1500.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens RPMI-8226 IC50 570.0 nM 10.1021/acsmedchemlett.9b00084
Homo sapiens RPMI-8226 IC50 585.8 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens RPMI-8226 IC50 660.0 nM 10.1016/j.bmc.2018.03.002
Homo sapiens RPMI-8226 IC50 678.18 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 684.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens RPMI-8226 IC50 870.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens RPMI-8226 IC50 1250.0 nM 10.1016/j.ejmech.2017.01.035
Homo sapiens RPMI-8226 IC50 2390.0 nM 10.1016/j.bmc.2015.06.071
Homo sapiens RPMI-8226 IC50 2400.0 nM 10.1021/np5006778
Homo sapiens RPMI-8226 IC50 10600.0 nM 10.1016/j.bmcl.2018.12.052
Homo sapiens RPMI-8866 IC50 813.67 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 Activity nan None 10.1021/acs.jmedchem.0c00442
Homo sapiens RS4-11 IC50 832.45 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 3980.0 nM 10.1016/j.ejmech.2021.114058
Homo sapiens RT-112 IC50 1592.84 nM 10.6019/CHEMBL1201861
Homo sapiens RVH-421 IC50 5499.08 nM 10.6019/CHEMBL1201861
Homo sapiens RWPE-1 IC50 480.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens RWPE-1 IC50 3640.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens RXF 393 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens RXF 393 GI50 1300.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens RXF 393 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens RXF 393 IC50 3532.94 nM 10.6019/CHEMBL1201861
Homo sapiens S-117 IC50 8253.53 nM 10.6019/CHEMBL1201861
Homo sapiens SAOS-2 IC50 2300.0 nM 10.1021/jm0703136
Homo sapiens SAOS-2 IC50 9521.95 nM 10.6019/CHEMBL1201861
Homo sapiens SAS IC50 1040.81 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-1 IC50 793.84 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-5 IC50 2061.47 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 1938.19 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 2490.0 nM 10.1021/jm901453q
Homo sapiens SCC-25 IC50 1930.0 nM 10.1021/jm901453q
Homo sapiens SCC-25 IC50 4358.19 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-4 IC50 2630.12 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-9 IC50 9718.16 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 4157.43 nM 10.6019/CHEMBL1201861
Homo sapiens Serine/threonine-protein kinase AKT Inhibition nan % 10.1016/j.bmcl.2010.08.113
Homo sapiens Serine/threonine-protein kinase AKT Inhibition nan % 10.1016/j.ejmech.2017.12.061
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotransferrin K 0.0 10'2/min 10.1021/jm401053m
Homo sapiens Serum T1/2 1.5 hr 10.1021/acs.jmedchem.5b00539
Homo sapiens SF-126 IC50 10472.73 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens SF-268 IC50 3045.23 nM 10.6019/CHEMBL1201861
Homo sapiens SF-295 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens SF-295 IC50 1066.24 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 Activity 16.8 % 10.1021/acs.jmedchem.2c01276
Homo sapiens SF-539 GI50 2000.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens SF-539 GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens SF-539 IC50 5266.32 nM 10.6019/CHEMBL1201861
Homo sapiens SGC-7901 GI90 9.4 uM 10.1021/jm3011838
Homo sapiens SGC-7901 IC50 640.0 nM 10.1016/j.ejmech.2021.113893
Homo sapiens SGC-7901 IC50 1030.0 nM 10.1016/j.bmcl.2019.07.045
Homo sapiens SGC-7901 IC50 2120.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens SGC-7901 IC50 3300.0 nM 10.1021/acs.jnatprod.2c00101
Homo sapiens SGC-7901 IC50 135710.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens SH-4 IC50 9493.64 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 7139.52 nM 10.6019/CHEMBL1201861
Homo sapiens SH-SY5Y Activity 33.8 % 10.1021/jm801529c
Homo sapiens SH-SY5Y Activity 34.0 % 10.1021/jm801529c
Homo sapiens SH-SY5Y Activity nan None 10.1021/acsmedchemlett.8b00507
Homo sapiens SH-SY5Y EC50 17400.0 nM 10.1021/jm2001025
Homo sapiens SH-SY5Y EC50 25600.0 nM 10.1021/jm2001025
Homo sapiens SH-SY5Y EC50 50000.0 nM 10.1021/jm2001025
Homo sapiens SH-SY5Y IC50 730.0 nM 10.1016/j.ejmech.2021.113672
Homo sapiens SH-SY5Y IC50 2000.0 nM 10.1021/jm801529c
Homo sapiens SH-SY5Y IC50 7870.0 nM 10.1016/j.bmc.2023.117154
Homo sapiens Signal transducer and activator of transcription 3 Inhibition nan % 10.1016/j.bmc.2020.115345
Homo sapiens Signal transducer and activator of transcription 3 Inhibition nan % 10.1016/j.ejmech.2020.112677
Homo sapiens SiHa IC50 7837.07 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 6563.47 nM 10.6019/CHEMBL1201861
Homo sapiens SK-BR-3 EC50 2100.0 nM 10.1021/jm901358y
Homo sapiens SK-BR-3 GI50 1200.0 nM 10.1021/ml400175d
Homo sapiens SK-BR-3 IC50 800.0 nM 10.1021/jm7011408
Homo sapiens SK-BR-3 IC50 1190.0 nM 10.1021/jm901453q
Homo sapiens SK-BR-3 IC50 2130.0 nM 10.1016/j.ejmech.2021.113173
Homo sapiens SK-BR-3 IC50 2600.0 nM 10.1021/jm0703136
Homo sapiens SK-BR-3 IC50 2600.0 nM 10.1021/jm100665z
Homo sapiens SK-BR-3 IC50 10000.0 nM None
Homo sapiens SK-BR-3 IC50 10100.0 nM None
Homo sapiens SKG-IIIa IC50 1234.64 nM 10.6019/CHEMBL1201861
Homo sapiens SK-HEP1 GI90 17.0 uM 10.1021/jm3011838
Homo sapiens SK-HEP1 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SK-HEP1 IC50 1850.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens SK-HEP1 IC50 2743.91 nM 10.6019/CHEMBL1201861
Homo sapiens SK-HEP1 IC50 3300.0 nM 10.1016/j.bmc.2021.116454
Homo sapiens SK-HEP1 IC50 3460.0 nM 10.1021/jm901453q
Homo sapiens SK-HEP1 IC50 36930.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens SK-LU-1 IC50 23071.82 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 10783.79 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 GI50 1300.0 nM 10.1021/jm201496g
Homo sapiens SK-MEL-2 IC50 809.44 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-24 IC50 54826.52 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-28 GI50 1000.0 nM 10.1021/jm201496g
Homo sapiens SK-MEL-28 IC50 482.0 nM 10.1021/acsmedchemlett.7b00504
Homo sapiens SK-MEL-28 IC50 10019.32 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL3 IC50 3828.41 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-30 IC50 11407.94 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-5 GI50 630.0 nM 10.1021/jm201496g
Homo sapiens SK-MES-1 EC50 2420.0 nM 10.1021/jm801128g
Homo sapiens SK-MES-1 IC50 2420.0 nM 10.1021/jm200799p
Homo sapiens SK-MES-1 IC50 7054.27 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-AS IC50 700.0 nM 10.1039/C8MD00454D
Homo sapiens SK-N-AS IC50 988.1 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-BE(2) IC50 4580.0 nM 10.1016/j.bmc.2023.117242
Homo sapiens SK-N-DZ IC50 900.43 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 1416.93 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 4944.21 nM 10.6019/CHEMBL1201861
Homo sapiens SK-OV-3 Activity nan None 10.1039/C8MD00107C
Homo sapiens SK-OV-3 EC50 2500.0 nM 10.1021/jm049207j
Homo sapiens SK-OV-3 EC50 2500.0 nM 10.1021/jm7011408
Homo sapiens SK-OV-3 GI50 1000.0 nM 10.1021/jm201496g
Homo sapiens SK-OV-3 GI50 2500.0 nM 10.1021/jm900125m
Homo sapiens SK-OV-3 IC50 1130.0 nM 10.1016/j.ejmech.2019.05.089
Homo sapiens SK-OV-3 IC50 2200.0 nM 10.1021/jm0703136
Homo sapiens SK-OV-3 IC50 2200.0 nM 10.1021/jm100665z
Homo sapiens SK-OV-3 IC50 2300.0 nM 10.1016/j.bmcl.2013.07.001
Homo sapiens SK-OV-3 IC50 1660000.0 nM 10.1016/j.bmc.2010.01.060
Homo sapiens SK-PN-DW IC50 17420.14 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 5277.51 nM 10.6019/CHEMBL1201861
Homo sapiens SMMC-7721 GI90 20.0 uM 10.1021/jm3011838
Homo sapiens SMMC-7721 IC50 1990.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens SMMC-7721 IC50 5200.0 nM 10.1021/acs.jnatprod.8b00843
Homo sapiens SMMC-7721 IC50 5230.0 nM 10.1016/j.ejmech.2019.02.054
Homo sapiens SMMC-7721 IC50 5274.0 nM 10.1016/j.ejmech.2020.112073
Homo sapiens SMMC-7721 IC50 5460.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SMMC-7721 IC50 5460.0 nM 10.1016/j.ejmech.2020.112844
Homo sapiens SMMC-7721 IC50 5460.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens SMMC-7721 IC50 5610.0 nM 10.1016/j.ejmech.2017.12.061
Homo sapiens SMMC-7721 IC50 5610.0 nM 10.1039/C6MD00681G
Homo sapiens SN12C Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens SN12C GI50 2000.0 nM 10.1021/jm201496g
Homo sapiens SN12C IC50 2432.14 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-19 GI50 630.0 nM 10.1021/jm201496g
Homo sapiens SNB-75 Activity 16.8 % 10.1021/acs.jmedchem.2c01276
Homo sapiens SNB-75 GI50 790.0 nM 10.1021/jm201496g
Homo sapiens SNB-75 GI50 800.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens SNB-75 IC50 15072.89 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-78 EC50 16000.0 nM 10.1021/jm049207j
Homo sapiens SNB-78 EC50 16000.0 nM 10.1021/jm7011408
Homo sapiens SNB-78 GI50 16000.0 nM 10.1021/jm900125m
Homo sapiens SNU1 IC50 1023.31 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 Activity 2.48 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 3.12 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 3.16 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 3.51 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 4.21 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 5.77 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 6.19 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 6.4 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 6.85 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 9.98 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 10.46 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 15.42 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 77.22 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 80.33 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 80.66 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity 84.26 % 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 Activity nan None 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-16 IC50 290.0 nM 10.1021/acs.jmedchem.2c01413
Homo sapiens SNU-387 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SNU-387 IC50 2450.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens SNU-387 IC50 7853.47 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-398 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SNU-398 IC50 1390.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens SNU-423 IC50 79.0 nM 10.1016/j.ejmech.2021.113824
Homo sapiens SNU-423 IC50 1758.27 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-449 IC50 2891.82 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 7021.59 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 4247.69 nM 10.6019/CHEMBL1201861
Homo sapiens SQ20B IC50 3000.0 nM 10.1021/jm7011408
Homo sapiens SR GI50 400.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens SR GI50 400.0 nM 10.1021/jm201496g
Homo sapiens St-4 EC50 5200.0 nM 10.1021/jm049207j
Homo sapiens St-4 EC50 5200.0 nM 10.1021/jm7011408
Homo sapiens SU-DHL10 IC50 470.0 nM 10.1021/acs.jmedchem.2c00673
Homo sapiens SU-DHL-6 IC50 430.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SU-DHL-6 IC50 580.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens SUM-159-PT Activity nan None 10.1021/acs.jmedchem.2c01058
Homo sapiens SUM-159-PT IC50 1381.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens SUM-159-PT IC50 3000.0 nM 10.1021/acs.jmedchem.2c01058
Homo sapiens Survival motor neuron protein Activity nan None 10.1021/acs.jmedchem.6b01885
Homo sapiens SW1088 IC50 5029.44 nM 10.6019/CHEMBL1201861
Homo sapiens SW 1116 IC50 3462.69 nM 10.6019/CHEMBL1201861
Homo sapiens SW13 IC50 3078.74 nM 10.6019/CHEMBL1201861
Homo sapiens SW1417 IC50 25249.79 nM 10.6019/CHEMBL1201861
Homo sapiens SW1463 IC50 100744.74 nM 10.6019/CHEMBL1201861
Homo sapiens SW1573 IC50 2960.82 nM 10.6019/CHEMBL1201861
Homo sapiens SW1710 IC50 5415.54 nM 10.6019/CHEMBL1201861
Homo sapiens SW1783 IC50 14239.12 nM 10.6019/CHEMBL1201861
Homo sapiens SW1990 IC50 3800.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens SW1990 IC50 5720.0 nM 10.1021/acs.jmedchem.2c00866
Homo sapiens SW1990 IC50 54994.11 nM 10.6019/CHEMBL1201861
Homo sapiens SW48 IC50 3656.57 nM 10.6019/CHEMBL1201861
Homo sapiens SW480 IC50 2120.0 nM 10.1016/j.bmcl.2022.128846
Homo sapiens SW480 IC50 3970.0 nM 10.1021/acs.jmedchem.5b01052
Homo sapiens SW480 IC50 nan None 10.1016/j.bmcl.2022.128663
Homo sapiens SW-620 Activity nan None 10.1016/j.bmcl.2020.127537
Homo sapiens SW-620 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens SW-620 GI50 540.0 nM 10.1021/ml400175d
Homo sapiens SW-620 GI50 630.0 nM 10.1021/jm201496g
Homo sapiens SW-620 IC50 0.5 ug.mL-1 10.1016/j.bmcl.2011.07.124
Homo sapiens SW-620 IC50 600.0 nM 10.1021/jm7011408
Homo sapiens SW-620 IC50 1120.0 nM 10.1016/j.bmcl.2020.127537
Homo sapiens SW-620 IC50 1290.18 nM 10.6019/CHEMBL1201861
Homo sapiens SW-620 IC50 1700.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens SW-620 IC50 1700.0 nM 10.1016/j.ejmech.2019.111970
Homo sapiens SW-620 IC50 2800.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SW-620 IC50 3200.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens SW-620 IC50 3700.0 nM 10.1016/j.ejmech.2013.10.045
Homo sapiens SW-620 IC50 3870.0 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens SW-620 IC50 4310.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens SW-620 IC50 6940.0 nM 10.1021/acs.jmedchem.9b02178
Homo sapiens SW626 IC50 1948.99 nM 10.6019/CHEMBL1201861
Homo sapiens SW684 IC50 9461.16 nM 10.6019/CHEMBL1201861
Homo sapiens SW756 IC50 3296.29 nM 10.6019/CHEMBL1201861
Homo sapiens SW780 IC50 4857.66 nM 10.6019/CHEMBL1201861
Homo sapiens SW837 IC50 5378.78 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 15221.84 nM 10.6019/CHEMBL1201861
Homo sapiens SW900 IC50 6762.21 nM 10.6019/CHEMBL1201861
Homo sapiens SW948 IC50 2184.56 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 863.16 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 4780.11 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 3805.51 nM 10.6019/CHEMBL1201861
Homo sapiens T-24 Activity nan None 10.1021/acs.jmedchem.8b01090
Homo sapiens T-24 EC50 120.0 nM 10.1016/j.bmcl.2008.11.081
Homo sapiens T-24 EC50 250.0 nM 10.1016/j.bmcl.2008.11.081
Homo sapiens T-24 IC50 2400.0 nM 10.1021/acs.jmedchem.8b01090
Homo sapiens T-24 IC50 3150.7 nM 10.6019/CHEMBL1201861
Homo sapiens T47D Activity 4.48 % 10.1021/acs.jmedchem.8b00209
Homo sapiens T47D Activity 20.4 % 10.1021/acs.jmedchem.8b00209
Homo sapiens T47D Activity 26.4 % 10.1021/acs.jmedchem.8b00209
Homo sapiens T47D Activity 48.6 % 10.1021/acs.jmedchem.8b00209
Homo sapiens T47D GC50 1.4 uM 10.1016/j.bmc.2017.04.043
Homo sapiens T47D GI50 500.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens T47D GI50 500.0 nM 10.1021/jm201496g
Homo sapiens T47D IC50 1250.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens T47D IC50 2243.0 nM 10.1016/j.ejmech.2020.112677
Homo sapiens T47D IC50 3010.0 nM 10.1021/acs.jmedchem.8b00209
Homo sapiens T47D IC50 3236.27 nM 10.6019/CHEMBL1201861
Homo sapiens T84 IC50 559616.09 nM 10.6019/CHEMBL1201861
Homo sapiens T98G IC50 4221.57 nM 10.6019/CHEMBL1201861
Homo sapiens TALL-1 Activity nan None 10.1021/acs.jmedchem.1c01119
Homo sapiens TCC-SUP IC50 1728.29 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 791.1 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 3920.1 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 7151.84 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 16187.28 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 7028.81 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 4939.77 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 2157.65 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 6898.47 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC11TKB IC50 2471.77 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC1TKB IC50 8735.35 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 14953.88 nM 10.6019/CHEMBL1201861
Homo sapiens THLE-2 LC50 3590.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens THP-1 Activity nan None 10.1016/j.ejmech.2020.112291
Homo sapiens THP-1 Activity nan None 10.1021/acs.jmedchem.8b01090
Homo sapiens THP-1 GI 91.0 % 10.1021/acs.jmedchem.7b00322
Homo sapiens THP-1 GI50 15500.0 nM 10.1021/acs.jmedchem.0c00491
Homo sapiens THP-1 IC50 10.0 ug.mL-1 10.1016/j.bmcl.2014.08.060
Homo sapiens THP-1 IC50 1100.0 nM 10.1021/acs.jmedchem.7b00322
Homo sapiens THP-1 IC50 3900.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens THP-1 IC50 9500.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens THP-1 IC50 18000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens THP-1 Inhibition 84.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens THP-1 Inhibition 97.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens THP-1 Inhibition 98.0 % 10.1016/j.ejmech.2020.112338
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens TI-73 IC50 1590.6 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens TK-10 GI50 630.0 nM 10.1021/jm201496g
Homo sapiens TK-10 IC50 3137.24 nM 10.6019/CHEMBL1201861
Homo sapiens Trypsin Inhibition nan % 10.1021/jm401053m
Homo sapiens TSGH IC50 2090.0 nM 10.1021/jm401899x
Homo sapiens Tubulin IC50 nan None 10.1016/j.ejmech.2021.113790
Homo sapiens Tubulin Inhibition nan % 10.1021/jm100244y
Homo sapiens TYK-nu IC50 1498.51 nM 10.6019/CHEMBL1201861
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase ABL IC50 100000.0 nM 10.1021/jm800988r
Homo sapiens Tyrosine-protein kinase JAK1 IC50 nan None 10.1021/acs.jmedchem.0c02111
Homo sapiens Tyrosine-protein kinase JAK2 IC50 10000.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens Tyrosine-protein kinase JAK2 IC50 nan None 10.1021/acs.jmedchem.8b00393
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition nan % 10.1021/acs.jmedchem.0c02111
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition nan % 10.1021/acs.jmedchem.8b01597
Homo sapiens Tyrosine-protein kinase JAK3 IC50 nan None 10.1021/acs.jmedchem.0c02111
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 10000.0 nM 10.1016/j.ejmech.2015.03.034
Homo sapiens Tyrosine-protein kinase TYK2 IC50 nan None 10.1021/acs.jmedchem.0c02111
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 421.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 595.7 nM None
Homo sapiens U-118-MG IC50 23721.69 nM 10.6019/CHEMBL1201861
Homo sapiens U-251 GI50 1530.0 nM 10.1021/ml400175d
Homo sapiens U-251 GI50 1600.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens U-251 GI50 1600.0 nM 10.1021/jm201496g
Homo sapiens U-251 GI50 2000.0 nM 10.1016/j.bmcl.2013.03.002
Homo sapiens U-251 GI50 6500.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens U-251 IC50 1000.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens U-251 IC50 5390.96 nM 10.6019/CHEMBL1201861
Homo sapiens U-251 IC50 17870.0 nM 10.1021/acs.jmedchem.1c01726
Homo sapiens U-251 IC50 nan None 10.1021/acs.jmedchem.1c01726
Homo sapiens U-251 LC50 100000.0 nM 10.1016/j.bmcl.2010.05.020
Homo sapiens U-251 TGI 40.0 % 10.1016/j.bmcl.2010.05.020
Homo sapiens U-266 IC50 590.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens U-266 IC50 880.0 nM 10.1016/j.bmc.2017.06.039
Homo sapiens U-266 IC50 2771.21 nM 10.6019/CHEMBL1201861
Homo sapiens U-266 IC50 3070.0 nM 10.1021/acs.jmedchem.9b02161
Homo sapiens U-266 IC50 42600.0 nM 10.1016/j.bmcl.2018.12.052
Homo sapiens U2932 IC50 1100.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens U2932 IC50 2700.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens U2OS IC50 1079.11 nM 10.6019/CHEMBL1201861
Homo sapiens U2OS IC50 2230.0 nM 10.1016/j.ejmech.2022.114807
Homo sapiens U2OS IC50 5700.0 nM 10.1016/j.ejmech.2020.112679
Homo sapiens U-87 MG IC50 10000.0 nM 10.1021/acs.jmedchem.9b00390
Homo sapiens U-87 MG IC50 15710.0 nM 10.1016/j.ejmech.2021.113338
Homo sapiens U-87 MG IC50 20641.3 nM 10.6019/CHEMBL1201861
Homo sapiens U-937 Activity 0.04 % 10.1021/jm401877m
Homo sapiens U-937 Activity 0.05 % 10.1021/jm401877m
Homo sapiens U-937 Activity 0.12 % 10.1021/jm401877m
Homo sapiens U-937 Activity 0.16 % 10.1021/jm401877m
Homo sapiens U-937 Activity 1.02 % 10.1021/jm401877m
Homo sapiens U-937 Activity 1.51 % 10.1021/jm401877m
Homo sapiens U-937 Activity 1.56 % 10.1021/jm401877m
Homo sapiens U-937 Activity 1.91 % 10.1021/jm401877m
Homo sapiens U-937 Activity 2.27 % 10.1021/jm401877m
Homo sapiens U-937 Activity 2.44 % 10.1021/jm401877m
Homo sapiens U-937 Activity 2.62 % 10.1021/jm401877m
Homo sapiens U-937 Activity 2.88 % 10.1021/jm401877m
Homo sapiens U-937 Activity 3.73 % 10.1021/jm401877m
Homo sapiens U-937 Activity 6.16 % 10.1016/j.ejmech.2014.10.077
Homo sapiens U-937 Activity 6.65 % 10.1016/j.ejmech.2014.10.077
Homo sapiens U-937 Activity 9.63 % 10.1021/jm401877m
Homo sapiens U-937 Activity 14.57 % 10.1016/j.ejmech.2014.10.077
Homo sapiens U-937 Activity 16.8 % 10.1016/j.bmcl.2008.03.055
Homo sapiens U-937 Activity 17.2 % 10.1021/jm401877m
Homo sapiens U-937 Activity 20.0 % 10.1016/j.ejmech.2020.112670
Homo sapiens U-937 Activity 21.22 % 10.1016/j.ejmech.2014.10.077
Homo sapiens U-937 Activity 21.5 % 10.1016/j.bmcl.2008.03.055
Homo sapiens U-937 Activity 25.0 % 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 Activity 32.0 % 10.1021/jm0605536
Homo sapiens U-937 Activity 48.0 % 10.1021/jm0605536
Homo sapiens U-937 Activity 48.0 % 10.1021/jm500303u
Homo sapiens U-937 Activity 72.15 % 10.1021/jm401877m
Homo sapiens U-937 Activity 72.62 % 10.1016/j.ejmech.2014.10.077
Homo sapiens U-937 Activity 94.19 % 10.1021/jm401877m
Homo sapiens U-937 Activity 94.56 % 10.1021/jm401877m
Homo sapiens U-937 Activity 95.78 % 10.1021/jm401877m
Homo sapiens U-937 Activity 96.17 % 10.1021/jm401877m
Homo sapiens U-937 Activity 98.0 % 10.1021/jm0605536
Homo sapiens U-937 Activity nan None 10.1016/j.bmc.2010.12.026
Homo sapiens U-937 Activity nan None 10.1016/j.bmcl.2008.03.055
Homo sapiens U-937 Activity nan None 10.1016/j.ejmech.2022.114409
Homo sapiens U-937 Activity nan None 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 Activity nan None 10.1021/jm0605536
Homo sapiens U-937 Activity nan None 10.1021/jm070028m
Homo sapiens U-937 Activity nan None 10.1021/jm401877m
Homo sapiens U-937 Activity nan None 10.1021/jm500303u
Homo sapiens U-937 Activity nan None 10.1021/ml5000959
Homo sapiens U-937 CC50 780.0 nM 10.1021/acsmedchemlett.8b00012
Homo sapiens U-937 CC50 1050.0 nM 10.1021/jm9004303
Homo sapiens U-937 EC50 820.0 nM 10.1021/jm901358y
Homo sapiens U-937 EC50 880.0 nM 10.1016/j.ejmech.2017.10.076
Homo sapiens U-937 EC50 33000.0 nM 10.1016/j.bmcl.2003.10.055
Homo sapiens U-937 GI50 390.0 nM 10.1016/j.bmcl.2010.09.016
Homo sapiens U-937 GI50 450.0 nM 10.1021/jm101177s
Homo sapiens U-937 GI50 1460.0 nM 10.1021/acs.jmedchem.5b01044
Homo sapiens U-937 IC50 370.0 nM 10.1016/j.bmc.2015.05.048
Homo sapiens U-937 IC50 540.0 nM 10.1016/j.bmc.2017.05.058
Homo sapiens U-937 IC50 540.0 nM 10.1016/j.ejmech.2017.04.017
Homo sapiens U-937 IC50 720.0 nM 10.1016/j.bmc.2018.06.016
Homo sapiens U-937 IC50 907.5 nM 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 IC50 1235.0 nM 10.1016/j.ejmech.2021.113790
Homo sapiens U-937 IC50 1450.0 nM 10.1021/jm401877m
Homo sapiens U-937 IC50 1530.0 nM 10.1016/j.bmc.2018.02.033
Homo sapiens U-937 IC50 1530.0 nM 10.1016/j.bmc.2019.03.008
Homo sapiens U-937 IC50 1640.0 nM 10.1016/j.bmc.2017.06.039
Homo sapiens U-937 IC50 2300.0 nM 10.1021/ml300366t
Homo sapiens U-937 IC50 2830.0 nM 10.1016/j.bmc.2015.04.028
Homo sapiens U-937 IC50 3350.0 nM 10.1016/j.bmc.2015.08.040
Homo sapiens U-937 IC50 4330.0 nM 10.1039/C4MD00203B
Homo sapiens U-937 IC50 4820.0 nM 10.1016/j.bmc.2015.06.015
Homo sapiens U-937 IC50 100000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens U-937 Inhibition 45.0 % 10.1021/acsmedchemlett.0c00014
Homo sapiens U-937 Inhibition nan % 10.1021/acsmedchemlett.0c00014
Homo sapiens U-937 Ratio 0.6 None 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 Ratio 0.9 None 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 Ratio 1.5 None 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 Ratio 2.5 None 10.1021/acs.jmedchem.6b00772
Homo sapiens U-937 TGI 32.1 % 10.1021/jm401877m
Homo sapiens UACC-257 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens UACC-257 IC50 5028.45 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-62 GI50 400.0 nM 10.1021/jm201496g
Homo sapiens UACC-62 IC50 42550.47 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-893 IC50 23103.82 nM 10.6019/CHEMBL1201861
Homo sapiens UMC-11 IC50 110898.9 nM 10.6019/CHEMBL1201861
Homo sapiens UMUC3 IC50 5626.51 nM 10.6019/CHEMBL1201861
Homo sapiens UO-31 Activity nan None 10.1021/acs.jmedchem.2c01276
Homo sapiens UO-31 GI50 500.0 nM 10.1021/jm201496g
Homo sapiens UO-31 IC50 15802.81 nM 10.6019/CHEMBL1201861
Homo sapiens VA-ES-BJ IC50 1324.77 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10000.0 nM 10.1016/j.bmcl.2015.10.006
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10000.0 nM 10.1016/j.ejmech.2015.12.033
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 10000.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Vascular endothelial growth factor receptor 2 Inhibition nan % 10.1021/acs.jmedchem.8b00384
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Activity nan None 10.1016/j.bmc.2010.03.078
Homo sapiens VM-CUB-1 IC50 1191.08 nM 10.6019/CHEMBL1201861
Homo sapiens VMRC-RCZ IC50 36302.15 nM 10.6019/CHEMBL1201861
Homo sapiens WI-38 IC50 10070.0 nM 10.1016/j.ejmech.2022.114827
Homo sapiens WI-38 IC50 30000.0 nM 10.1021/acs.jmedchem.2c01276
Homo sapiens WI-38 IC50 49870.0 nM 10.1016/j.ejmech.2021.113888
Homo sapiens WM-115 IC50 3781.95 nM 10.6019/CHEMBL1201861
Homo sapiens YAPC IC50 33764.81 nM 10.6019/CHEMBL1201861
Homo sapiens YH-13 IC50 1498.94 nM 10.6019/CHEMBL1201861
Homo sapiens YKG-1 IC50 2454.37 nM 10.6019/CHEMBL1201861
Homo sapiens Z-138 IC50 700.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens ZR-75-30 IC50 19096.84 nM 10.6019/CHEMBL1201861
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 3.2 % 10.1016/j.ejmech.2021.113213
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 600.0 nM 10.1021/np400889x
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1200.0 nM 10.1021/acsmedchemlett.8b00012
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.0 None 10.1021/acsmedchemlett.8b00012
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Activity 22.0 % 10.1021/acs.jmedchem.9b00462
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Activity 60.0 % 10.1021/acs.jmedchem.9b00462
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein EC50 2300.0 nM 10.1021/acs.jmedchem.9b00462
Leishmania donovani Leishmania donovani Activity nan None 10.1016/j.bmcl.2014.12.051
Leishmania donovani Leishmania donovani IC50 0.5 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 21.5 ug.mL-1 10.1021/jm100507q
Leishmania donovani Leishmania donovani IC50 25.7 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 29.7 ug.mL-1 10.1016/j.bmc.2009.10.042
Leishmania donovani Leishmania donovani IC50 40.0 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 81000.0 nM 10.1021/acs.jmedchem.6b01595
Leishmania donovani Leishmania donovani IC50 nan None 10.1016/j.bmcl.2014.12.051
Leishmania donovani Leishmania donovani IC90 51.7 ug.mL-1 10.1021/jm100507q
Leishmania donovani Leishmania donovani IC90 57.9 ug.mL-1 10.1016/j.bmc.2009.10.042
Leishmania donovani Leishmania donovani Ratio IC50 50.0 None 10.1016/j.bmcl.2014.08.060
Leishmania infantum Leishmania infantum IC50 6300.0 nM 10.1021/acs.jmedchem.9b02016
Mus musculus 4T1 Activity 1.23 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 1.68 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 2.08 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 4.98 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 5.27 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 13.4 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 14.3 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 22.68 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 23.63 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 28.6 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 29.5 % 10.1021/acs.jmedchem.2c00866
Mus musculus 4T1 Activity 35.6 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 48.9 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 53.69 % 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity 65.2 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity 78.7 % 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 Activity nan None 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 Activity nan None 10.1021/acs.jmedchem.8b00209
Mus musculus 4T1 FC 2.0 None 10.1021/acs.jmedchem.2c00866
Mus musculus 4T1 FC 2.3 None 10.1021/acs.jmedchem.2c00866
Mus musculus 4T1 IC50 1590.0 nM 10.1021/acs.jmedchem.0c02111
Mus musculus 4T1 IC50 4317.0 nM 10.1016/j.ejmech.2020.112677
Mus musculus 4T1 IC50 4760.0 nM 10.1021/acs.jmedchem.8b00209
Mus musculus 4T1 IC50 12120.0 nM 10.1021/acs.jmedchem.2c00866
Mus musculus 4T1 TGI 75.6 % 10.1021/acs.jmedchem.8b00209
Mus musculus 4T1 TGI 76.8 % 10.1021/acs.jmedchem.8b00209
Mus musculus 4T1 TGI nan None 10.1016/j.ejmech.2020.112677
Mus musculus B16 IC50 2260.0 nM 10.1016/j.ejmech.2022.114228
Mus musculus B16 IC50 4440.0 nM 10.1016/j.bmc.2015.06.015
Mus musculus B16-F10 Activity nan None 10.1021/acs.jmedchem.1c02225
Mus musculus B16-F10 FC 1.3 None 10.1021/acs.jmedchem.1c02225
Mus musculus B16-F10 FC 1.5 None 10.1021/acs.jmedchem.1c02225
Mus musculus B16-F10 FC 1.6 None 10.1021/acs.jmedchem.1c02225
Mus musculus B16-F10 IC50 11360.0 nM 10.1021/acs.jmedchem.1c01863
Mus musculus B16-F10 IC50 13100.0 nM 10.1016/j.bmcl.2017.01.044
Mus musculus B16-F10 IC50 13520.0 nM 10.1021/acs.jmedchem.1c02225
Mus musculus C2C12 Activity 80.2 % 10.1021/acs.jmedchem.5b00062
Mus musculus CCRF S-180 Activity 1.53 g 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Activity 1.61 g 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Inhibition 6.34 % 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Inhibition 11.91 % 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Inhibition 71.7 % 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Inhibition 81.68 % 10.1016/j.bmcl.2010.03.112
Mus musculus CCRF S-180 Inhibition nan % 10.1016/j.bmcl.2010.03.112
Mus musculus Class 1 histone deacetylase Inhibition nan % 10.1016/j.bmc.2019.06.036
Mus musculus CT26 Activity 21.12 % 10.1016/j.ejmech.2022.114228
Mus musculus CT26 Activity 26.0 % 10.1016/j.ejmech.2022.114228
Mus musculus CT26 Activity 27.99 % 10.1016/j.ejmech.2022.114228
Mus musculus CT26 Activity 32.56 % 10.1016/j.ejmech.2022.114228
Mus musculus CT26 Activity 57.83 % 10.1016/j.ejmech.2022.114228
Mus musculus CT26 GI50 2350.0 nM 10.1016/j.ejmech.2022.114326
Mus musculus CT26 GI50 2700.0 nM 10.1021/acs.jmedchem.1c01155
Mus musculus CT26 IC50 5650.0 nM 10.1016/j.ejmech.2022.114228
Mus musculus CT26 IC50 5970.0 nM 10.1021/acsmedchemlett.7b00487
Mus musculus CT26 TGI 53.0 % 10.1016/j.ejmech.2022.114228
Mus musculus FL5.12 Activity nan None 10.1016/j.ejmech.2018.09.043
Mus musculus H22 Activity 61.0 % 10.1021/acs.jmedchem.2c00681
Mus musculus H22 Activity nan None 10.1021/jm200577a
Mus musculus Histone deacetylase Inhibition 85.0 % 10.1016/j.ejmech.2018.09.043
Mus musculus Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2018.09.043
Mus musculus Histone deacetylase Inhibition nan % 10.1021/acsmedchemlett.9b00071
Mus musculus Histone deacetylase 1 IC50 0.03 ug.mL-1 10.1016/j.bmcl.2006.12.028
Mus musculus Histone deacetylase 1 IC50 112.0 nM 10.1021/jm011088+
Mus musculus Histone deacetylase 1 IC50 112.0 nM 10.1021/jm031036f
Mus musculus Histone deacetylase 1 IC50 112.0 nM 10.1021/jm0605536
Mus musculus Histone deacetylase 1 IC50 112.0 nM 10.1021/jm7011408
Mus musculus Histone deacetylase 1 IC50 112.2 nM 10.1021/jm031036f
Mus musculus Histone deacetylase 1 Inhibition nan % 10.1016/j.ejmech.2022.114228
Mus musculus Histone deacetylase 1 Ki 67.61 nM 10.1021/jm011088+
Mus musculus Histone deacetylase 6 Inhibition nan % 10.1016/j.bmcl.2017.01.044
Mus musculus Histone deacetylase 6 Inhibition nan % 10.1021/acs.jmedchem.8b01590
Mus musculus L929 CC50 nan None 10.1021/acs.jmedchem.9b02016
Mus musculus Leukotriene A4 hydrolase IC50 6150.0 nM 10.1021/acs.jmedchem.6b01507
Mus musculus Leukotriene A4 hydrolase Inhibition nan % 10.1021/acs.jmedchem.6b01507
Mus musculus Lewis lung carcinoma cell line IC50 9680.0 nM 10.1021/acsmedchemlett.7b00487
Mus musculus Lewis lung carcinoma cell line TGI 41.4 % 10.1021/acsmedchemlett.7b00487
Mus musculus Liver CL 33.0 mL.min-1.kg-1 10.1021/jm502011f
Mus musculus Liver T1/2 0.4667 hr 10.1021/ml400158k
Mus musculus Liver T1/2 1.0 hr 10.1021/jm2003552
Mus musculus Liver T1/2 1.367 hr 10.1021/jm201496g
Mus musculus MC-38 GI50 2400.0 nM 10.1021/acs.jmedchem.1c01155
Mus musculus MC-38 GI50 2740.0 nM 10.1016/j.ejmech.2022.114326
Mus musculus MC-38 IC50 1260.0 nM 10.1016/j.ejmech.2022.114634
Mus musculus MC-38 TGI 51.5 % 10.1016/j.ejmech.2022.114634
Mus musculus MEF Activity nan None 10.1016/j.bmc.2012.02.032
Mus musculus MEF IC50 4400.0 nM 10.1021/jm400179b
Mus musculus Mus musculus Activity -6.1 % 10.1021/acs.jmedchem.5b01342
Mus musculus Mus musculus Activity -3.0 % 10.1021/acs.jmedchem.5b01342
Mus musculus Mus musculus Activity 0.67 U/g 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity 1.79 mg/ml 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity 1.9 % 10.1021/jm2003552
Mus musculus Mus musculus Activity 2.0 % 10.1016/j.ejmech.2008.11.005
Mus musculus Mus musculus Activity 4.0 % 10.1016/j.ejmech.2008.11.005
Mus musculus Mus musculus Activity 4.0 % 10.1021/jm5008209
Mus musculus Mus musculus Activity 4.6 % 10.1021/jm2003552
Mus musculus Mus musculus Activity 5.0 % 10.1016/j.bmcl.2009.04.011
Mus musculus Mus musculus Activity 5.5 % 10.1021/jm2003552
Mus musculus Mus musculus Activity 5.9 10^3/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity 7.6 10^6/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity 7.7 um3 10.1021/jm901358y
Mus musculus Mus musculus Activity 8.3 10^3/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity 8.3 10^6/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity 8.4 um3 10.1021/jm901358y
Mus musculus Mus musculus Activity 8.9 % 10.1021/jm2003552
Mus musculus Mus musculus Activity 9.3 % 10.1021/jm2003552
Mus musculus Mus musculus Activity 10.0 % 10.1021/jm800079s
Mus musculus Mus musculus Activity 14.2 % 10.1016/j.ejmech.2015.11.014
Mus musculus Mus musculus Activity 21.23 g 10.1016/j.ejmech.2017.03.069
Mus musculus Mus musculus Activity 33.7 % 10.1021/jm901358y
Mus musculus Mus musculus Activity 34.09 pg/ml 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity 36.5 % 10.1021/jm901358y
Mus musculus Mus musculus Activity 40.0 % 10.1021/acs.jmedchem.7b00115
Mus musculus Mus musculus Activity 43.19 pg/ml 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity 44.1 um3 10.1021/jm901358y
Mus musculus Mus musculus Activity 44.5 um3 10.1021/jm901358y
Mus musculus Mus musculus Activity 49.74 pg/ml 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity 94.9 % 10.1021/jm901358y
Mus musculus Mus musculus Activity 96.2 % 10.1021/jm901358y
Mus musculus Mus musculus Activity 538.0 10^3/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity 617.0 10^3/mm3 10.1021/jm901358y
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2015.05.048
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2008.11.005
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2016.01.013
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2016.06.023
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2019.111915
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.5b01342
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.6b00579
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.8b00393
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.9b02178
Mus musculus Mus musculus Activity nan None 10.1021/acsmedchemlett.7b00414
Mus musculus Mus musculus Activity nan None 10.1021/jm101605z
Mus musculus Mus musculus Activity nan None 10.1021/jm2003552
Mus musculus Mus musculus Activity nan None 10.1021/jm901358y
Mus musculus Mus musculus AUC 200.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus AUC 200.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus AUC 600.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus AUC 600.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus AUC 619.0 ng.hr.mL-1 10.1021/jm502011f
Mus musculus Mus musculus AUC 657.0 ng.hr.mL-1 10.1021/jm901502p
Mus musculus Mus musculus AUC 1486.0 ng.hr.mL-1 10.1021/jm502011f
Mus musculus Mus musculus CL 0.1122 mL.min-1.kg-1 10.1021/jm200146u
Mus musculus Mus musculus CL 78.0 mL.min-1.kg-1 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus CL 78.0 mL.min-1.kg-1 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus CL 112.0 mL.min-1.kg-1 10.1021/jm502011f
Mus musculus Mus musculus CL 112.17 mL.min-1.kg-1 10.1016/j.bmcl.2010.04.041
Mus musculus Mus musculus CL 127.0 mL.min-1.kg-1 10.1021/jm901502p
Mus musculus Mus musculus Cmax 1895429.78 nM 10.1021/jm502011f
Mus musculus Mus musculus F 8.0 % 10.1021/jm502011f
Mus musculus Mus musculus F 8.3 % 10.1016/j.bmcl.2010.04.041
Mus musculus Mus musculus F 8.3 % 10.1021/jm2003552
Mus musculus Mus musculus F 8.33 % 10.1021/jm401899x
Mus musculus Mus musculus F 10.0 % 10.1021/jm200146u
Mus musculus Mus musculus F 12.1 % 10.1021/jm901502p
Mus musculus Mus musculus F 14.0 % 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus F 14.0 % 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus F 61.0 % 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus F 61.0 % 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus Inhibition 25.0 % 10.1016/s0960-894x(03)00301-9
Mus musculus Mus musculus Inhibition 37.0 % 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Inhibition 44.0 % 10.1016/s0960-894x(03)00301-9
Mus musculus Mus musculus Inhibition 70.0 % 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus Inhibition nan % 10.1021/acs.jmedchem.6b01507
Mus musculus Mus musculus LBF 5.4 L/hr/kg 10.1021/jm901502p
Mus musculus Mus musculus LC50 4910.0 nM 10.1021/acs.jmedchem.6b00908
Mus musculus Mus musculus %max 3.0 % 10.1021/acs.jmedchem.6b00579
Mus musculus Mus musculus %max 5.2 % 10.1021/acs.jmedchem.6b00579
Mus musculus Mus musculus MST 10.0 day 10.1021/acs.jmedchem.8b00393
Mus musculus Mus musculus MTD 100.0 mg kg-1 10.1021/jm800079s
Mus musculus Mus musculus MTD 100.0 mg Kg-1 10.1021/jm9004303
Mus musculus Mus musculus MTD 160.0 mg kg-1 10.1016/j.bmcl.2010.04.041
Mus musculus Mus musculus MTD 200.0 mg kg-1 10.1016/j.bmcl.2009.01.041
Mus musculus Mus musculus Ratio 0.83 None 10.1016/j.ejmech.2019.111915
Mus musculus Mus musculus Ratio 0.878 None 10.1016/j.ejmech.2019.111915
Mus musculus Mus musculus T1/2 0.38 hr 10.1016/j.bmcl.2010.04.041
Mus musculus Mus musculus T1/2 0.4 hr 10.1021/jm502011f
Mus musculus Mus musculus T1/2 0.5 hr 10.1021/jm901502p
Mus musculus Mus musculus T1/2 0.8 hr 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus T1/2 0.8 hr 10.1016/j.bmcl.2006.10.048
Mus musculus Mus musculus Vdss 0.81 L.kg-1 10.1016/j.bmcl.2010.04.041
Mus musculus Mus musculus Vdss 1.2 L.kg-1 10.1021/jm901502p
Mus musculus Mus musculus Vdss 2.1 L.kg-1 10.1016/j.bmcl.2006.10.045
Mus musculus Mus musculus Vdss 2.1 L.kg-1 10.1016/j.bmcl.2006.10.048
Mus musculus N2a IC50 1450.0 nM 10.1016/j.ejmech.2021.113419
Mus musculus N9 Activity nan None 10.1021/acsmedchemlett.9b00071
Mus musculus NIH3T3 Activity 7.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 17.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 22.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 31.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 49.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 62.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 Activity 83.0 % 10.1021/acs.jmedchem.1c00184
Mus musculus NIH3T3 TC50 2.5 uM 10.1016/j.ejmech.2022.114409
Mus musculus P388 Activity 0.0 % 10.1016/j.ejmech.2008.06.020
Mus musculus P388 Activity 11.0 % 10.1016/j.ejmech.2008.06.020
Mus musculus P388 Activity 14.0 % 10.1016/j.ejmech.2008.06.020
Mus musculus P388 Activity nan None 10.1021/acs.jmedchem.7b00322
Mus musculus Plasma Cp 1.0 uM 10.1021/acs.jmedchem.6b01507
Mus musculus Plasma T1/2 3.0 hr 10.1039/C5MD00247H
Mus musculus Plasma T1/2 3.3 hr 10.1021/jm201496g
Mus musculus Protein Wnt-3a Activity nan None 10.1016/j.bmc.2008.10.077
Mus musculus Protein Wnt-3a IC50 50000.0 nM None
Mus musculus RAW264.7 Activity 87.0 % 10.1021/acs.jnatprod.2c00101
Mus musculus RAW264.7 IC50 760.0 nM 10.1021/jm0613828
Mus musculus RAW264.7 IC50 1880.0 nM 10.1021/jm0613828
Mus musculus RAW264.7 LD50 2200.0 nM 10.1128/aac.00439-08
Mus musculus Serine racemase Inhibition nan % 10.1021/jm900775q
Mus musculus TAMH IC50 7860.0 nM 10.1021/acs.jmedchem.7b00678
Mus musculus Zinc finger protein GLI1 IC50 2230.0 nM None
Plasmodium berghei Plasmodium berghei IC50 7.7 nM 10.1016/j.ejmech.2018.09.018
Plasmodium berghei Plasmodium berghei IC50 140.0 nM 10.1016/j.ejmech.2014.05.050
Plasmodium berghei Plasmodium berghei IC50 150.0 nM 10.1016/j.ejmech.2014.05.050
Plasmodium berghei Plasmodium berghei IC50 150.0 nM 10.1021/acs.jmedchem.6b01595
Plasmodium berghei Plasmodium berghei IC50 290.0 nM 10.1016/j.ejmech.2020.113065
Plasmodium falciparum Histone deacetylase IC50 59.0 nM 10.1021/jm801654y
Plasmodium falciparum Histone deacetylase IC50 130.0 nM 10.1021/jm100507q
Plasmodium falciparum Plasmodium falciparum Activity 90.0 % 10.1021/acs.jmedchem.1c00821
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1021/acs.jmedchem.1c00821
Plasmodium falciparum Plasmodium falciparum IC50 0.2616 ug.mL-1 10.1016/j.bmc.2009.10.042
Plasmodium falciparum Plasmodium falciparum IC50 0.279 ug.mL-1 10.1021/jm100507q
Plasmodium falciparum Plasmodium falciparum IC50 0.392 ug.mL-1 10.1021/jm100507q
Plasmodium falciparum Plasmodium falciparum IC50 0.4789 ug.mL-1 10.1016/j.bmc.2009.10.042
Plasmodium falciparum Plasmodium falciparum IC50 25.0 nM 10.1016/j.bmcl.2014.12.051
Plasmodium falciparum Plasmodium falciparum IC50 69.0 nM 10.1016/j.ejmech.2020.113065
Plasmodium falciparum Plasmodium falciparum IC50 109.0 nM 10.1016/j.ejmech.2014.05.050
Plasmodium falciparum Plasmodium falciparum IC50 109.7 nM 10.1128/aac.00439-08
Plasmodium falciparum Plasmodium falciparum IC50 110.0 nM 10.1021/jm701606b
Plasmodium falciparum Plasmodium falciparum IC50 110.0 nM 10.1128/aac.00439-08
Plasmodium falciparum Plasmodium falciparum IC50 120.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 127.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 130.0 nM 10.1016/j.ejmech.2014.05.050
Plasmodium falciparum Plasmodium falciparum IC50 139.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 146.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 160.9 nM 10.1128/aac.00439-08
Plasmodium falciparum Plasmodium falciparum IC50 161.0 nM 10.1021/jm701606b
Plasmodium falciparum Plasmodium falciparum IC50 161.0 nM 10.1128/aac.01220-10
Plasmodium falciparum Plasmodium falciparum IC50 175.0 nM 10.1021/acs.jmedchem.1c00821
Plasmodium falciparum Plasmodium falciparum IC50 210.0 nM 10.1021/jm801654y
Plasmodium falciparum Plasmodium falciparum IC50 246.6 nM 10.1128/aac.00439-08
Plasmodium falciparum Plasmodium falciparum IC50 247.0 nM 10.1021/jm701606b
Plasmodium falciparum Plasmodium falciparum IC50 247.0 nM 10.1128/aac.01220-10
Plasmodium falciparum Plasmodium falciparum IC50 260.0 nM 10.1016/j.ejmech.2016.12.041
Plasmodium falciparum Plasmodium falciparum IC50 262.0 nM 10.1016/j.ejmech.2019.111755
Plasmodium falciparum Plasmodium falciparum IC50 274.0 nM 10.1016/j.ejmech.2019.111755
Plasmodium falciparum Plasmodium falciparum IC50 301.0 nM 10.1128/aac.01220-10
Plasmodium falciparum Plasmodium falciparum IC50 309.5 nM 10.1128/aac.00439-08
Plasmodium falciparum Plasmodium falciparum IC50 310.0 nM 10.1021/jm701606b
Plasmodium falciparum Plasmodium falciparum IC50 329.0 nM 10.1128/aac.01220-10
Plasmodium falciparum Plasmodium falciparum IC50 520.0 nM 10.1128/aac.01220-10
Plasmodium falciparum Plasmodium falciparum IC50 725.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 750.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 800.0 nM 10.1128/aac.00757-07
Plasmodium falciparum Plasmodium falciparum IC50 810.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 820.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 900.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 950.0 nM 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum IC50 1300.0 nM 10.1128/aac.00757-07
Plasmodium falciparum Plasmodium falciparum IC50 1410.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 1680.0 nM 10.1021/acs.jmedchem.6b01595
Plasmodium falciparum Plasmodium falciparum IC50 2800.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.ejmech.2016.12.041
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1128/aac.00729-08
Plasmodium falciparum Plasmodium falciparum Potency 134.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 213.3 nM None
Plasmodium falciparum 3D7 Histone deacetylase FC 2.5 None 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum 3D7 Histone deacetylase IC50 100.0 nM 10.1128/aac.00439-08
Plasmodium vivax Plasmodium vivax IC50 147.0 nM 10.1128/aac.01220-10
Plasmodium vivax Plasmodium vivax IC50 159.0 nM 10.1128/aac.01220-10
Plasmodium vivax Plasmodium vivax IC50 170.0 nM 10.1128/aac.01220-10
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Histone deacetylase IC50 165.0 nM 10.1021/jm0208119
Rattus norvegicus Histone deacetylase IC50 165.0 nM 10.1021/jm0303094
Rattus norvegicus Histone deacetylase IC50 440.0 nM 10.1021/jm051010j
Rattus norvegicus Histone deacetylase Inhibition 20.0 % 10.1016/j.bmcl.2015.02.007
Rattus norvegicus Histone deacetylase Inhibition 34.0 % 10.1016/j.bmc.2014.05.001
Rattus norvegicus Histone deacetylase Inhibition 55.0 % 10.1016/j.bmcl.2015.02.007
Rattus norvegicus Histone deacetylase Inhibition 96.0 % 10.1016/j.bmc.2014.05.001
Rattus norvegicus L6 IC50 266.0 nM 10.1016/j.bmcl.2014.12.051
Rattus norvegicus Liver microsomes T1/2 1.0 hr 10.1016/j.bmcl.2010.04.041
Rattus norvegicus Liver microsomes T1/2 1.0 hr 10.1021/jm2003552
Rattus norvegicus Liver microsomes T1/2 1.9 hr 10.1016/j.bmcl.2011.06.015
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 EC50 2500.0 nM 10.1124/dmd.110.035105
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Efficacy 307.6 % 10.1124/dmd.110.035105
Rattus norvegicus PC-12 Activity -0.51 % 10.1016/j.bmc.2023.117178
Rattus norvegicus Peripheral myelin protein 22 Potency 1018.2 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 2237.0 nM None
Rattus norvegicus Plasma T1/2 1.433 hr 10.1016/j.bmc.2017.06.039
Rattus norvegicus Plasma T1/2 9.7 hr 10.1021/jm900648x
Rattus norvegicus Rattus norvegicus Activity 20.0 % 10.1021/acs.jmedchem.7b00115
Rattus norvegicus Rattus norvegicus AUC 400.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.045
Rattus norvegicus Rattus norvegicus AUC 400.0 ng.hr.mL-1 10.1016/j.bmcl.2006.10.048
Rattus norvegicus Rattus norvegicus CL 67.0 mL.min-1.kg-1 10.1016/j.bmcl.2006.10.045
Rattus norvegicus Rattus norvegicus CL 67.0 mL.min-1.kg-1 10.1016/j.bmcl.2006.10.048
Rattus norvegicus Rattus norvegicus F 11.0 % 10.1016/j.bmcl.2017.09.036
Rattus norvegicus Rattus norvegicus F 16.0 % 10.1016/j.bmcl.2006.10.045
Rattus norvegicus Rattus norvegicus F 16.0 % 10.1016/j.bmcl.2006.10.048
Rattus norvegicus Rattus norvegicus T1/2 0.2 hr 10.1016/j.bmcl.2017.09.036
Rattus norvegicus Rattus norvegicus T1/2 0.7 hr 10.1016/j.bmcl.2006.10.045
Rattus norvegicus Rattus norvegicus T1/2 0.7 hr 10.1016/j.bmcl.2006.10.048
Rattus norvegicus Rattus norvegicus Vdss 1.6 L.kg-1 10.1016/j.bmcl.2006.10.045
Rattus norvegicus Rattus norvegicus Vdss 1.6 L.kg-1 10.1016/j.bmcl.2006.10.048
Rattus norvegicus T/5 Activity nan None 10.1021/jm00008a020
Rattus norvegicus T/5 Concentration 1e-06 M 10.1021/jm00008a020
Rattus norvegicus T/5 Concentration 1e-05 M 10.1021/jm00008a020
Rattus norvegicus T/5 Concentration 0.0001 M 10.1021/jm00008a020
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1016/j.bmc.2017.05.058
Schistosoma mansoni Histone deacetylase 8 IC50 590.0 nM 10.1016/j.bmc.2017.02.020
Schistosoma mansoni Histone deacetylase 8 IC50 1548.82 nM 10.1016/j.bmc.2017.02.020
Schistosoma mansoni Histone deacetylase 8 IC50 1560.0 nM 10.1016/j.ejmech.2021.113745
Schistosoma mansoni Histone deacetylase 8 IC50 1560.0 nM 10.1021/acs.jmedchem.5b01478
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.447 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score -0.06059 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.33 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 8.66 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index -0.4243 None 10.1101/2020.04.03.023846
Sus scrofa Aminopeptidase N IC50 nan None 10.1016/j.bmc.2013.12.025
Sus scrofa Aminopeptidase N Inhibition nan % 10.1016/j.bmc.2015.09.013
Toxoplasma gondii Toxoplasma gondii IC50 83.0 nM 10.1021/acs.jmedchem.6b01595
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3170.0 nM 10.1016/j.bmcl.2014.12.051
Trypanosoma cruzi Trypanosoma cruzi IC50 10100.0 nM 10.1016/j.bmcl.2014.12.051
Zea mays Histone deacetylase HD1B IC50 0.007 ug.mL-1 10.1016/j.bmcl.2006.12.028
Zea mays Histone deacetylase HD1B IC50 28.0 nM 10.1021/jm0605536
Zea mays Histone deacetylase HD1B IC50 30.0 nM 10.1016/j.ejmech.2007.05.004
Zea mays Histone deacetylase HD2 IC50 0.013 ug.mL-1 10.1016/j.bmcl.2006.12.028
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1016/j.bmcl.2005.07.081
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm011088+
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm015515v
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm030990+
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm031036f
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm034167p
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm049002a
Zea mays Histone deacetylase HD2 IC50 50.0 nM 10.1021/jm0605536
Zea mays Histone deacetylase HD2 IC50 50.12 nM 10.1021/jm031036f
Zea mays Histone deacetylase HD2 IC50 1000.0 nM 10.1021/jm0208119
Zea mays Histone deacetylase HD2 IC50 1000.0 nM 10.1021/jm0303094
Zea mays Histone deacetylase HD2 Ki 131.83 nM 10.1021/jm011088+
Zea mays Histone deacetylase HD2 Ki 131.83 nM 10.1021/jm015515v
None ADMET Activity -4.5 % 10.1021/acs.jmedchem.7b01465
None ADMET Activity -3.1 % 10.1021/acs.jmedchem.7b01465
None ADMET Activity 17.9 g 10.1021/acsmedchemlett.0c00369
None ADMET Activity 18.1 g 10.1021/acsmedchemlett.0c00369
None ADMET Activity 30.0 % 10.1021/acs.jmedchem.6b00670
None ADMET Activity 46.0 % 10.1016/j.bmcl.2015.11.086
None ADMET Activity nan None 10.1016/j.bmcl.2015.11.011
None ADMET Activity nan None 10.1016/j.ejmech.2020.112677
None ADMET Activity nan None 10.1016/j.ejmech.2021.113870
None ADMET Activity nan None 10.1016/j.ejmech.2021.113961
None ADMET Activity nan None 10.1016/j.ejmech.2021.114058
None ADMET Activity nan None 10.1021/acs.jmedchem.1c02225
None ADMET Activity nan None 10.1021/acs.jmedchem.2c00130
None ADMET Activity nan None 10.1021/acs.jmedchem.2c00866
None ADMET Activity nan None 10.1021/acs.jmedchem.2c01413
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01597
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01825
None ADMET Activity nan None 10.1021/jm5008962
None ADMET Activity nan None 10.1021/jm901561u
None ADMET Activity nan None 10.1038/nchembio815
None ADMET AUC 965.14 ng.hr.mL-1 10.1016/j.ejmech.2020.112648
None ADMET AUC 968.32 ng.hr.mL-1 10.1016/j.ejmech.2020.112648
None ADMET CC50 1900.0 nM 10.1021/jm501330g
None ADMET CL 2.04 mL.min-1.g-1 10.1016/j.ejmech.2022.114228
None ADMET CL 4.02 mL.min-1.g-1 10.1016/j.ejmech.2022.114228
None ADMET CL 28.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CLH 5.0 uL/min 10.1016/j.bmcl.2018.06.029
None ADMET Cmax 449.83 nM 10.1016/j.ejmech.2020.112648
None ADMET Drug metabolism nan None 10.1021/acs.jmedchem.6b01385
None ADMET Drug uptake nan None 10.1021/acs.jmedchem.8b01597
None ADMET EC50 4800.0 nM 10.1021/acs.jmedchem.5b00539
None ADMET EC50 10000.0 nM 10.1021/jm801128g
None ADMET F 8.0 % 10.1021/acsmedchemlett.9b00471
None ADMET F 8.3 % 10.1021/acs.jmedchem.7b01465
None ADMET Fu 0.75 None 10.1021/acsmedchemlett.1c00074
None ADMET GI50 1650.0 nM 10.1021/acs.jmedchem.5b01044
None ADMET GI50 6080.0 nM 10.1021/acs.jmedchem.5b01044
None ADMET GI50 6100.0 nM 10.1021/np400198r
None ADMET GI50 9950.0 nM 10.1021/acs.jmedchem.5b01052
None ADMET GI50 18950.0 nM 10.1021/ml400158k
None ADMET Hepatocyte stability 3.0 uL/min/10e6 cells 10.1016/j.bmcl.2006.10.045
None ADMET Hepatocyte stability 12.0 uL/min/10e6 cells 10.1016/j.bmcl.2006.10.045
None ADMET IC50 1300.0 nM 10.1021/jm701606b
None ADMET IC50 1300.0 nM 10.1021/jm8002894
None ADMET IC50 2200.0 nM 10.1016/j.ejmech.2014.05.050
None ADMET IC50 14000.0 nM 10.1021/jm800079s
None ADMET IC50 31000.0 nM 10.1039/c1md00220a
None ADMET IC50 100000.0 nM 10.1021/jm901561u
None ADMET IC50 300000.0 nM 10.1128/aac.00757-07
None ADMET MRT 0.3 hr 10.1124/dmd.108.020479
None ADMET MST 13.8 day 10.1021/acs.jmedchem.1c01726
None ADMET MST 14.4 day 10.1021/acs.jmedchem.1c01726
None ADMET MTD 3.1 mg kg-1 10.1021/acs.jmedchem.1c01928
None ADMET MTD 400.0 mg kg-1 10.1021/acs.jmedchem.1c00136
None ADMET Papp 3.0 10^-6 cm/s 10.1016/j.ejmech.2020.112887
None ADMET Papp 6.33 10^-6 cm/s 10.1016/j.ejmech.2020.112887
None ADMET Peff 2.3 nm/s 10.1021/acs.jmedchem.6b00908
None ADMET permeability 1.0 10^-5 cm/s 10.1016/j.ejmech.2021.113338
None ADMET %R 97.0 % 10.1016/j.bmcl.2006.10.045
None ADMET %R 114.0 % 10.1016/j.bmcl.2006.10.045
None ADMET Ratio 1.1 None 10.1021/jm5008209
None ADMET Ratio 2.11 None 10.1016/j.ejmech.2020.112887
None ADMET Ratio CC50/EC50 1.1 None 10.1016/j.bmcl.2019.06.006
None ADMET Ratio CC50/EC50 5.0 None 10.1021/jm501330g
None ADMET Ratio CC50/IC50 1.0 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 2.6 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 5.5 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 83.0 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio EC50 155.0 None 10.1021/jm901358y
None ADMET RatioGI50 0.96 None 10.1021/acs.jmedchem.5b01044
None ADMET RatioGI50 4.8 None 10.1021/ml400175d
None ADMET Ratio IC50 0.21 None 10.1021/jm400467w
None ADMET Ratio IC50 1.64 None 10.1021/acs.jmedchem.5b00099
None ADMET Ratio IC50 3.0 None 10.1016/j.bmc.2015.10.045
None ADMET Ratio IC50 3.92 None 10.1021/acsmedchemlett.2c00126
None ADMET Ratio IC50 13.1 None 10.1021/acs.jmedchem.6b00157
None ADMET Ratio IC50 19.36 None 10.1021/acs.jmedchem.2c01276
None ADMET Ratio IC50 20.55 None 10.1021/acs.jmedchem.2c01276
None ADMET Ratio IC50 22.12 None 10.1016/j.ejmech.2021.113824
None ADMET Ratio IC50 22.2 None 10.1021/acsmedchemlett.2c00126
None ADMET Ratio IC50 26.0 None 10.1016/j.ejmech.2020.113065
None ADMET Ratio IC50 37.0 None 10.1016/j.bmcl.2011.06.015
None ADMET Ratio IC50 37.0 None 10.1021/jm200388e
None ADMET Ratio IC50 110.0 None 10.1016/j.ejmech.2020.113065
None ADMET Selectivity Index 1.6 None 10.1016/j.bmc.2021.116185
None ADMET Stability 20.0 % 10.1016/j.ejmech.2022.114228
None ADMET Stability 77.0 % 10.1016/j.ejmech.2022.114228
None ADMET Stability 82.0 % 10.1016/j.ejmech.2015.11.010
None ADMET Stability nan % 10.1016/j.ejmech.2021.113824
None ADMET Stability nan % 10.1021/acs.jmedchem.2c00866
None ADMET Survival 13.8 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 14.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 18.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 100.0 % 10.1021/acs.jmedchem.7b01465
None ADMET t1/2 nan None 10.1021/acs.jmedchem.7b01465
None ADMET T1/2 0.32 hr 10.1016/j.ejmech.2020.112648
None ADMET T1/2 0.4667 hr 10.1021/jm901502p
None ADMET T1/2 0.5 hr 10.1016/j.bmc.2021.116599
None ADMET T1/2 0.5 hr 10.1016/j.bmcl.2010.04.041
None ADMET T1/2 0.7333 hr 10.1016/j.bmc.2021.116599
None ADMET T1/2 0.7333 hr 10.1039/C6MD00681G
None ADMET T1/2 0.76 hr 10.1124/dmd.108.020479
None ADMET T1/2 1.0 hr 10.1016/j.bmc.2021.116599
None ADMET T1/2 1.0 hr 10.1021/acs.jmedchem.1c00184
None ADMET T1/2 1.25 hr 10.1016/j.ejmech.2020.112887
None ADMET T1/2 1.333 hr 10.1039/C5MD00247H
None ADMET T1/2 1.433 hr 10.1016/j.ejmech.2020.112887
None ADMET T1/2 1.45 hr 10.1016/j.ejmech.2020.112887
None ADMET T1/2 1.917 hr 10.1016/j.ejmech.2020.112887
None ADMET T1/2 3.3 hr 10.1021/acs.jmedchem.0c01967
None ADMET T1/2 4.323 hr 10.1016/j.ejmech.2022.114228
None ADMET T1/2 11.55 hr 10.1016/j.ejmech.2022.114228
None ADMET T1/2 22.0 hr 10.1039/C5MD00247H
None ADMET T1/2 24.0 hr 10.1039/C5MD00247H
None ADMET Tmax 0.15 hr 10.1016/j.ejmech.2020.112648
None ADMET Vdss 0.5 L.kg-1 10.1124/dmd.108.020479
None BMDM CC50 5000.0 nM 10.1021/acs.jmedchem.9b02016
None DNA Activity nan None 10.1016/j.ejmech.2022.114634
None Erythroleukemia cell line Activity 70.0 % 10.1021/jm00008a020
None Friend leukemia cell line IC50 990.0 nM 10.1021/jm0208119
None Friend leukemia cell line IC50 990.0 nM 10.1021/jm0303094
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Microglia Activity nan None 10.1021/acsmedchemlett.8b00507
None Molecular identity unknown Activity 2.8 % 10.1016/j.bmcl.2014.08.007
None Molecular identity unknown Activity 14.0 % 10.1016/j.bmcl.2014.08.007
None Molecular identity unknown Activity 17.1 % 10.1016/j.bmcl.2014.08.007
None Molecular identity unknown Activity 65.3 % 10.1016/j.bmcl.2014.08.007
None Molecular identity unknown Activity nan None 10.1016/j.bmcl.2011.07.053
None Molecular identity unknown Activity nan None 10.1021/ml200136e
None Molecular identity unknown Activity nan None 10.1021/ml5000959
None Molecular identity unknown Inhibition nan % 10.1021/acs.jnatprod.8b00843
None NCI IC50 nan None 10.1021/jm0703136
None NON-PROTEIN TARGET AbsAC35_uM 0.468 uM None
None NON-PROTEIN TARGET AC50 1750.0 nM None
None NON-PROTEIN TARGET Activity 0.62 g 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET Activity 18.0 % 10.1016/j.bmcl.2015.11.086
None NON-PROTEIN TARGET Activity 20.0 % 10.1016/j.bmcl.2015.11.086
None NON-PROTEIN TARGET Activity 23.0 % 10.1016/j.bmcl.2015.11.086
None NON-PROTEIN TARGET Activity 32.4 % 10.1021/acs.jmedchem.6b00579
None NON-PROTEIN TARGET Activity 36.6 % 10.1021/acs.jmedchem.5b01342
None NON-PROTEIN TARGET Activity 59.2 % 10.1021/acs.jmedchem.5b01342
None NON-PROTEIN TARGET EC50 720.0 nM 10.1021/acsmedchemlett.6b00124
None NON-PROTEIN TARGET EC50 880.0 nM 10.1021/acsmedchemlett.6b00124
None NON-PROTEIN TARGET EC50 1200.0 nM 10.1021/acsmedchemlett.6b00124
None NON-PROTEIN TARGET EC50 3000.0 nM 10.1016/j.bmcl.2016.08.073
None NON-PROTEIN TARGET EC50 12000.0 nM 10.1016/j.bmcl.2016.08.073
None NON-PROTEIN TARGET FC 4.0 None 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET FC 12.5 None 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET FC 13.9 None 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET Fu 0.29 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI 18.06 % 10.1016/j.bmcl.2010.03.112
None NON-PROTEIN TARGET GI 56.9 % 10.1016/j.bmcl.2010.03.112
None NON-PROTEIN TARGET GI 63.08 % 10.1016/j.bmcl.2010.03.112
None NON-PROTEIN TARGET GI 69.59 % 10.1016/j.bmcl.2010.03.112
None NON-PROTEIN TARGET GI nan None 10.1021/acsmedchemlett.6b00124
None NON-PROTEIN TARGET GI nan None 10.1021/jm401225q
None NON-PROTEIN TARGET GI50 80.0 nM 10.1021/acs.jmedchem.5b01493
None NON-PROTEIN TARGET GI50 150.0 nM 10.1016/j.ejmech.2016.06.023
None NON-PROTEIN TARGET GI50 160.0 nM 10.1021/jm201496g
None NON-PROTEIN TARGET GI50 521.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET GI50 530.0 nM 10.1021/ml400175d
None NON-PROTEIN TARGET GI50 542.0 nM 10.1021/acs.jmedchem.5b01044
None NON-PROTEIN TARGET GI50 550.0 nM 10.1016/j.ejmech.2015.03.034
None NON-PROTEIN TARGET GI50 650.0 nM 10.1016/j.bmcl.2014.06.080
None NON-PROTEIN TARGET GI50 678.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET GI50 680.0 nM 10.1016/j.ejmech.2014.09.024
None NON-PROTEIN TARGET GI50 690.0 nM 10.1021/jm300197a
None NON-PROTEIN TARGET GI50 730.0 nM 10.1016/j.ejmech.2016.06.023
None NON-PROTEIN TARGET GI50 750.0 nM 10.1016/j.bmcl.2014.06.080
None NON-PROTEIN TARGET GI50 790.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET GI50 960.0 nM 10.1016/j.bmcl.2014.06.080
None NON-PROTEIN TARGET GI50 1020.0 nM 10.1016/j.ejmech.2016.06.023
None NON-PROTEIN TARGET GI50 1040.0 nM 10.1016/j.ejmech.2015.03.034
None NON-PROTEIN TARGET GI50 1210.0 nM 10.1016/j.ejmech.2011.06.002
None NON-PROTEIN TARGET GI50 1420.0 nM 10.1016/j.ejmech.2014.09.024
None NON-PROTEIN TARGET GI50 1740.0 nM 10.1016/j.ejmech.2016.06.023
None NON-PROTEIN TARGET GI50 1770.0 nM 10.1016/j.ejmech.2016.01.013
None NON-PROTEIN TARGET GI50 1780.0 nM 10.1016/j.ejmech.2015.03.034
None NON-PROTEIN TARGET GI50 1790.0 nM 10.1016/j.ejmech.2014.09.024
None NON-PROTEIN TARGET GI50 2000.0 nM 10.1021/jm900125m
None NON-PROTEIN TARGET GI50 2030.0 nM 10.1016/j.ejmech.2016.01.013
None NON-PROTEIN TARGET GI50 2090.0 nM 10.1016/j.ejmech.2016.01.013
None NON-PROTEIN TARGET GI50 2100.0 nM 10.1021/jm101177s
None NON-PROTEIN TARGET GI50 2490.0 nM 10.1021/acs.jmedchem.5b00062
None NON-PROTEIN TARGET GI50 2690.0 nM 10.1021/acs.jmedchem.5b00062
None NON-PROTEIN TARGET GI50 2800.0 nM 10.1021/jm501399d
None NON-PROTEIN TARGET GI50 2800.0 nM 10.1039/C4MD00252K
None NON-PROTEIN TARGET GI50 2940.0 nM 10.1021/acs.jmedchem.5b00062
None NON-PROTEIN TARGET GI50 4260.0 nM 10.1016/j.ejmech.2014.09.024
None NON-PROTEIN TARGET GI50 4640.0 nM 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET GI50 5000.0 nM 10.1021/jm201496g
None NON-PROTEIN TARGET GI50 17000.0 nM 10.1021/jm900125m
None NON-PROTEIN TARGET GI90 18.0 uM 10.1021/jm3011838
None NON-PROTEIN TARGET GI90 30.0 uM 10.1021/jm3011838
None NON-PROTEIN TARGET IC50 50.0 nM None
None NON-PROTEIN TARGET IC50 310.0 nM 10.1016/j.ejmech.2016.02.001
None NON-PROTEIN TARGET IC50 330.0 nM 10.1016/j.ejmech.2016.02.003
None NON-PROTEIN TARGET IC50 420.0 nM 10.1016/j.ejmech.2016.02.003
None NON-PROTEIN TARGET IC50 423.0 nM 10.1021/acs.jmedchem.5b01342
None NON-PROTEIN TARGET IC50 490.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 500.0 nM None
None NON-PROTEIN TARGET IC50 581.0 nM 10.1021/acs.jmedchem.5b01342
None NON-PROTEIN TARGET IC50 590.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 600.0 nM 10.1016/j.bmcl.2015.02.007
None NON-PROTEIN TARGET IC50 606.0 nM 10.1016/j.bmcl.2007.04.089
None NON-PROTEIN TARGET IC50 630.0 nM 10.1016/j.bmc.2016.10.006
None NON-PROTEIN TARGET IC50 640.0 nM 10.1016/j.bmc.2015.05.048
None NON-PROTEIN TARGET IC50 650.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 680.0 nM 10.1016/j.bmc.2015.06.015
None NON-PROTEIN TARGET IC50 680.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 686.0 nM 10.1016/j.bmcl.2010.08.113
None NON-PROTEIN TARGET IC50 700.0 nM 10.1016/j.bmcl.2015.09.006
None NON-PROTEIN TARGET IC50 700.0 nM 10.1039/c4md00401a
None NON-PROTEIN TARGET IC50 710.0 nM 10.1021/jm401899x
None NON-PROTEIN TARGET IC50 750.0 nM None
None NON-PROTEIN TARGET IC50 757.0 nM 10.1016/j.ejmech.2015.11.010
None NON-PROTEIN TARGET IC50 800.0 nM 10.1021/jm5008962
None NON-PROTEIN TARGET IC50 800.0 nM 10.1021/jm701606b
None NON-PROTEIN TARGET IC50 820.0 nM 10.1016/j.ejmech.2016.02.003
None NON-PROTEIN TARGET IC50 820.0 nM 10.1021/jm401899x
None NON-PROTEIN TARGET IC50 850.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 870.0 nM 10.1021/acs.jmedchem.6b00579
None NON-PROTEIN TARGET IC50 900.0 nM 10.1016/j.bmc.2016.02.005
None NON-PROTEIN TARGET IC50 940.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 970.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2006.11.042
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2009.04.058
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.ejmech.2016.02.003
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/acs.jmedchem.5b01342
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/jm0703136
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/jm8002894
None NON-PROTEIN TARGET IC50 1000.0 nM None
None NON-PROTEIN TARGET IC50 1020.0 nM None
None NON-PROTEIN TARGET IC50 1030.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 1090.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 1100.0 nM 10.1021/jm5008962
None NON-PROTEIN TARGET IC50 1110.0 nM 10.1039/C4MD00203B
None NON-PROTEIN TARGET IC50 1150.0 nM 10.1016/j.bmc.2014.01.045
None NON-PROTEIN TARGET IC50 1151.0 nM 10.1039/C3MD00285C
None NON-PROTEIN TARGET IC50 1180.0 nM 10.1021/jm401899x
None NON-PROTEIN TARGET IC50 1180.0 nM 10.1039/C5MD00247H
None NON-PROTEIN TARGET IC50 1190.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 1200.0 nM 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET IC50 1200.0 nM 10.1021/jm701606b
None NON-PROTEIN TARGET IC50 1200.0 nM 10.1021/jm901667k
None NON-PROTEIN TARGET IC50 1220.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 1250.0 nM 10.1021/jm401899x
None NON-PROTEIN TARGET IC50 1280.0 nM 10.1016/j.ejmech.2015.04.002
None NON-PROTEIN TARGET IC50 1300.0 nM 10.1021/jm701606b
None NON-PROTEIN TARGET IC50 1300.0 nM 10.1021/jm901667k
None NON-PROTEIN TARGET IC50 1350.0 nM 10.1016/j.bmc.2015.08.040
None NON-PROTEIN TARGET IC50 1400.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 1450.0 nM 10.1021/acs.jmedchem.6b00579
None NON-PROTEIN TARGET IC50 1590.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 1590.0 nM 10.1021/jm401877m
None NON-PROTEIN TARGET IC50 1760.0 nM 10.1021/jm0703136
None NON-PROTEIN TARGET IC50 1800.0 nM 10.1021/jm901453q
None NON-PROTEIN TARGET IC50 1830.0 nM None
None NON-PROTEIN TARGET IC50 1850.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 1900.0 nM 10.1016/j.bmc.2016.10.006
None NON-PROTEIN TARGET IC50 1900.0 nM 10.1016/j.bmcl.2003.07.012
None NON-PROTEIN TARGET IC50 1900.0 nM 10.1016/s0960-894x(02)00622-4
None NON-PROTEIN TARGET IC50 2000.0 nM 10.1016/j.bmcl.2012.08.006
None NON-PROTEIN TARGET IC50 2000.0 nM None
None NON-PROTEIN TARGET IC50 2100.0 nM 10.1016/j.bmcl.2013.07.001
None NON-PROTEIN TARGET IC50 2120.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 2200.0 nM 10.1016/j.bmcl.2015.09.006
None NON-PROTEIN TARGET IC50 2200.0 nM 10.1016/j.ejmech.2014.04.021
None NON-PROTEIN TARGET IC50 2200.0 nM 10.1016/j.ejmech.2016.02.001
None NON-PROTEIN TARGET IC50 2280.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 2290.0 nM 10.1016/j.bmc.2016.10.006
None NON-PROTEIN TARGET IC50 2300.0 nM 10.1016/j.bmcl.2013.07.001
None NON-PROTEIN TARGET IC50 2390.0 nM 10.1016/j.bmc.2014.08.030
None NON-PROTEIN TARGET IC50 2440.0 nM 10.1021/jm901453q
None NON-PROTEIN TARGET IC50 2500.0 nM 10.1016/j.bmcl.2013.07.001
None NON-PROTEIN TARGET IC50 2580.0 nM 10.1016/j.bmc.2016.10.006
None NON-PROTEIN TARGET IC50 2670.0 nM 10.1016/j.bmc.2016.10.006
None NON-PROTEIN TARGET IC50 2730.0 nM None
None NON-PROTEIN TARGET IC50 2750.0 nM 10.1016/j.bmc.2015.07.008
None NON-PROTEIN TARGET IC50 2810.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 2830.0 nM 10.1016/j.ejmech.2015.04.002
None NON-PROTEIN TARGET IC50 2830.0 nM 10.1016/j.ejmech.2016.02.003
None NON-PROTEIN TARGET IC50 2910.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 2950.0 nM 10.1016/j.bmc.2015.06.015
None NON-PROTEIN TARGET IC50 3000.0 nM 10.1021/ml500327q
None NON-PROTEIN TARGET IC50 3000.0 nM None
None NON-PROTEIN TARGET IC50 3220.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 3270.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 3400.0 nM 10.1016/j.bmcl.2013.11.072
None NON-PROTEIN TARGET IC50 3400.0 nM 10.1016/j.bmcl.2015.09.006
None NON-PROTEIN TARGET IC50 3400.0 nM 10.1016/j.ejmech.2014.04.021
None NON-PROTEIN TARGET IC50 3400.0 nM 10.1016/j.ejmech.2016.02.001
None NON-PROTEIN TARGET IC50 3450.0 nM 10.1016/j.bmc.2014.08.030
None NON-PROTEIN TARGET IC50 3450.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 3460.0 nM 10.1016/j.bmc.2015.05.048
None NON-PROTEIN TARGET IC50 3460.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 3570.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 3810.0 nM 10.1021/jm0703136
None NON-PROTEIN TARGET IC50 4250.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 4260.0 nM 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET IC50 4320.0 nM 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET IC50 4500.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 4660.0 nM 10.1039/C4MD00203B
None NON-PROTEIN TARGET IC50 4700.0 nM None
None NON-PROTEIN TARGET IC50 4800.0 nM None
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmc.2016.12.032
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmcl.2006.07.080
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmcl.2007.09.041
None NON-PROTEIN TARGET IC50 5060.0 nM 10.1039/C5MD00247H
None NON-PROTEIN TARGET IC50 5400.0 nM 10.1016/j.bmcl.2013.04.067
None NON-PROTEIN TARGET IC50 5490.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 5530.0 nM 10.1021/acs.jmedchem.5b01052
None NON-PROTEIN TARGET IC50 5790.0 nM 10.1016/j.bmc.2014.09.039
None NON-PROTEIN TARGET IC50 6000.0 nM 10.1016/j.bmc.2016.09.022
None NON-PROTEIN TARGET IC50 6000.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 6210.0 nM 10.1021/jm101605z
None NON-PROTEIN TARGET IC50 6550.0 nM 10.1021/acs.jmedchem.5b00317
None NON-PROTEIN TARGET IC50 7240.0 nM 10.1016/j.bmcl.2006.07.080
None NON-PROTEIN TARGET IC50 7260.0 nM 10.1016/j.bmc.2016.02.005
None NON-PROTEIN TARGET IC50 7860.0 nM 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 8200.0 nM 10.1021/jm200388e
None NON-PROTEIN TARGET IC50 8460.0 nM None
None NON-PROTEIN TARGET IC50 10110.0 nM 10.1016/j.bmc.2015.05.048
None NON-PROTEIN TARGET IC50 11000.0 nM 10.1021/jm0703136
None NON-PROTEIN TARGET IC50 12700.0 nM 10.1021/ml300366t
None NON-PROTEIN TARGET IC50 14800.0 nM 10.1016/j.bmcl.2013.04.067
None NON-PROTEIN TARGET IC50 32460.0 nM 10.1039/C5MD00247H
None NON-PROTEIN TARGET IC50 79300.0 nM 10.1016/j.bmc.2015.05.048
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmcl.2014.08.060
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2016.02.001
None NON-PROTEIN TARGET IC50 nan None 10.1021/acs.jmedchem.6b00157
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm0703136
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm301769u
None NON-PROTEIN TARGET Inhibition -23.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition -10.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition -4.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition -3.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition 0.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition 5.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition 6.0 % 10.1021/jm8005355
None NON-PROTEIN TARGET Inhibition 69.0 % 10.1021/jm500303u
None NON-PROTEIN TARGET Inhibition nan % 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET Inhibition nan % 10.1039/C4MD00252K
None NON-PROTEIN TARGET LC50 3590.0 nM 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET LC50 4850.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET LC50 10000.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET Potency 375.5 nM None
None NON-PROTEIN TARGET Potency 38196.8 nM None
None NON-PROTEIN TARGET Selectivity ratio 0.4 None 10.1021/acs.jmedchem.6b00908
None NON-PROTEIN TARGET T/C 71.7 % 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET T/C 75.53 % 10.1016/j.bmc.2015.05.048
None NON-PROTEIN TARGET TGI 30.0 % 10.1016/j.ejmech.2016.01.013
None NON-PROTEIN TARGET TGI 35.7 % 10.1016/j.ejmech.2014.10.077
None NON-PROTEIN TARGET TGI 48.0 % 10.1016/j.ejmech.2016.02.001
None NON-PROTEIN TARGET TGI 61.5 % 10.1016/j.ejmech.2016.06.023
None NON-PROTEIN TARGET TGI 2350.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET TGI 3260.0 nM 10.1021/np500387h
None NON-PROTEIN TARGET TGI 10000.0 nM 10.1021/np500387h
None No relevant target Activity 1.0 equiv 10.1016/j.bmc.2018.10.022
None No relevant target IC50 67474.0 nM None
None No relevant target Ka 403.0 /M 10.1039/c4md00401a
None No relevant target Kd 2500.0 nM 10.1039/c4md00401a
None No relevant target LogD 1.0 None 10.1021/jm201496g
None No relevant target LogD 1.04 None 10.1016/j.bmcl.2010.04.041
None No relevant target LogD 1.04 None 10.1021/jm2003552
None No relevant target LogD 1.05 None 10.1021/acs.jmedchem.7b01465
None No relevant target LogD 1.46 None 10.1016/j.ejmech.2020.112887
None No relevant target LogD 2.0 None 10.1021/acs.jmedchem.6b00908
None No relevant target LogP 0.99 None 10.1021/acs.jmedchem.1c01215
None No relevant target Peff 2.34 nm/s 10.1016/j.ejmech.2018.03.005
None No relevant target permeability 15.0 nm/s 10.1039/C3MD00285C
None No relevant target Ratio 0.0 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 0.08 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 0.14 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 0.41 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 0.61 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 1.0 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 1.14 None 10.1021/acs.jmedchem.0c01541
None No relevant target Ratio 1.19 None 10.1021/acs.jmedchem.0c01541
None No relevant target Retention_time 8.42 min 10.1016/j.bmc.2019.02.046
None No relevant target Retention_time 10.7 min 10.1021/acs.jmedchem.5b00539
None No relevant target Solubility 100.0 ug.mL-1 10.1016/j.ejmech.2020.112628
None No relevant target Solubility 100.0 ug.mL-1 10.1016/j.ejmech.2020.112887
None No relevant target Solubility 166.0 ug.mL-1 10.1016/j.bmcl.2010.04.041
None No relevant target Solubility 170.0 ug.mL-1 10.1021/jm201496g
None No relevant target Solubility 311.0 ug.mL-1 10.1021/jm5008962
None No relevant target Solubility 385.0 ug.mL-1 10.1021/jm502011f
None No relevant target Solubility 400.0 ug.mL-1 10.1016/j.ejmech.2020.112887
None No relevant target Solubility 19000.0 nM 10.1016/j.bmcl.2011.06.015
None No relevant target Solubility 200000.0 nM 10.1021/jm2003552
None No relevant target Solubility 250000.0 nM 10.1016/j.bmcl.2010.04.041
None No relevant target Solubility 307000.0 nM 10.1039/C3MD00285C
None No relevant target Solubility 1230300.0 nM 10.6019/CHEMBL3301361
None No relevant target Solubility 32000000.0 nM 10.1016/j.bmcl.2018.06.029
None No relevant target Solubility 87000000.0 nM 10.1016/j.bmcl.2018.06.029
None No relevant target Stability nan % 10.1021/jm5008209
None No relevant target T1/2 22.0 hr 10.1021/jm201496g
None No relevant target T1/2 24.0 hr 10.1021/jm201496g
None No relevant target V0 5.2 microM/min 10.1016/j.bmc.2018.10.022
None No relevant target V0 5.3 microM/min 10.1016/j.bmc.2018.10.022
None No relevant target V0 34.9 microM/min 10.1016/j.bmc.2018.10.022
None Osteoclast-like EC50 150000.0 nM 10.1016/j.bmcl.2003.10.055
None PBL IC50 3400.0 nM 10.1021/acs.jmedchem.8b00050
None Unchecked AbsAC26_uM 0.0582 uM None
None Unchecked AbsAC30_uM 1.47 uM None
None Unchecked AbsAC35_uM 0.803 uM None
None Unchecked AbsAC35_uM 14.17 uM None
None Unchecked Ac50 0.4467 uM None
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 15.85 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked Ac50 31.62 uM None
None Unchecked AC50 446.7 nM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 933.0 nM None
None Unchecked AC50 15848.9 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked AC50 31622.8 nM None
None Unchecked AC50 31630.0 nM None
None Unchecked Activity 0.55 g 10.1021/acsmedchemlett.0c00369
None Unchecked Activity 1.8 % 10.1021/acs.jmedchem.8b00050
None Unchecked Activity 2.1 % 10.1016/j.ejmech.2021.113971
None Unchecked Activity 6.7 % 10.1021/acs.jmedchem.8b00050
None Unchecked Activity 14.7 % 10.1016/j.ejmech.2021.113971
None Unchecked Activity 21.0 % 10.1016/j.ejmech.2021.113971
None Unchecked Activity 45.77 % 10.1021/acsmedchemlett.0c00369
None Unchecked Activity 49.0 % 10.1016/j.bmcl.2017.06.033
None Unchecked Activity 52.0 % 10.1021/acsmedchemlett.9b00071
None Unchecked Activity 62.2 % 10.1016/j.ejmech.2021.113971
None Unchecked Activity 65.0 % 10.1021/acs.jmedchem.7b01465
None Unchecked Activity 70.0 % 10.1021/acsmedchemlett.9b00071
None Unchecked Activity 78.0 % 10.1016/j.bmcl.2017.06.033
None Unchecked Activity 80.2 % 10.1016/j.ejmech.2016.11.055
None Unchecked Activity 84.0 % 10.1021/acs.jmedchem.7b01465
None Unchecked Activity 86.0 % 10.1016/j.bmcl.2017.06.033
None Unchecked Activity 94.0 % 10.1021/acs.jmedchem.7b01465
None Unchecked Activity 97.0 % 10.1016/j.bmcl.2017.06.033
None Unchecked Activity 100.0 % 10.1016/j.bmcl.2016.01.022
None Unchecked Activity nan None 10.1016/j.bmc.2021.116251
None Unchecked Activity nan None 10.1016/j.bmcl.2008.04.017
None Unchecked Activity nan None 10.1016/j.ejmech.2019.111991
None Unchecked Activity nan None 10.1016/j.ejmech.2020.113095
None Unchecked Activity nan None 10.1016/j.ejmech.2021.113971
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114634
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c01454
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c01726
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c02225
None Unchecked Activity nan None 10.1021/acs.jmedchem.2c01058
None Unchecked Activity nan None 10.1021/acs.jmedchem.2c01413
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b01885
None Unchecked Activity nan None 10.1021/acs.jmedchem.7b00533
None Unchecked Activity nan None 10.1021/acs.jmedchem.9b02161
None Unchecked Activity nan None 10.1021/acsmedchemlett.0c00302
None Unchecked Activity nan None 10.1021/acsmedchemlett.8b00440
None Unchecked Activity nan None 10.1021/acsmedchemlett.9b00071
None Unchecked Activity nan None 10.1021/jm070028m
None Unchecked Activity nan None 10.1021/jm900775q
None Unchecked Activity nan None 10.1021/ml200136e
None Unchecked Activity nan None 10.1021/np049666n
None Unchecked Activity nan None 10.1074/jbc.m609885200
None Unchecked EC50 3.9 nM 10.1016/j.ejmech.2021.113213
None Unchecked EC50 700.0 nM 10.1016/j.bmcl.2003.10.055
None Unchecked EC50 950.0 nM 10.1016/j.bmcl.2016.01.022
None Unchecked EC50 1000.0 nM 10.1016/j.ejmech.2018.08.073
None Unchecked EC50 1900.0 nM 10.1021/acs.jmedchem.9b00462
None Unchecked EC50 2000.0 nM 10.1021/jm049207j
None Unchecked EC50 2000.0 nM 10.1021/jm7011408
None Unchecked EC50 2931.0 nM None
None Unchecked EC50 4336.0 nM None
None Unchecked EC50 5259.0 nM None
None Unchecked EC50 6670.0 nM 10.1021/jm100665z
None Unchecked EC50 30000.0 nM 10.1021/acs.jmedchem.7b01465
None Unchecked EC50 120000.0 nM None
None Unchecked EC50 350000.0 nM None
None Unchecked FC 1.0 None 10.1016/j.bmcl.2017.06.027
None Unchecked FC 1.0 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 1.06 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 1.41 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 1.5 None 10.1016/j.bmcl.2017.06.027
None Unchecked FC 1.5 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 1.5 None 10.1021/acs.jmedchem.6b00908
None Unchecked FC 1.53 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 1.95 None 10.1021/acs.jmedchem.6b00908
None Unchecked FC 2.99 None 10.1016/j.ejmech.2018.07.069
None Unchecked FC 4.0 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC 12.5 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC 13.9 None 10.1016/j.ejmech.2018.03.005
None Unchecked FC 15.0 None 10.1021/ml200136e
None Unchecked FC 25.0 None 10.1021/ml200136e
None Unchecked FC 30.0 None 10.1021/ml200136e
None Unchecked FC 47.0 None 10.1016/j.ejmech.2021.113213
None Unchecked FC 100.0 None 10.1021/ml200136e
None Unchecked FC nan None 10.1016/j.ejmech.2018.03.005
None Unchecked Fold selectivity 7.0 None 10.1021/jm034167p
None Unchecked GI50 2000.0 nM 10.1021/acs.jmedchem.2c01276
None Unchecked GI50 4000.0 nM 10.1016/j.bmc.2021.116454
None Unchecked IC50 0.66 nM 10.1016/j.bmcl.2017.03.020
None Unchecked IC50 10.0 nM 10.1016/j.bmcl.2009.04.102
None Unchecked IC50 22.0 nM 10.1016/j.bmcl.2009.04.102
None Unchecked IC50 28.0 nM 10.1016/j.bmcl.2005.07.081
None Unchecked IC50 29.0 nM 10.1021/jm100507q
None Unchecked IC50 30.0 nM 10.1021/jm034167p
None Unchecked IC50 30.0 nM 10.1021/jm049002a
None Unchecked IC50 42.96 nM 10.1016/j.bmcl.2017.09.036
None Unchecked IC50 50.0 nM 10.1016/j.ejmech.2018.08.073
None Unchecked IC50 51.6 nM 10.1016/j.ejmech.2017.11.092
None Unchecked IC50 53.0 nM 10.1016/j.bmcl.2009.09.100
None Unchecked IC50 88.0 nM 10.1016/j.bmc.2015.10.045
None Unchecked IC50 110.0 nM 10.1016/j.bmcl.2010.08.117
None Unchecked IC50 110.0 nM 10.1016/j.bmcl.2013.03.002
None Unchecked IC50 110.0 nM 10.1016/j.ejmech.2016.11.055
None Unchecked IC50 110.0 nM 10.1021/jm3009376
None Unchecked IC50 120.06 nM 10.1016/j.ejmech.2016.11.033
None Unchecked IC50 131.26 nM 10.1016/j.ejmech.2017.03.079
None Unchecked IC50 154.8 nM 10.1016/j.bmc.2015.08.040
None Unchecked IC50 160.8 nM 10.1016/j.bmc.2016.12.001
None Unchecked IC50 170.0 nM 10.1016/j.bmc.2017.04.043
None Unchecked IC50 178.0 nM 10.1016/j.bmcl.2005.07.081
None Unchecked IC50 180.0 nM 10.1016/j.ejmech.2007.05.004
None Unchecked IC50 180.0 nM 10.1021/jm049002a
None Unchecked IC50 180.0 nM 10.1021/jm0605536
None Unchecked IC50 193.8 nM 10.1016/j.bmc.2017.06.039
None Unchecked IC50 200.0 nM 10.1016/j.bmcl.2017.06.033
None Unchecked IC50 200.0 nM 10.1021/jm034167p
None Unchecked IC50 250.0 nM 10.1021/acs.jmedchem.2c01413
None Unchecked IC50 259.0 nM 10.1016/j.ejmech.2020.112677
None Unchecked IC50 263.0 nM 10.1021/jm7011408
None Unchecked IC50 268.48 nM None
None Unchecked IC50 300.0 nM 10.1021/acs.jmedchem.2c01058
None Unchecked IC50 338.4 nM None
None Unchecked IC50 460.0 nM 10.1021/acs.jmedchem.1c00821
None Unchecked IC50 473.0 nM 10.1016/j.ejmech.2017.03.064
None Unchecked IC50 498.82 nM None
None Unchecked IC50 553.3 nM 10.1021/acs.jmedchem.6b00772
None Unchecked IC50 590.0 nM 10.1016/j.ejmech.2021.113173
None Unchecked IC50 606.0 nM 10.1016/j.ejmech.2019.111725
None Unchecked IC50 630.1 nM 10.1016/j.ejmech.2019.05.089
None Unchecked IC50 639.23 nM None
None Unchecked IC50 690.0 nM 10.1016/j.ejmech.2020.112679
None Unchecked IC50 750.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 770.0 nM 10.1016/j.ejmech.2021.113672
None Unchecked IC50 880.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 900.0 nM 10.1016/j.ejmech.2020.112679
None Unchecked IC50 950.0 nM 10.1016/j.ejmech.2021.114011
None Unchecked IC50 968.0 nM 10.1021/acs.jmedchem.9b02161
None Unchecked IC50 970.0 nM 10.1016/j.bmc.2023.117242
None Unchecked IC50 1000.0 nM 10.1016/j.ejmech.2020.112904
None Unchecked IC50 1021.0 nM 10.1021/acs.jmedchem.6b00772
None Unchecked IC50 1100.0 nM 10.1016/j.ejmech.2017.11.021
None Unchecked IC50 1133.94 nM None
None Unchecked IC50 1340.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 1361.55 nM None
None Unchecked IC50 1410.0 nM 10.1016/j.bmc.2018.02.033
None Unchecked IC50 1430.0 nM 10.1016/j.ejmech.2021.113173
None Unchecked IC50 1500.0 nM 10.1021/acs.jmedchem.0c00102
None Unchecked IC50 1600.0 nM 10.1016/j.ejmech.2020.112887
None Unchecked IC50 1650.02 nM None
None Unchecked IC50 1680.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 1710.8 nM None
None Unchecked IC50 1750.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 1800.0 nM 10.1016/j.ejmech.2017.11.021
None Unchecked IC50 1900.0 nM 10.1016/j.ejmech.2021.113971
None Unchecked IC50 2000.0 nM 10.1016/j.ejmech.2018.03.002
None Unchecked IC50 2000.0 nM 10.1021/acs.jmedchem.1c00787
None Unchecked IC50 2067.0 nM 10.1016/j.ejmech.2020.112677
None Unchecked IC50 2200.0 nM 10.1021/acs.jmedchem.1c01726
None Unchecked IC50 2223.63 nM None
None Unchecked IC50 2252.35 nM None
None Unchecked IC50 2510.0 nM 10.1016/j.ejmech.2018.09.018
None Unchecked IC50 2820.0 nM 10.1021/acs.jmedchem.6b01538
None Unchecked IC50 3110.0 nM 10.1016/j.ejmech.2021.113524
None Unchecked IC50 3300.0 nM 10.1016/j.ejmech.2017.11.021
None Unchecked IC50 3500.0 nM 10.1016/j.ejmech.2020.112904
None Unchecked IC50 3560.0 nM 10.1016/j.ejmech.2021.113524
None Unchecked IC50 3600.0 nM 10.1016/j.ejmech.2021.113961
None Unchecked IC50 3670.0 nM 10.1021/acsmedchemlett.8b00440
None Unchecked IC50 3790.0 nM 10.1021/acsmedchemlett.8b00440
None Unchecked IC50 3950.0 nM 10.1021/acsmedchemlett.8b00440
None Unchecked IC50 4100.0 nM 10.1016/j.ejmech.2017.11.021
None Unchecked IC50 5000.0 nM 10.1021/acs.jmedchem.1c00420
None Unchecked IC50 5000.0 nM 10.1021/acs.jmedchem.1c01585
None Unchecked IC50 5000.0 nM 10.1038/nchembio.275
None Unchecked IC50 6500.0 nM 10.1016/j.ejmech.2017.11.021
None Unchecked IC50 6520.0 nM 10.1016/j.bmcl.2018.11.027
None Unchecked IC50 7500.0 nM 10.1016/j.bmc.2021.116085
None Unchecked IC50 8300.0 nM 10.1016/j.ejmech.2021.113971
None Unchecked IC50 9270.0 nM 10.1016/j.bmc.2019.03.008
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2021.113971
None Unchecked IC50 10000.0 nM None
None Unchecked IC50 14000.0 nM 10.1021/jm800936s
None Unchecked IC50 16000.0 nM 10.1021/acs.jmedchem.7b00322
None Unchecked IC50 18900.0 nM 10.1021/acs.jmedchem.9b02161
None Unchecked IC50 25000.0 nM 10.1021/acsmedchemlett.9b00471
None Unchecked IC50 33000.0 nM 10.1016/j.ejmech.2021.113971
None Unchecked IC50 42275.0 nM 10.1016/j.ejmech.2017.03.064
None Unchecked IC50 43500.0 nM 10.1021/jm7011408
None Unchecked IC50 50000.0 nM 10.1039/C9MD00306A
None Unchecked IC50 52000.0 nM 10.1016/j.ejmech.2021.113971
None Unchecked IC50 79200.0 nM 10.1021/acs.jmedchem.7b00678
None Unchecked IC50 120000.0 nM 10.1016/j.ejmech.2021.114011
None Unchecked IC50 420000.0 nM 10.1021/jm800936s
None Unchecked IC50 540000.0 nM 10.1021/jm201048w
None Unchecked IC50 540000.0 nM 10.1021/jm800936s
None Unchecked IC50 700000.0 nM 10.1021/jm800936s
None Unchecked IC50 nan None 10.1021/acs.jmedchem.7b00678
None Unchecked IC50 nan None 10.1021/jm7011408
None Unchecked Imax 37.4 % 10.1016/j.bmc.2015.10.045
None Unchecked INH 50.0 uM 10.1021/acs.jmedchem.6b01507
None Unchecked Inhibition 30.0 % 10.1021/acsmedchemlett.0c00014
None Unchecked Inhibition 46.0 % 10.1039/C9MD00306A
None Unchecked Inhibition nan % 10.1016/j.bmc.2011.01.013
None Unchecked Inhibition nan % 10.1016/j.bmc.2016.12.032
None Unchecked Inhibition nan % 10.1016/j.bmc.2021.116251
None Unchecked Inhibition nan % 10.1016/j.bmcl.2010.08.113
None Unchecked Inhibition nan % 10.1016/j.bmcl.2023.129148
None Unchecked Inhibition nan % 10.1016/j.ejmech.2016.06.023
None Unchecked Inhibition nan % 10.1016/j.ejmech.2017.03.079
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.112677
None Unchecked Inhibition nan % 10.1016/j.ejmech.2021.113961
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.0c02111
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b00772
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.7b01465
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.7b00126
None Unchecked Inhibition nan % 10.1039/C4MD00211C
None Unchecked Ki 14.0 nM 10.1016/j.bmcl.2017.02.050
None Unchecked Ki 120.0 nM 10.1016/j.bmcl.2017.02.050
None Unchecked Ki 320.0 nM 10.1016/j.bmcl.2017.02.050
None Unchecked Potency 63.1 nM None
None Unchecked Potency 95.9 nM None
None Unchecked Potency 135.5 nM None
None Unchecked Potency 428.6 nM None
None Unchecked Potency 480.9 nM None
None Unchecked Potency 1865.5 nM None
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 17061.9 nM None
None Unchecked Potency 38196.8 nM None
None Unchecked Ratio 0.34 None 10.1016/j.ejmech.2016.11.055
None Unchecked Ratio 0.7 None 10.1016/j.ejmech.2016.11.055
None Unchecked Ratio 1.4 None 10.1016/j.ejmech.2016.11.055
None Unchecked Ratio 1.6 None 10.1016/j.ejmech.2016.11.055
None Unchecked Ratio 2.49 None 10.1021/acs.jmedchem.8b01090
None Unchecked Ratio 3.4 None 10.1021/acs.jmedchem.8b01090
None Unchecked Ratio 5.22 None 10.1021/acs.jmedchem.8b01090
None Unchecked Ratio 21.0 None 10.1021/jm900125m
None Unchecked Ratio 22.0 None 10.1128/aac.00439-08
None Unchecked Ratio 26.0 None 10.1021/jm900125m
None Unchecked Ratio 29.0 None 10.1021/jm900125m
None Unchecked Ratio CC50/EC50 0.65 None 10.1021/acsmedchemlett.8b00012
None Unchecked Ratio IC50 0.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 0.01 None 10.1021/ml300371t
None Unchecked Ratio IC50 0.04 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 0.04 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 0.06 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 0.06 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 0.16 None 10.1016/j.bmcl.2017.08.011
None Unchecked Ratio IC50 0.16 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 0.17 None 10.1016/j.bmcl.2017.08.011
None Unchecked Ratio IC50 0.2 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 0.2 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 0.24 None 10.1016/j.ejmech.2019.111672
None Unchecked Ratio IC50 0.26 None 10.1016/j.bmc.2015.05.048
None Unchecked Ratio IC50 0.31 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 0.33 None 10.1016/j.bmc.2022.117028
None Unchecked Ratio IC50 0.33 None 10.1021/np400198r
None Unchecked Ratio IC50 0.43 None 10.1016/j.ejmech.2018.12.056
None Unchecked Ratio IC50 0.45 None 10.1016/j.ejmech.2021.113392
None Unchecked Ratio IC50 0.47 None 10.1016/j.ejmech.2018.12.056
None Unchecked Ratio IC50 0.5 None 10.1016/j.ejmech.2021.113971
None Unchecked Ratio IC50 0.6 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 0.6 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 0.63 None 10.1128/aac.00729-08
None Unchecked Ratio IC50 0.69 None 10.1016/j.ejmech.2021.113392
None Unchecked Ratio IC50 0.7 None 10.1021/acs.jmedchem.5b01342
None Unchecked Ratio IC50 0.7 None 10.1021/jm401877m
None Unchecked Ratio IC50 0.76 None 10.1021/acs.jmedchem.2c00909
None Unchecked Ratio IC50 0.8 None 10.1021/jm701606b
None Unchecked Ratio IC50 0.9 None 10.1016/j.bmcl.2010.09.100
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2021.128207
None Unchecked Ratio IC50 1.0 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 1.0 None 10.1016/j.ejmech.2018.12.056
None Unchecked Ratio IC50 1.0 None 10.1016/j.ejmech.2019.111755
None Unchecked Ratio IC50 1.0 None 10.1021/acs.jmedchem.1c00184
None Unchecked Ratio IC50 1.0 None 10.1021/acs.jmedchem.1c01585
None Unchecked Ratio IC50 1.0 None 10.1021/acs.jmedchem.8b01090
None Unchecked Ratio IC50 1.0 None 10.1021/jm801128g
None Unchecked Ratio IC50 1.17 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 1.2 None 10.1016/j.bmcl.2021.128286
None Unchecked Ratio IC50 1.3 None 10.1021/jm100507q
None Unchecked Ratio IC50 1.41 None 10.1016/j.ejmech.2016.11.033
None Unchecked Ratio IC50 1.6 None 10.1016/j.ejmech.2017.11.021
None Unchecked Ratio IC50 1.6 None 10.1016/j.ejmech.2021.113971
None Unchecked Ratio IC50 1.65 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 1.65 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 1.8 None 10.1021/jm401877m
None Unchecked Ratio IC50 1.86 None 10.1016/j.bmc.2019.06.036
None Unchecked Ratio IC50 2.0 None 10.1016/j.ejmech.2020.113065
None Unchecked Ratio IC50 2.0 None 10.1021/acs.jmedchem.2c01418
None Unchecked Ratio IC50 2.0 None 10.1021/acs.jmedchem.5b01493
None Unchecked Ratio IC50 2.0 None 10.1021/acsmedchemlett.9b00287
None Unchecked Ratio IC50 2.0 None 10.1021/jm401877m
None Unchecked Ratio IC50 2.2 None 10.1016/j.ejmech.2022.114582
None Unchecked Ratio IC50 2.32 None 10.1016/j.bmcl.2020.127638
None Unchecked Ratio IC50 2.35 None 10.1016/j.bmcl.2022.128821
None Unchecked Ratio IC50 2.46 None 10.1016/j.ejmech.2022.114228
None Unchecked Ratio IC50 2.5 None 10.1016/j.bmc.2009.10.042
None Unchecked Ratio IC50 2.7 None 10.1016/j.bmc.2017.08.029
None Unchecked Ratio IC50 2.7 None 10.1016/j.ejmech.2021.113392
None Unchecked Ratio IC50 3.0 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2021.113383
None Unchecked Ratio IC50 3.0 None 10.1021/acs.jmedchem.2c01659
None Unchecked Ratio IC50 3.0 None 10.1021/acs.jmedchem.9b01888
None Unchecked Ratio IC50 3.0 None 10.1039/C8MD00454D
None Unchecked Ratio IC50 3.5 None 10.1021/jm100507q
None Unchecked Ratio IC50 4.0 None 10.1021/acs.jmedchem.8b01090
None Unchecked Ratio IC50 4.1 None 10.1016/j.bmc.2022.117028
None Unchecked Ratio IC50 4.38 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 4.5 None 10.1016/j.ejmech.2022.114582
None Unchecked Ratio IC50 4.6 None 10.1016/j.ejmech.2016.11.033
None Unchecked Ratio IC50 4.8 None 10.1016/j.bmc.2009.10.042
None Unchecked Ratio IC50 4.9 None 10.1021/jm100507q
None Unchecked Ratio IC50 5.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 5.0 None 10.1021/acs.jmedchem.0c02210
None Unchecked Ratio IC50 5.3 None 10.1021/jm401877m
None Unchecked Ratio IC50 6.0 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 6.0 None 10.1016/j.ejmech.2007.05.004
None Unchecked Ratio IC50 6.0 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 7.0 None 10.1016/j.ejmech.2014.05.050
None Unchecked Ratio IC50 7.0 None 10.1021/jm2016182
None Unchecked Ratio IC50 7.6 None 10.1021/jm101605z
None Unchecked Ratio IC50 7.7 None 10.1016/j.bmcl.2012.06.017
None Unchecked Ratio IC50 9.41 None 10.1016/j.bmcl.2022.128821
None Unchecked Ratio IC50 10.8 None 10.1016/j.ejmech.2021.113392
None Unchecked Ratio IC50 11.0 None 10.1016/j.ejmech.2014.05.050
None Unchecked Ratio IC50 11.0 None 10.1021/acsmedchemlett.7b00223
None Unchecked Ratio IC50 11.5 None 10.1021/acs.jmedchem.5b01342
None Unchecked Ratio IC50 12.0 None 10.1016/j.bmcl.2011.06.015
None Unchecked Ratio IC50 12.0 None 10.1021/jm401899x
None Unchecked Ratio IC50 13.8 None 10.1021/jm101605z
None Unchecked Ratio IC50 15.0 None 10.1016/j.ejmech.2019.111755
None Unchecked Ratio IC50 16.0 None 10.1016/j.bmcl.2009.10.028
None Unchecked Ratio IC50 16.0 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 16.0 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 16.3 None 10.1021/jm2001025
None Unchecked Ratio IC50 17.0 None 10.1016/j.ejmech.2018.09.018
None Unchecked Ratio IC50 22.7 None 10.1016/j.bmcl.2021.128286
None Unchecked Ratio IC50 27.0 None 10.1016/j.bmcl.2017.06.033
None Unchecked Ratio IC50 27.0 None 10.1016/j.ejmech.2017.10.076
None Unchecked Ratio IC50 27.0 None 10.1016/j.ejmech.2018.09.018
None Unchecked Ratio IC50 29.0 None 10.1021/jm801128g
None Unchecked Ratio IC50 33.0 None 10.1016/j.ejmech.2018.09.018
None Unchecked Ratio IC50 36.0 None 10.1021/acs.jmedchem.5b01493
None Unchecked Ratio IC50 38.0 None 10.1016/j.bmc.2021.116085
None Unchecked Ratio IC50 42.0 None 10.1016/j.bmc.2021.116085
None Unchecked Ratio IC50 42.0 None 10.1021/acsmedchemlett.8b00487
None Unchecked Ratio IC50 43.0 None 10.1021/jm401899x
None Unchecked Ratio IC50 45.0 None 10.1016/j.bmcl.2009.10.028
None Unchecked Ratio IC50 46.0 None 10.1021/acs.jmedchem.1c01863
None Unchecked Ratio IC50 67.06 None 10.1016/j.bmcl.2022.128821
None Unchecked Ratio IC50 68.0 None 10.1016/j.bmc.2021.116085
None Unchecked Ratio IC50 71.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 75.0 None 10.1016/j.bmc.2021.116085
None Unchecked Ratio IC50 90.0 None 10.1016/j.bmcl.2021.128286
None Unchecked Ratio IC50 128.0 None 10.1016/j.bmc.2022.117028
None Unchecked Ratio IC50 129.6 None 10.1016/j.ejmech.2018.12.056
None Unchecked Ratio IC50 154.0 None 10.1021/acs.jmedchem.0c02210
None Unchecked Ratio IC50 230.0 None 10.1128/aac.00757-07
None Unchecked Ratio IC50 311.76 None 10.1016/j.bmcl.2022.128821
None Unchecked Ratio IC50 326.0 None 10.1016/j.ejmech.2018.09.018
None Unchecked Ratio IC50 326.4 None 10.1016/j.ejmech.2018.12.056
None Unchecked Ratio IC50 357.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 375.0 None 10.1128/aac.00757-07
None Unchecked Ratio IC50 1245.0 None 10.1016/j.ejmech.2022.114582
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2012.06.017
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2016.12.041
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2017.08.041
None Unchecked Selectivity index 6.3 None 10.1016/j.bmcl.2005.07.081
None Unchecked Selectivity Index 1.46 None 10.1021/acs.jmedchem.5b01493
None Unchecked Selectivity Index 1.53 None 10.1021/acs.jmedchem.5b01493
None Unchecked Selectivity Index 1.86 None 10.1016/j.bmc.2023.117154
None Unchecked Selectivity Index 2.54 None 10.1021/acs.jmedchem.5b01493
None Unchecked Selectivity Index 3.2 None 10.1021/acs.jmedchem.5b01493
None Unchecked Selectivity Index 4.0 None 10.1016/j.ejmech.2019.111755
None Unchecked Selectivity Index 4.84 None 10.1021/acs.jmedchem.5b01493
None Unchecked Selectivity Index 5.0 None 10.1016/j.ejmech.2019.111755
None Unchecked Selectivity Index 5.25 None 10.1021/acs.jmedchem.5b01493
None Unchecked SI 6.0 None 10.1021/jm049002a
None Unchecked TGI 49.28 % 10.1016/j.ejmech.2021.114058

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT022353 O=C(CCCCCCC(=O)Nc1ccccc1)NO.O=C(O)[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>O=C(CCCCCCC(=O)Nc1ccccc1)NO[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O enzymemap_34691