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name Structure Reference Source Properties Activities Metabolism

4-Hydroxybenzoic acid; Hydrazide

AlkaPlorer ID: AK027134

Synonym: None

IUPAC Name: 4-hydroxybenzohydrazide

Structure

SMILES: NNC(=O)C1=CC=C(O)C=C1

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InChI: InChI=1S/C7H8N2O2/c8-9-7(11)5-1-3-6(10)4-2-5/h1-4,10H,8H2,(H,9,11)

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InChIKey: ZMZGIVVRBMFZSG-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 152.153

TPSA？: 75.35

MolLogP？: -0.0043000000000002

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agaricus bisporus Tyrosinase Ki 177200.0 nM 10.1016/j.bmc.2010.04.021
Capra hircus Cathepsin B Activity 35.33 % 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin B Ki 1900.0 nM 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin H Activity 91.62 % 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin H Ki 8200.0 nM 10.1016/j.ejmech.2014.03.007
Escherichia coli K-12 Endonuclease 4 Potency 3162.3 nM None
Homo sapiens Bloom syndrome protein Potency 1.0 nM None
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 3A4 Potency 5011.9 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 1258.9 nM None
Homo sapiens Dopamine D1 receptor Potency 1032.2 nM None
Homo sapiens FAD-linked sulfhydryl oxidase ALR AC50 4281.0 nM None
Homo sapiens Histone acetyltransferase GCN5 Potency 39810.7 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 33.6 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 354.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 70794.6 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 25118.9 nM None
Homo sapiens Lysine-specific demethylase 5A IC50 13000.0 nM 10.1016/j.bmcl.2016.03.048
Homo sapiens Myeloperoxidase IC50 2000.0 nM 10.1016/j.bmcl.2018.11.031
Homo sapiens Myeloperoxidase Inhibition nan % 10.1039/C7MD00268H
Homo sapiens Peripheral myelin protein 22 Potency 379.3 nM None
Mycobacterium tuberculosis Mycobacterium tuberculosis log(1/MIC) -1.079 None 10.1016/j.ejmech.2013.10.029
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 12.0 ug.mL-1 10.1016/j.ejmech.2013.10.029
Mycobacterium tuberculosis Mycobacterium tuberculosis pMIC 1.92 None 10.1021/jm049913k
Photinus pyralis Luciferin 4-monooxygenase Potency 12589.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 31622.8 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 14.83 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.09 % 10.6019/CHEMBL4495565
Trypanosoma brucei 6-phospho-1-fructokinase Potency 47754.8 nM None
None No relevant target LogP -1.512 None 10.1016/j.ejmech.2013.10.029
None Unchecked Activity 27.2 % 10.1016/j.ejmech.2014.03.007
None Unchecked Activity 94.14 % 10.1016/j.ejmech.2014.03.007
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Potency 100.0 nM None
None Unchecked Potency 290.9 nM None
None Unchecked Potency 1458.1 nM None
None Unchecked Potency 6510.4 nM None

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT004685 CC(=O)[CoA].NNC(=O)c1ccc(O)cc1>>CC(=O)NNC(=O)c1ccc(O)cc1 enzymemap_31208