Navigation

name Structure Reference Source Properties Activities Metabolism

8-Anilino-1-naphthalenesulfonic acid

AlkaPlorer ID: AK028766

Synonym: None

IUPAC Name: 8-anilinonaphthalene-1-sulfonic acid

Structure

SMILES: O=S(=O)(O)C1=CC=CC2=C1C(NC1=CC=CC=C1)=CC=C2

copy

InChI: InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)

copy

InChIKey: FWEOQOXTVHGIFQ-UHFFFAOYSA-N

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 299.351

TPSA？: 66.4

MolLogP？: 3.8301000000000016

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) Dengue virus type 2 NS3 protein IC50 100000.0 nM None
Escherichia coli K-12 Beta-lactamase AmpC IC50 1600000.0 nM 10.1021/jm010533y
Homo sapiens Ataxin-2 Potency 22387.2 nM None
Homo sapiens CDK2/Cyclin A2 IC50 91000.0 nM 10.1016/j.ejmech.2019.01.003
Homo sapiens CDK2/Cyclin A2 IC50 91000.0 nM 10.1021/acs.jmedchem.1c02190
Homo sapiens Choline acetylase Ki 200000.0 nM 10.1021/jm00144a035
Homo sapiens Cyclin-dependent kinase 2 IC50 91000.0 nM 10.1039/C4MD00364K
Homo sapiens Cyclin-dependent kinase 2 Kd 37000.0 nM 10.1016/j.bmc.2011.09.049
Homo sapiens Cyclin-dependent kinase 2 Kd 37000.0 nM 10.1016/j.ejmech.2019.01.003
Homo sapiens Cyclin-dependent kinase 2 Kd 37000.0 nM 10.1021/acs.jmedchem.1c02190
Homo sapiens DNA polymerase eta Potency 19952.6 nM None
Homo sapiens DNA polymerase iota Potency 3162.3 nM None
Homo sapiens DNA polymerase iota Potency 28183.8 nM None
Homo sapiens DNA polymerase kappa Potency 35481.3 nM None
Homo sapiens DNA polymerase kappa Potency 56234.1 nM None
Homo sapiens Fatty acid binding protein adipocyte Kd 150.0 nM 10.1016/j.bmcl.2006.12.044
Homo sapiens Fatty acid binding protein adipocyte Ki 1000.0 nM 10.1016/j.bmcl.2006.12.044
Homo sapiens Fibroblast growth factor 22 AbsAC1 9.29 uM None
Homo sapiens Flap endonuclease 1 Potency 35481.3 nM None
Homo sapiens Flap endonuclease 1 Potency 89125.1 nM None
Homo sapiens Geminin Potency 16360.1 nM None
Homo sapiens Geminin Potency 20596.2 nM None
Homo sapiens GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 Potency 35481.3 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 35481.3 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 50118.7 nM None
Homo sapiens MAP kinase p38 alpha IC50 1200.0 nM 10.1021/acs.jmedchem.8b01749
Homo sapiens MAP kinase p38 beta IC50 40000.0 nM 10.1021/acs.jmedchem.8b01749
Homo sapiens MAP kinase p38 delta IC50 40000.0 nM 10.1021/acs.jmedchem.8b01749
Homo sapiens MAP kinase p38 gamma IC50 40000.0 nM 10.1021/acs.jmedchem.8b01749
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 17782.8 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Potency 15003.0 nM None
Homo sapiens Sphingomyelin phosphodiesterase Potency 25118.9 nM None
Homo sapiens Transthyretin Activity 44.0 % 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Activity nan None 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 1100.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 1400.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 1800.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 4300.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 4800.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 5200.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Transthyretin Kd 10000.0 nM 10.1016/j.bmc.2009.11.025
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20596.2 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 39810.7 nM None
Homo sapiens Vitamin D receptor Potency 35481.3 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 56234.1 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 70794.6 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -34.08 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.14 % 10.6019/CHEMBL4495565
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.9b00258
None Unchecked Activity nan None 10.1016/j.bmc.2009.11.025
None Unchecked DLS Concentration 1000.0 uM 10.1021/jm010533y
None Unchecked IC50 19470.0 nM None
None Unchecked IC50 1600000.0 nM 10.1021/jm020427b
None Unchecked Kd 3200.0 nM 10.1016/j.bmc.2009.11.025
None Unchecked Kd 4500.0 nM 10.1016/j.bmc.2009.11.025
None Unchecked Kd 6700.0 nM 10.1016/j.bmc.2009.11.025
None Unchecked Potency 2511.9 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 12995.3 nM None

Metabolism Information