Molecule

Himeic Acid A

AlkaPlorer ID: AK029986

Synonym: None

IUPAC Name: (E)-11-[5-[[(3S)-3-carboxybutanoyl]carbamoyl]-4-oxopyran-2-yl]undec-10-enoic acid

Structure

SMILES: C[C@@H](CC(O)=NC(=O)C1=COC(/C=C/CCCCCCCCC(=O)O)=CC1=O)C(=O)O

InChI: InChI=1S/C22H29NO8/c1-15(22(29)30)12-19(25)23-21(28)17-14-31-16(13-18(17)24)10-8-6-4-2-3-5-7-9-11-20(26)27/h8,10,13-15H,2-7,9,11-12H2,1H3,(H,26,27)(H,29,30)(H,23,25,28)/b10-8+/t15-/m0/s1

InChIKey: OKGLROPOZIVCCZ-HQPKTYMTSA-N

Reference

Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin‐Activating Enzyme (E1) Inhibitor in <i>Aspergillus japonicus</i> MF275

PubChem CID: 11774903

LOTUS: LTS0216636

SuperNatural Ⅲ: SN0267769-02

NPASS: NPC265662

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NPAtlas: NPA010543

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Selliguea feei	Selliguea	Polypodiaceae	Polypodiales	Polypodiopsida	Streptophyta	Viridiplantae	Eukaryota
Shuteria involucrata	Shuteria	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Perilla frutescens	Perilla	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Mytilus edulis	Mytilus	Mytilidae	Mytilida	Bivalvia	Mollusca	Metazoa	Eukaryota
Agave aurea	Agave	Asparagaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Trillium camschatcense	Trillium	Melanthiaceae	Liliales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Achillea macrophylla	Achillea	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Encephalartos altensteinii	Encephalartos	Zamiaceae	Cycadales	Cycadopsida	Streptophyta	Viridiplantae	Eukaryota
Ajuga spectabilis	Ajuga	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Callistemon viminalis	Callistemon	Myrtaceae	Myrtales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Prangos pabularia	Prangos	Apiaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Gardenia collinsae	Gardenia	Rubiaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Pentzia incana	Pentzia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ligularia muliensis	Ligularia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Emilia sonchifolia	Emilia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Crinum erubescens	Crinum	Amaryllidaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Gymnosporia senegalensis	Gymnosporia	Celastraceae	Celastrales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Myrmica sabuleti	Myrmica	Formicidae	Hymenoptera	Insecta	Arthropoda	Metazoa	Eukaryota
Alstroemeria revoluta	Alstroemeria	Alstroemeriaceae	Liliales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Aspergillus sp.	Aspergillus	Aspergillaceae	Eurotiales	Eurotiomycetes	Ascomycota	Fungi	Eukaryota
Euphorbia marginata	Euphorbia	Euphorbiaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Marrubium alysson	Marrubium	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Astragalus tragacantha	Astragalus	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ircinia oros	Ircinia	Irciniidae	Dictyoceratida	Demospongiae	Porifera	Metazoa	Eukaryota
Hyrtios reticulatus	Hyrtios	Thorectidae	Dictyoceratida	Demospongiae	Porifera	Metazoa	Eukaryota
Baphia nitida	Baphia	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Nuphar lutea	Nuphar	Nymphaeaceae	Nymphaeales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Xenorhabdus bovienii	Xenorhabdus	Morganellaceae	Enterobacterales	Gammaproteobacteria	Pseudomonadota	None	Bacteria
Trifolium subterraneum	Trifolium	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Guanomyces polythrix	Guanomyces	None	Sordariales	Sordariomycetes	Ascomycota	Fungi	Eukaryota
Penicillium olsonii	Penicillium	Aspergillaceae	Eurotiales	Eurotiomycetes	Ascomycota	Fungi	Eukaryota
Teucrium oxylepis	Teucrium	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 435.4730000000002

TPSA？: 154.47

MolLogP？: 4.065900000000002

Number of H-Donors: 3

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	Ubiquitin-like modifier-activating enzyme 1	Inhibition	nan	%	10.1016/j.bmc.2012.05.044
None	Unchecked	IC50	50000.0	nM	10.1021/jm301420b