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2-Amino-8-(hydroxymethyl)-3H-phenoxazin-3-one; N-(Hydroxyacetyl) 

AlkaPlorer ID: AK030174

Synonym: Chandrananimycin D

IUPAC Name: 2-hydroxy-N-[8-(hydroxymethyl)-3-oxophenoxazin-2-yl]acetamide

Structure

SMILES: O=C1C=C2OC3=CC=C(CO)C=C3N=C2C=C1N=C(O)CO

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InChI: InChI=1S/C15H12N2O5/c18-6-8-1-2-13-10(3-8)16-11-4-9(17-15(21)7-19)12(20)5-14(11)22-13/h1-5,18-19H,6-7H2,(H,17,21)

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InChIKey: OQMHQWLKGNKBET-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Croton californicus Croton Euphorbiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Malva crispa Malva Malvaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Albugo candida Albugo Albuginaceae Albuginales None Oomycota None Eukaryota
Dendrobium rotundatum Dendrobium Orchidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Graphis elongata Graphis Graphidaceae Ostropales Lecanoromycetes Ascomycota Fungi Eukaryota
Distolasterias nipon Distolasterias Asteriidae Forcipulatida Asteroidea Echinodermata Metazoa Eukaryota
Rhinella paracnemis Rhinella Bufonidae Anura Amphibia Chordata Metazoa Eukaryota
Toxicodendron succedaneum Toxicodendron Anacardiaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces griseus Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Picrorhiza kurrooa Picrorhiza Plantaginaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ratibida latipalearis Ratibida Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phellinus xeranticus Phellinus Hymenochaetaceae Hymenochaetales Agaricomycetes Basidiomycota Fungi Eukaryota
Weddellina squamulosa Weddellina Podostemaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptomyces venezuelae Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria
Homarus americanus Homarus Nephropidae Decapoda Malacostraca Arthropoda Metazoa Eukaryota
Culcitium canescens Culcitium Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 300.27000000000004

TPSA？: 116.15

MolLogP？: 1.3653999999999995

Number of H-Donors: 3

Number of H-Acceptors: 6

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis Activity nan None 10.1021/np100344u
Candida albicans Candida albicans Activity nan None 10.1021/np100344u
Enterococcus faecalis Enterococcus faecalis Activity nan None 10.1021/np100344u
Escherichia coli Escherichia coli Activity nan None 10.1021/np100344u
Homo sapiens A2780 IC50 30.0 ug.mL-1 10.1016/j.bmcl.2012.10.096
Homo sapiens A549 IC50 30.0 ug.mL-1 10.1016/j.bmcl.2012.10.096
Homo sapiens BGC-823 IC50 30.0 ug.mL-1 10.1016/j.bmcl.2012.10.096
Homo sapiens HCT-8 IC50 30.0 ug.mL-1 10.1016/j.bmcl.2012.10.096
Homo sapiens HEK293 GI50 10300.0 nM 10.1021/np100344u
Homo sapiens HeLa CC50 90600.0 nM 10.1021/np100344u
Homo sapiens HepG2 GI50 6600.0 nM 10.1021/np100344u
Homo sapiens HUVEC GI50 5300.0 nM 10.1021/np100344u
Homo sapiens K562 GI50 16600.0 nM 10.1021/np100344u
Homo sapiens MCF7 GI50 1300.0 nM 10.1021/np100344u
Homo sapiens Raji GI50 9600.0 nM 10.1021/np100344u
Homo sapiens THP-1 GI50 27600.0 nM 10.1021/np100344u
Mycolicibacterium vaccae Mycolicibacterium vaccae Activity nan None 10.1021/np100344u
Penicillium chrysogenum Penicillium chrysogenum Activity nan None 10.1021/np100344u
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/np100344u
Sporobolomyces salmonicolor Sporobolomyces salmonicolor Activity nan None 10.1021/np100344u
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/np100344u
None NON-PROTEIN TARGET IC50 30.0 ug.mL-1 10.1016/j.bmcl.2012.10.096

Metabolism Information