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Norarmepavine

AlkaPlorer ID: AK030682

Synonym: None

IUPAC Name: 4-[[(1S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]phenol

Structure

SMILES: COC1=CC2=C(C=C1OC)[C@H](CC1=CC=C(O)C=C1)NCC2

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InChI: InChI=1S/C18H21NO3/c1-21-17-10-13-7-8-19-16(15(13)11-18(17)22-2)9-12-3-5-14(20)6-4-12/h3-6,10-11,16,19-20H,7-9H2,1-2H3/t16-/m0/s1

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InChIKey: NKBBUUNAVOMVER-INIZCTEOSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Bos taurus Bos Bovidae Artiodactyla Mammalia Chordata Metazoa Eukaryota
Myristica argentea Myristica Myristicaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Bubalus bubalis Bubalus Bovidae Artiodactyla Mammalia Chordata Metazoa Eukaryota
Carassius auratus Carassius Cyprinidae Cypriniformes Actinopteri Chordata Metazoa Eukaryota
Cheilanthes mysurensis Cheilanthes Pteridaceae Polypodiales Polypodiopsida Streptophyta Viridiplantae Eukaryota
Mimosa pudica Mimosa Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Albizia julibrissin Albizia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Erinaceus europaeus Erinaceus Erinaceidae Eulipotyphla Mammalia Chordata Metazoa Eukaryota
Passiflora quadrangularis Passiflora Passifloraceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pisum sativum Pisum Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Doris montereyensis Doris Dorididae Nudibranchia Gastropoda Mollusca Metazoa Eukaryota
Artemisia arbuscula Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Citrus reshni Citrus Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Egregia menziesii Egregia Lessoniaceae Laminariales Phaeophyceae None None Eukaryota
Hemiechinus auritus Hemiechinus Erinaceidae Eulipotyphla Mammalia Chordata Metazoa Eukaryota
Portulaca oleracea Portulaca Portulacaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phaseolus coccineus Phaseolus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cylas formicarius Cylas Brentidae Coleoptera Insecta Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 299.37000000000006

TPSA？: 50.72

MolLogP？: 2.8389000000000006

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Escherichia coli K-12 Beta-lactamase AmpC Potency 631.0 nM None
Homo sapiens Ataxin-2 Potency 44668.4 nM None
Homo sapiens Chromobox protein homolog 1 Potency 112201.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 8912.5 nM None
Homo sapiens Geminin Potency 4.6 nM None
Homo sapiens Geminin Potency 16360.1 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 28183.8 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 3548.1 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 100000.0 nM None
Homo sapiens Importin subunit beta-1/Snurportin-1 Potency 125892.5 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 22387.2 nM None
Homo sapiens Parathyroid hormone receptor Potency 44668.4 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 50118.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 14581.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 16360.1 nM None
Homo sapiens Vitamin D receptor Potency 70794.6 nM None
Rattus norvegicus Aorta Activity 71.2 % 10.1021/np960354x
Rattus norvegicus Aorta Activity 105.7 % 10.1021/np960354x
Rattus norvegicus Aorta Activity 121.9 % 10.1021/np960354x
Rattus norvegicus Dopamine transporter IC50 37000.0 nM 10.1021/np50124a001
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 25118.9 nM None
None Platelet Activity 57.8 % 10.1021/np960354x
None Platelet Activity 69.7 % 10.1021/np960354x
None Platelet Activity 75.5 % 10.1021/np960354x
None Platelet Activity 83.4 % 10.1021/np960354x
None Unchecked EC50 23380.0 nM None
None Unchecked IC50 87029.0 nM None
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Ratio IC50 0.3 None 10.1021/np50124a001
None Unchecked Ratio IC50 0.6 None 10.1021/np50124a001

Metabolism Information