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name Structure Reference Source Properties Activities Metabolism

pyridin-2-ol

AlkaPlorer ID: AK031134

Synonym: '', '2-Pyridinol', '2-Pyridone', '2-pyridinol', '2-hydroxypyridine', '2-pyridone', '2-Hydroxypyridine'

IUPAC Name: 1H-pyridin-2-one

Structure

SMILES: OC1=CC=CC=N1

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InChI: InChI=1S/C5H5NO/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)

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InChIKey: UBQKCCHYAOITMY-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Lotus corniculatus Lotus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 95.101

TPSA？: 33.120000000000005

MolLogP？: 0.7871999999999999

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens MIA PaCa-2 IC50 68137.0 nM 10.1021/jm070396q
Homo sapiens MIA PaCa-2 IC50 68804.0 nM 10.1021/jm070396q
Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Activity nan None 10.1021/acs.jmedchem.0c00120
Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Kd 1300000.0 nM 10.1021/acs.jmedchem.0c00120
Mus musculus Matrix metalloproteinase 9 Inhibition 5.0 % 10.1016/s0960-894x(02)00365-7
Rattus norvegicus Neuronal acetylcholine receptor Inhibition 259.0 % 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 880000.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd 160000000.0 nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Kd nan nM 10.1021/jm00147a021
Rattus norvegicus Neuronal acetylcholine receptor Mean enhancement of binding 10.0 None 10.1021/jm00147a021
None Erythroleukemia cell line Benzidine positive cells 95.0 % 10.1021/jm00141a016
None Erythroleukemia cell line Cell growth 77.0 % 10.1021/jm00141a016
None Erythroleukemia cell line Cell growth 114.0 % 10.1021/jm00141a016
None Erythroleukemia cell line Concentration 16.0 mM 10.1021/jm00141a016
None Unchecked Activity 8.6 mM 10.1021/jm00207a007
None Unchecked Activity 11.0 % 10.1021/jm00207a007
None Unchecked Activity 26.0 % 10.1021/jm00207a007
None Unchecked Activity 95.0 % 10.1021/jm00207a007
None Unchecked Activity nan None 10.1021/jm00207a007

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT024383 O=c1cccc[nH]1>>O=c1ccc(O)c[nH]1 enzymemap_15599
AKRT024891 Oc1ccccn1>>Oc1ccc(O)nc1 MNXR189407