Phenazinolin B
AlkaPlorer ID: AK032122
Synonym: 'Phenazinoline B', 'Phenazinolin B'
IUPAC Name: (2S,14S,28S)-28-hydroxy-1,4,11,20-tetrazaheptacyclo[13.11.1.12,14.03,12.05,10.019,27.021,26]octacosa-3,5,7,9,11,15(27),17,19,21,23,25-undecaen-16-one
Structure
SMILES: O=C1C=CC2=NC3=CC=CC=C3N3C2=C1[C@@H]1CC2=NC4=CC=CC=C4N=C2[C@H]3[C@H]1O
InChI: InChI=1S/C24H16N4O2/c29-19-10-9-16-22-20(19)12-11-17-21(27-14-6-2-1-5-13(14)25-17)23(24(12)30)28(22)18-8-4-3-7-15(18)26-16/h1-10,12,23-24,30H,11H2/t12-,23-,24-/m0/s1
InChIKey: OQDMMLQMJGUYRL-KHFQTWQWSA-N
Reference
Phenazinolins A–E: novel diphenazines from a tin mine tailings-derived Streptomyces species
PubChem CID: 53359170
LOTUS: LTS0186650
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces diastaticus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 392.4180000000001
TPSA？: 80.9
MolLogP？: 3.048100000000001
Number of H-Donors: 1
Number of H-Acceptors: 6
RingCount: 7
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Aspergillus niger | Aspergillus niger | MIC | 12000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| Bacillus subtilis | Bacillus subtilis | MIC | 12000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| Botrytis cinerea | Botrytis cinerea | MIC | 12000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| Homo sapiens | NCI-H460 | IC50 | 14000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| Mus musculus | P388 | IC50 | 14000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 12000.0 | nM | 10.1016/j.bmc.2017.01.002 |
| None | Unchecked | IC50 | 14000.0 | nM | 10.1016/j.bmc.2017.01.002 |