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tricholomic acid

AlkaPlorer ID: AK032314

Synonym: '', 'Tricholomic acid', 'alpha-Amino-3-oxo-5-isoxazolidineacetic acid'

IUPAC Name: (2S)-2-amino-2-[(5S)-3-oxo-1,2-oxazolidin-5-yl]acetic acid

Structure

SMILES: N[C@H](C(=O)O)[C@@H]1CC(=O)NO1

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InChI: InChI=1S/C5H8N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h2,4H,1,6H2,(H,7,8)(H,9,10)/t2-,4-/m0/s1

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InChIKey: NTHMUJMQOXQYBR-OKKQSCSOSA-N

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Reference

PubChem CID: 441456

CAS: 2644-49-7

SuperNatural Ⅲ: SN0254718-02

NPASS: NPC118524

Source

Species Genus Family Order Class Phylum Kingdom Domain
Crotalaria tetragona Crotalaria Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 160.129

TPSA？: 101.65000000000002

MolLogP？: -1.7815999999999994

Number of H-Donors: 3

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Excitatory amino acid transporter 1 Inhibition nan % 10.1016/j.ejmech.2014.01.029
Homo sapiens Excitatory amino acid transporter 2 Inhibition nan % 10.1016/j.ejmech.2014.01.029
Homo sapiens Excitatory amino acid transporter 3 Inhibition nan % 10.1016/j.ejmech.2014.01.029
Rattus norvegicus Glutamate NMDA receptor Ki 39810.72 nM 10.1016/j.ejmech.2014.01.029
Rattus norvegicus Glutamate NMDA receptor Ki 39810.72 nM 10.1021/jm701394a
Rattus norvegicus Glutamate NMDA receptor Ki 41000.0 nM 10.1016/j.ejmech.2014.01.029
Rattus norvegicus Glutamate NMDA receptor Ki 41000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 1 Activity 90.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 1 EC50 114815.36 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 1 EC50 120000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 2 Activity 74.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 2 EC50 480000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 2 EC50 2238721138568.34 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 3 Activity 88.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 3 EC50 154881.66 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 3 EC50 170000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 4 Activity 91.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 4 EC50 29512.09 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic, AMPA 4 EC50 30000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 1 Activity 91.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 1 EC50 251188.64 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 1 EC50 280000.0 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 2 Activity 91.0 % 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 2 EC50 81283.05 nM 10.1021/jm701394a
Rattus norvegicus Glutamate receptor ionotropic kainate 2 EC50 82000.0 nM 10.1021/jm701394a
Rattus norvegicus Metabotropic glutamate receptor 1 EC50 610000.0 nM 10.1021/jm701394a
Rattus norvegicus Metabotropic glutamate receptor 1 EC50 1737800828749.38 nM 10.1021/jm701394a
Rattus norvegicus Metabotropic glutamate receptor 2 EC50 1000000.0 nM 10.1021/jm701394a
Rattus norvegicus Metabotropic glutamate receptor 4 EC50 1000000.0 nM 10.1021/jm701394a
None Unchecked IC50 281.84 nM 10.1016/j.ejmech.2014.01.029
None Unchecked IC50 281.84 nM 10.1021/jm701394a
None Unchecked IC50 290.0 nM 10.1016/j.ejmech.2014.01.029
None Unchecked IC50 290.0 nM 10.1021/jm701394a
None Unchecked IC50 950.0 nM 10.1016/j.ejmech.2014.01.029
None Unchecked IC50 950.0 nM 10.1021/jm701394a
None Unchecked IC50 954.99 nM 10.1016/j.ejmech.2014.01.029
None Unchecked IC50 954.99 nM 10.1021/jm701394a

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT020172 N[C@H](C(=O)O)[C@@H]1CC(=O)NO1>>N[C@H](C(=O)O)c1cc(O)no1 RXN-21516
AKRT020179 N[C@H](C(=O)O)[C@H](O)CC(=O)NO>>N[C@H](C(=O)O)[C@@H]1CC(=O)NO1 RXN-21517