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L-m-tyrosine

AlkaPlorer ID: AK034157

Synonym: 'L-m-tyrosine', 'L-m-Tyr', 'meta-tyrosine', 'L-mTyr', 'm-tyrosine'

IUPAC Name: (2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid

Structure

SMILES: N[C@@H](CC1=CC(O)=CC=C1)C(=O)O

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InChI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-2-1-3-7(11)4-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

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InChIKey: JZKXXXDKRQWDET-QMMMGPOBSA-N

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Reference

PubChem CID: 6950577

CAS: 26049-12-7

SuperNatural Ⅲ: SN0179501-02

NPASS: NPC30324

Properties Information

Molecule Weight: 181.191

TPSA？: 83.55

MolLogP？: 0.3466

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens L-type amino acid transporter 1 Activity 96.0 % 10.1021/acs.jmedchem.8b01007
Homo sapiens L-type amino acid transporter 1 IC50 130000.0 nM 10.1021/acs.jmedchem.8b01007
Homo sapiens L-type amino acid transporter 1 Inhibition 97.0 % 10.1021/acs.jmedchem.8b01007

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT005244 CC(C)=CCOP(=O)(O)OP(=O)(O)O.N[C@@H](Cc1cccc(O)c1)C(=O)O>>CC(C)=CCc1cc(O)cc(C[C@@H](N)C(=O)O)c1 enzymemap_40483
AKRT005245 CC(C)=CCOP(=O)(O)OP(=O)(O)O.N[C@@H](Cc1cccc(O)c1)C(=O)O>>CC(C)=CCc1ccc(C[C@@H](N)C(=O)O)cc1O enzymemap_40483
AKRT020005 N[C@@H](Cc1cccc(O)c1)C(=O)O.O=C(O)CCC(=O)C(=O)O>>N[C@@H](CCC(=O)O)C(=O)O 67168
AKRT020006 N[C@@H](Cc1cccc(O)c1)C(=O)O.O=C(O)CCC(=O)C(=O)O>>O=C(O)C(=O)Cc1cccc(O)c1 67168
AKRT020007 N[C@@H](Cc1cccc(O)c1)C(=O)O>>NCCc1cccc(O)c1 enzymemap_81633
AKRT020008 N[C@@H](Cc1cccc(O)c1)C(=O)O>>N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O enzymemap_14461
AKRT020009 N[C@@H](Cc1cccc(O)c1)C(=O)O>>O=C(O)/C=C/c1cccc(O)c1 enzymemap_85679
AKRT020010 N[C@@H](Cc1cccc(O)c1)C(=O)O>>O=C=O enzymemap_81633
AKRT020093 N[C@@H](Cc1ccccc1)C(=O)O>>N[C@@H](Cc1cccc(O)c1)C(=O)O RXN-13555
AKRT022560 O=C(O)/C=C/c1cccc(O)c1>>N[C@@H](Cc1cccc(O)c1)C(=O)O enzymemap_85620