Navigation

name Structure Reference Source Properties Activities Metabolism

Indinavir

AlkaPlorer ID: AK034805

Synonym: None

IUPAC Name: (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide

Structure

SMILES: CC(C)(C)N=C(O)[C@@H]1CN(CC2=CC=CN=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(O)=N[C@H]1C2=CC=CC=C2C[C@H]1O

copy

InChI: InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1

copy

InChIKey: CBVCZFGXHXORBI-PXQQMZJSSA-N

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain
Comatula rotalaria Comatula Comatulidae Comatulida Crinoidea Echinodermata Metazoa Eukaryota

Properties Information

Molecule Weight: 613.8030000000003

TPSA？: 125.01000000000002

MolLogP？: 4.547500000000004

Number of H-Donors: 4

Number of H-Acceptors: 7

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Canis lupus familiaris Canis familiaris AUC 188.44 ng.hr.mL-1 10.1016/s0960-894x(01)00824-1
Canis lupus familiaris Canis familiaris AUC 7672.5 ng.hr.mL-1 10.1016/j.bmcl.2003.08.049
Canis lupus familiaris Canis familiaris AUC 7672.5 ng.hr.mL-1 10.1016/s0960-894x(02)00424-9
Canis lupus familiaris Canis familiaris AUC 7672.5 ng.hr.mL-1 10.1016/s0960-894x(03)00475-x
Canis lupus familiaris Canis familiaris C8h 0.0 uM 10.1021/jm9903848
Canis lupus familiaris Canis familiaris CL 16.0 mL.min-1.kg-1 10.1016/s0960-894x(03)00475-x
Canis lupus familiaris Canis familiaris Cmax 358.0 nM 10.1016/s0960-894x(01)00824-1
Canis lupus familiaris Canis familiaris Cmax 11400.0 nM 10.1016/j.bmcl.2003.08.049
Canis lupus familiaris Canis familiaris Cmax 11400.0 nM 10.1016/s0960-894x(02)00424-9
Canis lupus familiaris Canis familiaris Cmax 11400.0 nM 10.1016/s0960-894x(03)00475-x
Canis lupus familiaris Canis familiaris Cmax 11400.0 nM 10.1021/jm00047a001
Canis lupus familiaris Canis familiaris Cmax 11400.0 nM 10.1021/jm9903848
Canis lupus familiaris Canis familiaris F 71.6 % 10.1016/s0960-894x(02)00424-9
Canis lupus familiaris Canis familiaris F 72.0 % 10.1016/s0960-894x(03)00475-x
Canis lupus familiaris Canis familiaris T1/2 0.4517 hr 10.1016/s0960-894x(01)00824-1
Canis lupus familiaris Canis familiaris T1/2 0.4667 hr 10.1016/s0960-894x(03)00475-x
Canis lupus familiaris Canis familiaris T1/2 0.6333 hr 10.1016/s0960-894x(02)00424-9
Canis lupus familiaris Canis familiaris T max 40.0 nM 10.1016/s0960-894x(01)00824-1
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 17000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 21200.0 nM 10.1002/hep.27206
Homo sapiens Bile salt export pump IC50 21200.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 21200.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 93.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity nan None 10.1097/00002030-200211220-00009
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 83000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 30000.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens Cytochrome P450 2C9 IC50 30000.0 nM 10.1016/s0960-894x(03)00475-x
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition 68.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2C9 Inhibition 89.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2C9 Inhibition 93.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 30000.0 nM 10.1016/j.bmcl.2003.08.049
Homo sapiens Cytochrome P450 2D6 IC50 30000.0 nM 10.1016/s0960-894x(02)00425-0
Homo sapiens Cytochrome P450 2D6 IC50 30000.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens Cytochrome P450 2D6 IC50 30000.0 nM 10.1016/s0960-894x(03)00475-x
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition 31.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2D6 Inhibition 82.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2D6 Inhibition 100.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 150.0 nM 10.1016/j.bmcl.2003.08.049
Homo sapiens Cytochrome P450 3A4 IC50 150.0 nM 10.1016/s0960-894x(02)00425-0
Homo sapiens Cytochrome P450 3A4 IC50 150.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens Cytochrome P450 3A4 IC50 150.0 nM 10.1016/s0960-894x(03)00475-x
Homo sapiens Cytochrome P450 3A4 IC50 400.0 nM None
Homo sapiens Cytochrome P450 3A4 Inhibition 0.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 3A4 Inhibition 5.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 3A4 Inhibition 27.0 % 10.1021/jm990281p
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 K 0.3 mM 10.1074/jbc.m610346200
Homo sapiens Cytochrome P450 3A4 Ki 480.0 nM 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Kinact 0.22 min-1 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Log 1/Km -0.1139 None 10.1016/j.bmcl.2005.06.015
Homo sapiens Cytochrome P450 3A5 mechanism based inhibition nan None 10.2174/138920005774330639
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HepG2 CC50 74700.0 nM 10.1039/C1MD00147G
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition 1.38 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 5.25 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity 14.0 % 10.1128/aac.00671-07
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens Activity nan None 10.1128/aac.00671-07
Homo sapiens Homo sapiens AUC 7650.0 ng.hr.mL-1 10.1128/aac.00420-06
Homo sapiens Homo sapiens AUC 23816.67 ng.hr.mL-1 10.1128/aac.00420-06
Homo sapiens Homo sapiens AUC 27713.07 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens CL 18.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL/F 697.0 ml/min 10.1128/aac.00420-06
Homo sapiens Homo sapiens CL/F 3558.0 ml/min 10.1128/aac.00420-06
Homo sapiens Homo sapiens CL_renal 1.53 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 7119.58 nM 10.1128/aac.00420-06
Homo sapiens Homo sapiens Cmax 11730.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Cmax 15102.64 nM 10.1128/aac.00420-06
Homo sapiens Homo sapiens Cmin 128.0 ng/ml 10.1128/aac.00420-06
Homo sapiens Homo sapiens Cmin 806.0 ng/ml 10.1128/aac.00420-06
Homo sapiens Homo sapiens Css 5.644 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fabs 63.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens Tmax 1.85 hr 10.1128/aac.00420-06
Homo sapiens Homo sapiens Tmax 1.883 hr 10.1128/aac.00420-06
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MT2 CC10 10.0 uM 10.1021/jm000013n
Homo sapiens MT2 CC50 69800.0 nM 10.1128/aac.00689-08
Homo sapiens MT2 CC50 69800.0 nM 10.1128/aac.01413-06
Homo sapiens MT2 CC50 100000.0 nM 10.1039/C1MD00147G
Homo sapiens MT4 CC50 100000.0 nM 10.1128/aac.00149-07
Homo sapiens MT4 ED50 0.04 ug ml-1 10.1021/jm970777b
Homo sapiens MT4 ED50 0.05 uM 10.1021/jm0499110
Homo sapiens MT4 IC50 40.0 nM 10.1016/s0960-894x(00)00163-3
Homo sapiens MT4 IC50 50.0 nM 10.1016/j.bmcl.2003.12.008
Homo sapiens MT4 IC50 50.0 nM 10.1016/j.bmcl.2006.01.035
Homo sapiens MT4 IC50 330.0 nM 10.1016/j.bmcl.2003.12.008
Homo sapiens MT4 IC50 330.0 nM 10.1016/j.bmcl.2006.01.035
Homo sapiens MT4 IC50 440.0 nM 10.1016/j.bmcl.2003.12.008
Homo sapiens MT4 IC50 440.0 nM 10.1016/j.bmcl.2006.01.035
Homo sapiens MT4 IC95 25.0 nM 10.1021/jm00047a001
Homo sapiens MT4 IC95 45.0 nM 10.1016/s0960-894x(03)00262-2
Homo sapiens MT4 IC95 50.0 nM 10.1016/j.bmcl.2004.06.092
Homo sapiens MT4 IC95 50.0 nM 10.1016/s0960-894x(02)00424-9
Homo sapiens MT4 IC95 50.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens MT4 IC95 50.0 nM 10.1016/s0960-894x(03)00475-x
Homo sapiens MT4 IC95 50.0 nM 10.1016/s0960-894x(03)00680-2
Homo sapiens MT4 IC95 50.5 nM 10.1016/s0960-894x(00)00276-6
Homo sapiens MT4 IC95 400.0 nM 10.1016/j.bmcl.2004.06.092
Homo sapiens MT4 IC95 400.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens MT4 IC95 890.0 nM 10.1016/s0960-894x(03)00262-2
Homo sapiens MT4 IC95 1000.0 nM 10.1016/j.bmcl.2003.08.049
Homo sapiens MT4 IC95 1000.0 nM 10.1016/j.bmcl.2004.06.092
Homo sapiens MT4 IC95 1000.0 nM 10.1016/s0960-894x(03)00262-2
Homo sapiens MT4 IC95 1000.0 nM 10.1016/s0960-894x(03)00474-8
Homo sapiens MT4 IC95 1000.0 nM 10.1016/s0960-894x(03)00475-x
Homo sapiens MT4 IC95 1000.0 nM 10.1016/s0960-894x(03)00680-2
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 1700.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 1900.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 7800.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 7800.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 500000.0 nM 10.1021/jm301302s
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1097/00002030-200209060-00005
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 5101.0 nM None
Homo sapiens Neurokinin 2 receptor Ki 1700.0 nM None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens PBMC EC50 3000.0 nM 10.1021/jm990281p
Homo sapiens PBMC EC50 16550.0 nM 10.1021/jm990281p
Homo sapiens PBMC EC50 100000.0 nM 10.1021/jm990281p
Homo sapiens PBMC TC50 100.0 uM 10.1021/jm990281p
Homo sapiens P-glycoprotein 1 Activity nan None 10.1097/00002030-200006160-00034
Homo sapiens P-glycoprotein 1 Activity nan None 10.1172/jci1269
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 IC50 44000.0 nM None
Homo sapiens P-glycoprotein 1 IC50 100000.0 nM 10.1128/aac.00671-07
Homo sapiens P-glycoprotein 1 Inhibition 25.0 % 10.1128/aac.00671-07
Homo sapiens P-glycoprotein 1 % maximum response 0.14 % None
Homo sapiens P-glycoprotein 1 Papp 8.69 nm/s None
Homo sapiens P-glycoprotein 1 Papp 176.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 9.59 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 20.3 None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum albumin KD1 495.0 uM 10.1021/jm049343o
Homo sapiens Serum albumin KD2 559.0 uM 10.1021/jm049343o
Homo sapiens Serum albumin k_off 0.011 s-1 10.1021/jm049343o
Homo sapiens Serum albumin k_off 1.23 s-1 10.1021/jm049343o
Homo sapiens Serum albumin k_on 21.2 M-1.s-1 10.1021/jm049343o
Homo sapiens Serum albumin k_on 2500.0 M-1.s-1 10.1021/jm049343o
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier family 22 member 1 IC50 208000.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 1 Inhibition 43.0 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 2 IC50 142000.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 3 IC50 500000.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier organic anion transporter family member 1A2 Activity 70.0 % None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Activity nan None 10.1124/jpet.102.043026
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 71.9 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 18.1 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 17.8 % 10.1021/jm300212s
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 1851.0 nM None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Human immunodeficiency virus HIV protease Ki 0.38 nM 10.1021/acs.jmedchem.7b00718
Human immunodeficiency virus Human immunodeficiency virus EC50 44.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus Human immunodeficiency virus IC50 50.0 nM 10.1016/j.bmcl.2005.05.129
Human immunodeficiency virus Human immunodeficiency virus IC50 330.0 nM 10.1016/j.bmcl.2005.05.129
Human immunodeficiency virus Human immunodeficiency virus IC50 440.0 nM 10.1016/j.bmcl.2005.05.129
Human immunodeficiency virus Human immunodeficiency virus IC95 50.0 nM 10.1016/j.bmcl.2005.08.072
Human immunodeficiency virus Human immunodeficiency virus IC95 50.0 nM 10.1016/S0960-894X(01)80592-8
Human immunodeficiency virus Human immunodeficiency virus IC95 400.0 nM 10.1016/j.bmcl.2005.08.072
Human immunodeficiency virus Human immunodeficiency virus IC95 1000.0 nM 10.1016/j.bmcl.2005.08.072
Human immunodeficiency virus Human immunodeficiency virus Resistance 0.5 None 10.1021/jm960586t
Human immunodeficiency virus Human immunodeficiency virus Resistance 1.8 None 10.1021/jm960586t
Human immunodeficiency virus Human immunodeficiency virus Resistance 2.5 None 10.1021/jm960586t
Human immunodeficiency virus Human immunodeficiency virus Resistance 3.6 None 10.1021/jm960586t
Human immunodeficiency virus Human immunodeficiency virus Resistance 6.5 None 10.1021/jm960586t
Human immunodeficiency virus Human immunodeficiency virus Resistance 18.0 None 10.1021/jm960586t
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 72.0 % 10.1021/acs.jnatprod.0c00267
Human immunodeficiency virus 1 Human immunodeficiency virus 1 CC10 10.0 uM 10.1021/jm000013n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.005 nM 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.05 nM 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 0.5 nM 10.1128/aac.01455-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 None 10.1021/jm0003844
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 None 10.1021/jm0003844
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.6 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.8 nM 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.2 nM 10.1021/np900654a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.8 nM 10.1128/aac.00401-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 12.4 nM 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 14.8 nM 10.1021/jm401438g
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 17.0 None 10.1021/jm0003844
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 19.0 None 10.1021/jm0003844
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 21.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 22.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 28.0 nM 10.1021/jm900303m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 34.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 37.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 38.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 40.0 None 10.1021/jm0003844
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 41.0 nM 10.1021/jm070680h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 43.0 nM 10.1128/aac.01766-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 44.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 44.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 48.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 50.0 nM 10.1021/jm901165g
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 59.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 67.0 nM 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 87.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 113.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 145.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 200.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 220.0 nM 10.1128/aac.00401-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 220.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 250.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 270.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 270.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 280.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 290.0 nM 10.1021/jm900303m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 300.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 330.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 340.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 340.0 nM 10.1128/aac.01766-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 388.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 401.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 464.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 640.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 753.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 819.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1021/jm900303m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1000.0 nM 10.1128/aac.01766-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1500.0 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5900.0 nM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5970.0 nM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6390.0 nM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6470.0 nM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7400.0 nM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 ED50 0.073 uM 10.1021/jm0011169
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 3.4 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 8.6 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 9.7 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 37.4 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 40.1 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 60.1 None 10.1128/aac.00906-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 1.2 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 1.3 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 2.4 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 3.8 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 4.1 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 5.5 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 5.7 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 6.4 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 8.6 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 9.1 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 11.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 19.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 27.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 38.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 42.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 53.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 58.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 63.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 73.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 78.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 92.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 118.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 138.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 152.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 178.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Fold change 400.0 None 10.1128/aac.00690-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 14.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 24.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 25.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 26.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 26.0 nM 10.1021/jm8004543
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 27.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1016/j.ejmech.2018.09.046
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1021/jm1012787
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1021/jm200649p
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 30.0 nM 10.1021/jm400768f
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 32.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 43.0 nM 10.1021/jm900695w
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 45.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 260.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 290.0 nM 10.1021/jm8004543
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 340.0 nM 10.1021/jm900695w
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 500.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1000.0 nM 10.1021/jm060561m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1000.0 nM 10.1021/jm8004543
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 1000.0 nM 10.1021/jm900695w
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC90 50.0 nM 10.1021/jm9602773
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 25.0 nM 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 25.0 nM 10.1021/jm0204587
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 45.0 nM 10.1016/j.bmcl.2007.07.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.0 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.0 nM 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.0 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.0 nM 10.1016/s0960-894x(02)00425-0
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.5 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 50.5 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 55.0 nM 10.1021/jm000176b
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 100.0 nM 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 400.0 nM 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 400.0 nM 10.1016/s0960-894x(02)00425-0
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 500.0 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 890.0 nM 10.1016/j.bmcl.2007.07.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 1000.0 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 1000.0 nM 10.1016/j.bmcl.2007.07.040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 1000.0 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 1000.0 nM 10.1016/s0960-894x(02)00425-0
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 1500.0 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 3000.0 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1128/aac.01228-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 pCC50 4.49 uM 10.1021/jm049454n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.4 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.0 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.0 None 10.1128/aac.01228-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.6 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.6 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.9 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 6.0 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 6.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 6.4 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 6.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.4 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.9 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 8.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 8.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 9.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 10.0 None 10.1021/jm900303m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 10.4 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 11.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 11.4 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 12.4 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 14.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 15.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 16.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 16.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 18.5 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 18.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 18.9 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 19.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 19.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 20.1 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 21.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 21.7 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 23.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 24.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 24.5 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 24.6 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 26.0 None 10.1128/aac.00401-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 26.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 29.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 30.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 30.3 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 31.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 32.8 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 33.5 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 34.0 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 36.0 None 10.1021/jm900303m
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 36.1 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 36.5 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 42.5 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 48.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 51.0 None 10.1039/C1MD00147G
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 52.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 61.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 71.0 None 10.1128/aac.00689-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 76.0 None 10.1128/aac.01132-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 93.2 None 10.1128/aac.00149-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 97.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 106.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 194.0 None 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 5.0 None 10.1021/jm900695w
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 23.0 None 10.1021/jm900695w
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 nan None 10.1016/j.ejmech.2010.05.070
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.36 nM 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.36 nM 10.1021/jm0204587
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.36 nM 10.1021/jm970195u
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.41 nM 10.1016/S0960-894X(01)80592-8
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.56 nM 10.1021/jm00047a001
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.59 nM 10.1016/j.bmcl.2005.08.072
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.59 nM 10.1016/s0960-894x(00)00276-6
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.59 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.59 nM 10.1016/s0960-894x(02)00424-9
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.59 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/j.bmcl.2004.06.092
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/s0960-894x(03)00262-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/s0960-894x(03)00474-8
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/s0960-894x(03)00475-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 0.6 nM 10.1016/s0960-894x(03)00680-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 1.6 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 20.1 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 20.1 nM 10.1016/s0960-894x(03)00475-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 20.1 nM 10.1016/s0960-894x(03)00680-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 35.3 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 43.6 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 43.6 nM 10.1016/s0960-894x(03)00262-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 43.6 nM 10.1016/s0960-894x(03)00475-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 43.6 nM 10.1016/s0960-894x(03)00680-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 52.0 nM 10.1021/jm000013n
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 56.0 nM 10.1021/jm000013n
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 61.0 nM 10.1016/j.bmcl.2004.06.092
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 61.2 nM 10.1016/j.bmcl.2003.08.049
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 61.2 nM 10.1016/s0960-894x(03)00262-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 61.2 nM 10.1016/s0960-894x(03)00475-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 61.2 nM 10.1016/s0960-894x(03)00680-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 89.0 nM 10.1016/s0960-894x(01)00824-1
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC50 370.0 nM 10.1016/s0960-894x(02)00220-2
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC90 28.0 nM 10.1021/jm960586t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC90 50.0 nM 10.1021/jm970288b
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC90 93.0 nM 10.1021/jm000013n
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC95 25.0 nM 10.1021/jm970195u
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease IC95 25.0 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Inhibition 86.99 % 10.1016/j.bmc.2022.116612
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Kd 1.07 nM 10.1021/jm0208370
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Kd 1.07 nM 10.1021/jm0499110
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.07 nM 10.1016/j.bmcl.2003.12.008
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.07 nM 10.1016/j.bmcl.2004.08.038
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.07 nM 10.1016/s0960-894x(00)00163-3
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.24 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.28 nM 10.1021/jm020537i
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.31 nM 10.1021/jm0208370
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.31 nM 10.1021/jm0499110
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.36 nM 10.1021/acs.jmedchem.5b01697
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.37 nM 10.1021/jm9602773
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.37 nM 10.1021/jm960586t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.37 nM 10.1021/jm970288b
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.52 nM 10.1021/jm990412m
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.6 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.8 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 0.88 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 1.34 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 2.51 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 7.0 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 10.4 nM 10.1021/jm050943c
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 13.0 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 15.0 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 21.0 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 33.0 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 40.0 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 47.0 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 50.0 nM 10.1021/jm9903848
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ki 56.0 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease k_off 0.00158 s-1 10.1021/jm0208370
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease k_off 0.00158 s-1 10.1021/jm0499110
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease k_on 1530000.0 M-1.s-1 10.1021/jm0208370
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease k_on 1530000.0 M-1.s-1 10.1021/jm0499110
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Ratio CIC95/IC50 69.0 None 10.1016/j.bmcl.2005.11.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.ejmech.2010.05.070
Human immunodeficiency virus 1 Protease IC50 0.4 nM 10.1016/j.bmcl.2008.09.044
Human immunodeficiency virus 1 Protease IC50 0.6 nM 10.1016/j.bmcl.2007.07.040
Human immunodeficiency virus 1 Protease IC50 0.88 nM 10.1016/j.bmcl.2015.03.047
Human immunodeficiency virus 1 Protease IC50 10.0 nM 10.1016/j.bmcl.2014.04.008
Human immunodeficiency virus 1 Protease IC50 10.0 nM 10.1016/j.ejmech.2010.05.070
Human immunodeficiency virus 1 Protease Inhibition 90.0 % 10.1016/j.bmc.2009.02.051
Human immunodeficiency virus 1 Protease Inhibition 96.9 % 10.1016/j.bmcl.2014.04.008
Human immunodeficiency virus 1 Protease Inhibition nan % 10.1016/j.bmc.2013.06.018
Human immunodeficiency virus 1 Protease Inhibition nan % 10.1016/j.ejmech.2019.111699
Human immunodeficiency virus 1 Protease Kd 1.2 nM 10.1016/j.bmc.2012.05.070
Human immunodeficiency virus 1 Protease Kd 1.38 nM 10.1016/j.bmc.2012.05.070
Human immunodeficiency virus 1 Protease Kd 5.45 nM 10.1016/j.bmc.2012.05.070
Human immunodeficiency virus 1 Protease Ki 0.12 nM 10.1021/jm8002334
Human immunodeficiency virus 1 Protease Ki 0.3 nM 10.1021/jm901165g
Human immunodeficiency virus 1 Protease Ki 0.52 nM 10.1021/jm070680h
Human immunodeficiency virus 1 Protease Ki 0.54 nM 10.1021/jm500402c
Human immunodeficiency virus 1 Protease Ki 0.571 nM 10.1039/C1MD00147G
Human immunodeficiency virus 1 Protease Ki 0.739 nM 10.1016/j.bmc.2007.10.062
Human immunodeficiency virus 1 Protease Ki 1.9 nM 10.1021/acs.jmedchem.5b00258
Human immunodeficiency virus 1 Protease Ki 1.945 nM 10.1128/aac.00149-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 22.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 24.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 24.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 33.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 34.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 52.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 54.0 nM 10.1128/aac.01413-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 65.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 108.0 nM 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 4.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 6.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 10.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 13.0 nM 10.1021/jm060561m
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 16.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 20.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 30.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 64.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 72.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 100.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 143.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 200.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 236.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 388.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 400.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 544.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 825.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 1112.0 nM 10.1128/aac.00870-06
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 3800.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 6400.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 10000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 11000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 12000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 18000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 10.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 20.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 100.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 200.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 300.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 400.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 500.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 600.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 2600.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 3100.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 30000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 51000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 82000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 90000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 95000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 99000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC90 2794000.0 nM 10.1128/aac.01284-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 Ratio EC50 0.5 None 10.1128/aac.00146-07
Human immunodeficiency virus 2 Human immunodeficiency virus 2 Ratio EC50 0.8 None 10.1128/aac.00146-07
Human rhinovirus sp. Human rhinovirus A protease Ki 3.3 nM 10.1021/jm990412m
Leishmania donovani Leishmania donovani IC50 42270.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 140890.0 nM 10.6019/CHEMBL3392926
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus P-glycoprotein 3 Activity nan None 10.1172/jci1269
Mus musculus P-glycoprotein 3 Activity nan None None
Mus musculus Plasma Ratio AUC 2.0 None 10.1124/dmd.110.034629
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum IC50 6030.0 nM 10.6019/CHEMBL3392926
Plasmodium knowlesi Plasmodium knowlesi Inhibition nan % 10.1016/j.bmcl.2015.02.014
Plasmodium yoelii yoelii Plasmodium yoelii yoelii IC50 5000.0 nM 10.1128/aac.01043-07
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver IC50 nan None 10.1002/hep.27206
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma PPB 60.0 % 10.1128/aac.00420-06
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 358.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 360.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 392.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 471.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 58.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 69.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 69.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 78.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 91.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 108.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 713.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 733.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 790.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 833.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 190.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 229.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 232.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 252.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 39.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 130.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 157.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1480.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1506.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1626.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1673.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 38.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 126300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 84.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 90.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 126.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 139.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9775.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10578.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12018.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13819.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 82.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.17 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 371700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 373700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 381000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 382000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.6 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 37.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 67.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 78.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 118.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 16.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 923.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1137.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1698.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2420.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 141.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 144.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1269330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1318330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1363670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1456330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.81 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.98 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.23 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.69 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 64300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5330000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5370000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5580000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5940000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.37 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.93 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Solute carrier family 22 member 1 IC50 61700.0 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 0.47 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 26.83 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 99.03 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1733 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2525 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 10000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.0 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.02 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.29 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 29.47 % 10.21203/rs.3.rs-23951/v1
Simian immunodeficiency virus Simian immunodeficiency virus EC50 100.0 nM 10.1007/s00044-010-9307-4
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 48190.0 nM 10.6019/CHEMBL3392926
Trypanosoma cruzi Trypanosoma cruzi IC50 93550.0 nM 10.6019/CHEMBL3392926
None ADMET CL 10.23 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 18.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 49.5 mL.min-1.kg-1 10.1016/j.bmcl.2003.08.049
None ADMET CL 50.0 mL.min-1.kg-1 10.1016/s0960-894x(03)00474-8
None ADMET CL 50.0 mL.min-1.kg-1 10.1016/s0960-894x(03)00475-x
None ADMET CL 53.7 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET Cmax 12000.0 nM 10.1021/jm990412m
None ADMET DNAUC 3.13 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 5.34 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 46.1 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 52.98 kg.min/L 10.1080/00498250400028197
None ADMET F 76.0 % 10.1016/j.ejmech.2017.07.044
None ADMET F 90.0 % 10.1021/jm990412m
None ADMET MRT 0.76 hr 10.1124/dmd.108.020479
None ADMET Papp 2.4 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 12.6 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 15.2 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 22.8 ucm/s 10.1124/dmd.110.034629
None ADMET PPB 62.94 % 10.6019/CHEMBL3301361
None ADMET PPB 78.79 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.8 None 10.1124/dmd.110.034629
None ADMET Ratio 9.7 None 10.1124/dmd.110.034629
None ADMET Ratio 45.0 None 10.1124/dmd.110.034629
None ADMET Ratio 91.0 None 10.1124/dmd.110.034629
None ADMET Ratio 546.0 None 10.1124/dmd.110.034629
None ADMET Remaining compound 85.0 % 10.1021/jm049560p
None ADMET Remaining compound 95.0 % 10.1021/jm049560p
None ADMET Remaining compound 97.0 % 10.1021/jm049560p
None ADMET T1/2 1.0 hr 10.1124/dmd.108.020479
None ADMET TC50 100.0 uM 10.1007/s00044-010-9307-4
None ADMET TI 1000.0 None 10.1007/s00044-010-9307-4
None ADMET Tmax 1.0 hr 10.1021/jm990412m
None ADMET Vdss 0.82 L.kg-1 10.1124/dmd.108.020479
None Hepatocyte TC50 8.77 10'3nM 10.1128/aac.01043-07
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 54.8 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 5.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 13.7 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 44.5 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LTKB_BD DILI severity score 8.0 None 10.1016/j.drudis.2011.05.007
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 137.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 116.4 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None NON-PROTEIN TARGET C/I 69.0 None 10.1021/jm0204587
None NON-PROTEIN TARGET Fu 0.36 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.78 None 10.1021/jm401963n
None NON-PROTEIN TARGET Hepatotoxicity (acute) 9.1 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 8.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 5.0 nM 10.1128/aac.01284-07
None NON-PROTEIN TARGET IC50 42270.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 140890.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC90 40.0 nM 10.1128/aac.01284-07
None No relevant target CLogP 3.68 None 10.1016/j.bmcl.2005.05.087
None No relevant target LogD7.4 2.9 None 10.6019/CHEMBL3301361
None No relevant target LogP 2.92 None 10.1021/jm00047a001
None No relevant target LogP 2.92 None 10.1021/jm9903848
None No relevant target S 70.0 None 10.1021/jm9903848
None No relevant target Solubility 70.0 ug.mL-1 10.1021/jm00047a001
None Unchecked Activity 100.0 % 10.1021/acsmedchemlett.0c00521
None Unchecked Hepatotoxicity (acute) 12.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 8.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 10.0 nM 10.1016/j.bmcl.2011.04.070
None Unchecked IC50 43.6 nM 10.1016/j.bmcl.2007.07.040
None Unchecked IC50 61.0 nM 10.1016/j.bmcl.2007.07.040
None Unchecked IC50 nan None 10.1021/acsmedchemlett.0c00521
None Unchecked IC50 nan None None
None Unchecked Inhibition 40.0 % 10.1128/aac.00671-07
None Unchecked Inhibition 71.8 % 10.1021/jm500402c
None Unchecked Inhibition 91.2 % 10.1021/jm500402c
None Unchecked Inhibition 95.4 % 10.1021/jm500402c
None Unchecked Inhibition 98.8 % 10.1016/j.bmcl.2011.04.070
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b00694
None Unchecked Ki 7.0 nM 10.1021/jm8002334
None Unchecked Ki 46.0 nM 10.1021/jm8002334
None Unchecked Ki 110.0 nM 10.1021/jm8002334
None Unchecked Ki 180.0 nM 10.1021/jm8002334
None Unchecked Ki 280.0 nM 10.1021/jm8002334
None Unchecked Ki 390.0 nM 10.1021/jm8002334
None Unchecked Ki 470.0 nM 10.1021/jm8002334
None Unchecked Ki 3500.0 nM 10.1021/jm500402c
None Unchecked Ki nan None None
None Unchecked Ratio 0.068 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.266 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.49 None 10.1021/jm301302s
None Unchecked Ratio 2.01 None 10.1021/jm301302s
None Unchecked Ratio 2.25 None 10.1021/jm301302s
None Unchecked Ratio 69.0 None 10.1021/jm970195u
None Unchecked Ratio CC50/EC50 1450.0 None 10.1128/aac.01413-06
None Unchecked Ratio CC50/EC50 1493.0 None 10.1128/aac.00149-07
None Unchecked Ratio EC50 0.5 None 10.1128/aac.00146-07
None Unchecked Ratio EC50 0.8 None 10.1128/aac.00146-07
None Unchecked Ratio EC50 2.6 None 10.1128/aac.00146-07
None Unchecked Ratio IC50 5.0 None 10.1021/jm301302s
None Unchecked Resistance 2.8 None 10.1021/jm960586t
None Unchecked Selectivity Index 1.754 None 10.1128/aac.01043-07
None Unchecked Selectivity Index 1600.0 None 10.1128/aac.00689-08
None Unchecked SI 107.5 None 10.1021/jm000013n

Metabolism Information