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name Structure Reference Source Properties Activities Metabolism

4-methoxy-2-phenylquinoline

AlkaPlorer ID: AK035207

Synonym: 'MLS000549196', 'SMR000113849', '4-methoxy-2-phenylquinoline'

IUPAC Name: 4-methoxy-2-phenylquinoline

Structure

SMILES: COC1=CC(C2=CC=CC=C2)=NC2=CC=CC=C12

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InChI: InChI=1S/C16H13NO/c1-18-16-11-15(12-7-3-2-4-8-12)17-14-10-6-5-9-13(14)16/h2-11H,1H3

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InChIKey: CVJHRDUVYHASOG-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Lunasia amara Lunasia Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 235.286

TPSA？: 22.12

MolLogP？: 3.910400000000002

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Escherichia coli K-12 Beta-lactamase AmpC Potency 8912.5 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens A549 EC50 10.0 ug.mL-1 10.1021/jm00061a005
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 56234.1 nM None
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 11220.2 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 39810.7 nM None
Homo sapiens HCT-8 EC50 10.0 ug.mL-1 10.1021/jm00061a005
Homo sapiens Homo sapiens Aggregation 0.0 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 9.3 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 9.4 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 18.5 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 38.6 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 53.4 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 56.8 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 62.8 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 65.8 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 85.0 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 86.0 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 87.2 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 89.2 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 90.8 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 90.9 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 92.0 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens Aggregation 92.5 % 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens IC50 1700.0 nM 10.1016/s0960-894x(00)00652-1
Homo sapiens Homo sapiens IC50 2130.0 nM 10.1016/s0960-894x(00)00652-1
Homo sapiens KB EC50 10.0 ug.mL-1 10.1021/jm00061a005
Homo sapiens Lysine-specific demethylase 4A Potency 89125.1 nM None
Homo sapiens N9 Activity 6.0 % 10.1021/jm2012563
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Survival motor neuron protein Potency 11220.2 nM None
Leishmania braziliensis Leishmania braziliensis IC90 50.0 ug.mL-1 10.1021/np50099a013
Mucor circinelloides Mucor circinelloides Activity 95.8 % 10.1016/j.bmcl.2022.128649
Mucor circinelloides Mucor circinelloides Activity 97.8 % 10.1016/j.bmcl.2022.128649
Mus musculus HT-22 Activity nan None 10.1021/jm2012563
Mus musculus HT-22 EC50 750.0 nM 10.1021/jm2012563
Mus musculus P388 EC50 4.5 ug.mL-1 10.1021/jm00061a005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1016/j.ejmech.2022.114173
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2011.12.029
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2022.114173
Rattus norvegicus PC-12 Activity nan None 10.1021/jm2012563
Trypanosoma cruzi Trypanosoma cruzi IC90 100.0 ug.mL-1 10.1021/np50099a013
None L1210 (1565) EC50 10.0 ug.mL-1 10.1021/jm00061a005
None NON-PROTEIN TARGET Activity 0.12 equiv 10.1021/jm2012563
None Unchecked Kd 1000000.0 nM 10.1016/j.bmcl.2010.11.110
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 20596.2 nM None

Metabolism Information