Mukonidine
AlkaPlorer ID: AK036102
Synonym: None
IUPAC Name: methyl 2-hydroxy-9H-carbazole-3-carboxylate
Structure
SMILES: COC(=O)C1=CC2=C(C=C1O)NC1=CC=CC=C12
InChI: InChI=1S/C14H11NO3/c1-18-14(17)10-6-9-8-4-2-3-5-11(8)15-12(9)7-13(10)16/h2-7,15-16H,1H3
InChIKey: SJVKEEPWQLIYIJ-UHFFFAOYSA-N
Reference
γ-Lactone Carbazoles from <i>Clausena anisata</i>
PubChem CID: 10999153
CAS: 24949-00-6
LOTUS: LTS0081674
COCONUT: CNP0328616
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Clausena excavata | Clausena | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 241.246
TPSA？: 62.32
MolLogP？: 2.813300000000001
Number of H-Donors: 2
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Chlorocebus sabaeus | Vero | IC50 | nan | None | 10.1016/j.bmc.2016.12.038 |
| Escherichia coli | Escherichia coli | MIC | 128.0 | ug.mL-1 | 10.1021/np3000365 |
| Homo sapiens | HepG2 | IC50 | 160000.0 | nM | 10.1016/j.ejmech.2011.10.047 |
| Homo sapiens | HL-60 | Activity | nan | None | 10.1021/np800735m |
| Homo sapiens | KB | IC50 | nan | None | 10.1021/np3000365 |
| Homo sapiens | MCF7 | IC50 | 204800.0 | nM | 10.1021/np3000365 |
| Homo sapiens | NCI-H187 | IC50 | 134200.0 | nM | 10.1021/np3000365 |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC90 | 23300.0 | nM | 10.1016/j.bmc.2016.12.038 |
| Salmonella enterica subsp. enterica serovar Typhimurium | Salmonella typhimurium | MIC | 32.0 | ug.mL-1 | 10.1021/np3000365 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 64.0 | ug.mL-1 | 10.1021/np3000365 |