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6H-quinindoline

AlkaPlorer ID: AK036294

Synonym: ''

IUPAC Name: 6H-indolo[2,3-b]quinoline

Structure

SMILES: C1=CC=C2N=C3NC4=CC=CC=C4C3=CC2=C1

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InChI: InChI=1S/C15H10N2/c1-3-7-13-10(5-1)9-12-11-6-2-4-8-14(11)17-15(12)16-13/h1-9H,(H,16,17)

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InChIKey: RDFSPMPXDYGXHP-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Justicia betonica Justicia Acanthaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 218.259

TPSA？: 28.68

MolLogP？: 3.8693000000000017

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens 786-0 GI50 19.91 nM None
Homo sapiens A498 GI50 3334.26 nM None
Homo sapiens A549 GI50 245.47 nM None
Homo sapiens ACHN GI50 113.24 nM None
Homo sapiens BT-549 GI50 511.68 nM None
Homo sapiens CAKI-1 GI50 523.6 nM None
Homo sapiens CCRF-CEM GI50 196.79 nM None
Homo sapiens COLO 205 GI50 207.01 nM None
Homo sapiens DU-145 GI50 1264.74 nM None
Homo sapiens EKVX GI50 395.37 nM None
Homo sapiens HCC 2998 GI50 756.83 nM None
Homo sapiens HCT-116 GI50 31.05 nM None
Homo sapiens HCT-15 GI50 228.56 nM None
Homo sapiens HepG2 IC50 1000.0 ug.mL-1 10.1007/s00044-012-0015-0
Homo sapiens HL-60 GI50 191.87 nM None
Homo sapiens HOP-92 GI50 7261.06 nM None
Homo sapiens Hs-578T GI50 966.05 nM None
Homo sapiens HT-29 GI50 30.34 nM None
Homo sapiens IGROV-1 GI50 286.42 nM None
Homo sapiens K562 GI50 188.8 nM None
Homo sapiens KB ID50 0.6 uM ml-1 10.1021/jm00047a008
Homo sapiens KM12 GI50 348.34 nM None
Homo sapiens LOX IMVI GI50 180.3 nM None
Homo sapiens M14 GI50 535.8 nM None
Homo sapiens Malme-3M GI50 920.45 nM None
Homo sapiens MCF7 GI50 304.09 nM None
Homo sapiens MCF7 IC50 1000.0 ug.mL-1 10.1007/s00044-012-0015-0
Homo sapiens MDA-MB-231 GI50 1238.8 nM None
Homo sapiens MDA-MB-435 GI50 539.51 nM None
Homo sapiens MDA-N GI50 641.21 nM None
Homo sapiens MOLT-4 GI50 94.19 nM None
Homo sapiens NCI/ADR-RES GI50 1282.33 nM None
Homo sapiens NCI-H226 GI50 1023.29 nM None
Homo sapiens NCI-H23 GI50 615.18 nM None
Homo sapiens NCI-H322M GI50 244.34 nM None
Homo sapiens NCI-H460 GI50 127.94 nM None
Homo sapiens NCI-H522 GI50 82.41 nM None
Homo sapiens OVCAR-4 GI50 1028.02 nM None
Homo sapiens OVCAR-5 GI50 1686.55 nM None
Homo sapiens OVCAR-8 GI50 363.08 nM None
Homo sapiens PC-3 GI50 231.74 nM None
Homo sapiens RPMI-8226 GI50 326.59 nM None
Homo sapiens RXF 393 GI50 457.09 nM None
Homo sapiens SF-268 GI50 598.41 nM None
Homo sapiens SF-295 GI50 500.03 nM None
Homo sapiens SF-539 GI50 367.28 nM None
Homo sapiens SK-MEL-2 GI50 444.63 nM None
Homo sapiens SK-MEL-28 GI50 1312.2 nM None
Homo sapiens SK-MEL-5 GI50 698.23 nM None
Homo sapiens SK-OV-3 GI50 839.46 nM None
Homo sapiens SN12C GI50 629.51 nM None
Homo sapiens SNB-19 GI50 785.24 nM None
Homo sapiens SNB-75 GI50 2103.78 nM None
Homo sapiens SR GI50 44.06 nM None
Homo sapiens SW-620 GI50 156.31 nM None
Homo sapiens TK-10 GI50 1538.15 nM None
Homo sapiens U-251 GI50 453.94 nM None
Homo sapiens UACC-257 GI50 636.8 nM None
Homo sapiens UACC-62 GI50 632.41 nM None
Homo sapiens UO-31 GI50 597.04 nM None
None No relevant target pKa 5.55 None 10.1021/jm00047a008
None Nucleic Acid Delta Tm 0.3 degrees C 10.1021/jm00047a008

Metabolism Information