alpha-Homomannojirimycin
AlkaPlorer ID: AK036545
Synonym: '', 'beta-Homomannojirimycin', '(+)-alpha-Homomannojirimycin', 'alpha-Homonojirimycin', 'beta-Homonojirimycin', '(+)-alpha-Homonojirimycin'
IUPAC Name: (2R,3R,5S,6R)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol
Structure
SMILES: OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H](O)[C@H]1O
InChI: InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7-/m1/s1
InChIKey: CLVUFWXGNIFGNC-BNWJMWRWSA-N
Reference
α-Glucosidase-inhibitory iminosugars from the leaves of Suregada glomerulata
LOTUS: LTS0204783
SuperNatural Ⅲ: SN0049287-02
NPASS: NPC223386
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Suregada glomerulata | Suregada | Euphorbiaceae | Malpighiales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| None | Aglaonema | Araceae | Alismatales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 193.199
TPSA？: 113.18
MolLogP？: -3.605899999999999
Number of H-Donors: 6
Number of H-Acceptors: 6
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bos taurus | Beta-galactosidase | IC50 | 160000.0 | nM | 10.1016/s0960-894x(99)00551-x |
| Homo sapiens | Alpha-galactosidase A | FC | 2.0 | None | 10.1021/jm301557k |
| Homo sapiens | Alpha-L-fucosidase I | Inhibition | 50.0 | % | 10.1016/s0960-894x(99)00551-x |
| Homo sapiens | Neutral alpha-glucosidase C | IC50 | 80000.0 | nM | 10.1016/s0960-894x(99)00551-x |
| Mus musculus | Neutral alpha-glucosidase C | IC50 | 50000.0 | nM | 10.1016/s0960-894x(99)00551-x |
| Rattus norvegicus | Alpha-galactosidase A | IC50 | 67000.0 | nM | 10.1016/s0960-894x(99)00551-x |
| None | Unchecked | IC50 | 24950.0 | nM | 10.1016/j.bmc.2013.07.048 |