Molecule

alpha-Homomannojirimycin

AlkaPlorer ID: AK036548

Synonym: '', 'beta-Homomannojirimycin', '(+)-alpha-Homomannojirimycin', 'alpha-Homonojirimycin', 'beta-Homonojirimycin', '(+)-alpha-Homonojirimycin'

IUPAC Name: (2R,3R,5S,6R)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol

Structure

SMILES: OC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI: InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1

InChIKey: CLVUFWXGNIFGNC-OVHBTUCOSA-N

Reference

Antihyperglycemic Effects of N-Containing Sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in Streptozotocin-Diabetic Mice

CAS: 119557-99-2

LOTUS: LTS0161003

SuperNatural Ⅲ: SN0049287-06

NPASS: NPC75435

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Castanospermum australe	Castanospermum	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Suregada glomerulata	Suregada	Euphorbiaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
None	Aglaonema	Araceae	Alismatales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Xanthocercis zambesiaca	Xanthocercis	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Morus bombycis	Morus	Moraceae	Rosales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 193.199

TPSA？: 113.18

MolLogP？: -3.605899999999999

Number of H-Donors: 6

Number of H-Acceptors: 6

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bos taurus	Beta-galactosidase	Inhibition	50.0	%	10.1016/s0960-894x(99)00551-x
Homo sapiens	Alpha-galactosidase A	Inhibition	50.0	%	10.1021/jm970836l
Homo sapiens	Alpha-L-fucosidase I	Inhibition	50.0	%	10.1016/s0960-894x(99)00551-x
Homo sapiens	Alpha-L-fucosidase I	Inhibition	50.0	%	10.1021/jm970836l
Homo sapiens	Beta-glucocerebrosidase	Inhibition	50.0	%	10.1016/j.bmc.2008.06.026
Homo sapiens	Lysosomal alpha-glucosidase	IC50	100.0	nM	10.1016/j.bmc.2008.06.026
Homo sapiens	Lysosomal alpha-glucosidase	IC50	1000.0	nM	10.1016/j.bmc.2008.06.026
Homo sapiens	Maltase-glucoamylase	IC50	40.0	nM	10.1021/jm970836l
Homo sapiens	Neutral alpha-glucosidase C	Inhibition	50.0	%	10.1016/s0960-894x(99)00551-x
Mus musculus	Lysosomal alpha-glucosidase	EC50	281000.0	nM	None
Mus musculus	Mus musculus	Activity	126.0	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	129.3	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	136.4	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	149.9	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	161.2	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	176.4	mg/dl	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	Activity	nan	None	10.1021/np970277l
Mus musculus	Mus musculus	AUC	2682000.0	ng.hr.mL-1	10.1016/j.bmc.2013.07.048
Mus musculus	Mus musculus	AUC	2994000.0	ng.hr.mL-1	10.1016/j.bmc.2013.07.048
Mus musculus	Neutral alpha-glucosidase C	IC50	340.0	nM	10.1016/s0960-894x(99)00551-x
Oryctolagus cuniculus	Glycogen debranching enzyme	IC50	110.0	nM	10.1016/j.bmc.2008.06.026
Rattus norvegicus	Acidic alpha-glucosidase	IC50	80.0	nM	10.1016/j.bmc.2008.06.026
Rattus norvegicus	Acidic alpha-glucosidase	IC50	170.0	nM	10.1021/jm970836l
Rattus norvegicus	Acidic alpha-glucosidase	IC50	260.0	nM	10.1021/jm970836l
Rattus norvegicus	Acidic alpha-glucosidase	IC50	340.0	nM	10.1021/jm970836l
Rattus norvegicus	Acidic alpha-glucosidase	IC50	700.0	nM	10.1021/jm970836l
Rattus norvegicus	Acidic alpha-glucosidase	IC50	8400.0	nM	10.1021/jm970836l
Rattus norvegicus	Alpha-galactosidase A	Inhibition	50.0	%	10.1016/s0960-894x(99)00551-x
Rattus norvegicus	Alpha-L-fucosidase I	Inhibition	50.0	%	10.1021/jm970836l
Rattus norvegicus	Sucrase-isomaltase	IC50	170.0	nM	10.1016/j.bmc.2008.06.026
Rattus norvegicus	Sucrase-isomaltase	IC50	700.0	nM	10.1016/j.bmc.2008.06.026
Rattus norvegicus	Trehalase	IC50	34000.0	nM	10.1021/jm970836l
None	Unchecked	IC50	90.0	nM	10.1016/j.bmc.2013.07.048
None	Unchecked	Inhibition	50.0	%	10.1016/j.bmc.2008.06.026
None	Unchecked	Inhibition	50.0	%	10.1021/jm970836l