alpha-Homomannojirimycin
AlkaPlorer ID: AK036553
Synonym: '', 'beta-Homomannojirimycin', '(+)-alpha-Homomannojirimycin', 'alpha-Homonojirimycin', 'beta-Homonojirimycin', '(+)-alpha-Homonojirimycin'
IUPAC Name: (2S,3S,5R,6R)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol
Structure
SMILES: OC[C@@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InChI: InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4+,5-,6+,7+
InChIKey: CLVUFWXGNIFGNC-GGTDAZAQSA-N
Reference
α-Glucosidase-inhibitory iminosugars from the leaves of Suregada glomerulata
LOTUS: LTS0087238
SuperNatural Ⅲ: SN0049287-03
NPASS: NPC198341
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Suregada glomerulata | Suregada | Euphorbiaceae | Malpighiales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 193.199
TPSA？: 113.18
MolLogP？: -3.605899999999999
Number of H-Donors: 6
Number of H-Acceptors: 6
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Alpha-galactosidase A | Inhibition | 50.0 | % | 10.1021/jm970836l |
| Homo sapiens | Alpha-L-fucosidase I | Inhibition | 50.0 | % | 10.1021/jm970836l |
| Homo sapiens | Maltase-glucoamylase | IC50 | 8400.0 | nM | 10.1021/jm970836l |
| Rattus norvegicus | Acidic alpha-glucosidase | IC50 | 7200.0 | nM | 10.1021/jm970836l |
| Rattus norvegicus | Acidic alpha-glucosidase | IC50 | 8200.0 | nM | 10.1021/jm970836l |
| Rattus norvegicus | Acidic alpha-glucosidase | IC50 | 15000.0 | nM | 10.1021/jm970836l |
| Rattus norvegicus | Alpha-L-fucosidase I | Inhibition | 50.0 | % | 10.1021/jm970836l |
| Rattus norvegicus | Trehalase | Inhibition | 50.0 | % | 10.1021/jm970836l |
| None | Unchecked | IC50 | 24340.0 | nM | 10.1016/j.bmc.2013.07.048 |
| None | Unchecked | Inhibition | 50.0 | % | 10.1021/jm970836l |