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Baraphenazine G

AlkaPlorer ID: AK037030

Synonym: 'Baraphenazine G'

IUPAC Name: (1R,17R)-9,17,21-trihydroxy-16-oxa-4,11,19,26-tetrazaheptacyclo[15.11.1.02,15.03,12.05,10.018,27.020,25]nonacosa-2(15),3,5(10),6,8,11,13,18,20(25),21,23,26-dodecaene-13-carboxylic acid

Structure

SMILES: O=C(O)C1=CC2=C(C3=NC4=CC=CC(O)=C4N=C13)[C@@H]1CC3=NC4=CC=CC(O)=C4N=C3[C@@](O)(C1)O2

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InChI: InChI=1S/C25H16N4O6/c30-15-5-2-4-13-20(15)28-19-11(24(32)33)8-17-18(22(19)27-13)10-7-14-23(25(34,9-10)35-17)29-21-12(26-14)3-1-6-16(21)31/h1-6,8,10,30-31,34H,7,9H2,(H,32,33)/t10-,25-/m1/s1

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InChIKey: IKZAYRLYTAVSAG-REFGNXHDSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
None None Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 468.4250000000003

TPSA？: 158.77999999999997

MolLogP？: 3.103100000000003

Number of H-Donors: 4

Number of H-Acceptors: 9

RingCount: 7

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Ambystoma mexicanum Ambystoma mexicanum Activity nan None 10.1021/acs.jnatprod.9b00289
Bacillus subtilis Bacillus subtilis MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Escherichia coli Escherichia coli MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Homo sapiens A549 IC50 50000.0 nM 10.1021/acs.jnatprod.9b00289
Homo sapiens PC-3 IC50 50000.0 nM 10.1021/acs.jnatprod.9b00289
Micrococcus luteus Micrococcus luteus MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Mycolicibacterium aurum Mycolicibacterium aurum MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Salmonella enterica Salmonella enterica MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Staphylococcus aureus Staphylococcus aureus MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289

Metabolism Information