Mukonine
AlkaPlorer ID: AK037048
Synonym: None
IUPAC Name: methyl 1-methoxy-9H-carbazole-3-carboxylate
Structure
SMILES: COC(=O)C1=CC(OC)=C2NC3=CC=CC=C3C2=C1
InChI: InChI=1S/C15H13NO3/c1-18-13-8-9(15(17)19-2)7-11-10-5-3-4-6-12(10)16-14(11)13/h3-8,16H,1-2H3
InChIKey: GIKICDROPGNERQ-UHFFFAOYSA-N
Reference
Carbazole alkaloids from the stems of <i>Clausena excavata</i>
PubChem CID: 5319913
CAS: 23523-94-6
LOTUS: LTS0273105
COCONUT: CNP0218940
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Clausena excavata | Clausena | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 255.273
TPSA？: 51.32
MolLogP？: 3.1163000000000007
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HCT-116 | Activity | 11.7 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | HCT-116 | Activity | 17.4 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | HCT-116 | Activity | 70.8 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | HCT-116 | IC50 | 43000.0 | nM | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | MCF7 | IC50 | 30000.0 | nM | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW48 | Activity | 9.0 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW48 | Activity | 14.1 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW48 | Activity | 76.7 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW48 | IC50 | 62000.0 | nM | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW480 | Activity | 10.3 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW480 | Activity | 33.8 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW480 | Activity | 55.8 | % | 10.1016/j.bmc.2007.05.033 |
| Homo sapiens | SW480 | IC50 | 72000.0 | nM | 10.1016/j.bmc.2007.05.033 |
| None | NON-PROTEIN TARGET | IC50 | 80000.0 | nM | 10.1016/j.bmc.2007.05.033 |