Erymelanthine
AlkaPlorer ID: AK037273
Synonym: None
IUPAC Name: methyl (2R,13bS)-2-methoxy-2,6,8,9-tetrahydro-1H-indolo[7a,1-a][2,6]naphthyridine-12-carboxylate
Structure
SMILES: COC(=O)C1=NC=C2CCN3CC=C4C=C[C@H](OC)C[C@@]43C2=C1
InChI: InChI=1S/C18H20N2O3/c1-22-14-4-3-13-6-8-20-7-5-12-11-19-16(17(21)23-2)9-15(12)18(13,20)10-14/h3-4,6,9,11,14H,5,7-8,10H2,1-2H3/t14-,18-/m0/s1
InChIKey: KCJQBANVNQOQJT-KSSFIOAISA-N
Reference
TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina
PubChem CID: 44570488
LOTUS: LTS0267824
SuperNatural Ⅲ: SN0181800-01
NPASS: NPC123395
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Erythrina velutina | Erythrina | Fabaceae | Fabales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 312.3690000000001
TPSA？: 51.66
MolLogP？: 1.8365
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Jurkat | IC50 | 50.0 | ug.mL-1 | 10.1016/j.bmcl.2008.10.111 |
| Homo sapiens | Jurkat | Inhibition | 1.1 | % | 10.1016/j.bmcl.2008.10.111 |
| Homo sapiens | Jurkat | Inhibition | 24.2 | % | 10.1016/j.bmcl.2008.10.111 |