Molecule

1-(2-methyl-3-sulfanylpropanoyl)pyrrolidine-2-carboxylic acid

AlkaPlorer ID: AK037355

Synonym: None

IUPAC Name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

Structure

SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O

InChI: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChIKey: FAKRSMQSSFJEIM-RQJHMYQMSA-N

Reference

PubChem CID: 44093

CAS: 138452-88-7

NPASS: NPC483990

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Phyllanthus niruri	Phyllanthus	Phyllanthaceae	Malpighiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Microcystis aeruginosa	Microcystis	Microcystaceae	Chroococcales	Cyanophyceae	Cyanobacteriota	None	Bacteria

Properties Information

Molecule Weight: 217.29

TPSA？: 57.61

MolLogP？: 0.6279000000000001

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Acinetobacter baumannii	Acinetobacter baumannii	Inhibition	30.0	%	10.6019/CHEMBL4513141
Agaricus bisporus	Tyrosinase	Inhibition	nan	%	10.1021/jm401053m
Bacillus anthracis	Beta-lactamase II	IC50	25800.0	nM	10.1016/j.bmcl.2012.08.012
Bacillus anthracis	Beta-lactamase II	Ki	17900.0	nM	10.1016/j.bmcl.2012.08.012
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	28183.8	nM	None
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	50118.7	nM	None
Bacillus subtilis	4'-phosphopantetheinyl transferase ffp	Potency	56234.1	nM	None
Bacteria	Bacterial beta-lactamase TEM	Ki	300000.0	nM	10.1021/acs.jmedchem.9b00735
Bos taurus	Progesterone receptor	IC50	nan	None	None
Bos taurus	Progesterone receptor	Ki	nan	None	None
Candida albicans	Candida albicans	Inhibition	2.59	%	10.6019/CHEMBL4513141
Canis lupus familiaris	Canis familiaris	Activity	nan	None	10.1021/jm00168a012
Canis lupus familiaris	Canis familiaris	ID50	0.057	mg.kg-1	10.1021/jm00379a013
Canis lupus familiaris	Canis familiaris	SBP decrease	-19.0	%	10.1021/jm00153a017
Canis lupus familiaris	Canis familiaris	SBP decrease	-15.0	%	10.1021/jm00153a017
Cavia porcellus	Cavia porcellus	IC50	0.05	ug.mL-1	10.1021/jm00186a020
Cavia porcellus	Leukotriene A-4 hydrolase	IC50	630000.0	nM	10.1016/j.bmcl.2008.07.043
Cavia porcellus	Leukotriene A-4 hydrolase	Inhibition	59.0	%	10.1016/j.bmcl.2008.07.043
Cavia porcellus	Leukotriene C4 synthase	IC50	nan	None	None
Cavia porcellus	Leukotriene C4 synthase	Ki	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	IC50	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	Ki	nan	None	None
Chlorocebus sabaeus	Vero C1008	AUC cytotoxicity	271.9	None	10.1038/s41586-020-2286-9
Chlorocebus sabaeus	Vero C1008	pCC50	5.91	None	10.1038/s41586-020-2286-9
Cryptococcus neoformans	Cryptococcus neoformans	Inhibition	1.67	%	10.6019/CHEMBL4513141
Cryptosporidium parvum	Cryptosporidium parvum	IC50	nan	None	10.1016/j.bmc.2010.01.068
Entamoeba histolytica	Entamoeba histolytica	IC50	nan	None	10.1016/j.bmc.2010.01.068
Escherichia coli	Class A carbapenemase KPC-2	MIC	4.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
Escherichia coli	Class A carbapenemase KPC-2	MIC	16.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
Escherichia coli	Escherichia coli	Activity	nan	None	10.1016/j.bmcl.2009.09.077
Escherichia coli	Escherichia coli	Inhibition	4.92	%	10.6019/CHEMBL4513141
Felis catus	Felis catus	Activity	20.91	%	10.1016/j.bmc.2009.03.008
Felis catus	Felis catus	Activity	21.89	%	10.1016/j.bmc.2009.03.008
Felis catus	Felis catus	Activity	97.6	mmHg	10.1016/j.bmc.2009.03.008
Felis catus	Felis catus	Activity	105.9	mmHg	10.1016/j.bmc.2009.03.008
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	Succinyl-diaminopimelate desuccinylase	IC50	3300.0	nM	10.1016/j.bmcl.2009.09.077
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	Succinyl-diaminopimelate desuccinylase	Ki	1820.0	nM	10.1016/j.bmcl.2009.09.077
Homo sapiens	Acetylcholinesterase	IC50	nan	None	None
Homo sapiens	Acetylcholinesterase	Ki	nan	None	None
Homo sapiens	Adenosine A1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A1 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A1 receptor	Ki	nan	None	None
Homo sapiens	Adenosine A2a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A2a receptor	IC50	nan	None	None
Homo sapiens	Adenosine A2a receptor	Ki	nan	None	None
Homo sapiens	Adenosine A3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A3 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A3 receptor	Ki	nan	None	None
Homo sapiens	Alpha-1a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1d adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-1d adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2b adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2c adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	Ki	nan	None	None
Homo sapiens	Angiotensin-converting enzyme	Duration	1.5	hr	10.1021/jm00168a013
Homo sapiens	Angiotensin-converting enzyme	EC50	18539.58	nM	10.1016/j.bmcl.2006.07.034
Homo sapiens	Angiotensin-converting enzyme	EC50	21208.01	nM	10.1016/j.bmcl.2006.07.034
Homo sapiens	Angiotensin-converting enzyme	EC50	1422656.33	nM	10.1016/j.bmcl.2006.07.034
Homo sapiens	Angiotensin-converting enzyme	ED50	0.1	mg.kg-1	10.1021/jm00168a012
Homo sapiens	Angiotensin-converting enzyme	IC50	0.12	nM	10.1016/j.bmcl.2009.06.064
Homo sapiens	Angiotensin-converting enzyme	IC50	0.63	nM	10.1021/jm701575k
Homo sapiens	Angiotensin-converting enzyme	IC50	1.61	nM	10.1021/acs.jnatprod.5b00092
Homo sapiens	Angiotensin-converting enzyme	IC50	5.0	nM	10.1021/np50056a033
Homo sapiens	Angiotensin-converting enzyme	IC50	6.3	nM	10.1016/j.bmcl.2022.128983
Homo sapiens	Angiotensin-converting enzyme	IC50	6.3	nM	10.1021/acs.jmedchem.7b00718
Homo sapiens	Angiotensin-converting enzyme	IC50	9.0	nM	10.1021/jm00140a010
Homo sapiens	Angiotensin-converting enzyme	IC50	9.0	nM	10.1021/jm00353a005
Homo sapiens	Angiotensin-converting enzyme	IC50	10.0	nM	10.1016/S0960-894X(01)80703-4
Homo sapiens	Angiotensin-converting enzyme	IC50	11.0	nM	10.1016/j.ejmech.2014.04.009
Homo sapiens	Angiotensin-converting enzyme	IC50	12.0	nM	10.1021/acs.jmedchem.6b01029
Homo sapiens	Angiotensin-converting enzyme	IC50	12.0	nM	10.1021/jm00133a021
Homo sapiens	Angiotensin-converting enzyme	IC50	12.9	nM	10.1021/jm00127a033
Homo sapiens	Angiotensin-converting enzyme	IC50	13.0	nM	10.1021/jm00160a026
Homo sapiens	Angiotensin-converting enzyme	IC50	15.0	nM	10.1021/jm00149a010
Homo sapiens	Angiotensin-converting enzyme	IC50	20.0	nM	10.1021/jm00381a021
Homo sapiens	Angiotensin-converting enzyme	IC50	20.0	nM	10.1021/jm00382a008
Homo sapiens	Angiotensin-converting enzyme	IC50	21.0	nM	10.1021/jm401053m
Homo sapiens	Angiotensin-converting enzyme	IC50	22.91	nM	10.1021/jm00068a017
Homo sapiens	Angiotensin-converting enzyme	IC50	22.91	nM	10.1039/C2MD20214J
Homo sapiens	Angiotensin-converting enzyme	IC50	23.0	nM	10.1016/j.bmcl.2008.07.043
Homo sapiens	Angiotensin-converting enzyme	IC50	23.0	nM	10.1016/S0960-894X(01)80694-6
Homo sapiens	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm058225d
Homo sapiens	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm990412m
Homo sapiens	Angiotensin-converting enzyme	IC50	25.0	nM	10.1021/acs.jnatprod.7b00829
Homo sapiens	Angiotensin-converting enzyme	IC50	25.0	nM	10.1021/jm00168a013
Homo sapiens	Angiotensin-converting enzyme	IC50	30.0	nM	10.1016/j.bmcl.2022.128983
Homo sapiens	Angiotensin-converting enzyme	IC50	30.0	nM	10.1016/S0960-894X(01)80994-X
Homo sapiens	Angiotensin-converting enzyme	IC50	79.43	nM	10.1021/jm970211n
Homo sapiens	Angiotensin-converting enzyme	IC50	208.93	nM	10.1016/j.bmcl.2022.128983
Homo sapiens	Angiotensin-converting enzyme	IC50	300.0	nM	10.1021/jm00146a014
Homo sapiens	Angiotensin-converting enzyme	IC50	300.0	nM	10.1021/jm00186a020
Homo sapiens	Angiotensin-converting enzyme	IC50	420.0	nM	10.1016/j.ejmech.2021.113877
Homo sapiens	Angiotensin-converting enzyme	IC50	1300.0	nM	10.1021/jm00147a030
Homo sapiens	Angiotensin-converting enzyme	IC50	239883.29	nM	10.1021/jm00068a017
Homo sapiens	Angiotensin-converting enzyme	Inhibition	64.0	%	10.1021/jm00168a013
Homo sapiens	Angiotensin-converting enzyme	Inhibition	95.03	%	10.1016/j.bmcl.2017.07.016
Homo sapiens	Angiotensin-converting enzyme	Inhibition	97.7	%	10.1021/np040021x
Homo sapiens	Angiotensin-converting enzyme	Ki	2.0	nM	10.1021/jm400813y
Homo sapiens	Angiotensin-converting enzyme	Time to max. inhibition	0.2	hr	10.1021/jm00168a013
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	AC50	100000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	IC50	nan	None	None
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	Ki	nan	None	None
Homo sapiens	Arachidonate 15-lipoxygenase	Potency	25118.9	nM	None
Homo sapiens	Beta-1 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-1 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-1 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Bile salt export pump	AC50	300000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bile salt export pump	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Bradykinin B2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bradykinin B2 receptor	IC50	nan	None	None
Homo sapiens	Bradykinin B2 receptor	Ki	nan	None	None
Homo sapiens	Calcitonin receptor	IC50	nan	None	None
Homo sapiens	Calcitonin receptor	Ki	nan	None	None
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	104.0	%	10.1021/jm7015683
Homo sapiens	Canalicular multispecific organic anion transporter 1	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Canalicular multispecific organic anion transporter 2	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Cannabinoid CB1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	IC50	nan	None	None
Homo sapiens	Cannabinoid CB1 receptor	Ki	nan	None	None
Homo sapiens	Carbonic anhydrase II	IC50	nan	None	None
Homo sapiens	Carbonic anhydrase II	Inhibition	nan	%	10.1021/jm401053m
Homo sapiens	Carbonic anhydrase II	Ki	nan	None	None
Homo sapiens	Caspase-1	IC50	nan	None	None
Homo sapiens	Caspase-1	Ki	nan	None	None
Homo sapiens	Cathepsin G	IC50	nan	None	None
Homo sapiens	Cathepsin G	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	Ki	nan	None	None
Homo sapiens	Cholecystokinin A receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cholecystokinin A receptor	IC50	nan	None	None
Homo sapiens	Cholecystokinin A receptor	Ki	nan	None	None
Homo sapiens	Cholecystokinin B receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Chromobox protein homolog 1	Potency	79432.8	nM	None
Homo sapiens	Cyclooxygenase-1	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-1	Inhibition	48.0	%	10.1021/jm400813y
Homo sapiens	Cyclooxygenase-1	Ki	17000.0	nM	10.1021/jm400813y
Homo sapiens	Cyclooxygenase-1	Ki	nan	None	None
Homo sapiens	Cyclooxygenase-2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cyclooxygenase-2	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-2	Inhibition	61.0	%	10.1021/jm400813y
Homo sapiens	Cyclooxygenase-2	Ki	12000.0	nM	10.1021/jm400813y
Homo sapiens	Cyclooxygenase-2	Ki	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	IC50	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 1A2	IC50	nan	None	None
Homo sapiens	Cytochrome P450 1A2	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2A6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2A6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2C19	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C19	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2C9	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 2C9	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2D6	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 2D6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2D6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2E1	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2E1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 3A4	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 3A4	IC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	Ki	nan	None	None
Homo sapiens	Delta opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Delta opioid receptor	IC50	nan	None	None
Homo sapiens	Delta opioid receptor	Ki	nan	None	None
Homo sapiens	Dopamine D1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D1 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D1 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D2 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D2 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D3 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D4 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D4 receptor	Ki	nan	None	None
Homo sapiens	Dopamine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	IC50	nan	None	None
Homo sapiens	Dopamine transporter	Ki	nan	None	None
Homo sapiens	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Potency	39810.7	nM	None
Homo sapiens	Endothelin-converting enzyme 1	Ki	10000.0	nM	10.1021/jm0005454
Homo sapiens	Endothelin receptor ET-A	IC50	nan	None	None
Homo sapiens	Endothelin receptor ET-A	Ki	nan	None	None
Homo sapiens	Epidermal growth factor receptor erbB1	IC50	nan	None	None
Homo sapiens	Epidermal growth factor receptor erbB1	Ki	nan	None	None
Homo sapiens	Equilibrative nucleoside transporter 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	IC50	nan	None	None
Homo sapiens	Estrogen receptor alpha	Ki	nan	None	None
Homo sapiens	Estrogen receptor beta	IC50	nan	None	None
Homo sapiens	Estrogen receptor beta	Ki	nan	None	None
Homo sapiens	Ghrelin receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	IC50	nan	None	None
Homo sapiens	Glucocorticoid receptor	Ki	nan	None	None
Homo sapiens	HEK293	Potency	410.8	nM	None
Homo sapiens	HERG	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HERG	IC50	nan	None	None
Homo sapiens	HERG	Ki	nan	None	None
Homo sapiens	Histamine H1 receptor	AC50	530.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H1 receptor	IC50	nan	None	None
Homo sapiens	Histamine H1 receptor	Ki	nan	None	None
Homo sapiens	Histamine H2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H2 receptor	IC50	nan	None	None
Homo sapiens	Histamine H2 receptor	Ki	nan	None	None
Homo sapiens	Histamine H3 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histone deacetylase 2	Inhibition	nan	%	10.1021/jm401053m
Homo sapiens	Histone deacetylase 6	Inhibition	-40.44	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	2.87	%	10.6019/CHEMBL4808148
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	7079.5	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	10000.0	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	12589.3	nM	None
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Potency	39810.7	nM	None
Homo sapiens	HMG-CoA reductase	IC50	nan	None	None
Homo sapiens	HMG-CoA reductase	Ki	nan	None	None
Homo sapiens	Homo sapiens	Activity	0.84	%	10.1016/j.ejmech.2009.11.034
Homo sapiens	Homo sapiens	CL	0.0	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL	12.0	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL	12.0	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL_renal	12.0	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL_renal	12.0	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	DILI_Concern	nan	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	DILI_severity_class	7.0	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	Fa	0.84	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	F_fraction	0.62	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fg	0.74	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fh	1.0	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	T1/2	1.0	hr	10.1021/jm00098a019
Homo sapiens	Homo sapiens	Vdss	0.75	L.kg-1	10.1021/jm901371v
Homo sapiens	Interleukin-8 receptor A	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor A	Ki	nan	None	None
Homo sapiens	Interleukin-8 receptor B	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor B	Ki	nan	None	None
Homo sapiens	Kappa opioid receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Kappa opioid receptor	IC50	nan	None	None
Homo sapiens	Kappa opioid receptor	Ki	nan	None	None
Homo sapiens	Leukocyte common antigen	IC50	nan	None	None
Homo sapiens	Leukocyte common antigen	Ki	nan	None	None
Homo sapiens	Leukocyte elastase	IC50	nan	None	None
Homo sapiens	Leukocyte elastase	Ki	nan	None	None
Homo sapiens	Leukotriene A4 hydrolase	Delta Tm	0.7	degrees C	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	Delta Tm	1.5	degrees C	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	IC50	70.0	nM	10.1016/S0960-894X(01)80464-9
Homo sapiens	Leukotriene A4 hydrolase	IC50	3600.0	nM	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	IC50	10000.0	nM	10.1016/0960-894X(95)00441-U
Homo sapiens	Leukotriene A4 hydrolase	IC50	14000.0	nM	10.1016/j.bmcl.2008.07.043
Homo sapiens	Leukotriene A4 hydrolase	Kd	6250.0	nM	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	Kd	6370.0	nM	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	Kd	8470.0	nM	10.1016/j.bmc.2016.08.047
Homo sapiens	Leukotriene A4 hydrolase	Ki	3700.0	nM	10.1016/j.bmc.2016.08.047
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	11220.2	nM	None
Homo sapiens	MAP kinase ERK1	IC50	nan	None	None
Homo sapiens	MAP kinase ERK1	Ki	nan	None	None
Homo sapiens	MAP kinase ERK2	IC50	nan	None	None
Homo sapiens	MAP kinase ERK2	Ki	nan	None	None
Homo sapiens	MAP kinase p38 alpha	IC50	nan	None	None
Homo sapiens	MAP kinase p38 alpha	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase 12	Inhibition	nan	%	10.1021/jm401053m
Homo sapiens	Matrix metalloproteinase-2	Inhibition	10.0	%	10.1021/jm401053m
Homo sapiens	Matrix metalloproteinase 9	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase 9	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 3	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 3	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 4	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 4	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 4	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 5	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 5	Ki	nan	None	None
Homo sapiens	Microtubule-associated protein tau	Potency	17782.8	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	22387.2	nM	None
Homo sapiens	Microtubule-associated protein tau	Potency	25118.9	nM	None
Homo sapiens	Monoamine oxidase A	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Monoamine oxidase A	IC50	nan	None	None
Homo sapiens	Monoamine oxidase A	Ki	nan	None	None
Homo sapiens	Motilin receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	M-phase phosphoprotein 8	Potency	1000.0	nM	None
Homo sapiens	Multidrug resistance-associated protein 4	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Mu opioid receptor	IC50	nan	None	None
Homo sapiens	Mu opioid receptor	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M3	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	Ki	nan	None	None
Homo sapiens	Neprilysin	IC50	830000.0	nM	10.1021/jm058225d
Homo sapiens	Neurokinin 1 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 1 receptor	Ki	nan	None	None
Homo sapiens	Neurokinin 2 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 2 receptor	Ki	nan	None	None
Homo sapiens	Neuronal acetylcholine receptor protein alpha-4 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 1	Ki	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	Ki	nan	None	None
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Norepinephrine transporter	IC50	nan	None	None
Homo sapiens	Norepinephrine transporter	Ki	nan	None	None
Homo sapiens	Oligopeptide transporter small intestine isoform	Activity	62.0	%	10.1248/bpb.25.885
Homo sapiens	Oligopeptide transporter small intestine isoform	Activity	132.0	%	10.1248/bpb.25.885
Homo sapiens	Oligopeptide transporter small intestine isoform	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Peripheral myelin protein 22	Potency	84921.4	nM	None
Homo sapiens	P-glycoprotein 1	Activity	nan	None	10.1016/s0024-3205(01)01494-1
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4D	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 5A	IC50	nan	None	None
Homo sapiens	Phosphodiesterase 5A	Ki	nan	None	None
Homo sapiens	Platelet activating factor receptor	IC50	nan	None	None
Homo sapiens	Platelet activating factor receptor	Ki	nan	None	None
Homo sapiens	Pregnane X receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Prelamin-A/C	Potency	12589.3	nM	None
Homo sapiens	Progesterone receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Protein kinase C alpha	IC50	nan	None	None
Homo sapiens	Protein kinase C alpha	Ki	nan	None	None
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	IC50	nan	None	None
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	Ki	nan	None	None
Homo sapiens	Renin	Ki	1.7	nM	10.1021/jm00136a001
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	IC50	nan	None	None
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	Ki	nan	None	None
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	13721.8	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2a (5-HT2a) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2c (5-HT2c) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 3a (5-HT3a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 6 (5-HT6) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 6 (5-HT6) receptor	Ki	nan	None	None
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	IC50	nan	None	None
Homo sapiens	Serotonin transporter	Ki	nan	None	None
Homo sapiens	Serotransferrin	K	0.0	10'2/min	10.1021/jm401053m
Homo sapiens	Serum albumin	Log K'	2.69	None	10.1021/jm010960b
Homo sapiens	Sigma opioid receptor	IC50	nan	None	None
Homo sapiens	Sigma opioid receptor	Ki	nan	None	None
Homo sapiens	Solute carrier family 15 member 2	Activity	nan	None	10.1038/nrd3028
Homo sapiens	Solute carrier family 22 member 1	Inhibition	0.3	%	10.1021/jm8003152
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	18.6	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	167.02	%	10.1124/mol.112.084152
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Inhibition	4.0	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Inhibition	105.18	%	10.1124/mol.112.084152
Homo sapiens	Solute carrier organic anion transporter family member 2B1	Inhibition	39.1	%	10.1021/jm300212s
Homo sapiens	TAR DNA-binding protein 43	Potency	28183.8	nM	None
Homo sapiens	Thrombin	Ki	48.0	nM	10.1016/j.bmcl.2004.05.002
Homo sapiens	Thrombopoietin	Potency	12589.3	nM	None
Homo sapiens	Thromboxane-A synthase	IC50	nan	None	None
Homo sapiens	Thromboxane-A synthase	Ki	nan	None	None
Homo sapiens	Trypsin	Inhibition	nan	%	10.1021/jm401053m
Homo sapiens	Type-1 angiotensin II receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Tyrosine-protein kinase FYN	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase FYN	Ki	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	Ki	nan	None	None
Homo sapiens	Vanilloid receptor	Potency	5011.9	nM	None
Homo sapiens	Vascular endothelial growth factor receptor 1	IC50	nan	None	None
Homo sapiens	Vascular endothelial growth factor receptor 1	Ki	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	IC50	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	Ki	nan	None	None
Homo sapiens	Vasopressin V1a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vasopressin V1a receptor	IC50	nan	None	None
Homo sapiens	Vasopressin V1a receptor	Ki	nan	None	None
Homo sapiens	Vasopressin V2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Klebsiella pneumoniae	Beta-lactamase NDM-1	IC50	49800.0	nM	10.1016/j.bmcl.2016.03.004
Klebsiella pneumoniae	Beta-lactamase NDM-1	IC50	50118.72	nM	10.1016/j.bmcl.2016.03.004
Klebsiella pneumoniae	Beta-lactamase NDM-1	Kd	14000.0	nM	10.1016/j.bmcl.2016.03.004
Klebsiella pneumoniae	Beta-lactamase NDM-1	Kd	14125.38	nM	10.1016/j.bmcl.2016.03.004
Klebsiella pneumoniae	Beta-lactamase NDM-1	MIC	32.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
Klebsiella pneumoniae	Beta-lactamase NDM-1	Ratio	3.5	None	10.1016/j.bmcl.2016.03.004
Klebsiella pneumoniae	Klebsiella pneumoniae	Inhibition	9.36	%	10.6019/CHEMBL4513141
Leishmania amazonensis	Leishmania amazonensis	IC50	nan	None	10.1016/j.bmc.2010.01.068
Leishmania donovani	Leishmania donovani	IC50	nan	None	10.1016/j.bmc.2010.01.068
Leishmania infantum	Leishmania infantum	IC50	nan	None	10.1016/j.bmc.2010.01.068
Leishmania major	Leishmania major	IC50	nan	None	10.1016/j.bmc.2010.01.068
Leishmania mexicana	Leishmania mexicana	IC50	nan	None	10.1016/j.bmc.2010.01.068
Mus musculus	Indoleamine 2,3-dioxygenase 2	Inhibition	55.0	%	10.1016/j.bmcl.2012.10.010
Mus musculus	Monoamine oxidase A	Activity	nan	None	10.1021/jm800656v
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.9b02101
Mus musculus	Nitric oxide synthase, inducible	IC50	nan	None	None
Mus musculus	Nitric oxide synthase, inducible	Ki	nan	None	None
Mus musculus	Solute carrier family 22 member 6	Activity	nan	None	10.1074/jbc.274.3.1519
Oryctolagus cuniculus	Angiotensin-converting enzyme	Duration	2.0	hr	10.1021/jm00168a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	2.7e-05	nM	10.1021/jm00381a012
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	0.005	ug.mL-1	10.1016/S0960-894X(01)80885-4
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	2.3	nM	10.1016/S0960-894X(01)81155-0
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	3.6	nM	10.1016/S0960-894X(01)81155-0
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	10.0	nM	10.1021/jm00026a009
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	13.0	nM	10.1016/s0960-894x(98)00377-1
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	15.0	nM	10.1021/jm00363a011
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	15.0	nM	10.1021/jm00363a012
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	15.0	nM	10.1021/jm00372a022
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	17.0	nM	10.1021/jm00155a032
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	17.0	nM	10.1021/jm00379a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	18.0	nM	10.1021/jm00168a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	20.0	nM	10.1016/S0960-894X(01)80597-7
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	20.0	nM	10.1021/jm00345a011
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	22.0	nM	10.1021/jm00399a033
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1016/S0960-894X(01)80371-1
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm00372a022
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm00379a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm00396a033
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	27.0	nM	10.1021/jm00379a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	130.0	nM	None
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	2400.0	nM	10.1016/S0960-894X(01)81155-0
Oryctolagus cuniculus	Angiotensin-converting enzyme	ID50	0.001	mg.kg-1	10.1021/jm00399a033
Oryctolagus cuniculus	Angiotensin-converting enzyme	Inhibition	2.7	nM	10.1021/jm00098a019
Oryctolagus cuniculus	Angiotensin-converting enzyme	Inhibition	69.0	%	10.1021/jm00168a013
Oryctolagus cuniculus	Angiotensin-converting enzyme	Ki	1.7	nM	10.1021/jm00401a014
Oryctolagus cuniculus	Angiotensin-converting enzyme	Ki	nan	None	None
Oryctolagus cuniculus	Angiotensin-converting enzyme	Residual peptide	99.2	%	10.1021/jm9701132
Oryctolagus cuniculus	Angiotensin-converting enzyme	Time to max. inhibition	0.7	hr	10.1021/jm00168a013
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	IC50	nan	None	None
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	Ki	nan	None	None
Oryctolagus cuniculus	Neprilysin	Ki	1000.0	nM	10.1021/jm0005454
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1016/j.bmc.2010.01.068
Pneumocystis carinii	Pneumocystis carinii	IC50	nan	None	10.1016/j.bmc.2010.01.068
Pseudomonas aeruginosa	Beta-lactamase	IC50	5000.0	nM	10.1016/j.bmcl.2012.08.012
Pseudomonas aeruginosa	Beta-lactamase	Ki	2400.0	nM	10.1016/j.bmcl.2012.08.012
Pseudomonas aeruginosa	Beta-lactamase	Kiuc	2.0	mM	10.1016/j.bmcl.2011.10.116
Pseudomonas aeruginosa	Beta-lactamase VIM-2	IC50	3500.0	nM	10.1021/acs.jmedchem.5b01289
Pseudomonas aeruginosa	Beta-lactamase VIM-2	Ka	4.2	10'4/M/s	10.1021/acs.jmedchem.5b01289
Pseudomonas aeruginosa	Beta-lactamase VIM-2	Kd	0.025	/s	10.1021/acs.jmedchem.5b01289
Pseudomonas aeruginosa	Beta-lactamase VIM-2	Kd	600.0	nM	10.1021/acs.jmedchem.5b01289
Pseudomonas aeruginosa	Pseudomonas aeruginosa	Inhibition	11.48	%	10.6019/CHEMBL4513141
Rattus norvegicus	Acetylcholinesterase	Inhibition	56.5	%	10.1007/s00044-008-9150-z
Rattus norvegicus	Aldose reductase	IC50	nan	None	None
Rattus norvegicus	Aldose reductase	Ki	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Androgen Receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Androgen Receptor	IC50	nan	None	None
Rattus norvegicus	Androgen Receptor	Ki	nan	None	None
Rattus norvegicus	Angiotensin-converting enzyme	Delta MABP	-27.66	mmHg	10.1021/jm00357a013
Rattus norvegicus	Angiotensin-converting enzyme	Delta MABP	21.67	mmHg	10.1021/jm00357a013
Rattus norvegicus	Angiotensin-converting enzyme	IC50	0.45	ug.mL-1	10.1021/jm00398a012
Rattus norvegicus	Angiotensin-converting enzyme	IC50	3.0	nM	10.1021/jm00058a006
Rattus norvegicus	Angiotensin-converting enzyme	IC50	3.23	nM	10.1016/j.ejmech.2017.08.019
Rattus norvegicus	Angiotensin-converting enzyme	IC50	11.0	nM	10.1021/jm00357a014
Rattus norvegicus	Angiotensin-converting enzyme	IC50	12.0	nM	10.1021/jm00389a006
Rattus norvegicus	Angiotensin-converting enzyme	IC50	15.0	nM	10.1021/jm00148a024
Rattus norvegicus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm00146a015
Rattus norvegicus	Angiotensin-converting enzyme	IC50	23.0	nM	10.1021/jm00401a014
Rattus norvegicus	Angiotensin-converting enzyme	IC50	70.0	nM	10.1021/jm00148a024
Rattus norvegicus	Angiotensin-converting enzyme	IC50	156.0	nM	10.1021/jm00357a013
Rattus norvegicus	Angiotensin-converting enzyme	IC50	590.0	nM	10.1021/jm00153a017
Rattus norvegicus	Angiotensin-converting enzyme	ID50	0.015	mg.kg-1	10.1021/jm00379a013
Rattus norvegicus	Angiotensin-converting enzyme	ID50	0.071	mg.kg-1	10.1021/jm00127a033
Rattus norvegicus	Angiotensin-converting enzyme	ID50	0.071	mg.kg-1	10.1021/jm00399a033
Rattus norvegicus	Angiotensin-converting enzyme	ID50	0.1	mg.kg-1	10.1021/jm00379a013
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	3.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	13.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	13.0	%	10.1021/jm960323z
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	26.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	36.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	36.0	%	10.1021/jm960323z
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	60.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	78.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	78.0	%	10.1021/jm960323z
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	96.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	100.0	%	10.1021/jm00026a009
Rattus norvegicus	Angiotensin-converting enzyme	Inhibition	100.0	%	10.1021/jm960323z
Rattus norvegicus	Angiotensin-converting enzyme	Ki	2.0	nM	10.1021/jm0005454
Rattus norvegicus	Angiotensin-converting enzyme	Reduction	-80.0	%	10.1021/jm00153a017
Rattus norvegicus	Angiotensin-converting enzyme	Reduction	-50.0	%	10.1021/jm00153a017
Rattus norvegicus	Angiotensin II receptor (AT-1) type-1	Duration	100.0	min	10.1021/jm00155a032
Rattus norvegicus	Angiotensin II receptor (AT-1) type-1	Inhibition	50.0	%	10.1021/jm00155a032
Rattus norvegicus	Cyclooxygenase-1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	GABA receptor alpha-1 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glycine receptor	IC50	nan	None	None
Rattus norvegicus	Glycine receptor	Ki	nan	None	None
Rattus norvegicus	Insulin receptor	IC50	nan	None	None
Rattus norvegicus	Insulin receptor	Ki	nan	None	None
Rattus norvegicus	Neprilysin	IC50	830000.0	nM	10.1016/S0960-894X(01)80371-1
Rattus norvegicus	Nitric-oxide synthase, brain	IC50	nan	None	None
Rattus norvegicus	Nitric-oxide synthase, brain	Ki	nan	None	None
Rattus norvegicus	Plasma	Fu	0.73	None	10.1021/jm901371v
Rattus norvegicus	Rattus norvegicus	Activity	29.7	mmHg	10.1016/j.ejmech.2018.06.053
Rattus norvegicus	Rattus norvegicus	Activity	30.0	%	10.1016/j.bmc.2012.09.043
Rattus norvegicus	Rattus norvegicus	Activity	34.0	%	10.1016/j.ejmech.2019.111729
Rattus norvegicus	Rattus norvegicus	Activity	36.45	mmHg/min	10.1016/j.ejmech.2007.04.003
Rattus norvegicus	Rattus norvegicus	Activity	42.0	mmHg/min	10.1016/j.ejmech.2007.04.003
Rattus norvegicus	Rattus norvegicus	Activity	52.04	None	10.1016/j.ejmech.2007.04.003
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2010.04.027
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2012.09.043
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2008.12.102
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2012.08.040
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.ejmech.2007.04.003
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm0600186
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1039/C8MD00611C
Rattus norvegicus	Rattus norvegicus	AI recovery time	80.0	min	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	AI recovery time	170.0	min	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	AI recovery time	170.0	min	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	AI recovery time	240.0	min	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	AI recovery time	240.0	min	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	ALB	34000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	35000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	36000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	37000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	38000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	39000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	39500.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	40000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	40700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	40800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	41000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	41300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	42000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALB	42300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	43700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALBGLOB	1.7	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	1.8	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	1.9	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	2.0	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	2.1	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	2.2	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALBGLOB	2.3	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	363.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	365.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	377.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	391.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	396.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	415.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	617.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	633.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	661.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	667.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	691.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	701.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	725.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	734.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	736.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	755.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	768.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	794.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	824.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	845.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	857.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	859.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	862.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	868.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	891.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	902.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	916.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	943.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	971.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	971.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	996.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1012.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1038.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1040.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1045.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1047.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1064.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALP	1094.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	30.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	30.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	31.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	31.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	32.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	32.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	32.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	32.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	33.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	34.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	35.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	35.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	35.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	36.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	36.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	37.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	37.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	37.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	39.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	39.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	40.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	40.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	40.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	40.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	45.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ALT	46.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	51.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	53.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	54.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	55.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	62.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	APTT	15.5	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	15.6	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	15.7	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	15.9	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.0	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.1	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.2	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.3	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.4	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.5	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.6	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.7	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	16.9	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	APTT	17.2	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	53.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	55.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	55.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	55.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	57.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	58.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	58.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	58.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	59.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	59.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	60.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	61.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	61.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	61.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	62.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	63.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	63.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	64.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	65.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	65.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	66.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	66.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	67.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	67.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	68.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	71.5	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	AST	83.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	87.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	89.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	99.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	102.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	118.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BASO	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BASOLE	0.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BASOLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILDIR	0.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.02	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.06	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.08	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.1	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.12	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.15	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.16	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.18	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.2	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.22	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.24	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.26	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.28	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.58	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.78	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.8	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.82	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILDIR	0.84	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILI	2.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	2.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	2.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	3.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILI	4.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BILI	5.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BP	152.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BP	163.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BP	169.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BP	181.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BP	185.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BP	192.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	BUN	118.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	130.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	134.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	138.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	145.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	153.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	155.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	158.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	166.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	168.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	170.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	174.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	176.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	178.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	182.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	188.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	200.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	204.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	206.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	212.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	218.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	222.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	226.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	244.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	256.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	308.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	320.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	388.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	BUN	393.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	464.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	103.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	104.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	105.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	106.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	107.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	108.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	109.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	110.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	111.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	112.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	113.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	114.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CALCIUM	115.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Change	-101.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Change	-93.0	hr	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	Change	-93.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Change	-19.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	CHLORIDE	99.67	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	100.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	100.67	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	101.83	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	102.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	626.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	652.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	660.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	678.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	684.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	688.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	690.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	692.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	698.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	703.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	704.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	706.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	708.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	716.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	726.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	728.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	736.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	746.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	760.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	768.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	776.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	788.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	792.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	794.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	796.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	806.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	810.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	814.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	824.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	848.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	854.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CHOL	882.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CK	326.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	344.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	349.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	594.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	771.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	1308.83	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Cl	101.2	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	101.8	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	102.8	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	103.0	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	103.2	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	103.4	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	103.8	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	104.8	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	105.2	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	105.4	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	105.6	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	105.8	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	106.0	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	106.2	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	106.6	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	107.0	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	108.2	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	108.4	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	109.0	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Cl	109.6	meq/L	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CO2	22830000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	24000000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	24330000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	24670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	28330000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	30670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.6	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	3.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	4.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CREAT	5.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	CREAT	6.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Decrease in mean arterial pressure	49.0	%	10.1021/jm00147a030
Rattus norvegicus	Rattus norvegicus	Delta blood pressure	7.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	Delta blood pressure	11.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	Delta blood pressure	23.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	Delta blood pressure	29.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	Delta blood pressure	40.0	mmHg	10.1021/jm00364a027
Rattus norvegicus	Rattus norvegicus	Duration	22.0	hr	10.1021/jm00155a032
Rattus norvegicus	Rattus norvegicus	ED25	17.78	mg kg-1	10.1021/jm00357a014
Rattus norvegicus	Rattus norvegicus	ED50	0.00062	mg.kg-1	10.1016/j.ejmech.2007.04.003
Rattus norvegicus	Rattus norvegicus	ED50	0.092	umol.kg-1	10.1021/jm00396a033
Rattus norvegicus	Rattus norvegicus	ED50	0.55	mg.kg-1	10.1021/jm00363a011
Rattus norvegicus	Rattus norvegicus	ED50	0.73	umol.kg-1	10.1021/jm00396a033
Rattus norvegicus	Rattus norvegicus	EOS	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	80.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	130.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.5	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	EOSLE	0.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	EOSLE	1.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	EOSLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	1.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	EOSLE	1.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2012.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2040.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2048.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2056.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2058.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2070.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2072.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2092.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2104.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2142.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2148.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2160.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2162.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2218.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2228.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2256.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2262.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2268.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2282.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2288.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2290.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2298.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2350.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2382.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2452.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2480.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2490.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2570.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2576.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	FIBRINO	2580.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	0.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	0.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	0.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	1.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	1.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	1.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	1.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	1.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	2.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GGT	2.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1406.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1453.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1523.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1546.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1565.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1875.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1894.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1896.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1912.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1918.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1920.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1922.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1924.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1928.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1934.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1936.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1940.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1954.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1974.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1976.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1980.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1982.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	1998.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2004.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2024.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2026.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2036.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2038.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2052.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2070.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2086.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2094.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2114.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2130.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	GLUC	2136.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	32.43	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	32.47	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	34.3	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	34.7	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	34.87	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	35.65	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	37.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	37.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	38.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	38.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	38.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	38.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	38.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	39.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	40.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	40.3	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	40.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	40.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	41.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	42.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	43.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	43.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HCT	44.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	127000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	127700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	128000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	129000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	129800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	130000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	131000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	132000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	133000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	134000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	135000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	136000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	136000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	138000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	138300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	140000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	141000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	142000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	142200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	143000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	145000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	HGB	148000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	ID50	0.57	mg.kg-1	10.1021/jm00357a014
Rattus norvegicus	Rattus norvegicus	Inhibition	-45.0	%	10.1021/jm00148a024
Rattus norvegicus	Rattus norvegicus	Inhibition	0.0	%	10.1021/np50083a025
Rattus norvegicus	Rattus norvegicus	Inhibition	10.0	%	10.1021/np50083a025
Rattus norvegicus	Rattus norvegicus	Inhibition	18.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	20.0	%	10.1021/jm00363a011
Rattus norvegicus	Rattus norvegicus	Inhibition	42.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	45.5	%	10.1021/np50083a025
Rattus norvegicus	Rattus norvegicus	Inhibition	60.0	%	10.1007/s00044-008-9150-z
Rattus norvegicus	Rattus norvegicus	Inhibition	61.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	66.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	66.6	%	10.1021/np50083a025
Rattus norvegicus	Rattus norvegicus	Inhibition	69.0	%	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	Inhibition	70.0	%	10.1021/jm00363a011
Rattus norvegicus	Rattus norvegicus	Inhibition	70.0	%	10.1021/jm00363a012
Rattus norvegicus	Rattus norvegicus	Inhibition	78.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	78.5	%	10.1021/np50083a025
Rattus norvegicus	Rattus norvegicus	Inhibition	79.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	82.0	%	10.1021/jm00148a024
Rattus norvegicus	Rattus norvegicus	Inhibition	87.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	90.0	%	10.1021/jm00363a012
Rattus norvegicus	Rattus norvegicus	Inhibition	91.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	93.0	%	10.1021/jm00401a014
Rattus norvegicus	Rattus norvegicus	Inhibition	95.0	%	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	Inhibition over time	0.0	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	1.8	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	8.3	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	18.7	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	27.3	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	51.1	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	60.5	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	71.5	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	78.3	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	Inhibition over time	83.5	%	10.1021/jm00398a012
Rattus norvegicus	Rattus norvegicus	LDH	53.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	71.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	72.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	72.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	73.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	75.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	76.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	76.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	77.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	78.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	78.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	84.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	85.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	86.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	86.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	89.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	90.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	92.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	100.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	102.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	104.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	104.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	106.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	109.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	110.2	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	110.4	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	113.0	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	113.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	115.6	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	116.8	IU.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LDH	230.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	356.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	380.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	506.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	544.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	1114.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	10.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	10.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	11.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	11.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	12.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	16.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	10386.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	12459.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	12527.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	12668.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	13301.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	14323.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	71.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	74.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	76.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	76.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	77.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	77.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	79.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	79.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	79.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	79.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	79.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	80.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	80.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	80.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	81.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	82.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	82.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	82.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	83.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	83.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	83.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	83.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	84.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	85.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	86.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	89.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	90.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	90.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	LYMLE	90.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	92.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	93.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MABP	-101.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MABP	-93.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MABP	-25.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MABP	186.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MABP	189.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MABP	192.0	mmHg	10.1021/jm00160a026
Rattus norvegicus	Rattus norvegicus	MAP	-30.0	%	10.1021/jm00155a032
Rattus norvegicus	Rattus norvegicus	Max delta BP	-55.0	mM	10.1021/jm00363a012
Rattus norvegicus	Rattus norvegicus	Max delta BP	-45.0	mM	10.1021/jm00363a012
Rattus norvegicus	Rattus norvegicus	Max delta BP	-45.0	None	10.1021/jm00363a011
Rattus norvegicus	Rattus norvegicus	Max delta BP	-25.0	mg kg-1 p.o.	10.1021/jm00363a011
Rattus norvegicus	Rattus norvegicus	Max effect	85.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Max effect	99.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Max effect	170.0	mmHg	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Max inhibition	16.0	%	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Max inhibition	69.0	%	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	Max inhibition	95.0	%	10.1021/jm00140a010
Rattus norvegicus	Rattus norvegicus	MCH	18.8	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	19.0	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	19.3	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	19.9	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	20.0	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	20.5	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	20.6	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	20.7	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	20.8	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.0	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.1	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.2	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.3	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.4	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.5	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.6	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.7	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	21.8	pg	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCH	24.73	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.0	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.03	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.23	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.63	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.65	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	32.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	32.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	32.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	33.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCHC	393300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	396700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	398800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	399000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	400800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	404300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	56.6	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	57.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	60.0	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	60.1	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	60.7	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	61.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	62.1	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	62.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	62.4	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	62.73	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	62.95	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.33	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	63.5	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	63.53	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.6	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	63.9	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.0	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.1	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.3	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.35	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	64.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.5	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	64.8	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	65.3	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	65.4	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	65.6	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	65.9	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MCV	66.5	fL	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	-101.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	-93.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	-25.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	93.0	mmHg	10.1021/jm00146a014
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	99.0	mmHg	10.1021/jm00146a014
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	99.0	mmHg	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	186.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	189.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	192.0	mmHg	10.1021/jm00146a014
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	192.0	mmHg	10.1021/jm00353a005
Rattus norvegicus	Rattus norvegicus	Mean aortic blood pressure	192.0	mmHg	10.1021/jm00389a006
Rattus norvegicus	Rattus norvegicus	MONO	88.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	96.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	119.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	180.83	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	193.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	220.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	2.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	3.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	4.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	4.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	4.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	4.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	4.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	5.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	5.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	5.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	5.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	5.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	6.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	6.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	6.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	6.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	7.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	MONOLE	8.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	5.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	6.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	6.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	7.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	7.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	7.83	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	8.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	9.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	9.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	10.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	10.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	10.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	11.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	11.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	12.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	12.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	13.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	13.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	14.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	14.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	14.8	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	15.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	15.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	16.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	16.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	16.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	17.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	19.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTLE	20.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	NEUTSG	645.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	946.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1008.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1180.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1187.83	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1556.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	74.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	75.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	77.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	78.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	80.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	81.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	82.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	84.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	85.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	86.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	88.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	89.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	93.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	96.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	97.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	98.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	99.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	100.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	101.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	104.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	104.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	105.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	106.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	108.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	110.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOS	115.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	120.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	125.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	142.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1128.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1182.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1224.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1276.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1278.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1300.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1306.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1318.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1320.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1322.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1336.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1356.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1396.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1414.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1420.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1424.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1434.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1442.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1460.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1476.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1484.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1488.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1500.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1506.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1510.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1516.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1518.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1566.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PHOSLPD	1696.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	962000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1016670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1043000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1063000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1069000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1078000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1088000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1103000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1114000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1122000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1124000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1136000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1137000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1141000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1155000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1167000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1173000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1174000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1181000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1185330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1186000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1188000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1189000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1192000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1200000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1221000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1223000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1232000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1238000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1272000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1284000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1285330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1341670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1343000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PLAT	1353670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1393000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.3	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.5	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.6	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.7	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.9	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.0	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.1	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.3	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.71	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.8	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.81	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.84	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	6.98	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	51000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	52000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	53000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	54000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	55000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	56000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	56800.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	57000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	57300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	58000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	58700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	59000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	60000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	60000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	60300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	61000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	62000.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PROT	63700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PT	10.4	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	10.6	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	10.7	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	10.8	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	10.9	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.1	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.2	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.3	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.4	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.5	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.6	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.7	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.8	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	11.9	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	12.1	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	12.2	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	12.3	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	12.4	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	PT	12.6	s	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	5110000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5160000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5510000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5540000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5894000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	5918000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	5952000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	5956000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6042000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6044000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6070000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6134000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6138000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6140000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6146000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6150000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6152000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6208000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6216000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6232000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6238000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6242000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6250000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6258000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6322000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6328000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6364000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6396000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6534000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6648000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6718000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	6948000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	7170000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	7246000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	7618000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBC	7908000.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.0	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.17	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.33	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.67	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RETIRBC	2.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	2.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	2.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	3.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	3.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	3.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	4.0	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	4.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	4.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	4.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	4.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	6.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	6.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	6.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.5	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	7.9	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	8.2	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	8.4	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	8.6	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	8.7	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	RETIRBC	9.1	%	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	133.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	135.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	135.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	136.0	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	136.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	137.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	137.6	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	137.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	138.0	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	138.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	138.4	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	138.6	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	138.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.0	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.4	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.6	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.8	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	139.9	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	140.0	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	140.2	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	141.27	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	141.4	mEq.L-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	SODIUM	141.83	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	141.93	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	142.53	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	144.13	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	TERMBW	215.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	220.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	220.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	220.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	220.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	221.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	222.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	222.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	222.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	224.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	224.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	225.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	233.8	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	234.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	235.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	235.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	236.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	237.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	239.8	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	245.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	249.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	259.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	261.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	274.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	288.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	305.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	310.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	322.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	333.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	346.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	359.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TERMBW	402.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Tissue Severity Score	nan	None	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	Tissue Severity Score	nan	None	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	TRIG	274.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	426.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	484.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	490.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	504.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	526.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	538.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	558.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	600.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	626.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	648.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	670.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	680.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	686.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	728.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	734.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	738.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	790.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	798.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	836.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	856.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	860.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	928.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	934.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	958.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1006.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1018.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1040.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1046.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1146.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1424.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	TRIG	1520.0	ug.mL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	URATE	12.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	13.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	14.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	18.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	21.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	28.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	8260.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	8910.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	9270.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	9370.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	9580.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10180.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10200.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10330.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10510.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10590.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	10810.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	11030.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	11090.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	11380.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	11400.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	11480.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	11910.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12140.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12230.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12440.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12540.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12620.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	12760.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	13120.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	13370.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	13730.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	13870.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	13930.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	14100.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	14490.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	14750.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	15420.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	16020.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	16100.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	16520.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	18320.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WBC	23650.0	cells.uL-1	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	0.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	1.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.8	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	2.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	3.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	9.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	9.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	9.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	9.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	10.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	10.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	10.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	10.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	10.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.2	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.6	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.8	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	11.9	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	12.3	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	12.4	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	13.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	13.5	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	13.8	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	15.1	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	15.7	g	10.6019/CHEMBL3885861
Rattus norvegicus	Rattus norvegicus	WEIGHT	17.0	g	10.6019/CHEMBL3885861
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Ki	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	Ki	nan	None	None
Rattus norvegicus	Solute carrier family 15 member 1	Ki	8700000.0	nM	10.1016/s0005-2736(98)00093-5
Rattus norvegicus	Voltage-gated L-type calcium channel alpha-1C subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Schistosoma mansoni	Thioredoxin glutathione reductase	Potency	11220.2	nM	None
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	10.43	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	28.3	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Activity	nan	None	10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	AUC	275.7	None	10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	389.05	nM	10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	19952.62	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	20000.0	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.27	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.17	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	8.7	%	10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition index	0.02263	None	10.1101/2020.04.03.023846
Staphylococcus aureus	Staphylococcus aureus	Inhibition	-7.06	%	10.6019/CHEMBL4513141
Toxoplasma gondii	Toxoplasma gondii	IC50	nan	None	10.1016/j.bmc.2010.01.068
Trichomonas vaginalis	Trichomonas vaginalis	IC50	nan	None	10.1016/j.bmc.2010.01.068
Trypanosoma brucei	6-phospho-1-fructokinase	Potency	30131.3	nM	None
Trypanosoma brucei	Trypanosoma brucei	IC50	nan	None	10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	nan	None	10.1016/j.bmc.2010.01.068
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	nan	None	10.1016/j.bmc.2010.01.068
Trypanosoma cruzi	Trypanosoma cruzi	IC50	nan	None	10.1016/j.bmc.2010.01.068
None	ADMET	AUC Ratio	0.986	None	10.1038/s41586-020-2286-9
None	ADMET	CL	10.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	12.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	12.0	mL.min-1.kg-1	10.1124/dmd.108.020479
None	ADMET	CL	13.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	19.0	mL.min-1.kg-1	10.1002/jps.20373
None	ADMET	CL	57.11	uL.min-1.(10^6cells)-1	10.6019/CHEMBL3301361
None	ADMET	delta logD	0.9	None	10.1021/jm0000564
None	ADMET	F	79.0	%	10.1021/jm0000564
None	ADMET	log10(%HIA +10)	1.892	None	10.1016/j.ejmech.2010.11.005
None	ADMET	MRT	1.0	hr	10.1124/dmd.108.020479
None	ADMET	PPB	90.12	%	10.6019/CHEMBL3301361
None	ADMET	T1/2	2.0	hr	10.1124/dmd.108.020479
None	ADMET	Vdss	0.75	L.kg-1	10.1124/dmd.108.020479
None	ADMET	Vdss	0.81	L.kg-1	10.1002/jps.20373
None	ADMET	Vdss	1.7	mL/min/kg	10.1002/jps.20373
None	ADMET	Vdss	2.5	L.kg-1	10.1002/jps.20373
None	ADMET	Vdss	3.6	L.kg-1	10.1002/jps.20373
None	Hepatotoxicity	Alkaline Phosphatase Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	Alkaline Phosphatase Increase - Index Value	1.1	None	10.2174/1570163043334794
None	Hepatotoxicity	Alkaline Phosphatase Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Active	0.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Marginal	0.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Composite Activity - Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Index Value	0.0	None	10.2174/1570163043334794
None	Hepatotoxicity	GGT Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx1000865
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx900326k
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1124/dmd.110.035113
None	Hepatotoxicity	HepSE_bilirubinemia	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholecystitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholelithiasis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cirrhosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_Combined Scores	2.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_elevated liver function tests	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic failure	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic necrosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatitis	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatomegaly	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_jaundice	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver disease	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver fatty	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver function tests abnormal	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	LDH Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	LDH Increase - Index Value	0.4	None	10.2174/1570163043334794
None	Hepatotoxicity	LDH Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	LTKB_BD DILI severity score	6.0	None	10.1016/j.drudis.2011.05.007
None	Hepatotoxicity	SGOT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	SGOT Increase - Index Value	1.5	None	10.2174/1570163043334794
None	Hepatotoxicity	SGOT Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Activity Score	nan	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Index Value	0.7	None	10.2174/1570163043334794
None	Hepatotoxicity	SGPT Increase - Number of Reports	4.0	None	10.2174/1570163043334794
None	NON-PROTEIN TARGET	Fu	0.73	None	10.1124/dmd.108.020479
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	0.1	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	4.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	5.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	6500.0	nM	10.1016/j.ejmech.2009.07.020
None	NON-PROTEIN TARGET	IC50	7100.0	nM	10.1016/j.ejmech.2009.07.020
None	NON-PROTEIN TARGET	IC50	13070000.0	nM	10.1021/jm2001663
None	NON-PROTEIN TARGET	IC50	15670000.0	nM	10.1021/jm2001663
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.bmc.2010.01.068
None	NON-PROTEIN TARGET	Inhibition	80.0	%	10.1016/j.ejmech.2009.07.020
None	NON-PROTEIN TARGET	Potency	17782.8	nM	None
None	NON-PROTEIN TARGET	TIME	3.383	hr	10.1016/j.ejmech.2009.07.020
None	NON-PROTEIN TARGET	TIME	4.5	hr	10.1016/j.ejmech.2009.07.020
None	No relevant target	Activity	nan	None	10.1016/j.ejmech.2021.113702
None	No relevant target	Activity	nan	None	10.1021/acs.jmedchem.7b00407
None	No relevant target	IC50	4400.0	nM	10.1016/j.ejmech.2021.113702
None	No relevant target	IC50	23300.0	nM	10.1016/j.ejmech.2021.113702
None	No relevant target	IC50	157400.0	nM	10.1016/j.ejmech.2021.113702
None	No relevant target	LogD	-1.78	None	10.1021/jm0000564
None	No relevant target	LogP	1.02	None	10.1016/j.ejmech.2010.07.027
None	No relevant target	pKa	3.7	None	10.1021/jm0000564
None	No relevant target	pKa_A1	3.45	None	10.6019/CHEMBL3301361
None	No relevant target	pKa_A2	9.89	None	10.6019/CHEMBL3301361
None	No relevant target	Ratio	0.0	None	10.1021/acs.jmedchem.0c01541
None	No relevant target	Ratio	1.0	None	10.1021/acs.jmedchem.0c01541
None	No relevant target	Ratio	1.17	None	10.1021/acs.jmedchem.0c01541
None	Radical scavenging activity	IC50	43000.0	nM	10.1016/j.ejmech.2009.07.020
None	Unchecked	Ac50	8.913	uM	None
None	Unchecked	Ac50	12.59	uM	None
None	Unchecked	Ac50	14.13	uM	None
None	Unchecked	AC50	8912.5	nM	None
None	Unchecked	AC50	12589.3	nM	None
None	Unchecked	AC50	12590.0	nM	None
None	Unchecked	AC50	14125.4	nM	None
None	Unchecked	Activity	10.0	%	10.1021/acs.jmedchem.7b00407
None	Unchecked	Activity	42.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	47.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	48.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	94.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	95.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	96.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	97.0	%	10.1016/j.bmcl.2008.12.102
None	Unchecked	Activity	nan	None	10.1021/acs.jmedchem.7b00407
None	Unchecked	Hepatotoxicity (acute)	26.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	16.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	7.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	7.7	nM	10.1016/j.bmcl.2007.11.130
None	Unchecked	IC50	2000.0	nM	10.1016/0960-894X(95)00441-U
None	Unchecked	IC50	2454.71	nM	10.1016/j.ejmech.2018.01.032
None	Unchecked	IC50	2470.0	nM	10.1016/j.bmcl.2018.02.025
None	Unchecked	IC50	2470.0	nM	10.1016/j.ejmech.2018.01.032
None	Unchecked	IC50	4400.0	nM	10.1039/D1MD00187F
None	Unchecked	IC50	6100.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	10000.0	nM	10.1021/jm400769b
None	Unchecked	IC50	13200.0	nM	10.1021/jm400769b
None	Unchecked	IC50	23300.0	nM	10.1039/D1MD00187F
None	Unchecked	IC50	39000.0	nM	10.1016/j.bmcl.2013.10.068
None	Unchecked	IC50	58000.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	65000.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	83000.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	107600.0	nM	10.1021/np4000944
None	Unchecked	IC50	157400.0	nM	10.1016/j.bmc.2020.115902
None	Unchecked	IC50	157400.0	nM	10.1039/D1MD00187F
None	Unchecked	IC50	194984.46	nM	10.1016/j.ejmech.2018.01.032
None	Unchecked	IC50	196800.0	nM	10.1016/j.ejmech.2018.01.032
None	Unchecked	IC50	202000.0	nM	10.1016/j.bmc.2013.03.031
None	Unchecked	IC50	202000.0	nM	10.1016/j.bmc.2020.115437
None	Unchecked	IC50	202000.0	nM	10.1016/j.bmc.2020.115902
None	Unchecked	IC50	202000.0	nM	10.1016/j.ejmech.2021.113667
None	Unchecked	IC50	202000.0	nM	10.1021/acs.jmedchem.7b00407
None	Unchecked	IC50	202000.0	nM	10.1021/jm400769b
None	Unchecked	IC50	390500.0	nM	10.1016/j.bmc.2020.115437
None	Unchecked	IC50	nan	None	None
None	Unchecked	Inhibition	nan	%	10.1016/j.bmcl.2018.02.025
None	Unchecked	Inhibition	nan	%	10.1016/j.ejmech.2018.01.032
None	Unchecked	Inhibition	nan	%	10.1038/nchembio873
None	Unchecked	Kd	12000.0	nM	10.1016/j.bmc.2020.115437
None	Unchecked	Ki	71.5	nM	10.1021/jm00186a020
None	Unchecked	Ki	360.0	nM	10.1021/acs.jmedchem.9b00735
None	Unchecked	Ki	5000.0	nM	10.1021/jm400769b
None	Unchecked	Ki	5450.0	nM	10.1021/acs.jmedchem.9b00735
None	Unchecked	Ki	6600.0	nM	10.1021/jm400769b
None	Unchecked	Ki	7200.0	nM	10.1016/j.bmcl.2011.04.027
None	Unchecked	Ki	12500.0	nM	10.1016/j.bmcl.2011.04.027
None	Unchecked	Ki	300000.0	nM	10.1021/acs.jmedchem.9b00735
None	Unchecked	Ki	2000000.0	nM	10.1016/j.bmcl.2011.04.027
None	Unchecked	Ki	nan	None	None
None	Unchecked	MIC	8.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
None	Unchecked	MIC	16.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
None	Unchecked	MIC	32.0	ug.mL-1	10.1021/acs.jmedchem.9b00735
None	Unchecked	Potency	14.4	nM	None
None	Unchecked	Potency	7304.8	nM	None
None	Unchecked	Ratio IC50	1.2	None	10.1021/jm2001663
None	Unchecked	Selectivity ratio	10.0	None	10.1016/j.bmcl.2008.07.043

Metabolism Information

AKRT ID	Reaction	Reaction Link ID
AKRT001956	C=O.C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O>>C[C@H](CSC=O)C(=O)N1CCC[C@H]1C(=O)O	enzymemap_3914