1,2,3,4-Tetrahydro-6,7-dihydroxyisoquinoline; 7-Me ether, N-Me
AlkaPlorer ID: AK038910
Synonym: 1,2,3,4-Tetrahydro-7-methoxy-2-methyl-6-isoquinolinol, 1,2,3,4-Tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinoline, Isocorypalline
IUPAC Name: 7-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-6-ol
Structure
SMILES: COC1=CC2=C(C=C1O)CCN(C)C2
InChI: InChI=1S/C11H15NO2/c1-12-4-3-8-5-10(13)11(14-2)6-9(8)7-12/h5-6,13H,3-4,7H2,1-2H3
InChIKey: VKAPHOQGGQKBAI-UHFFFAOYSA-N
Reference
Alkaloids from Corydalis ambigua
PubChem CID: 2752173
LOTUS: LTS0200982
SuperNatural Ⅲ: SN0392380
NPASS: NPC301050
COCONUT: CNP0131547.1
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 193.24599999999995
TPSA？: 32.7
MolLogP？: 1.3887
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Mus musculus | Nicotinic acetylcholine receptor alpha-4/beta-2 | IC50 | 33000.0 | nM | 10.1021/jm4013592 |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | IC50 | 1000000.0 | nM | 10.1021/jm4013592 |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | Ki | 300000.0 | nM | 10.1021/jm4013592 |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Inhibition | nan | % | 10.1021/jm4013592 |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Ki | 10000.0 | nM | 10.1021/jm4013592 |
| Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta4 | Ki | 100000.0 | nM | 10.1021/jm4013592 |
| None | Unchecked | Ki | 500000.0 | nM | 10.1021/jm4013592 |