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Berberine

AlkaPlorer ID: AK039750

Synonym: None

IUPAC Name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene

Structure

SMILES: COC1=CC=C2C=C3C4=CC5=C(C=C4CC[N+]3=CC2=C1OC)OCO5

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InChI: InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

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InChIKey: YBHILYKTIRIUTE-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Thalictrum cultratum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum baicalense Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver radicatum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis microphylla Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis virgetorum Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Sanguinaria canadensis Sanguinaria Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum alpinum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tinospora baenzigeri Tinospora Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum przewalskii Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hydrastis canadensis Hydrastis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Coptis chinensis Coptis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Nandina domestica Nandina Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver rhoeas Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum minus Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phellodendron chinense Phellodendron Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis kawakamii Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver dubium Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Coscinium fenestratum Coscinium Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Burasaia madagascariensis Burasaia Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis lycium Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis yanhusuo Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tinospora smilacina Tinospora Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Echinacea purpurea Echinacea Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Meconopsis cambrica Meconopsis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis aquifolium Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Argemone albiflora Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum javanicum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis heteropoda Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis speciosa Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glaucium corniculatum Glaucium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis empetrifolia Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis crataegina Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis japonica Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum hernandezii Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum revolutum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver somniferum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum sachalinense Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Annona mucosa Annona Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Zanthoxylum monophyllum Zanthoxylum Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Coptis japonica Coptis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Coptis deltoidea Coptis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Festuca pratensis Festuca Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pseudofumaria lutea Pseudofumaria Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis fendleri Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Anamirta cocculus Anamirta Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glaucium squamigerum Glaucium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Zanthoxylum coco Zanthoxylum Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Xanthorhiza simplicissima Xanthorhiza Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Arcangelisia flava Arcangelisia Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis bealei Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis amurensis Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis solida Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tinospora cordifolia Tinospora Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Festuca rubra Festuca Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Argemone ochroleuca Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum lucidum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aquilegia vulgaris Aquilegia Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis ilicifolia Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum atriplex Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Penianthus zenkeri Penianthus Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Papaver bracteatum Papaver Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Argemone platyceras Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum dasycarpum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum aquilegiifolium Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis integerrima Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Coptis teeta Coptis Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ternata Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum podocarpum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Fibraurea chloroleuca Fibraurea Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis chitria Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Parabaena sagittata Parabaena Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum foliolosum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Eschscholzia californica Eschscholzia Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Apis cerana Apis Apidae Hymenoptera Insecta Arthropoda Metazoa Eukaryota
Tinospora crispa Tinospora Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis fortunei Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Argemone mexicana Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis darwinii Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis pallida Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis aristata Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum flavum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stylophorum diphyllum Stylophorum Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis buxifolia Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Argemone grandiflora Argemone Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis cheilanthifolia Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis vulgaris Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis cretica Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Orixa japonica Orixa Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum delavayi Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum foetidum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis stolonifera Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Achyranthes japonica Achyranthes Amaranthaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis govaniana Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum fendleri Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis nummularia Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis laurina Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis iliensis Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis turtschaninovii Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis thunbergii Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum petaloideum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum simplex Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis repens Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Berberis sibirica Berberis Berberidaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Phellodendron amurense Phellodendron Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum dioicum Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Capnoides sempervirens Capnoides Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chelidonium majus Chelidonium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tinospora sinensis Tinospora Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glaucium arabicum Glaucium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum wangii Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Thalictrum elegans Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 336.36700000000013

TPSA？: 40.8

MolLogP？: 3.096300000000001

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 0.3125 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 0.625 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 3.125 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 6.25 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 12.5 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 200.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 240.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 250.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 360.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 400.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Acinetobacter baumannii Acinetobacter baumannii MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Acinetobacter baumannii Acinetobacter baumannii MIC 190000.0 nM 10.1016/j.bmcl.2022.129012
Acinetobacter baumannii Acinetobacter baumannii MIC 1377000.0 nM 10.1021/acs.jmedchem.1c01592
Acinetobacter baumannii Acinetobacter baumannii MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Aspergillus flavus Aspergillus flavus MIC 1147300.0 nM 10.1016/j.bmcl.2017.02.071
Bacillus pumilus Bacillus pumilus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Bacillus spizizenii Bacillus spizizenii MIC 512.0 ug.mL-1 10.1039/C3MD00032J
Bacillus spizizenii Bacillus spizizenii MIC 512.0 ug.mL-1 10.1039/C6MD00688D
Bacillus subtilis Bacillus subtilis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Bacillus subtilis Bacillus subtilis MIC 512.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Bacillus subtilis Bacillus subtilis MIC 690000.0 nM 10.1016/j.ejmech.2018.01.038
Bacillus subtilis Bacillus subtilis MIC 1147300.0 nM 10.1016/j.bmcl.2017.02.071
Bacillus subtilis Bacillus subtilis MIC=>90 128.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Bacteria DNA Activity nan None 10.1039/C6MD00688D
Bos taurus Cholesterol esterase IC50 106.0 ug.mL-1 10.1007/s00044-012-0221-9
Bos taurus DNA K 8.99 10'3/M 10.1039/C3MD00136A
Candida Candida MIC80 128.0 ug.mL-1 10.1039/C3MD00032J
Candida albicans Candida albicans FICI 0.039 None 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans FICI 0.063 None 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans FICI 0.07 None 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans FICI 0.093 None 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans MIC 917900.0 nM 10.1016/j.bmcl.2017.02.071
Candida albicans Candida albicans MIC80 1.0 ug.mL-1 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans MIC80 2.0 ug.mL-1 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans MIC80 32.0 ug.mL-1 10.1016/j.bmcl.2017.08.053
Candida albicans Candida albicans MIC80 512.0 ug.mL-1 10.1039/C3MD00032J
Canis lupus familiaris MDCK CC50 70.22 ug.mL-1 10.1016/j.bmc.2017.07.006
Chikungunya virus Chikungunya virus Activity 85.0 % 10.1016/j.bmc.2017.06.049
Chikungunya virus Chikungunya virus EC50 1800.0 nM 10.1016/j.bmc.2017.06.049
Chikungunya virus Chikungunya virus EC50 1900.0 nM 10.1016/j.bmc.2017.06.049
Chlorocebus sabaeus Vero IC50 71.14 ug.mL-1 10.1016/j.ejmech.2019.111951
Chlorocebus sabaeus Vero C1008 CC50 221000.0 nM 10.1021/acs.jmedchem.9b00775
Clostridium perfringens Clostridium perfringens MIC 52200.0 nM 10.1016/j.bmc.2014.09.004
Cricetinae Hamster Activity 40.0 % 10.1016/j.ejmech.2017.09.020
Cricetinae Hamster Activity 42.0 % 10.1016/j.ejmech.2017.09.020
Cricetinae Hamster FC 2.6 None 10.1016/j.ejmech.2017.09.020
Cricetinae Hamster FC 3.5 None 10.1016/j.ejmech.2017.09.020
Cyberlindnera jadinii Cyberlindnera jadinii MIC 573700.0 nM 10.1016/j.bmcl.2017.02.071
Cyberlindnera jadinii Cyberlindnera jadinii MIC80 256.0 ug.mL-1 10.1039/C3MD00032J
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.bmc.2012.02.059
Electrophorus electricus Acetylcholinesterase IC50 374.0 nM 10.1016/j.ejmech.2011.09.051
Electrophorus electricus Acetylcholinesterase IC50 1600.0 nM 10.1016/j.bmc.2017.05.033
Entamoeba histolytica Entamoeba histolytica IC50 1.0 ug.mL-1 10.1007/s00044-011-9767-1
Enterobacter cloacae Enterobacter cloacae Activity nan None 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 0.07812 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 0.1562 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 0.1953 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 3.125 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 6.25 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 12.5 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 25.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterobacter cloacae Enterobacter cloacae MIC 50.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.08.123
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Enterococcus faecalis Enterococcus faecalis MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Enterococcus faecalis Enterococcus faecalis MIC 344000.0 nM 10.1021/acs.jmedchem.1c01592
Enterococcus faecalis Enterococcus faecalis MIC 380000.0 nM 10.1016/j.bmcl.2022.129012
Enterococcus faecalis Enterococcus faecalis MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Enterococcus faecalis Enterococcus faecalis MIC=>90 192.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Enterococcus faecalis Enterococcus faecalis MIC90 64.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Enterococcus faecium Enterococcus faecium MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Enterococcus faecium Enterococcus faecium MIC=>90 192.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Equus caballus Cholinesterase IC50 9400.0 nM 10.1016/j.bmc.2017.05.033
Equus caballus Cholinesterase IC50 18200.0 nM 10.1016/j.bmc.2012.02.059
Equus caballus Cholinesterase IC50 18200.0 nM 10.1016/j.ejmech.2011.09.051
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Escherichia coli Escherichia coli MIC 250.0 ug.mL-1 10.1016/j.bmc.2021.116527
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1039/C3MD00032J
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1039/C6MD00688D
Escherichia coli Escherichia coli MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Escherichia coli Escherichia coli MIC 172000.0 nM 10.1021/acs.jmedchem.1c01592
Escherichia coli Escherichia coli MIC 344000.0 nM 10.1021/acs.jmedchem.1c01592
Escherichia coli Escherichia coli MIC 380000.0 nM 10.1016/j.bmcl.2022.129012
Escherichia coli Escherichia coli MIC 690000.0 nM 10.1016/j.ejmech.2018.01.038
Escherichia coli Escherichia coli MIC 1147300.0 nM 10.1016/j.bmcl.2017.02.071
Escherichia coli Escherichia coli MIC 1376800.0 nM 10.1016/j.bmcl.2017.02.071
Escherichia coli Escherichia coli MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Escherichia coli Escherichia coli MIC=>90 192.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 3154.8 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 9976.3 nM None
Hepacivirus hominis Hepatitis C virus EC50 7870.0 nM 10.1016/j.bmc.2022.116699
Homo sapiens Acetylcholinesterase IC50 100.0 nM 10.1016/j.bmc.2015.04.080
Homo sapiens Acetylcholinesterase IC50 700.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Acetylcholinesterase IC50 1330.0 nM 10.1016/j.ejmech.2021.113492
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 44668.4 nM None
Homo sapiens Aldo-keto reductase family 1 member C2 IC50 6710.0 nM 10.1039/C9MD00201D
Homo sapiens Aldo-keto-reductase family 1 member C3 IC50 4080.0 nM 10.1021/acs.jmedchem.9b02138
Homo sapiens Aldo-keto-reductase family 1 member C3 IC50 5900.0 nM 10.1039/C9MD00201D
Homo sapiens AMP-activated protein kinase, AMPK Activity nan None 10.1016/j.bmc.2011.08.030
Homo sapiens AMPK alpha2/beta1/gamma1 Activity nan None 10.1021/acs.jnatprod.6b00789
Homo sapiens Butyrylcholinesterase IC50 1090.0 nM 10.1016/j.bmc.2015.04.080
Homo sapiens Butyrylcholinesterase IC50 30700.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens CWR22R IC50 12700.0 nM 10.1021/acs.jmedchem.2c01487
Homo sapiens Cytochrome c oxidase subunit 2 Inhibition 15.0 % 10.1016/j.ejmech.2017.12.059
Homo sapiens Cytochrome c oxidase subunit 2 Inhibition 16.0 % 10.1016/j.ejmech.2017.12.059
Homo sapiens Cytochrome P450 1A2 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 1B1 IC50 94.0 nM 10.1016/j.ejmech.2018.11.039
Homo sapiens Cytochrome P450 1B1 IC50 330.0 nM 10.1016/j.ejmech.2017.04.042
Homo sapiens Cytochrome P450 1B1 IC50 2500.0 nM 10.1016/j.ejmech.2018.11.039
Homo sapiens Cytochrome P450 1B1 Ki 44.0 nM 10.1016/j.ejmech.2017.04.042
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 2511.89 nM None
Homo sapiens Cytochrome P450 2D6 Potency 2511.9 nM None
Homo sapiens Cytochrome P450 3A4 AC50 12589.25 nM None
Homo sapiens Cytochrome P450 3A4 Potency 12589.3 nM None
Homo sapiens DOPA decarboxylase IC50 nan None 10.1016/j.bmcl.2014.04.047
Homo sapiens Glycogen synthase kinase-3 beta Inhibition nan % 10.1021/acs.jnatprod.8b00592
Homo sapiens HaCaT Activity 80.0 % 10.1016/j.ejmech.2021.113839
Homo sapiens HaCaT Activity nan None 10.1016/j.bmc.2019.115093
Homo sapiens HaCaT FC 3.0 None 10.1016/j.ejmech.2021.113839
Homo sapiens HaCaT Inhibition nan % 10.1016/j.bmc.2019.115093
Homo sapiens HEK293 Activity nan None 10.1016/j.bmc.2021.116527
Homo sapiens HeLa Activity 16.7 % 10.1016/j.ejmech.2019.111951
Homo sapiens HeLa Activity 29.6 % 10.1016/j.ejmech.2019.111951
Homo sapiens HeLa IC50 12.08 ug.mL-1 10.1016/j.ejmech.2019.111951
Homo sapiens HeLa 229 IC50 42930.0 nM 10.1016/j.ejmech.2019.111951
Homo sapiens Hep 3B2 IC50 50000.0 nM 10.1016/j.bmc.2023.117156
Homo sapiens HepG2 Activity 45.6 % 10.1016/j.bmcl.2016.08.027
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2016.08.027
Homo sapiens HepG2 IC50 46.9 ug.mL-1 10.1016/j.bmcl.2016.08.027
Homo sapiens HepG2 IC50 50000.0 nM 10.1016/j.bmc.2023.117156
Homo sapiens HERG IC50 66069.34 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens Histone deacetylase 6 Inhibition -6.81 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -1.53 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens Activity 25.0 % 10.1016/j.ejmech.2017.09.020
Homo sapiens Homo sapiens Activity 29.0 % 10.1016/j.ejmech.2017.09.020
Homo sapiens Homo sapiens Activity 35.0 % 10.1016/j.ejmech.2017.09.020
Homo sapiens Huh-7 IC50 50000.0 nM 10.1016/j.bmc.2023.117156
Homo sapiens HUVEC IC50 18340.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 2511.9 nM None
Homo sapiens Interleukin-8 IC50 50000.0 nM 10.1021/acs.jmedchem.0c01180
Homo sapiens LNCaP IC50 3400.0 nM 10.1021/acs.jmedchem.2c01487
Homo sapiens LNCaP C4-2B IC50 11200.0 nM 10.1021/acs.jmedchem.2c01487
Homo sapiens Lysine-specific histone demethylase 1 IC50 6970.0 nM 10.1016/j.ejmech.2021.113254
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Microtubule-associated protein tau Potency 12589.3 nM None
Homo sapiens PC-3 IC50 21500.0 nM 10.1021/acs.jmedchem.2c01487
Homo sapiens Peroxisome proliferator-activated receptor alpha Activity 102.0 % 10.1016/j.ejmech.2021.113535
Homo sapiens Peroxisome proliferator-activated receptor alpha EC50 580.0 nM 10.1016/j.ejmech.2021.113535
Homo sapiens Peroxisome proliferator-activated receptor alpha Ki 730.0 nM 10.1016/j.ejmech.2021.113535
Homo sapiens Peroxisome proliferator-activated receptor delta EC50 14000.0 nM 10.1016/j.ejmech.2021.113535
Homo sapiens Prolyl endopeptidase IC50 142000.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Prolyl endopeptidase IC50 145000.0 nM 10.1021/acs.jnatprod.8b00592
Homo sapiens Prostaglandin E synthase Inhibition 71.9 % 10.1016/j.ejmech.2017.12.059
Homo sapiens Protein-tyrosine phosphatase 1B IC50 67000.0 nM 10.1039/C7MD00126F
Homo sapiens quadruplex DNA Activity nan None 10.1021/acs.jmedchem.1c01508
Homo sapiens quadruplex DNA Ka 1.1 10'-5/M 10.1021/acsmedchemlett.9b00516
Homo sapiens quadruplex DNA Kd 9900.0 nM 10.1021/acs.jmedchem.1c01508
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 39810.7 nM None
Homo sapiens SK-HEP1 IC50 50000.0 nM 10.1016/j.bmc.2023.117156
Homo sapiens SMMC-7721 IC50 18340.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 32.0 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 19.4 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 18.5 % 10.1021/jm300212s
Homo sapiens Survival motor neuron protein Potency 7079.5 nM None
Homo sapiens SW1990 IC50 18340.0 nM 10.1016/j.ejmech.2019.01.017
Homo sapiens Telomerase reverse transcriptase IC50 37000.0 nM 10.1016/j.bmc.2012.01.017
Homo sapiens Thyroid stimulating hormone receptor Potency 12589.3 nM None
Influenza A virus Influenza A virus Activity nan None 10.1016/j.bmc.2017.07.006
Influenza A virus Influenza A virus IC50 31.35 ug.mL-1 10.1016/j.bmc.2017.07.006
Influenza A virus Influenza A virus Inhibition 12.1 % 10.1016/j.bmc.2017.07.006
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) Neuraminidase Ki 14300.0 nM 10.1016/j.bmc.2017.07.006
Influenza A virus (strain A/USSR/90/1977 H1N1) Neuraminidase IC50 32200.0 nM 10.1016/j.bmc.2014.09.004
Influenza A virus (strain A/USSR/90/1977 H1N1) Neuraminidase IC50 38500.0 nM 10.1016/j.bmc.2014.09.004
Klebsiella pneumoniae Klebsiella pneumoniae Activity 23.0 % 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.03906 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.07812 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.1562 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.3962 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.7812 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.562 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 3.125 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.25 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 12.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 12.5 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 25.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 50.0 ug.mL-1 10.1021/acs.jnatprod.1c00642
Klebsiella pneumoniae Klebsiella pneumoniae MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Klebsiella pneumoniae Klebsiella pneumoniae MIC 172000.0 nM 10.1021/acs.jmedchem.1c01592
Klebsiella pneumoniae Klebsiella pneumoniae MIC 190000.0 nM 10.1016/j.bmcl.2022.129012
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Mesocricetus auratus BHK-21 CC50 100000.0 nM 10.1016/j.bmc.2017.06.049
Micrococcus luteus Micrococcus luteus MIC 512.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Micrococcus luteus Micrococcus luteus MIC 512.0 ug.mL-1 10.1039/C3MD00032J
Micrococcus luteus Micrococcus luteus MIC 512.0 ug.mL-1 10.1039/C6MD00688D
Micrococcus luteus Micrococcus luteus MIC 690000.0 nM 10.1016/j.ejmech.2018.01.038
Micrococcus luteus Micrococcus luteus MIC 1376800.0 nM 10.1016/j.bmcl.2017.02.071
Mus musculus 3T3-L1 Activity 25.5 % 10.1021/acs.jnatprod.9b00903
Mus musculus 3T3-L1 Activity 45.0 % 10.1016/j.bmc.2017.08.013
Mus musculus 3T3-L1 Activity nan None 10.1016/j.bmc.2017.08.013
Mus musculus 3T3-L1 IC50 21840.0 nM 10.1016/j.bmc.2017.08.013
Mus musculus 3T3-L1 Inhibition nan % 10.1016/j.bmc.2017.08.013
Mus musculus 3T3-L1 Inhibition nan % 10.1016/j.ejmech.2017.11.017
Mus musculus C2C12 Activity nan None 10.1016/j.bmcl.2017.02.003
Mus musculus H22 TGI 42.3 % 10.1016/j.bmc.2023.117156
Mus musculus Lung Activity nan None 10.1021/acs.jmedchem.2c00592
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2021.116598
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.2c00592
Mus musculus Mus musculus F 1.0 % 10.1016/j.ejmech.2018.01.038
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmc.2021.116598
Mus musculus RAW264.7 Activity 129.1 % 10.1016/j.ejmech.2021.113583
Mus musculus RAW264.7 Activity nan None 10.1016/j.bmcl.2011.09.128
Mus musculus RAW264.7 IC50 6900.0 nM 10.1021/acs.jnatprod.8b00748
Mus musculus RAW264.7 IC50 30000.0 nM 10.1016/j.bmcl.2011.09.128
Mus musculus RAW264.7 Inhibition 4.1 % 10.1016/j.ejmech.2021.113583
Mus musculus RAW264.7 Inhibition 67.0 % 10.1021/acs.jnatprod.8b00748
Pichia norvegensis Pichia norvegensis MIC 286800.0 nM 10.1016/j.bmcl.2017.02.071
Plasmodium falciparum Plasmodium falciparum Potency 33.8 nM None
Plasmodium falciparum Plasmodium falciparum Potency 338.1 nM None
Proteus vulgaris Proteus vulgaris MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Proteus vulgaris Proteus vulgaris MIC 128.0 ug.mL-1 10.1039/C3MD00032J
Proteus vulgaris Proteus vulgaris MIC 688400.0 nM 10.1016/j.bmcl.2017.02.071
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 50.0 % 10.1021/acs.jnatprod.0c01151
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 100.0 % 10.1021/acs.jnatprod.0c01151
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1039/C3MD00032J
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1039/C6MD00688D
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 344000.0 nM 10.1021/acs.jmedchem.1c01592
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 380000.0 nM 10.1016/j.bmcl.2022.129012
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 573700.0 nM 10.1016/j.bmcl.2017.02.071
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 690000.0 nM 10.1016/j.ejmech.2018.01.038
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1522000.0 nM 10.1016/j.bmcl.2022.129012
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM Activity 2.0 log10CFU 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM FC 2.0 None 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM FC 16.0 None 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM Inhibition nan % 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 4.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) MexXY/OprM MIC 128.0 ug.mL-1 10.1021/acs.jnatprod.9b00317
Rattus norvegicus Inositol monophosphatase 1 Potency 5011.9 nM None
Rattus norvegicus Inositol monophosphatase 1 Potency 15848.9 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 4547.9 nM None
Rattus norvegicus Peripheral myelin protein 22 Potency 7937.3 nM None
Rattus norvegicus Rattus norvegicus AUC 24.18 ng.hr.mL-1 10.1007/s00044-011-9678-1
Rattus norvegicus Rattus norvegicus Cmax 20186.1 nM 10.1007/s00044-011-9678-1
Rattus norvegicus Rattus norvegicus T1/2 7.88 hr 10.1007/s00044-011-9678-1
Rattus norvegicus Rattus norvegicus Tmax 2.0 hr 10.1007/s00044-011-9678-1
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 286800.0 nM 10.1016/j.bmcl.2017.02.071
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC80 128.0 ug.mL-1 10.1039/C3MD00032J
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 458900.0 nM 10.1016/j.bmcl.2017.02.071
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Shigella dysenteriae Shigella dysenteriae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Shigella dysenteriae Shigella dysenteriae MIC 256.0 ug.mL-1 10.1039/C3MD00032J
Shigella dysenteriae Shigella dysenteriae MIC 256.0 ug.mL-1 10.1039/C6MD00688D
Shigella dysenteriae Shigella dysenteriae MIC 1147300.0 nM 10.1016/j.bmcl.2017.02.071
Staphylococcus aureus Cell division protein ftsZ Activity nan None 10.1016/j.bmc.2012.10.009
Staphylococcus aureus Cell division protein ftsZ IC50 10000.0 nM 10.1016/j.ejmech.2020.112132
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2021.116527
Staphylococcus aureus Staphylococcus aureus IZ 12.0 mm 10.1021/acs.jnatprod.5b00408
Staphylococcus aureus Staphylococcus aureus MIC 25.0 ug.mL-1 10.1016/j.ejmech.2017.01.012
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.08.123
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1016/j.bmc.2021.116527
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.05.112
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1039/C3MD00032J
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1039/C6MD00688D
Staphylococcus aureus Staphylococcus aureus MIC 150.0 ug.mL-1 10.1021/np200336g
Staphylococcus aureus Staphylococcus aureus MIC 300.0 ug.mL-1 10.1021/np200336g
Staphylococcus aureus Staphylococcus aureus MIC 500.0 ug.mL-1 10.1016/j.bmc.2021.116527
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1016/j.bmcl.2012.12.036
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1039/C3MD00032J
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1039/C6MD00688D
Staphylococcus aureus Staphylococcus aureus MIC 11000.0 nM 10.1016/j.ejmech.2019.06.068
Staphylococcus aureus Staphylococcus aureus MIC 172000.0 nM 10.1021/acs.jmedchem.1c01592
Staphylococcus aureus Staphylococcus aureus MIC 190000.0 nM 10.1016/j.bmcl.2022.129012
Staphylococcus aureus Staphylococcus aureus MIC 229500.0 nM 10.1016/j.bmcl.2017.02.071
Staphylococcus aureus Staphylococcus aureus MIC 340000.0 nM 10.1016/j.ejmech.2018.01.038
Staphylococcus aureus Staphylococcus aureus MIC 344000.0 nM 10.1021/acs.jmedchem.1c01592
Staphylococcus aureus Staphylococcus aureus MIC 380000.0 nM 10.1016/j.bmcl.2022.129012
Staphylococcus aureus Staphylococcus aureus MIC 446000.0 nM 10.1021/acs.jnatprod.5b01014
Staphylococcus aureus Staphylococcus aureus MIC 689000.0 nM 10.1021/acs.jmedchem.1c01592
Staphylococcus aureus Staphylococcus aureus MIC 761000.0 nM 10.1016/j.bmcl.2022.129012
Staphylococcus aureus Staphylococcus aureus MIC 1376800.0 nM 10.1016/j.bmcl.2017.02.071
Staphylococcus aureus Staphylococcus aureus MIC 1380000.0 nM 10.1016/j.ejmech.2018.01.038
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.ejmech.2017.01.012
Staphylococcus aureus Staphylococcus aureus MIC=>90 128.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus MIC=>90 192.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1016/j.bmc.2012.10.009
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Staphylococcus epidermidis Staphylococcus epidermidis MIC=>90 96.0 ug ml-1 10.1016/j.ejmech.2018.10.039
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113723
Toxoplasma gondii Toxoplasma gondii ID50 0.58 uM 10.1016/j.bmcl.2012.02.038
Toxoplasma gondii Toxoplasma gondii Ratio 30.0 None 10.1016/j.bmcl.2012.02.038
Trypanosoma brucei brucei Trypanosoma brucei brucei MIC 74400.0 nM 10.1021/acs.jnatprod.9b00397
Zika virus Zika virus IC50 39100.0 nM 10.1021/acs.jmedchem.9b00775
Zika virus Zika virus Inhibition 77.6 % 10.1021/acs.jmedchem.9b00775
None ADMET Drugexcretion 0.0939 % 10.1016/j.ejmech.2019.111951
None ADMET Drugexcretion 22.74 % 10.1016/j.ejmech.2019.111951
None ADMET Drugexcretion 22.83 % 10.1016/j.ejmech.2019.111951
None ADMET F 0.36 % 10.1016/j.ejmech.2021.113839
None ADMET LOAEL 1313.0 mg kg-1 10.1016/j.ejmech.2021.113839
None ADMET NOAEL 420.0 mg kg-1 10.1016/j.ejmech.2021.113839
None ADMET TD50 0.85 uM 10.1016/j.bmcl.2012.02.038
None ADMET TI 1.5 None 10.1016/j.bmcl.2012.02.038
None DNA Delta Tm 2.1 degrees C 10.1016/j.bmc.2023.117156
None Erythrocyte Activity nan None 10.1021/acs.jnatprod.9b00317
None Molecular identity unknown FC 10.0 None 10.1021/acs.jnatprod.0c01151
None Molecular identity unknown Inhibition nan % 10.1021/acs.jnatprod.0c01151
None No relevant target Activity nan None 10.1039/C7MD00126F
None No relevant target permeability 0.1 ucm/s 10.1021/acs.jnatprod.8b00592
None No relevant target Ratio 0.4 None 10.1016/j.ejmech.2011.09.051
None No relevant target solubility nan None 10.1016/j.bmc.2021.116527
None No relevant target Solubility 85.0 ug.mL-1 10.1039/C6MD00688D
None No relevant target Solubility 86.0 ug.mL-1 10.1016/j.ejmech.2018.01.038
None No relevant target Solubility 751000.0 nM 10.1021/acs.jmedchem.1c01592
None Nucleic Acid Activity 58.9 % 10.1016/j.bmcl.2011.12.143
None Nucleic Acid Inhibition nan % 10.1016/j.bmcl.2011.12.103
None Quadruplex DNA Delta Tm 1.6 degrees C 10.1016/j.bmc.2023.117156
None Unchecked Activity 10.0 uM 10.1016/j.bmc.2017.03.019
None Unchecked Activity nan None 10.1016/j.bmc.2017.03.019
None Unchecked Activity nan None 10.1021/acs.jnatprod.1c00642
None Unchecked Activity nan None 10.1021/acs.jnatprod.6b00558
None Unchecked Activity nan None 10.1039/C0MD00209G
None Unchecked CC50 100000.0 nM 10.1016/j.bmc.2017.06.049
None Unchecked Delta Tm 0.34 degrees C 10.1016/j.bmc.2017.03.019
None Unchecked Delta Tm 9.68 degrees C 10.1016/j.bmc.2017.03.019
None Unchecked Delta Tm 10.32 degrees C 10.1016/j.bmc.2017.03.019
None Unchecked FC 2.0 None 10.1021/acs.jnatprod.1c00642
None Unchecked FC 2.5 None 10.1021/acs.jnatprod.1c00642
None Unchecked IC50 6.9 ug.mL-1 10.1016/j.bmc.2021.116527
None Unchecked IC50 10000.0 nM 10.1016/j.ejmech.2015.03.026
None Unchecked IC50 13500.0 nM 10.1016/j.bmc.2014.09.004
None Unchecked IC50 16010.0 nM 10.1016/j.ejmech.2015.03.026
None Unchecked IC50 50000.0 nM 10.1016/j.bmc.2023.117156
None Unchecked IC50 nan None 10.1016/j.ejmech.2011.09.051
None Unchecked IC50 nan None 10.1016/j.ejmech.2017.01.012
None Unchecked Inhibition 8.9 % 10.1016/j.ejmech.2011.09.051
None Unchecked Inhibition 36.3 % 10.1016/j.bmc.2012.02.059
None Unchecked Inhibition 36.3 % 10.1016/j.ejmech.2011.09.051
None Unchecked Inhibition 50.0 % 10.1016/j.ejmech.2015.03.026
None Unchecked Inhibition 79.0 % 10.1016/j.ejmech.2016.07.058
None Unchecked Inhibition nan % 10.1016/j.bmc.2013.07.033
None Unchecked Inhibition nan % 10.1016/j.bmcl.2016.03.010
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.2c00592
None Unchecked Ka 0.65 10'-6/M 10.1039/C0MD00209G
None Unchecked Kd 1770.0 nM 10.1039/C1MD00020A
None Unchecked Kd 216400.0 nM 10.1039/C1MD00020A
None Unchecked Kdiss 0.02 None 10.1016/j.ejmech.2015.03.026
None Unchecked Ki 0.98 10'-4/M 10.1039/C0MD00209G
None Unchecked Ki 1.21 10'-4/M 10.1039/C0MD00209G
None Unchecked Ki 400.0 nM 10.1039/C0MD00209G
None Unchecked Ki 410.0 nM 10.1039/C0MD00209G
None Unchecked Ki 10000.0 nM 10.1039/C0MD00209G
None Unchecked Ki 11900.0 nM 10.1016/j.bmc.2014.09.004
None Unchecked %max 27.5 % 10.1021/acs.jmedchem.2c00592
None Unchecked Potency 501.2 nM None
None Unchecked Potency 1122.0 nM None
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 17782.8 nM None
None Unchecked Ratio 18.1 None 10.1016/j.bmc.2021.116527
None Unchecked Ratio CC50/EC50 52.6 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio CC50/EC50 55.6 None 10.1016/j.bmc.2017.06.049
None Unchecked Ratio IC50 44.0 None 10.1021/acs.jnatprod.8b00592
None Unchecked Ratio IC50 48.6 None 10.1016/j.bmc.2012.02.059
None Unchecked Ratio IC50 48.6 None 10.1016/j.ejmech.2011.09.051
None Unchecked Selectivity ratio 0.1 None 10.1039/C1MD00020A
None Unchecked Tm 58.0 degrees C 10.1039/C0MD00209G

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT011633 COc1cc2c(cc1O)-c1cc3ccc(OC)c(OC)c3c[n+]1CC2>>COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 R00044
AKRT011896 COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4>>COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 TETRAHYDROBERBERINE-OXIDASE-RXN
AKRT011929 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2>>COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1=C2)OCO4 RXN-15640
AKRT011930 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2>>COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 None
AKRT011931 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2>>COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@H]1C2)OCO4 R07169