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Meridine

AlkaPlorer ID: AK040247

Synonym: None

IUPAC Name: 6,10,20-triazapentacyclo[11.7.1.02,7.09,21.014,19]henicosa-1(20),2(7),4,9,11,13(21),14,16,18-nonaene-3,8-dione

Structure

SMILES: O=C1C2=C(C(O)=CC=N2)C2=C3C1=NC=CC3=C1C=CC=CC1=N2

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InChI: InChI=1S/C18H9N3O2/c22-12-6-8-20-17-14(12)15-13-10(5-7-19-16(13)18(17)23)9-3-1-2-4-11(9)21-15/h1-8H,(H,20,22)

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InChIKey: QSJNAFJALFWFMT-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 299.289

TPSA？: 75.97

MolLogP？: 3.095000000000001

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis MIC 3.1 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans IC50 1.0 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans IC50 50.0 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans IC50 100.0 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MFC 0.2 ug ml-1 10.1021/np50089a016
Candida albicans Candida albicans MFC 3.1 ug ml-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 0.2 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 0.31 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 0.62 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 1.2 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 2.5 ug.mL-1 10.1021/np50089a016
Candida albicans Candida albicans MIC 3.1 ug.mL-1 10.1021/np50089a016
Cryptococcus neoformans Cryptococcus neoformans MFC 6.2 ug ml-1 10.1021/np50089a016
Cryptococcus neoformans Cryptococcus neoformans MIC 0.8 ug.mL-1 10.1021/np50089a016
Epidermophyton floccosum Epidermophyton floccosum MIC 1.6 ug.mL-1 10.1021/np50089a016
Escherichia coli Escherichia coli Activity nan None 10.1021/np50089a016
Homo sapiens A-427 IC50 200.0 nM 10.1021/jm0108496
Homo sapiens A549 IC50 4.5 ug.mL-1 10.1021/np50096a015
Homo sapiens A549 IC50 80.0 nM 10.1021/jm0108496
Homo sapiens HCT-15 IC50 200.0 nM 10.1021/jm0108496
Homo sapiens HT-29 IC50 0.2 ug.mL-1 10.1021/np50096a015
Homo sapiens J82 IC50 8200.0 nM 10.1021/jm0108496
Homo sapiens LoVo IC50 70.0 nM 10.1021/jm0108496
Homo sapiens MCF7 IC50 90.0 nM 10.1021/jm0108496
Homo sapiens PC-3 IC50 500.0 nM 10.1021/jm0108496
Homo sapiens T47D IC50 70.0 nM 10.1021/jm0108496
Homo sapiens Telomerase reverse transcriptase IC50 11.0 ug.mL-1 10.1039/C0MD00241K
Homo sapiens Telomerase reverse transcriptase IC50 11000.0 nM 10.1016/j.ejmech.2013.07.022
Homo sapiens U373 MG IC50 100.0 nM 10.1021/jm0108496
Homo sapiens U-87 MG IC50 100.0 nM 10.1021/jm0108496
Mus musculus P388 IC50 2.0 ug.mL-1 10.1021/np50096a015
Nannizzia gypsea Nannizzia gypsea MIC 25.0 ug.mL-1 10.1021/np50089a016
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/np50089a016
Scopulariopsis brevicaulis Scopulariopsis brevicaulis MIC 25.0 ug.mL-1 10.1021/np50089a016
Sporothrix schenckii Sporothrix schenckii MIC 25.0 ug.mL-1 10.1021/np50089a016
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 6.2 ug.mL-1 10.1021/np50089a016
Trichosporon beigelii Trichosporon beigelii MIC 25.0 ug.mL-1 10.1021/np50089a016
None NON-PROTEIN TARGET IC50 8.8 ug.mL-1 10.1021/np50096a015
None Unchecked Activity nan None 10.1021/np50096a015
None Unchecked IC50 50.0 nM 10.1021/jm0108496
None Unchecked IC50 2000.0 nM 10.1021/jm0108496

Metabolism Information