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name Structure Reference Source Properties Activities Metabolism

oxotremorine

AlkaPlorer ID: AK040280

Synonym: None

IUPAC Name: 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one

Structure

SMILES: O=C1CCCN1CC#CCN1CCCC1

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InChI: InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2

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InChIKey: RSDOPYMFZBJHRL-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 206.289

TPSA？: 23.550000000000004

MolLogP？: 0.7080000000000002

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 7.42 % 10.6019/CHEMBL4296182
Candida albicans Candida albicans Inhibition 0.18 % 10.6019/CHEMBL4296182
Cavia porcellus Cavia porcellus EC50 35.0 nM 10.1021/jm00164a018
Cavia porcellus Cavia porcellus EC50 44.0 nM 10.1021/jm00396a024
Cavia porcellus Cavia porcellus Emax 100.0 None 10.1021/jm00164a018
Cavia porcellus Cavia porcellus Occupancy 3.5 % 10.1021/jm00150a004
Cavia porcellus Cavia porcellus Relative efficacy 1.0 None 10.1021/jm00150a004
Cavia porcellus Muscarinic acetylcholine receptor M3 Contraction 50.0 % 10.1016/j.bmcl.2004.04.042
Cavia porcellus Muscarinic acetylcholine receptor M3 EC50 50.0 nM 10.1021/jm00095a025
Cavia porcellus Muscarinic acetylcholine receptor M3 Efficacy 1.0 None 10.1021/jm00095a025
Cavia porcellus Muscarinic acetylcholine receptor M3 Efficiency 100.0 % 10.1021/jm00079a002
Cavia porcellus Muscarinic acetylcholine receptor M3 Emax 1.0 None 10.1021/jm00095a025
Cavia porcellus Muscarinic acetylcholine receptor M3 Kd 1200.0 nM 10.1021/jm00095a025
Cavia porcellus Muscarinic acetylcholine receptor M3 pD2 7.1 None 10.1021/jm00079a002
Cryptococcus neoformans Cryptococcus neoformans Inhibition -12.14 % 10.6019/CHEMBL4296182
Danio rerio Ion channel NompC EC50 29900.0 nM None
Drosophila melanogaster Muscarinic acetylcholine receptor DM1 Ki 19400.0 nM 10.1021/jf0631934
Drosophila melanogaster Muscarinic acetylcholine receptor DM1 Ki 21500.0 nM 10.1021/jf0631934
Escherichia coli Escherichia coli Inhibition 9.1 % 10.6019/CHEMBL4296182
Homo sapiens Cytochrome P450 1A2 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 158.49 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 Potency 158.5 nM None
Homo sapiens Cytochrome P450 2C9 AC50 1995.26 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 Potency 1000.0 nM None
Homo sapiens Cytochrome P450 2C9 Potency 1995.3 nM None
Homo sapiens Cytochrome P450 2D6 AC50 7943.28 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 Potency 7943.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 63095.7 nM None
Homo sapiens DNA polymerase iota Potency 22387.2 nM None
Homo sapiens Dopamine D1 receptor Potency 2909.1 nM None
Homo sapiens Endothelin receptor ET-A Relaxation 50.0 % 10.1016/j.bmcl.2004.04.042
Homo sapiens Histone deacetylase 6 Inhibition -1.23 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -0.21 % 10.6019/CHEMBL4808148
Homo sapiens MCOLN3 protein EC50 29900.0 nM None
Homo sapiens Muscarinic acetylcholine receptor ED50 0.026 uM l-1 10.1021/jm00150a004
Homo sapiens Muscarinic acetylcholine receptor EPMR 0.42 None 10.1021/jm00150a004
Homo sapiens Muscarinic acetylcholine receptor KA 0.68 None 10.1021/jm00150a004
Homo sapiens Muscarinic acetylcholine receptor Kd 930.0 nM 10.1021/jm00164a018
Homo sapiens Muscarinic acetylcholine receptor M1 EC50 1.6 nM 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M1 EC50 390.0 nM 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptor M1 Efficacy 108.1 % 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 2.3 nM 10.1016/s0960-894x(01)00559-5
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 364.0 nM 10.1016/S0960-894X(00)80535-1
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 9000.0 nM 10.1021/jm9705216
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 27100.0 nM 10.1016/s0960-894x(01)00559-5
Homo sapiens Muscarinic acetylcholine receptor M1 Inhibition 9.0 % 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M1 Ki 1.122 nM 10.1016/j.bmc.2007.12.036
Homo sapiens Muscarinic acetylcholine receptor M1 Ki 17.0 nM 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M1 Ratio 190.0 None 10.1021/jm9702903
Homo sapiens Muscarinic acetylcholine receptor M1 Ratio 11645.0 None 10.1016/s0960-894x(01)00559-5
Homo sapiens Muscarinic acetylcholine receptor M2 EC50 19.0 nM 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptor M2 Efficacy 112.8 % 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 400.0 nM 10.1021/jm9705216
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 17.0 nM 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 147.91 nM 10.1021/acs.jmedchem.6b01892
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 323.59 nM 10.1016/j.bmc.2007.12.036
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 660.0 nM 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 851.14 nM 10.1021/acs.jmedchem.9b02172
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 1023.29 nM 10.1021/acs.jmedchem.9b02172
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 1778.28 nM 10.1021/acs.jmedchem.9b02172
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 10000.0 nM 10.1021/acs.jmedchem.6b01892
Homo sapiens Muscarinic acetylcholine receptor M2 Ratio 2.4 None 10.1016/S0960-894X(01)80787-3
Homo sapiens Muscarinic acetylcholine receptor M3 EC50 210.0 nM 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptor M3 Efficacy 88.8 % 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 17000.0 nM 10.1021/jm9705216
Homo sapiens Muscarinic acetylcholine receptor M3 Inhibition 28.0 % 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M3 Inhibition nan % 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M4 EC50 9.0 nM 10.1021/acsmedchemlett.9b00106
Homo sapiens Muscarinic acetylcholine receptor M4 EC50 14.0 nM 10.1021/acsmedchemlett.9b00106
Homo sapiens Muscarinic acetylcholine receptor M4 EC50 33.0 nM 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptor M4 Efficacy 92.1 % 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M4 Emax 90.7 % 10.1021/acsmedchemlett.9b00106
Homo sapiens Muscarinic acetylcholine receptor M4 Emax 94.4 % 10.1021/acsmedchemlett.9b00106
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 5000.0 nM 10.1021/jm9705216
Homo sapiens Muscarinic acetylcholine receptor M4 Ki 1.5 nM 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M4 Ki 160.0 nM 10.1021/jm9904001
Homo sapiens Muscarinic acetylcholine receptor M5 EC50 55.0 nM 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptor M5 Efficacy 82.8 % 10.1016/j.bmcl.2015.02.012
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 8000.0 nM 10.1021/jm9705216
Homo sapiens Muscarinic acetylcholine receptors; M1 & M2 M2/M1 index 0.11 None 10.1021/jm00012a019
Homo sapiens Muscarinic acetylcholine receptors; M1 & M2 Ratio 0.049 None 10.1021/jm00012a019
Homo sapiens SK-N-SH PI turnover 33.0 % 10.1016/S0960-894X(01)80787-3
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 95.24 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 82.72 % 10.1124/mol.112.084152
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 0.9 nM None
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 1.39 % 10.6019/CHEMBL4296182
Mus musculus A9 PI turnover nan None 10.1021/jm00107a029
Mus musculus Acetylcholinesterase Ki 1.7 nM 10.1021/jm00084a015
Mus musculus Acetylcholinesterase Ki 1500.0 nM 10.1021/jm00084a015
Mus musculus Acetylcholinesterase Ratio 880.0 None 10.1021/jm00084a015
Mus musculus Muscarinic acetylcholine receptor M1 EC50 270.0 nM 10.1021/jm960467d
Mus musculus Muscarinic acetylcholine receptor M1 Smax 120.0 % 10.1021/jm960467d
Mus musculus Muscarinic acetylcholine receptor M2 Ki 1.7 nM 10.1021/jm00095a008
Mus musculus Muscarinic acetylcholine receptor M2 Ki 1500.0 nM 10.1021/jm00095a008
Mus musculus Muscarinic acetylcholine receptor M2 Ratio 880.0 None 10.1021/jm00095a008
Mus musculus Muscarinic acetylcholine receptor M3 PI turnover 35.6 None 10.1021/jm00107a029
Mus musculus Mus musculus Activity 3.0 None 10.1021/jm9702903
Mus musculus Mus musculus Antagonism nan None 10.1021/jm9506433
Mus musculus Mus musculus ED50 0.038 mg.kg-1 10.1021/jm9705216
Mus musculus Mus musculus ED50 0.05 umol.kg-1 10.1021/jm00398a031
Mus musculus Mus musculus ED50 0.07 mg.kg-1 10.1021/jm9702903
Mus musculus Mus musculus ED50 0.09 mg.kg-1 10.1021/jm981048e
Mus musculus Mus musculus ED50 0.1 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus ED50 0.11 mg.kg-1 10.1021/jm00112a002
Mus musculus Mus musculus ED50 0.19 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus ED50 0.2 mg.kg-1 10.1021/jm9705216
Mus musculus Mus musculus ED50 0.2 mg.kg-1 10.1021/jm981048e
Mus musculus Mus musculus ED50 0.22 umol.kg-1 10.1021/jm00398a031
Mus musculus Mus musculus ED50 0.221 mg.kg-1 10.1021/jm00112a002
Mus musculus Mus musculus ED50 0.24 mg.kg-1 10.1021/jm981048e
Mus musculus Mus musculus ED50 0.28 mg.kg-1 10.1021/jm00112a002
Mus musculus Mus musculus ED50 0.29 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus ED50 0.29 umol.kg-1 10.1021/jm00398a031
Mus musculus Mus musculus ED50 0.44 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus ED50 0.59 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus ED50 nan mg.kg-1 10.1021/jm9506433
Mus musculus Mus musculus ED Arec 0.023 mg kg-1 10.1021/jm9702903
Mus musculus Mus musculus LD50 6.7 umol.kg-1 10.1021/jm00150a004
Mus musculus Mus musculus LD50 6.7 umol.kg-1 10.1021/jm00396a024
Mus musculus Mus musculus Response nan None 10.1021/jm9506433
Photinus pyralis Luciferin 4-monooxygenase Potency 25118.9 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 4.27 % 10.6019/CHEMBL4296182
Rattus norvegicus Acetylcholinesterase IC50 nan nM 10.1021/jm9506433
Rattus norvegicus cyclic AMP phosphoprotein Inhibition 111.8 % 10.1021/jm00107a029
Rattus norvegicus Muscarinic acetylcholine receptor Efficacy ratio 308.0 None 10.1016/S0960-894X(00)80535-1
Rattus norvegicus Muscarinic acetylcholine receptor Efficiency 55.0 % 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor Efficiency 100.0 % 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor IC50 1.2 nM 10.1021/jm00012a019
Rattus norvegicus Muscarinic acetylcholine receptor IC50 1.5 nM 10.1016/S0960-894X(00)80535-1
Rattus norvegicus Muscarinic acetylcholine receptor IC50 2.0 nM 10.1016/S0960-894X(97)00150-9
Rattus norvegicus Muscarinic acetylcholine receptor IC50 2.8 nM 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor IC50 5.0 nM 10.1021/jm9705216
Rattus norvegicus Muscarinic acetylcholine receptor IC50 17.0 nM 10.1021/jm00085a016
Rattus norvegicus Muscarinic acetylcholine receptor IC50 17.0 nM 10.1021/jm00091a007
Rattus norvegicus Muscarinic acetylcholine receptor IC50 84.0 nM 10.1021/jm00012a019
Rattus norvegicus Muscarinic acetylcholine receptor IC50 93.0 nM 10.1021/jm00012a019
Rattus norvegicus Muscarinic acetylcholine receptor IC50 407.0 nM 10.1016/S0960-894X(00)80535-1
Rattus norvegicus Muscarinic acetylcholine receptor IC50 660.0 nM 10.1021/jm9506433
Rattus norvegicus Muscarinic acetylcholine receptor IC50 660.0 nM 10.1021/jm950644v
Rattus norvegicus Muscarinic acetylcholine receptor IC50 2300.0 nM 10.1021/jm00012a019
Rattus norvegicus Muscarinic acetylcholine receptor IC50 2700.0 nM 10.1021/jm9506433
Rattus norvegicus Muscarinic acetylcholine receptor IC50 2700.0 nM 10.1021/jm950644v
Rattus norvegicus Muscarinic acetylcholine receptor IC50 3300.0 nM 10.1021/jm00085a016
Rattus norvegicus Muscarinic acetylcholine receptor IC50 3300.0 nM 10.1021/jm00091a007
Rattus norvegicus Muscarinic acetylcholine receptor Ki 0.5 nM 10.1016/S0960-894X(00)80539-9
Rattus norvegicus Muscarinic acetylcholine receptor Ki 0.5 nM 10.1021/jm00112a002
Rattus norvegicus Muscarinic acetylcholine receptor Ki 0.5 nM 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor Ki 4.0 nM 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor Ki 6.0 nM 10.1021/jm9904001
Rattus norvegicus Muscarinic acetylcholine receptor Ki 13.0 nM 10.1021/jm9904001
Rattus norvegicus Muscarinic acetylcholine receptor Ki 60.0 nM 10.1016/S0960-894X(00)80539-9
Rattus norvegicus Muscarinic acetylcholine receptor Ki 60.0 nM 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor Ki 140.0 nM 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor Ki 193.0 nM 10.1021/jm00112a002
Rattus norvegicus Muscarinic acetylcholine receptor Ki 230.0 nM 10.1021/jm00095a025
Rattus norvegicus Muscarinic acetylcholine receptor Ki 330.0 nM 10.1021/jm9904001
Rattus norvegicus Muscarinic acetylcholine receptor Ki 830.0 nM 10.1021/jm00164a018
Rattus norvegicus Muscarinic acetylcholine receptor Ki 58000.0 nM 10.1021/jm9904001
Rattus norvegicus Muscarinic acetylcholine receptor Ki ratio 386.0 None 10.1021/jm00112a002
Rattus norvegicus Muscarinic acetylcholine receptor Ratio 4.2 None 10.1021/jm9506433
Rattus norvegicus Muscarinic acetylcholine receptor Ratio 55.0 None 10.1021/jm9904001
Rattus norvegicus Muscarinic acetylcholine receptor Ratio 190.0 None 10.1021/jm00085a016
Rattus norvegicus Muscarinic acetylcholine receptor Ratio 190.0 None 10.1021/jm00091a007
Rattus norvegicus Muscarinic acetylcholine receptor M1 IC50 100.0 nM 10.1016/S0960-894X(97)00150-9
Rattus norvegicus Muscarinic acetylcholine receptor M1 IC50 113.0 nM 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor M1 IC50 360.0 nM 10.1016/S0960-894X(01)80787-3
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 120.0 nM 10.1021/jm00075a007
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 196.0 nM 10.1021/jm00087a008
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 1584893192461111.0 nM 10.1021/jm9708588
Rattus norvegicus Muscarinic acetylcholine receptor M1 pD2 7.1 None 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor M1 pD2 8.0 None 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ratio 0.03 None 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ratio 1.0 None 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ratio 40.4 None 10.1021/jm00079a002
Rattus norvegicus Muscarinic acetylcholine receptor M1 Response 13.7 % 10.1021/jm00087a008
Rattus norvegicus Muscarinic acetylcholine receptor M2 IC50 84.0 nM 10.1016/S0960-894X(97)00150-9
Rattus norvegicus Muscarinic acetylcholine receptor M2 IC50 858.0 nM 10.1016/S0960-894X(00)80535-1
Rattus norvegicus Muscarinic acetylcholine receptor M2 IC50 860.0 nM 10.1016/S0960-894X(01)80787-3
Rattus norvegicus Muscarinic acetylcholine receptor M2 IC50 2000.0 nM 10.1016/S0960-894X(97)00150-9
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ki 0.5 nM 10.1021/jm00075a007
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ki 60.0 nM 10.1021/jm00075a007
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ki 84.0 nM 10.1021/jm00087a008
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ki 160.0 nM 10.1021/jm00075a007
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ki 5011872336272715.0 nM 10.1021/jm9708588
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ratio 35.0 None 10.1021/jm00174a015
Rattus norvegicus Muscarinic acetylcholine receptor M2 Ratio 120.0 None 10.1021/jm00075a007
Rattus norvegicus Muscarinic acetylcholine receptor M2 Response 59.4 % 10.1021/jm00087a008
Rattus norvegicus Muscarinic acetylcholine receptor M3 Ki 2511886431509582.0 nM 10.1021/jm9708588
Rattus norvegicus Muscarinic receptor M1 and M2 Ratio 0.04 None 10.1021/jm00075a007
Rattus norvegicus Muscarinic receptor M1 and M2 Ratio 1.3 None 10.1021/jm00075a007
Rattus norvegicus Muscarinic receptor M1 and M2 Ratio 32.0 None 10.1021/jm00075a007
Rattus norvegicus Muscarinic receptor M1 and M2 Ratio 120.0 None 10.1021/jm00174a015
Rattus norvegicus Muscarinic receptor M1 and M2 Selectivity ratio 0.32 None 10.1021/jm9708588
Rattus norvegicus Muscarinic receptor M2 and M3 Selectivity ratio 2.0 None 10.1021/jm9708588
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm981048e
Rattus norvegicus Rattus norvegicus ED50 4.4e-08 M 10.1021/jm9708588
Rattus norvegicus Rattus norvegicus ED50 0.3 mg.kg-1 10.1021/jm981048e
Rattus norvegicus Rattus norvegicus IC50 nan nM 10.1021/jm9506433
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Staphylococcus aureus Staphylococcus aureus Inhibition -8.85 % 10.6019/CHEMBL4296182
Trypanosoma brucei 6-phospho-1-fructokinase Potency 8492.1 nM None
None ADMET Binding energy 11.7 kCal mol-1 10.1021/jm00378a021
None ADMET Ratio 1.0 None 10.1021/jm00396a024
None No relevant target pKa 8.4 None 10.1007/s11095-013-1232-z
None Unchecked Agonist index 310.0 None 10.1021/jm00012a019
None Unchecked EPMR 49.0 None 10.1021/jm00150a004
None Unchecked IC50 5.0 nM 10.1021/jm981048e
None Unchecked Ratio 9.5 None 10.1016/S0960-894X(97)00150-9
None Unchecked Ratio 120.0 None 10.1016/S0960-894X(00)80539-9
None Unchecked Ratio 162.0 None 10.1016/S0960-894X(97)00150-9
None Unchecked Ratio 308.0 None 10.1016/S0960-894X(01)80787-3
None Unchecked Ratio 4500.0 None 10.1021/jm9904001
None Unchecked Selectivity ratio 0.63 None 10.1021/jm9708588
None Unchecked Selectivity ratio 2.4 None 10.1016/S0960-894X(00)80535-1

Metabolism Information