Arphamenin A
AlkaPlorer ID: AK041327
Synonym: 'Arphamenine A'
IUPAC Name: (2R,5S)-5-amino-2-benzyl-8-(diaminomethylideneamino)-4-oxooctanoic acid
Structure
SMILES: N=C(N)NCCC[C@H](N)C(=O)C[C@@H](CC1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C16H24N4O3/c17-13(7-4-8-20-16(18)19)14(21)10-12(15(22)23)9-11-5-2-1-3-6-11/h1-3,5-6,12-13H,4,7-10,17H2,(H,22,23)(H4,18,19,20)/t12-,13+/m1/s1
InChIKey: FQRLGZIGRMSTAX-OLZOCXBDSA-N
Reference
Arphamenines A and B,new inhibitors of aminopeptidase B,produced by bacteria.
PubChem CID: 5487158
LOTUS: LTS0239465
SuperNatural Ⅲ: SN0092932-04
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Chromobacterium violaceum | Chromobacterium | Chromobacteriaceae | Neisseriales | Betaproteobacteria | Pseudomonadota | None | Bacteria |
Properties Information
Molecule Weight: 320.39300000000003
TPSA？: 142.29
MolLogP？: 0.4796700000000006
Number of H-Donors: 5
Number of H-Acceptors: 4
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | Aminopeptidase B | Ki | 2.5 | nM | 10.1021/jm00126a039 |
| Rattus norvegicus | Cystinyl aminopeptidase | Ki | 100.0 | ug ml-1 | 10.1021/jm00126a039 |