Spindomycin A
AlkaPlorer ID: AK042685
Synonym: None
IUPAC Name: (5R,6S,7R)-5-hydroxy-1',6-dimethylspiro[2,3,5,6-tetrahydro-1H-indene-7,3'-indole]-2',4-dione
Structure
SMILES: C[C@@H]1[C@@H](O)C(=O)C2=C(CCC2)[C@]12C(=O)N(C)C1=CC=CC=C12
InChI: InChI=1S/C18H19NO3/c1-10-15(20)16(21)11-6-5-8-12(11)18(10)13-7-3-4-9-14(13)19(2)17(18)22/h3-4,7,9-10,15,20H,5-6,8H2,1-2H3/t10-,15-,18-/m1/s1
InChIKey: XYZWUTVMGFJRHN-QEIWDELWSA-N
Reference
Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9
PubChem CID: 118714680
LOTUS: LTS0129546
{NPAtlas: NPA005992
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. Xzqh-9 | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 297.354
TPSA？: 57.61
MolLogP？: 1.961
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | Inhibition | 10.0 | % | 10.1016/j.bmcl.2014.09.026 |
| Homo sapiens | HepG2 | Inhibition | 10.0 | % | 10.1016/j.bmcl.2014.09.026 |
| Homo sapiens | L-lactate dehydrogenase | Inhibition | nan | % | 10.1016/j.bmcl.2014.09.026 |
| Homo sapiens | MCF7 | Inhibition | 10.0 | % | 10.1016/j.bmcl.2014.09.026 |
| None | NON-PROTEIN TARGET | Inhibition | 10.0 | % | 10.1016/j.bmcl.2014.09.026 |
| None | No relevant target | Rf | 0.8 | None | 10.1016/j.bmcl.2014.09.026 |
| None | Unchecked | Inhibition | nan | % | 10.1016/j.bmcl.2014.09.026 |