Lyfoline
AlkaPlorer ID: AK044786
Synonym: None
IUPAC Name: (1S,13Z,17S,19R)-4,9-dihydroxy-5-methoxy-16-oxa-24-azapentacyclo[15.7.1.18,12.02,7.019,24]hexacosa-2,4,6,8,10,12(26),13-heptaen-15-one
Structure
SMILES: COC1=C(O)C=C2C(=C1)C1=CC(=CC=C1O)/C=C\C(=O)O[C@H]1C[C@H]3CCCCN3[C@H]2C1
InChI: InChI=1S/C25H27NO5/c1-30-24-14-18-19(13-23(24)28)21-12-17(11-16-4-2-3-9-26(16)21)31-25(29)8-6-15-5-7-22(27)20(18)10-15/h5-8,10,13-14,16-17,21,27-28H,2-4,9,11-12H2,1H3/b8-6-/t16-,17+,21+/m1/s1
InChIKey: CDTGNBVPXHNHGE-RDOPERODSA-N
Reference
The Structure of 10-epi-Lyfoline, a Novel Alkaloid from Heimia montana
PubChem CID: 6436825
CAS: 30356-01-5
LOTUS: LTS0099445
SuperNatural Ⅲ: SN0042967-04
NPASS: NPC32154
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Heimia salicifolia | Heimia | Lythraceae | Myrtales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 421.4930000000003
TPSA？: 79.22999999999999
MolLogP？: 4.401400000000003
Number of H-Donors: 2
Number of H-Acceptors: 6
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 2.8 | ug.mL-1 | 10.1016/j.bmc.2009.02.050 |