Molecule

Lipstatin

AlkaPlorer ID: AK045209

Synonym: None

IUPAC Name: [(2S,4Z,7Z)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl] (2S)-2-formamido-4-methylpentanoate

Structure

SMILES: CCCCC/C=C\C/C=C\C[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)N=CO

InChI: InChI=1S/C29H49NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h12-13,15-16,22-27H,5-11,14,17-21H2,1-4H3,(H,30,31)/b13-12-,16-15-/t24-,25-,26-,27-/m0/s1

InChIKey: OQMAKWGYQLJJIA-CUOOPAIESA-N

Reference

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.

PubChem CID: 9805651

LOTUS: LTS0016616

SuperNatural Ⅲ: SN0272551-02

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NPAtlas: NPA016962

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
None	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 491.7130000000004

TPSA？: 85.19000000000001

MolLogP？: 7.274200000000007

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Sus scrofa	Pancreatic triacylglycerol lipase	IC50	140.0	nM	10.1016/j.ejmech.2022.114405