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4-Methoxybenzoic acid; Hydrazide

AlkaPlorer ID: AK045518

Synonym: None

IUPAC Name: 4-methoxybenzohydrazide

Structure

SMILES: COC1=CC=C(C(=O)NN)C=C1

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InChI: InChI=1S/C8H10N2O2/c1-12-7-4-2-6(3-5-7)8(11)10-9/h2-5H,9H2,1H3,(H,10,11)

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InChIKey: REKQLYUAUXYJSZ-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 166.17999999999998

TPSA？: 64.35

MolLogP？: 0.2986999999999999

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Capra hircus Cathepsin B Activity 15.48 % 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin B Ki 640.0 nM 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin H Activity 45.0 % 10.1016/j.ejmech.2014.03.007
Capra hircus Cathepsin H Ki 588000.0 nM 10.1016/j.ejmech.2014.03.007
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 23099.9 nM None
Homo sapiens Carbonic anhydrase I Ki 7840.0 nM 10.1016/j.bmcl.2011.02.057
Homo sapiens Carbonic anhydrase II Ki 5750.0 nM 10.1016/j.bmcl.2011.02.057
Homo sapiens DNA polymerase iota Potency 89125.1 nM None
Homo sapiens microRNA 21 Potency 9268.3 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 35481.3 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 2818.4 nM None
Mycobacterium tuberculosis Mycobacterium tuberculosis log(1/MIC) -0.9031 None 10.1016/j.ejmech.2013.10.029
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.10.029
Plasmodium falciparum Plasmodium falciparum Potency 10417.9 nM None
None No relevant target LogP -0.926 None 10.1016/j.ejmech.2013.10.029
None Unchecked Activity 0.0 % 10.1016/j.ejmech.2014.03.007
None Unchecked Ki 87.0 nM 10.1016/j.bmcl.2011.02.057
None Unchecked Ki 810.0 nM 10.1016/j.bmcl.2011.02.057
None Unchecked Potency 6309.6 nM None
None Unchecked Ratio Ki 7.09 None 10.1016/j.bmcl.2011.02.057
None Unchecked Ratio Ki 66.1 None 10.1016/j.bmcl.2011.02.057

Metabolism Information