Navigation

name Structure Reference Source Properties Activities Metabolism

(6Z,10S,11R,19Z,23R)-1,14-diazatetracyclo[21.3.1.110,14.011,25]octacosa-6,19,24-triene

AlkaPlorer ID: AK047200

Synonym: None

IUPAC Name: (6Z,10S,11R,19Z,23R)-1,14-diazatetracyclo[21.3.1.110,14.011,25]octacosa-6,19,24-triene

Structure

SMILES: C1=C2CN3CCCC/C=C\CC[C@@H]4CN(CCCC/C=C\CC[C@H]1C3)CC[C@@H]24

copy

InChI: InChI=1S/C26H42N2/c1-3-7-11-16-27-18-15-26-24(21-27)14-10-6-2-4-8-12-17-28-20-23(13-9-5-1)19-25(26)22-28/h1-2,5-6,19,23-24,26H,3-4,7-18,20-22H2/b5-1-,6-2-/t23-,24-,26-/m1/s1

copy

InChIKey: UOAQLFVPXKOHCQ-ZUCXHZAFSA-N

copy

Reference

PubChem CID: 10628969

NPASS: NPC487842

Properties Information

Molecule Weight: 382.6360000000002

TPSA？: 6.48

MolLogP？: 5.823300000000007

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens CDK9/cyclin T1 Inhibition nan % 10.1021/acs.jnatprod.6b00939
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition nan % 10.1021/acs.jnatprod.6b00939
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition nan % 10.1021/acs.jnatprod.6b00939
Homo sapiens HeLa IC50 12000.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome component C5 IC50 480.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome Macropain subunit IC50 6300.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome Macropain subunit MB1 IC50 420.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome subunit beta type-10 IC50 8000.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome subunit beta type-8 IC50 630.0 nM 10.1016/j.bmcl.2018.11.028
Homo sapiens Proteasome subunit beta type-9 IC50 440.0 nM 10.1016/j.bmcl.2018.11.028
Mus musculus Dual specificity protein kinase CLK1 Inhibition nan % 10.1021/acs.jnatprod.6b00939
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.6b00939

Metabolism Information