Ochrolifuanine A
AlkaPlorer ID: AK048555
Synonym: None
IUPAC Name: (2S,3R,12bS)-3-ethyl-2-[[(1R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizine
Structure
SMILES: CC[C@H]1CN2CCC3C4=CC=CC=C4NC3[C@@H]2C[C@@H]1C[C@H]1NCCC2=C1NC1=CC=CC=C21
InChI: InChI=1S/C29H36N4/c1-2-18-17-33-14-12-23-21-8-4-6-10-25(21)32-29(23)27(33)16-19(18)15-26-28-22(11-13-30-26)20-7-3-5-9-24(20)31-28/h3-10,18-19,23,26-27,29-32H,2,11-17H2,1H3/t18-,19-,23?,26+,27-,29?/m0/s1
InChIKey: WPRCHZNIQPXBQO-IWOKYBKVSA-N
Reference
Antiplasmodial Activity of Alkaloids from Various <i>Strychnos</i> Species
PubChem CID: 44559929
LOTUS: LTS0118220
NPASS: NPC221786
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Strychnos potatorum | Strychnos | Loganiaceae | Gentianales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| Senna tora | Senna | Fabaceae | Fabales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 440.6350000000002
TPSA？: 43.09
MolLogP？: 5.443100000000005
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 7
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Entamoeba histolytica | Entamoeba histolytica | IC50 | 1.3 | ug.mL-1 | 10.1007/s00044-011-9767-1 |
| Homo sapiens | HCT-116 | IC50 | 16100.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 118.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 266.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 492.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 495.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 1020.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 1380.0 | nM | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 32.8 | None | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 60.7 | None | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 136.0 | None | 10.1021/np020070e |