Ochrolifuanine A
AlkaPlorer ID: AK048556
Synonym: None
IUPAC Name: (2S,3R,12bR)-3-ethyl-2-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizine
Structure
SMILES: CC[C@H]1CN2CCC3C4=CC=CC=C4NC3[C@H]2C[C@@H]1C[C@@H]1NCCC2=C1NC1=CC=CC=C21
InChI: InChI=1S/C29H36N4/c1-2-18-17-33-14-12-23-21-8-4-6-10-25(21)32-29(23)27(33)16-19(18)15-26-28-22(11-13-30-26)20-7-3-5-9-24(20)31-28/h3-10,18-19,23,26-27,29-32H,2,11-17H2,1H3/t18-,19-,23?,26-,27+,29?/m0/s1
InChIKey: WPRCHZNIQPXBQO-QTZZMGCWSA-N
Reference
Antiplasmodial Activity of Alkaloids from Various <i>Strychnos</i> Species
PubChem CID: 44559859
LOTUS: LTS0061702
NPASS: NPC474880
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Strychnos potatorum | Strychnos | Loganiaceae | Gentianales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 440.6350000000002
TPSA？: 43.09
MolLogP？: 5.443100000000005
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 7
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HCT-116 | IC50 | 5700.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 276.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 702.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 1900.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 1490.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 2420.0 | nM | 10.1021/np020070e |
| Plasmodium falciparum | Plasmodium falciparum | IC90 | 6760.0 | nM | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 3.0 | None | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 8.12 | None | 10.1021/np020070e |
| None | Unchecked | Ratio IC50 | 20.7 | None | 10.1021/np020070e |