Molecule

5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione

AlkaPlorer ID: AK050377

Synonym: None

IUPAC Name: 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Structure

SMILES: CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1

InChI: InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)

InChIKey: YASAKCUCGLMORW-UHFFFAOYSA-N

Reference

PubChem CID: 77999

CAS: 122320-73-4

NPASS: NPC479399

COCONUT: CNP0183528

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Tadehagi triquetrum	Tadehagi	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Scedosporium apiospermum	Scedosporium	Microascaceae	Microascales	Sordariomycetes	Ascomycota	Fungi	Eukaryota
Liriope spicata	Liriope	Asparagaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Murraya koenigii	Murraya	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Trigonella stellata	Trigonella	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 357.435

TPSA？: 71.53

MolLogP？: 2.490900000000001

Number of H-Donors: 1

Number of H-Acceptors: 6

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bos taurus	Progesterone receptor	IC50	nan	None	None
Bos taurus	Progesterone receptor	Ki	nan	None	None
Canis lupus familiaris	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/jm900097m
Cavia porcellus	Leukotriene C4 synthase	IC50	nan	None	None
Cavia porcellus	Leukotriene C4 synthase	Ki	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	IC50	nan	None	None
Cavia porcellus	Serotonin 4 (5-HT4) receptor	Ki	nan	None	None
Chlorocebus aethiops	COS-1	Activity	95.0	%	10.1016/j.ejmech.2018.06.034
Hepatitis B virus	Hepatitis B virus	IC50	5100.0	nM	10.1021/acs.jmedchem.2c01097
Homo sapiens	15-hydroxyprostaglandin dehydrogenase [NAD+]	Potency	28183.8	nM	None
Homo sapiens	Acetylcholinesterase	IC50	nan	None	None
Homo sapiens	Acetylcholinesterase	Ki	nan	None	None
Homo sapiens	Adenosine A1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A1 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A1 receptor	Ki	nan	None	None
Homo sapiens	Adenosine A2a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A2a receptor	IC50	nan	None	None
Homo sapiens	Adenosine A2a receptor	Ki	nan	None	None
Homo sapiens	Adenosine A3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A3 receptor	IC50	nan	None	None
Homo sapiens	Adenosine A3 receptor	Ki	nan	None	None
Homo sapiens	Alpha-1a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	10999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1d adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-1d adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	AC50	8600.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2a adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2b adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2b adrenergic receptor	Ki	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2c adrenergic receptor	IC50	nan	None	None
Homo sapiens	Alpha-2c adrenergic receptor	Ki	nan	None	None
Homo sapiens	AMP-activated protein kinase, AMPK	Activity	nan	None	10.1016/j.ejmech.2017.09.049
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	IC50	nan	None	None
Homo sapiens	Angiotensin II type 2 (AT-2) receptor	Ki	nan	None	None
Homo sapiens	Aquaporin-2	Activity	nan	None	10.1016/j.ejmech.2018.10.006
Homo sapiens	Beta-1 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-1 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-1 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-2 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-3 adrenergic receptor	IC50	nan	None	None
Homo sapiens	Beta-3 adrenergic receptor	Ki	nan	None	None
Homo sapiens	Bile acid receptor FXR	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bile acid transporter	IC50	5100.0	nM	10.1016/j.bmcl.2019.126623
Homo sapiens	Bile salt export pump	AC50	1000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bile salt export pump	IC50	2800.0	nM	10.1093/toxsci/kft176
Homo sapiens	Bile salt export pump	IC50	3750.0	nM	10.1002/hep.27206
Homo sapiens	Bile salt export pump	IC50	3800.0	nM	10.1021/acs.jmedchem.0c00524
Homo sapiens	Bile salt export pump	IC50	4400.0	nM	10.1093/toxsci/kfq269
Homo sapiens	Bile salt export pump	IC50	6362.0	nM	10.1124/dmd.112.047068
Homo sapiens	Bile salt export pump	IC50	6400.0	nM	10.1124/dmd.111.040758
Homo sapiens	Bradykinin B1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bradykinin B2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bradykinin B2 receptor	IC50	nan	None	None
Homo sapiens	Bradykinin B2 receptor	Ki	nan	None	None
Homo sapiens	Bromodomain-containing protein 4	Delta TM	-0.01567	C	None
Homo sapiens	Caco-2	Activity	100.0	%	10.1016/j.bmcl.2009.03.143
Homo sapiens	Calcitonin receptor	IC50	nan	None	None
Homo sapiens	Calcitonin receptor	Ki	nan	None	None
Homo sapiens	Canalicular multispecific organic anion transporter 1	Activity	nan	None	10.1093/toxsci/kft176
Homo sapiens	Canalicular multispecific organic anion transporter 2	IC50	133000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Cannabinoid CB1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	AC50	16000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	IC50	nan	None	None
Homo sapiens	Cannabinoid CB1 receptor	Ki	nan	None	None
Homo sapiens	Carbonic anhydrase II	IC50	4069.0	nM	None
Homo sapiens	Carbonic anhydrase II	Ki	nan	None	None
Homo sapiens	Carnitine O-palmitoyltransferase 1, liver isoform	IC50	10000.0	nM	10.6019/CHEMBL3431459
Homo sapiens	Carnitine O-palmitoyltransferase 1, muscle isoform	IC50	100000.0	nM	10.6019/CHEMBL3431459
Homo sapiens	Carnitine palmitoyltransferase 2	IC50	100000.0	nM	10.6019/CHEMBL3431459
Homo sapiens	Casein kinase I delta	Delta TM	0.07009	C	None
Homo sapiens	Caspase-1	IC50	nan	None	None
Homo sapiens	Caspase-1	Ki	nan	None	None
Homo sapiens	Cathepsin G	IC50	nan	None	None
Homo sapiens	Cathepsin G	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 2	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 4	Ki	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	IC50	nan	None	None
Homo sapiens	C-C chemokine receptor type 5	Ki	nan	None	None
Homo sapiens	CDGSH iron-sulfur domain-containing protein 1	IC50	731.0	nM	10.1016/j.bmcl.2016.09.009
Homo sapiens	CDGSH iron-sulfur domain-containing protein 1	Ki	31.0	nM	10.1016/j.bmcl.2016.09.009
Homo sapiens	CDGSH iron-sulfur domain-containing protein 2	IC50	2290.0	nM	10.1016/j.bmcl.2019.01.041
Homo sapiens	CDGSH iron-sulfur domain-containing protein 2	Inhibition	nan	%	10.1016/j.bmcl.2019.01.041
Homo sapiens	Cholecystokinin A receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cholecystokinin A receptor	IC50	nan	None	None
Homo sapiens	Cholecystokinin A receptor	Ki	nan	None	None
Homo sapiens	Cholecystokinin B receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Corticotropin releasing factor receptor 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Corticotropin releasing factor receptor 2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cyclin-dependent kinase 2	Delta TM	0.1369	C	None
Homo sapiens	Cyclooxygenase-1	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-1	Ki	nan	None	None
Homo sapiens	Cyclooxygenase-2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cyclooxygenase-2	IC50	nan	None	None
Homo sapiens	Cyclooxygenase-2	Ki	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	IC50	nan	None	None
Homo sapiens	Cysteinyl leukotriene receptor 1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 1A2	IC50	nan	None	None
Homo sapiens	Cytochrome P450 1A2	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 1A2	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 1A2	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2A6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2A6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2B6	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 2C19	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C19	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 2C19	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2C19	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2C8	Activity	nan	None	None
Homo sapiens	Cytochrome P450 2C8	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 2C9	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 2C9	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2C9	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2D6	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2D6	Inhibition	10.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 2D6	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 2D6	Ki	nan	None	None
Homo sapiens	Cytochrome P450 2E1	IC50	nan	None	None
Homo sapiens	Cytochrome P450 2E1	Ki	nan	None	None
Homo sapiens	Cytochrome P450 3A4	IC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	Inhibition	56.0	%	10.1124/dmd.111.039180
Homo sapiens	Cytochrome P450 3A4	Inhibition	nan	%	10.1021/tx300075j
Homo sapiens	Cytochrome P450 3A4	Ki	nan	None	None
Homo sapiens	Cytochrome P450 3A4	Potency	7943.3	nM	None
Homo sapiens	Delta opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Delta opioid receptor	IC50	nan	None	None
Homo sapiens	Delta opioid receptor	Ki	nan	None	None
Homo sapiens	Dopamine D1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D1 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D1 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D2 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D2 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D3 receptor	Ki	nan	None	None
Homo sapiens	Dopamine D4 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D4 receptor	IC50	nan	None	None
Homo sapiens	Dopamine D4 receptor	Ki	nan	None	None
Homo sapiens	Dopamine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	IC50	nan	None	None
Homo sapiens	Dopamine transporter	Ki	nan	None	None
Homo sapiens	DU-145	IC50	16000.0	nM	10.1016/j.ejmech.2014.06.013
Homo sapiens	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Potency	31622.8	nM	None
Homo sapiens	Endothelin receptor ET-A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Endothelin receptor ET-A	IC50	nan	None	None
Homo sapiens	Endothelin receptor ET-A	Ki	nan	None	None
Homo sapiens	Endothelin receptor ET-B	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Epidermal growth factor receptor erbB1	IC50	nan	None	None
Homo sapiens	Epidermal growth factor receptor erbB1	Ki	nan	None	None
Homo sapiens	Equilibrative nucleoside transporter 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	IC50	nan	None	None
Homo sapiens	Estrogen receptor alpha	Ki	nan	None	None
Homo sapiens	Estrogen receptor beta	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor beta	IC50	nan	None	None
Homo sapiens	Estrogen receptor beta	Ki	nan	None	None
Homo sapiens	Fibroblast	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	Fibroblast	Growth Rate	1.0	None	10.6019/CHEMBL4689842
Homo sapiens	Fibroblast growth factor receptor 3	Delta TM	0.1436	C	None
Homo sapiens	Free fatty acid receptor 1	EC50	11481.54	nM	10.1016/j.bmcl.2014.07.043
Homo sapiens	Free fatty acid receptor 1	EC50	nan	None	10.1016/j.bmc.2022.116615
Homo sapiens	Free fatty acid receptor 1	EC50	nan	None	10.1016/j.ejmech.2018.09.071
Homo sapiens	Free fatty acid receptor 1	EC50	nan	None	10.1016/j.ejmech.2021.114061
Homo sapiens	GABA-B receptor 1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Gastric inhibitory polypeptide receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Ghrelin receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucagon receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucocorticoid receptor	IC50	nan	None	None
Homo sapiens	Glucocorticoid receptor	Ki	nan	None	None
Homo sapiens	Glycogen synthase kinase-3 beta	Delta TM	-0.5207	C	None
Homo sapiens	HEK293	Activity	46.0	%	10.1021/jm900964r
Homo sapiens	HEK293	Activity	nan	None	10.1016/j.bmcl.2017.04.061
Homo sapiens	HEK293	GI	5.0	%	10.1016/j.bmc.2015.11.013
Homo sapiens	HEK-293T	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	HEK-293T	Growth Rate	1.0	None	10.6019/CHEMBL4689842
Homo sapiens	HepaRG	Activity	nan	None	10.1016/j.ejmech.2022.114240
Homo sapiens	HepG2	Activity	2.53	mM	10.1016/j.bmcl.2015.02.021
Homo sapiens	HepG2	Activity	7.0	%	10.1016/j.ejmech.2017.09.049
Homo sapiens	HepG2	Activity	13.87	%	10.1016/j.bmcl.2019.126709
Homo sapiens	HepG2	Activity	15.58	%	10.1016/j.ejmech.2011.02.033
Homo sapiens	HepG2	Activity	26.5	%	10.1016/j.bmcl.2015.02.021
Homo sapiens	HepG2	Activity	29.41	%	10.1016/j.ejmech.2011.02.033
Homo sapiens	HepG2	Activity	50.0	%	10.1016/j.ejmech.2019.05.045
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.bmcl.2010.12.077
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.bmcl.2015.03.020
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.bmcl.2018.11.047
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.ejmech.2017.09.049
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.ejmech.2020.112315
Homo sapiens	HepG2	Activity	nan	None	10.1016/j.ejmech.2021.113542
Homo sapiens	HepG2	Activity	nan	None	10.1021/jm301164y
Homo sapiens	HERG	AC50	12999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	HERG	IC50	29500.0	nM	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	IC50	nan	None	None
Homo sapiens	HERG	Inhibition	9.38	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Inhibition	17.26	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Inhibition	23.29	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Inhibition	30.06	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Inhibition	42.47	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Inhibition	57.9	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	HERG	Ki	nan	None	None
Homo sapiens	Histamine H1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H1 receptor	IC50	nan	None	None
Homo sapiens	Histamine H1 receptor	Ki	nan	None	None
Homo sapiens	Histamine H2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H2 receptor	IC50	nan	None	None
Homo sapiens	Histamine H2 receptor	Ki	nan	None	None
Homo sapiens	Histamine H3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histone deacetylase 6	Inhibition	-4.79	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	27.3	%	10.6019/CHEMBL4808148
Homo sapiens	HMG-CoA reductase	IC50	nan	None	None
Homo sapiens	HMG-CoA reductase	Ki	nan	None	None
Homo sapiens	Homo sapiens	Activity	0.5	%	10.1021/jm8013019
Homo sapiens	Homo sapiens	Activity	nan	None	10.1002/hep.27206
Homo sapiens	Homo sapiens	AUC	2865.6	ng.hr.mL-1	10.1093/toxsci/kft176
Homo sapiens	Homo sapiens	CL	0.65	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL	0.65	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL	0.7	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	CL_renal	0.0	mL.min-1.kg-1	10.1021/jm900403j
Homo sapiens	Homo sapiens	CL_renal	0.0	mL.min-1.kg-1	10.1021/jm901371v
Homo sapiens	Homo sapiens	Cmax	1044.0	nM	10.1002/hep.27206
Homo sapiens	Homo sapiens	Css	0.334	uM	10.1093/toxsci/kft176
Homo sapiens	Homo sapiens	DILI_Concern	nan	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	DILI_severity_class	3.0	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	Fa	1.0	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fa	95.0	%	10.1016/j.bmc.2015.03.071
Homo sapiens	Homo sapiens	F_fraction	0.99	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fg	1.02	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Fh	0.97	None	10.1021/jm901371v
Homo sapiens	Homo sapiens	Vdss	0.2	L.kg-1	10.1021/jm901371v
Homo sapiens	HT-29	Activity	65.0	%	10.1016/j.ejmech.2016.12.047
Homo sapiens	HT-29	IC50	45000.0	nM	10.1021/jm0510880
Homo sapiens	HUVEC	Activity	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	HUVEC	IC50	1100.0	nM	10.1021/acs.jnatprod.9b00003
Homo sapiens	HUVEC	Inhibition	nan	%	10.1021/acs.jnatprod.9b00003
Homo sapiens	Interleukin-8 receptor A	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor A	Ki	nan	None	None
Homo sapiens	Interleukin-8 receptor B	IC50	nan	None	None
Homo sapiens	Interleukin-8 receptor B	Ki	nan	None	None
Homo sapiens	Kappa opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Kappa opioid receptor	IC50	nan	None	None
Homo sapiens	Kappa opioid receptor	Ki	nan	None	None
Homo sapiens	L02	Activity	11.8	%	10.1016/j.ejmech.2018.10.006
Homo sapiens	Leukocyte common antigen	IC50	nan	None	None
Homo sapiens	Leukocyte common antigen	Ki	nan	None	None
Homo sapiens	Leukocyte elastase	IC50	nan	None	None
Homo sapiens	Leukocyte elastase	Ki	nan	None	None
Homo sapiens	Liver microsome	CL	2.2e-05	mL.min-1.g-1	10.1124/dmd.111.039180
Homo sapiens	Liver microsome	Drug metabolism	2.2	pmol/min	10.1124/dmd.111.039180
Homo sapiens	Liver microsome	PB	516.1	pmol	10.1124/dmd.111.039180
Homo sapiens	Liver microsomes	Activity	853.0	pmol	10.1021/tx300075j
Homo sapiens	Liver microsomes	Stability	21.0	%	10.1016/j.bmcl.2009.03.143
Homo sapiens	LXR-alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	LXR-beta	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Lysine-specific demethylase 4D-like	Potency	28183.8	nM	None
Homo sapiens	Lysine-specific histone demethylase 1	Inhibition	nan	%	10.1021/ml200196p
Homo sapiens	MAP kinase ERK1	IC50	nan	None	None
Homo sapiens	MAP kinase ERK1	Ki	nan	None	None
Homo sapiens	MAP kinase ERK2	Delta TM	-0.1666	C	None
Homo sapiens	MAP kinase ERK2	IC50	nan	None	None
Homo sapiens	MAP kinase ERK2	Ki	nan	None	None
Homo sapiens	MAP kinase p38 alpha	IC50	nan	None	None
Homo sapiens	MAP kinase p38 alpha	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase-1	Ki	nan	None	None
Homo sapiens	Matrix metalloproteinase 9	IC50	nan	None	None
Homo sapiens	Matrix metalloproteinase 9	Ki	nan	None	None
Homo sapiens	MCF7	IC50	50000.0	nM	10.1021/jm0510880
Homo sapiens	MCF7	IC50	nan	None	10.1016/j.ejmech.2014.06.013
Homo sapiens	MDA-MB-231	Activity	nan	None	10.1021/acs.jnatprod.0c00642
Homo sapiens	MDA-MB-231	IC50	5230.0	nM	10.1016/j.bmcl.2014.09.042
Homo sapiens	MDA-MB-231	IC50	nan	None	10.1016/j.ejmech.2014.06.013
Homo sapiens	MDA-MB-231	Inhibition	34.23	%	10.1016/j.bmcl.2014.09.042
Homo sapiens	MDA-MB-453	Activity	nan	None	10.1021/acs.jnatprod.0c00642
Homo sapiens	Melanocortin receptor 3	AC50	20799.8	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 3	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 3	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 4	AC50	23700.1	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 4	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 4	Ki	nan	None	None
Homo sapiens	Melanocortin receptor 5	IC50	nan	None	None
Homo sapiens	Melanocortin receptor 5	Ki	nan	None	None
Homo sapiens	Mesenchymal stem cells	Activity	nan	None	10.1021/acs.jmedchem.1c00560
Homo sapiens	Monoamine oxidase A	AC50	8000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Monoamine oxidase A	IC50	nan	None	None
Homo sapiens	Monoamine oxidase A	Ki	27600.0	nM	10.1021/ml200196p
Homo sapiens	Monoamine oxidase A	Ki	nan	None	None
Homo sapiens	Monoamine oxidase B	IC50	832.0	nM	10.1016/j.bmcl.2010.06.128
Homo sapiens	Monoamine oxidase B	IC50	832.0	nM	10.1016/j.bmcl.2022.128994
Homo sapiens	Monoamine oxidase B	Ki	4200.0	nM	10.1021/ml200196p
Homo sapiens	Motilin receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Multidrug resistance-associated protein 4	IC50	21000.0	nM	10.1093/toxsci/kft176
Homo sapiens	Mu opioid receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Mu opioid receptor	IC50	nan	None	None
Homo sapiens	Mu opioid receptor	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M1	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	21999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M2	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M3	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M3	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M4	Ki	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M5	IC50	nan	None	None
Homo sapiens	Muscarinic acetylcholine receptor M5	Ki	nan	None	None
Homo sapiens	NAD-dependent deacetylase sirtuin 1	Activity	5.0	%	10.1016/j.ejmech.2017.06.006
Homo sapiens	Neurokinin 1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neurokinin 1 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 1 receptor	Ki	nan	None	None
Homo sapiens	Neurokinin 2 receptor	IC50	nan	None	None
Homo sapiens	Neurokinin 2 receptor	Ki	nan	None	None
Homo sapiens	Neuronal acetylcholine receptor protein alpha-4 subunit	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 1	Ki	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 2	IC50	nan	None	None
Homo sapiens	Neuropeptide Y receptor type 2	Ki	nan	None	None
Homo sapiens	Neurotensin receptor 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neutrophil	Activity	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	NHDF	Activity	nan	None	10.1021/acs.jmedchem.9b01786
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Norepinephrine transporter	IC50	nan	None	None
Homo sapiens	Norepinephrine transporter	Ki	nan	None	None
Homo sapiens	Nuclear receptor subfamily 1 group I member 3	AC50	17999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	PC-3	FC	0.925	None	10.1038/nchembio790
Homo sapiens	PC-3	IC50	20300.0	nM	10.1016/j.ejmech.2014.06.013
Homo sapiens	Peregrin	Delta TM	-0.5405	C	None
Homo sapiens	Peroxisome proliferator-activated receptor	Activity	nan	None	10.1016/j.ejmech.2022.114240
Homo sapiens	Peroxisome proliferator-activated receptor	EC50	0.043	ug.mL-1	10.1016/j.bmc.2012.01.028
Homo sapiens	Peroxisome proliferator-activated receptor	EC50	1600.0	nM	10.1021/np500234f
Homo sapiens	Peroxisome proliferator-activated receptor	FC	2.0	None	10.1016/j.bmc.2015.11.013
Homo sapiens	Peroxisome proliferator-activated receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	1.0	%	10.1021/jm900097m
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	6.0	%	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	21.0	%	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	23.0	%	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	24.0	%	10.1016/j.bmcl.2007.05.079
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	43.0	%	10.1016/j.bmcl.2007.03.015
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmc.2019.07.032
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmcl.2007.01.060
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.ejmech.2018.06.034
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.ejmech.2022.114240
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/acsmedchemlett.1c00400
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/jm301018z
Homo sapiens	Peroxisome proliferator-activated receptor alpha	CTF	9.11	%	10.1016/j.bmcl.2004.10.042
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4.0	nM	10.1016/j.bmcl.2008.01.067
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	39.0	nM	10.1016/j.bmc.2008.09.045
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	140.0	nM	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	200.0	nM	10.1016/j.bmcl.2004.12.084
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	240.0	nM	10.1016/j.ejmech.2015.12.049
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	1000.0	nM	10.1016/j.bmc.2011.10.020
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3000.0	nM	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3000.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3000.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3000.0	nM	10.1021/jm900367w
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3390.0	nM	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3460.0	nM	10.1016/j.bmcl.2007.04.057
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3460.0	nM	10.1016/j.bmcl.2008.08.020
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	3460.0	nM	10.1021/jm8003416
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4100.0	nM	10.1016/j.bmcl.2004.12.084
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4100.0	nM	10.1016/j.bmcl.2007.03.015
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4100.0	nM	10.1016/s0960-894x(02)00881-8
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4100.0	nM	10.1021/jm010964g
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	4100.0	nM	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	5000.0	nM	10.1016/j.bmcl.2008.01.126
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmc.2011.03.053
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2005.07.049
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2007.05.051
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2007.05.079
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2008.01.067
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2009.02.072
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2009.03.036
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2010.01.089
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.bmcl.2010.11.030
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1016/j.ejmech.2017.06.006
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1021/jm048993p
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1021/jm061202u
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10000.0	nM	10.1021/jm801594x
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	10580.0	nM	10.1016/j.bmcl.2010.02.071
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	12000.0	nM	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	12000.0	nM	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	32000.0	nM	10.1021/jm0496436
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm030621d
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm030631e
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm0502844
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm990554g
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmc.2008.06.050
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmc.2011.11.035
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmc.2022.116615
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmcl.2011.03.020
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.bmcl.2018.03.010
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2014.11.044
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2017.06.033
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2018.09.071
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2021.113388
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2021.113807
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1016/j.ejmech.2021.114061
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/jm101233f
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/jm900941b
Homo sapiens	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1039/C5MD00151J
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	9.0	%	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	9.0	%	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	9.0	%	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	15.0	%	10.1016/j.bmc.2019.115162
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	20.0	%	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	20.0	%	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	20.0	%	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	20.0	%	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	24.0	%	10.1021/jm061202u
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	56.0	%	10.1016/j.bmcl.2007.04.057
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	100.0	%	10.1016/j.bmc.2008.09.045
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	nan	None	10.1021/jm0502844
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Efficacy	nan	None	10.1021/jm900941b
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	28.0	%	10.1016/j.ejmech.2017.06.006
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	56.0	%	10.1021/jm8003416
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	105.0	%	10.1016/j.bmc.2011.11.035
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	120.0	%	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	nan	None	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	nan	None	10.1016/j.ejmech.2014.11.044
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Emax	nan	None	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor alpha	FC	1.2	None	10.1016/j.bmcl.2022.128567
Homo sapiens	Peroxisome proliferator-activated receptor alpha	FC	43.0	None	10.1016/j.ejmech.2015.12.049
Homo sapiens	Peroxisome proliferator-activated receptor alpha	FC	nan	None	10.1016/j.bmc.2008.06.050
Homo sapiens	Peroxisome proliferator-activated receptor alpha	FC	nan	None	10.1016/j.bmcl.2008.08.112
Homo sapiens	Peroxisome proliferator-activated receptor alpha	FC	nan	None	10.1016/j.bmcl.2010.12.032
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Fold activation	1.77	None	10.1021/jm010143b
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Fold activation	43.0	%	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	5.0	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1016/j.bmcl.2004.10.042
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1016/j.bmcl.2009.03.036
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1021/jm021027r
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	10000.0	nM	10.1021/jm0510373
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	15000.0	nM	10.1016/j.bmcl.2008.01.126
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	15000.0	nM	10.1021/jm030621d
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	15000.0	nM	10.1021/jm900326c
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	50000.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	50000.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	50000.0	nM	10.1021/jm048993p
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	50000.0	nM	10.1021/jm900097m
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	50000.0	nM	10.1021/jm900367w
Homo sapiens	Peroxisome proliferator-activated receptor alpha	IC50	100000.0	nM	10.1021/jm0496436
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Inhibition	3.0	%	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Inhibition	21.0	%	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Inhibition	45.0	%	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Inhibition	45.0	%	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Inhibition	nan	%	10.1021/jm300068n
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Kd	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Kd	nan	None	10.1021/jm3013272
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Ki	33300.0	nM	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Ki	nan	nM	10.1016/s0960-894x(99)00603-4
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Ki	nan	nM	10.1021/jm030631e
Homo sapiens	Peroxisome proliferator-activated receptor alpha	%max	6.0	%	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor alpha	%max	23.0	%	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor alpha	%max	24.0	%	10.1016/j.bmcl.2007.05.051
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Max	43.0	%	10.1016/s0960-894x(02)00881-8
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Max	43.0	%	10.1021/jm010964g
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Max response	210.0	%	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor alpha	Transactivation	15.0	%	10.1016/j.bmcl.2005.07.049
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	7.0	%	10.1016/j.bmcl.2007.03.015
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	10.0	%	10.1016/j.bmcl.2007.05.079
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1016/j.ejmech.2022.114240
Homo sapiens	Peroxisome proliferator-activated receptor delta	Activity	nan	None	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	1000.0	nM	10.1016/j.bmc.2011.10.020
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	3000.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	3000.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	3620.0	nM	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	5248.0	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	8890.0	nM	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	10000.0	nM	10.1016/j.bmc.2011.03.053
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	10000.0	nM	10.1016/j.bmcl.2009.02.072
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	10000.0	nM	10.1016/j.bmcl.2010.11.030
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	10000.0	nM	10.1021/jm801594x
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1016/j.bmcl.2004.12.084
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1021/jm990554g
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.bmc.2022.116615
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.bmcl.2010.02.071
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.bmcl.2018.03.010
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.ejmech.2018.09.071
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.ejmech.2021.113388
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.ejmech.2021.113807
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1016/j.ejmech.2021.114061
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1021/jm101233f
Homo sapiens	Peroxisome proliferator-activated receptor delta	EC50	nan	None	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor delta	Efficacy	10.0	%	10.1021/jm061202u
Homo sapiens	Peroxisome proliferator-activated receptor delta	Efficacy	20.0	%	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor delta	Efficacy	20.0	%	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor delta	Efficacy	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	Peroxisome proliferator-activated receptor delta	Efficacy	nan	None	10.1039/C5MD00151J
Homo sapiens	Peroxisome proliferator-activated receptor delta	Emax	159.0	%	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor delta	Emax	nan	None	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor delta	Emax	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor delta	Emax	nan	None	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor delta	FC	1.2	None	10.1016/j.bmcl.2022.128567
Homo sapiens	Peroxisome proliferator-activated receptor delta	FC	nan	None	10.1016/j.bmc.2008.06.050
Homo sapiens	Peroxisome proliferator-activated receptor delta	FC	nan	None	10.1016/j.bmcl.2008.08.112
Homo sapiens	Peroxisome proliferator-activated receptor delta	FC	nan	None	10.1016/j.bmcl.2010.12.032
Homo sapiens	Peroxisome proliferator-activated receptor delta	Fold activation	7.0	%	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor delta	IC50	5.0	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor delta	IC50	10000.0	nM	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor delta	IC50	50000.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor delta	IC50	50000.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor delta	IC50	50000.0	nM	10.1021/jm030621d
Homo sapiens	Peroxisome proliferator-activated receptor delta	Inhibition	0.0	%	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor delta	Inhibition	nan	%	10.1021/jm300068n
Homo sapiens	Peroxisome proliferator-activated receptor delta	Kd	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor delta	Kd	nan	None	10.1021/jm3013272
Homo sapiens	Peroxisome proliferator-activated receptor delta	Ki	33300.0	nM	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor delta	Ki	nan	nM	10.1016/s0960-894x(99)00603-4
Homo sapiens	Peroxisome proliferator-activated receptor delta	%max	10.0	%	10.1016/j.bmcl.2007.05.051
Homo sapiens	Peroxisome proliferator-activated receptor delta	Max	7.0	%	10.1016/s0960-894x(02)00881-8
Homo sapiens	Peroxisome proliferator-activated receptor delta	Max	7.0	%	10.1021/jm010964g
Homo sapiens	Peroxisome proliferator-activated receptor delta	Max response	83.0	%	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor gamma	AC50	34.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Peroxisome proliferator-activated receptor gamma	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	0.12	uM	10.1016/s0960-894x(03)00401-3
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	0.19	uM	10.1016/s0960-894x(03)00401-3
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	15.0	%	10.1016/j.bmcl.2008.01.067
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	65.0	%	10.1021/acs.jmedchem.0c00048
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	84.0	%	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	85.0	%	10.1016/j.bmcl.2009.03.036
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	85.27	%	10.1016/j.ejmech.2014.09.010
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	86.0	%	10.1021/acsmedchemlett.1c00715
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	100.0	%	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	100.0	%	10.1016/j.bmcl.2013.07.067
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	100.0	%	10.1016/j.ejmech.2017.02.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	100.0	%	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	100.0	%	10.1021/acsmedchemlett.3c00056
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	168.0	%	10.1016/j.bmcl.2005.08.002
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	290.9	%	10.1021/np500234f
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2008.09.045
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2010.09.068
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2012.06.039
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2018.09.005
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2018.10.035
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2022.117130
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2005.01.074
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2012.11.060
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2014.05.034
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2014.09.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2015.08.062
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2016.03.028
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.ejmech.2014.11.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.ejmech.2018.06.034
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.0c00048
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.5b01239
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.8b00835
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.9b01786
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jnatprod.7b00846
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acsmedchemlett.1c00400
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acsmedchemlett.1c00715
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acsmedchemlett.8b00574
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/jm300911g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/jm900326c
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1038/nchembio790
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	CTF	100.0	%	10.1016/j.bmcl.2004.10.042
Homo sapiens	Peroxisome proliferator-activated receptor gamma	deltaT	2.0	degrees C	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Delta Tm	5.0	degrees C	10.1021/acs.jmedchem.1c01542
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	1.0	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	2.4	nM	10.1021/jm300068n
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	2.7	nM	10.1074/jbc.m702316200
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	3.8	nM	10.1074/jbc.m702316200
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	4.0	nM	10.1016/j.bmcl.2005.07.049
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	4.0	nM	10.1016/j.ejmech.2017.06.006
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	4.0	nM	10.1021/acs.jnatprod.9b00003
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	4.0	nM	10.1021/jm3013272
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	8.0	nM	10.1016/j.bmc.2018.10.033
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	9.0	nM	10.1016/j.ejmech.2017.02.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	10.0	nM	10.1016/j.bmcl.2014.09.053
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	10.0	nM	10.1016/j.ejmech.2011.03.040
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	10.0	nM	10.1016/j.ejmech.2013.02.015
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	10.0	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	11.0	nM	10.1016/j.bmcl.2010.02.073
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	11.0	nM	10.1016/j.bmcl.2011.12.066
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	11.0	nM	10.1016/j.ejmech.2012.05.040
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	14.0	nM	10.1016/j.ejmech.2019.111969
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	15.0	nM	10.1016/j.bmcl.2009.02.072
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	18.0	nM	10.1021/acs.jmedchem.8b01848
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1007/s00044-010-9428-9
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1016/j.bmcl.2005.03.092
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1016/j.ejmech.2008.01.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1021/jm030621d
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1021/jm048993p
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1021/jm900097m
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	20.0	nM	10.1021/jm900367w
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	21.0	nM	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	22.0	nM	10.1016/j.bmcl.2005.08.002
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	23.0	nM	10.1016/j.bmcl.2004.10.068
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	26.0	nM	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	27.0	nM	10.1021/acsmedchemlett.1c00715
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	30.0	nM	10.1016/j.bmcl.2007.04.057
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	30.0	nM	10.1016/j.bmcl.2010.01.089
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	30.0	nM	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	33.0	nM	10.1016/j.bmcl.2008.08.020
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	33.0	nM	10.1021/jm8003416
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	35.0	nM	10.1016/j.bmcl.2007.01.060
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	35.0	nM	10.1016/j.bmcl.2010.02.071
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1021/acs.jmedchem.8b00835
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1021/jm0502844
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1021/jm301018z
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1021/jm900941b
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	39.0	nM	10.1039/C5MD00151J
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1016/j.ejmech.2014.11.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1016/j.ejmech.2017.06.033
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1016/j.ejmech.2022.114240
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1021/acsmedchemlett.8b00574
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1021/jm030631e
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	40.0	nM	10.1021/jm800733h
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43.0	nM	10.1016/j.bmc.2011.08.003
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43.0	nM	10.1016/s0960-894x(01)00649-7
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43.0	nM	10.1021/jm101233f
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43.0	nM	10.1021/jm990554g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	45.0	nM	10.1016/j.bmcl.2008.01.126
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	46.0	nM	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	48.0	nM	10.1016/j.bmc.2011.10.020
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	49.0	nM	10.1021/acs.jmedchem.1c01542
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	50.0	nM	10.1016/j.bmc.2008.06.050
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	50.0	nM	10.1016/j.bmc.2009.05.082
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	50.0	nM	10.1016/j.bmcl.2011.03.020
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	52.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	76.0	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	76.0	nM	10.1021/jm0510880
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	82.0	nM	10.1016/j.bmcl.2006.11.050
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	83.0	nM	10.1016/j.bmcl.2018.03.010
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	83.0	nM	10.1021/acs.jmedchem.0c02063
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	87.0	nM	10.1021/acs.jmedchem.5b00849
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	89.13	nM	10.1016/j.bmcl.2010.04.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	89.13	nM	10.1016/s0960-894x(99)00603-4
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	89.13	nM	10.1021/jm9804127
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	95.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1016/j.bmc.2011.03.053
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1016/j.bmc.2012.11.058
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1016/j.bmcl.2010.01.089
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1016/j.bmcl.2010.11.030
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1016/j.ejmech.2018.09.071
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1021/acs.jmedchem.1c01331
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1021/jm100443s
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	100.0	nM	10.1021/jm300911g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	110.0	nM	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	114.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	115.0	nM	10.1021/acs.jmedchem.9b01786
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	117.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1016/j.bmc.2011.11.035
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1016/j.bmcl.2007.10.041
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1016/j.ejmech.2018.09.071
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1016/j.ejmech.2021.114061
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1021/jm0301888
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	120.0	nM	10.1021/jm300068n
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	134.0	nM	10.1016/j.bmc.2022.116615
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	140.0	nM	10.1021/jm0496436
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	144.0	nM	10.1021/acs.jmedchem.1c00560
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	156.0	nM	10.1016/j.ejmech.2021.113807
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	158.0	nM	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	158.0	nM	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	160.0	nM	10.1016/s0960-894x(02)00881-8
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	160.0	nM	10.1021/jm010964g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	160.0	nM	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	169.0	nM	10.1021/acs.jmedchem.1c02002
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	190.0	nM	10.1016/j.bmcl.2007.10.041
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	190.0	nM	10.1021/jm300068n
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	200.0	nM	10.1016/j.bmcl.2007.03.015
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	200.0	nM	10.1016/j.ejmech.2018.06.034
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	200.0	nM	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	210.0	nM	10.1021/acs.jmedchem.9b01786
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	220.0	nM	10.1021/jm0506930
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	220.0	nM	10.1021/jm0510373
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	220.0	nM	10.1021/jm060663c
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	220.0	nM	10.1021/jm801594x
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	223.0	nM	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	223.0	nM	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	240.0	nM	10.1016/j.bmcl.2018.03.051
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	259.42	nM	10.1016/j.bmcl.2019.126709
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	260.0	nM	10.1016/j.bmc.2016.08.045
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	260.0	nM	10.1016/j.bmc.2016.08.067
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	268.0	nM	10.1016/j.bmcl.2004.10.042
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	280.0	nM	10.1021/acs.jmedchem.9b01189
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	296.9	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	300.0	nM	10.1016/j.bmcl.2007.05.051
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	300.0	nM	10.1016/j.bmcl.2007.05.079
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	300.0	nM	10.1016/j.bmcl.2017.05.037
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	300.0	nM	10.1016/j.ejmech.2020.112311
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	308.0	nM	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	308.0	nM	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	308.0	nM	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	308.0	nM	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	310.0	nM	10.1021/jm061202u
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	316.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	320.0	nM	10.1016/j.bmcl.2007.06.073
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	320.0	nM	10.1021/jm060389m
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	326.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	332.0	nM	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	350.0	nM	10.1021/jm101063h
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	396.0	nM	10.1016/j.bmc.2018.09.005
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	396.0	nM	10.1016/j.bmc.2018.09.006
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	450.0	nM	10.1016/j.bmcl.2009.03.036
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	480.6	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	657.0	nM	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	657.0	nM	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	730.0	nM	10.1016/j.ejmech.2017.02.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	900.0	nM	10.1021/np300386d
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	1100.0	nM	10.1016/j.bmcl.2017.04.061
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	2880.0	nM	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43710.0	nM	10.1016/j.bmc.2012.11.040
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	43710.0	nM	10.1021/jm900964r
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	44000.0	nM	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	191500.0	nM	10.1016/j.ejmech.2021.113388
Homo sapiens	Peroxisome proliferator-activated receptor gamma	EC50	10000000.0	nM	10.1016/j.bmcl.2009.04.050
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	80.0	%	10.1021/jm300911g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	94.0	%	10.1016/j.bmcl.2017.04.061
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1016/j.bmc.2012.11.058
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1016/j.bmcl.2007.04.057
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1016/j.bmcl.2017.05.037
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/acs.jnatprod.9b00003
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/jm061202u
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/jm100443s
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/jm800733h
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	%	10.1021/jm900941b
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Efficacy	100.0	None	10.1021/jm0502844
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	13.49	%	10.1016/j.bmc.2010.12.023
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	82.0	%	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	84.0	%	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1016/j.bmcl.2009.04.050
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1016/j.ejmech.2014.10.083
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1016/j.ejmech.2014.11.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1016/j.ejmech.2022.114240
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1021/acs.jmedchem.1c01331
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1021/acs.jmedchem.8b00835
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	100.0	%	10.1021/jm8003416
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	104.0	%	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	105.0	%	10.1021/jm201061j
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	106.0	%	10.1016/j.bmcl.2010.02.073
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	106.0	%	10.1016/j.bmcl.2011.12.066
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	106.0	%	10.1016/j.ejmech.2012.05.040
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	136.0	%	10.1016/j.bmc.2011.11.035
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Emax	nan	None	10.1021/acs.jmedchem.1c01542
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	2.9	None	10.1021/jm900964r
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	3.0	None	10.1016/j.ejmech.2018.08.082
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	3.5	None	10.1021/acs.jnatprod.7b00707
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	3.83	None	10.1016/j.ejmech.2017.06.033
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	4.2	None	10.1021/jm900964r
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	7.22	None	10.1016/j.bmcl.2010.12.032
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	9.7	None	10.1016/j.bmcl.2008.07.034
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	10.2	None	10.1016/j.bmcl.2008.08.112
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	11.6	None	10.1016/j.bmc.2008.06.050
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	13.1	None	10.1016/j.bmcl.2022.128567
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	18.5	None	10.1039/C3MD00377A
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	25.0	None	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	43.1	None	10.1016/j.bmcl.2018.03.051
Homo sapiens	Peroxisome proliferator-activated receptor gamma	FC	50.0	None	10.1021/acs.jnatprod.9b01284
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold activation	9.0	None	10.1016/j.bmcl.2005.05.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold activation	18.4	None	10.1021/jm010143b
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold activation	28.0	None	10.1016/j.bmcl.2005.05.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold activation	100.0	%	10.1021/jm0309046
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold activation	176.0	None	10.1016/j.bmcl.2005.05.031
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Fold change	27.2	None	10.1016/j.ejmech.2006.11.005
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	7.7	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	10.0	nM	10.1016/j.bmc.2016.03.006
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	10.0	nM	10.1016/j.bmc.2016.11.014
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	11.0	nM	10.1016/j.ejmech.2013.01.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	12.0	nM	10.1016/j.bmc.2013.03.016
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	38.0	nM	10.1016/j.ejmech.2015.11.030
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	43.0	nM	10.1016/j.bmcl.2008.01.126
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	48.0	nM	10.1016/j.bmcl.2006.09.028
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	48.0	nM	10.1021/jm0155188
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	67.0	nM	10.1016/j.bmcl.2006.09.011
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	67.0	nM	10.1016/j.bmcl.2006.11.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	67.0	nM	10.1016/j.bmcl.2007.10.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	67.0	nM	10.1021/jm060617c
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	70.0	nM	10.1016/j.bmcl.2004.10.042
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	75.52	nM	10.1016/j.bmcl.2015.04.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	76.0	nM	10.1016/j.bmcl.2019.126664
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	88.4	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	90.0	nM	10.1016/j.bmcl.2006.08.003
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	90.0	nM	10.1021/acsmedchemlett.1c00715
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	92.0	nM	10.1021/jm0506930
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	92.0	nM	10.1021/jm0510373
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	103.0	nM	10.1016/j.ejmech.2017.07.015
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	112.0	nM	10.1016/j.bmc.2018.10.033
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	159.0	nM	10.1016/j.bmcl.2013.09.010
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	199.0	nM	10.1016/j.bmc.2010.09.068
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	200.0	nM	10.1016/j.bmc.2012.11.058
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	200.0	nM	10.1021/jm030621d
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	200.0	nM	10.1021/jm900097m
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	200.0	nM	10.1021/jm900367w
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	210.0	nM	10.1016/j.bmcl.2005.08.002
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	210.0	nM	10.1016/s0960-894x(03)00115-x
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1016/j.bmcl.2005.03.092
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1016/s0960-894x(03)00257-9
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1016/s0960-894x(03)00505-5
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1021/jm048993p
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1021/jm0496436
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	250.0	nM	10.1021/jm900326c
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	256.0	nM	10.1016/j.bmcl.2007.01.060
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	267.0	nM	10.1016/j.ejmech.2009.09.042
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	274.0	nM	10.1016/j.bmc.2008.03.043
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	274.0	nM	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	292.0	nM	10.1016/j.bmc.2017.01.015
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	298.0	nM	10.1016/j.bmc.2017.07.015
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	440.0	nM	10.1021/jm021027r
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	450.0	nM	10.1016/j.bmcl.2009.03.036
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	4400.0	nM	10.1021/acsmedchemlett.1c00715
Homo sapiens	Peroxisome proliferator-activated receptor gamma	IC50	22000.0	nM	10.1016/j.bmcl.2017.04.061
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Inhibition	46.4	%	10.1016/j.bmc.2007.11.062
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Inhibition	50.0	%	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Inhibition	76.72	%	10.1016/j.ejmech.2019.07.043
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Inhibition	nan	%	10.1021/acs.jmedchem.0c00048
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Intrinsic activity	90.0	%	10.1016/j.bmcl.2008.01.126
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Intrinsic activity	101.0	%	10.1016/j.bmcl.2007.01.060
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Intrinsic activity	108.0	%	10.1016/j.bmcl.2007.01.060
Homo sapiens	Peroxisome proliferator-activated receptor gamma	K	0.0164	/s	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	K	3.45	10^5/M/s	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	0.145	/s	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	1.2	nM	10.1016/j.ejmech.2016.12.047
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	7.0	nM	10.1021/jm3013272
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	14.8	nM	10.1074/jbc.m702316200
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	47.6	nM	10.1021/acs.jmedchem.0c01555
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	120.0	nM	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	3300.0	nM	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Kd	4980.0	nM	10.1016/j.bmcl.2006.06.093
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	5.8	nM	10.1016/j.ejmech.2013.01.044
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	8.0	nM	10.1016/j.bmcl.2005.07.049
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	8.0	nM	10.1016/j.bmcl.2008.01.067
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	10.0	nM	10.1016/j.bmc.2012.11.058
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	17.0	nM	10.1021/acs.jmedchem.0c01512
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	26.0	nM	10.1016/j.ejmech.2019.111969
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	27.11	nM	10.1016/j.bmcl.2015.04.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	46.77	nM	10.1016/s0960-894x(99)00603-4
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	46.77	nM	10.1021/jm9804127
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	49.0	nM	10.1016/S0960-894X(97)10017-8
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	50.0	nM	10.1021/jm030631e
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	59.0	nM	10.1016/j.bmcl.2019.126664
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	74.0	nM	10.1021/jm201306q
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	74.0	nM	10.1074/jbc.m702316200
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	120.0	nM	10.1016/s0960-894x(01)00649-7
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	136.0	nM	10.1016/s0960-894x(02)01029-6
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	440.0	nM	10.1016/j.bmcl.2006.08.105
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ki	440.0	nM	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor gamma	%max	84.0	%	10.1016/j.bmc.2009.09.001
Homo sapiens	Peroxisome proliferator-activated receptor gamma	%max	100.0	%	10.1016/j.bmcl.2006.08.110
Homo sapiens	Peroxisome proliferator-activated receptor gamma	%max	100.0	%	10.1016/j.ejmech.2008.01.029
Homo sapiens	Peroxisome proliferator-activated receptor gamma	%max	100.0	%	10.1021/jm060389m
Homo sapiens	Peroxisome proliferator-activated receptor gamma	%max	100.0	%	10.1021/jm501155f
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Max	100.0	%	10.1016/s0960-894x(02)00881-8
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Max	100.0	%	10.1021/jm010964g
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Max. activation	100.0	%	10.1016/j.bmcl.2005.03.092
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Maximal activation	100.0	%	10.1016/j.bmcl.2004.10.068
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Max response	14.0	%	10.1016/j.bmcl.2004.04.053
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	0.06	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	0.1	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	1.9	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	1.95	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	2.3	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	5.73	None	10.1016/j.bmcl.2015.02.021
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	12.2	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	14.2	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio	15.5	None	10.1021/acs.jmedchem.7b01285
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Ratio IC50	5.0	None	10.1016/j.bmc.2010.09.068
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Tm	-0.1	degrees C	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Tm	0.0	degrees C	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Tm	48.8	degrees C	10.1016/j.bmc.2022.116877
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Tm	49.0	degrees C	10.1016/j.bmcl.2013.09.010
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Transactivation	100.0	%	10.1016/j.bmcl.2005.07.049
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4D	AC50	29000.1	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 5A	IC50	nan	None	None
Homo sapiens	Phosphodiesterase 5A	Ki	nan	None	None
Homo sapiens	Plasma	fCmax	0.002	uM	10.1124/dmd.111.040758
Homo sapiens	Platelet activating factor receptor	IC50	nan	None	None
Homo sapiens	Platelet activating factor receptor	Ki	nan	None	None
Homo sapiens	Pregnane X receptor	AC50	14192.5	nM	10.1038/s41467-023-40064-9
Homo sapiens	Pregnane X receptor	AC50	17999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Pregnane X receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Prelamin-A/C	Potency	2.2	nM	None
Homo sapiens	Progesterone receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Protein kinase C alpha	IC50	nan	None	None
Homo sapiens	Protein kinase C alpha	Ki	nan	None	None
Homo sapiens	Protein-tyrosine phosphatase 1B	IC50	30000.0	nM	10.1016/j.bmc.2011.11.035
Homo sapiens	Protein-tyrosine phosphatase 1B	IC50	400000.0	nM	10.1016/j.bmcl.2009.09.020
Homo sapiens	Protein-tyrosine phosphatase 1B	IC50	400000.0	nM	10.1016/j.ejmech.2018.04.061
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	IC50	nan	None	None
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	Ki	nan	None	None
Homo sapiens	Retinoic acid receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Retinoic acid receptor beta	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Retinoic acid receptor gamma	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Retinoid X receptor alpha	Efficacy	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	RXR alpha/PPAR gamma	Activity	nan	None	10.1021/acs.jmedchem.0c01555
Homo sapiens	RXR alpha/PPAR gamma	Activity	nan	None	10.1021/acs.jnatprod.9b00003
Homo sapiens	SCC-15	Activity	25.54	%	10.1016/j.ejmech.2017.09.071
Homo sapiens	SCC-15	Activity	nan	None	10.1016/j.ejmech.2017.09.071
Homo sapiens	Serine/threonine-protein kinase Aurora-A	Delta TM	0.03474	C	None
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	IC50	nan	None	None
Homo sapiens	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	Ki	nan	None	None
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	28000.1	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2a (5-HT2a) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	14000.1	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2b (5-HT2b) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2c (5-HT2c) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 2c (5-HT2c) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 3a (5-HT3a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 6 (5-HT6) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 6 (5-HT6) receptor	IC50	nan	None	None
Homo sapiens	Serotonin 6 (5-HT6) receptor	Ki	nan	None	None
Homo sapiens	Serotonin 7 (5-HT7) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	IC50	nan	None	None
Homo sapiens	Serotonin transporter	Ki	nan	None	None
Homo sapiens	SGBS	Activity	nan	None	10.1016/j.bmc.2019.07.032
Homo sapiens	SGBS	Activity	nan	None	10.1016/j.ejmech.2018.06.034
Homo sapiens	Sigma opioid receptor	IC50	nan	None	None
Homo sapiens	Sigma opioid receptor	Ki	nan	None	None
Homo sapiens	Sodium channel protein type V alpha subunit	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	60.0	%	10.1124/dmd.32.3.291
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	79.1	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Inhibition	-32.1	%	10.1021/jm300212s
Homo sapiens	Solute carrier organic anion transporter family member 2B1	Inhibition	10.0	%	10.1021/jm300212s
Homo sapiens	Thromboxane A2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Thromboxane-A synthase	IC50	3560.0	nM	None
Homo sapiens	Thromboxane-A synthase	Ki	nan	None	None
Homo sapiens	Transcription intermediary factor 1-alpha	Delta TM	-1.646	C	None
Homo sapiens	Type-1 angiotensin II receptor	AC50	17990.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Tyrosine-protein kinase ABL	Delta TM	-0.07749	C	None
Homo sapiens	Tyrosine-protein kinase FYN	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase FYN	Ki	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	IC50	nan	None	None
Homo sapiens	Tyrosine-protein kinase LCK	Ki	nan	None	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	26608.6	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	33498.3	nM	None
Homo sapiens	U2OS	EC50	30.0	nM	10.1016/j.bmcl.2005.10.104
Homo sapiens	U2OS	EC50	nan	None	10.1016/j.bmcl.2005.10.104
Homo sapiens	U2OS	Emax	100.0	%	10.1016/j.bmcl.2005.10.104
Homo sapiens	U2OS	Emax	nan	None	10.1016/j.bmcl.2005.10.104
Homo sapiens	U2OS	Growth Rate	0.0	None	10.6019/CHEMBL4689842
Homo sapiens	U2OS	Growth Rate	1.0	None	10.6019/CHEMBL4689842
Homo sapiens	Ubiquitin carboxyl-terminal hydrolase 1	Potency	5011.9	nM	None
Homo sapiens	Vascular endothelial growth factor receptor 1	IC50	nan	None	None
Homo sapiens	Vascular endothelial growth factor receptor 1	Ki	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	IC50	nan	None	None
Homo sapiens	Vasoactive intestinal polypeptide receptor 1	Ki	nan	None	None
Homo sapiens	Vasopressin V1a receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vasopressin V1a receptor	IC50	nan	None	None
Homo sapiens	Vasopressin V1a receptor	Ki	nan	None	None
Homo sapiens	Vasopressin V2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Mesocricetus auratus	Syrian golden hamster	Activity	nan	None	10.1021/jm061299k
Mus musculus	3T3-L1	Activity	22.05	%	10.1016/j.bmc.2009.05.082
Mus musculus	3T3-L1	Activity	24.0	%	10.1016/j.ejmech.2013.01.054
Mus musculus	3T3-L1	Activity	34.1	%	10.1016/j.bmc.2009.05.082
Mus musculus	3T3-L1	Activity	35.87	%	10.1016/j.ejmech.2007.11.018
Mus musculus	3T3-L1	Activity	38.18	%	10.1016/j.ejmech.2007.11.018
Mus musculus	3T3-L1	Activity	100.0	%	10.1016/j.bmcl.2009.04.050
Mus musculus	3T3-L1	Activity	100.0	%	10.1016/j.ejmech.2013.03.001
Mus musculus	3T3-L1	Activity	118.8	pg/ml	10.1021/jm301164y
Mus musculus	3T3-L1	Activity	157.31	%	10.1016/j.ejmech.2011.02.033
Mus musculus	3T3-L1	Activity	236.0	pg/ml	10.1021/jm301164y
Mus musculus	3T3-L1	Activity	263.0	mg/dl	10.1016/j.bmcl.2012.04.108
Mus musculus	3T3-L1	Activity	335.6	%	10.1021/np2009797
Mus musculus	3T3-L1	Activity	450.32	%	10.1021/np100907d
Mus musculus	3T3-L1	Activity	984.24	%	10.1016/j.bmcl.2011.06.020
Mus musculus	3T3-L1	Activity	1324.73	ng/ml	10.1016/j.ejmech.2011.02.033
Mus musculus	3T3-L1	Activity	1773.67	pg/ml	10.1016/j.ejmech.2011.02.033
Mus musculus	3T3-L1	Activity	nan	None	10.1016/j.ejmech.2018.10.006
Mus musculus	3T3-L1	Activity	nan	None	10.1016/j.ejmech.2021.113542
Mus musculus	3T3-L1	Activity	nan	None	10.1021/acs.jmedchem.0c01555
Mus musculus	3T3-L1	Activity	nan	None	10.1021/acs.jmedchem.8b00835
Mus musculus	3T3-L1	Activity	nan	None	10.1021/jm100443s
Mus musculus	3T3-L1	Activity	nan	None	10.1021/jm200662c
Mus musculus	3T3-L1	Activity	nan	None	10.1021/jm201306q
Mus musculus	3T3-L1	Activity	nan	None	10.1021/np100907d
Mus musculus	3T3-L1	Activity	nan	None	10.1039/C3MD00178D
Mus musculus	3T3-L1	Concentration	nan	None	10.1021/jm0496436
Mus musculus	3T3-L1	EC	0.09	uM	10.1021/jm990522t
Mus musculus	3T3-L1	EC30	2.03e-08	M	10.1016/s0960-894x(03)00734-0
Mus musculus	3T3-L1	EC30	1.05	10'-7M	10.1016/j.bmcl.2009.04.050
Mus musculus	3T3-L1	EC50	120.0	nM	10.1021/acs.jnatprod.9b01096
Mus musculus	3T3-L1	EC50	1720.0	nM	10.1016/j.ejmech.2018.10.006
Mus musculus	3T3-L1	FC	1.0	None	10.1016/j.ejmech.2014.09.010
Mus musculus	3T3-L1	FC	1.5	None	10.1007/s00044-013-0814-y
Mus musculus	3T3-L1	FC	1.5	None	10.1016/j.bmcl.2014.09.044
Mus musculus	3T3-L1	FC	1.52	None	10.1016/j.bmcl.2015.08.062
Mus musculus	3T3-L1	FC	1.7	None	10.1021/np400533h
Mus musculus	3T3-L1	Inhibition	nan	%	10.1016/j.ejmech.2018.10.006
Mus musculus	3T3-L1	Inhibition	nan	%	10.1039/C3MD00178D
Mus musculus	3T3-L1	Insulin-sensitizing activity	100.0	%	10.1016/s0960-894x(03)00734-0
Mus musculus	C2C12	Activity	47.3	%	10.1021/np501049g
Mus musculus	C2C12	Activity	nan	None	10.1016/j.ejmech.2022.114240
Mus musculus	C2C12	Activity	nan	None	10.1021/np501049g
Mus musculus	Cardiotrophin-like cytokine factor 1	Activity	nan	None	10.1021/jm301204r
Mus musculus	Cardiotrophin-like cytokine factor 1	FC	2.56	None	10.1021/jm301204r
Mus musculus	Chloride transport protein 6	Activity	nan	None	10.1021/jm301204r
Mus musculus	Cyclin-dependent kinase 7	Activity	nan	None	10.1021/jm301204r
Mus musculus	Dihydrolipoyl dehydrogenase, mitochondrial	Activity	nan	None	10.1021/jm301204r
Mus musculus	Dynactin subunit 1	Activity	nan	None	10.1021/jm301204r
Mus musculus	Dystonin	Activity	nan	None	10.1021/jm301204r
Mus musculus	Fanconi anemia group M protein homolog	FC	2.94	None	10.1021/jm301204r
Mus musculus	Hepatocyte nuclear factor 6	Activity	nan	None	10.1021/jm301204r
Mus musculus	Importin-7	Activity	nan	None	10.1021/jm301204r
Mus musculus	Malate dehydrogenase, cytoplasmic	Activity	nan	None	10.1021/jm301204r
Mus musculus	Membrane transport protein XK	FC	1.88	None	10.1021/jm301204r
Mus musculus	Multiple PDZ domain protein	Activity	nan	None	10.1021/jm301204r
Mus musculus	Mus musculus	AC50	54.0	%	10.1016/j.bmc.2008.06.050
Mus musculus	Mus musculus	Activity	-5969.0	%	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	-73.0	%	10.1016/j.ejmech.2017.06.006
Mus musculus	Mus musculus	Activity	-57.0	%	10.1016/j.bmcl.2009.03.143
Mus musculus	Mus musculus	Activity	-57.0	%	10.1016/j.ejmech.2017.06.006
Mus musculus	Mus musculus	Activity	-56.0	%	10.1016/j.bmcl.2009.03.143
Mus musculus	Mus musculus	Activity	-55.0	%	10.1016/j.bmcl.2009.03.143
Mus musculus	Mus musculus	Activity	-53.8	%	10.1016/j.bmc.2010.12.023
Mus musculus	Mus musculus	Activity	-52.9	%	10.1016/j.bmc.2009.11.061
Mus musculus	Mus musculus	Activity	-46.0	%	10.1016/j.ejmech.2017.06.006
Mus musculus	Mus musculus	Activity	-41.1	%	10.1016/j.bmc.2010.12.023
Mus musculus	Mus musculus	Activity	-39.0	%	10.1021/jm8001636
Mus musculus	Mus musculus	Activity	-36.6	%	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	-29.0	%	10.1021/jm8001636
Mus musculus	Mus musculus	Activity	-22.6	%	10.1016/j.bmc.2009.11.061
Mus musculus	Mus musculus	Activity	-18.9	%	10.1016/j.bmc.2012.11.058
Mus musculus	Mus musculus	Activity	-18.6	%	10.1016/j.bmc.2012.11.058
Mus musculus	Mus musculus	Activity	-11.6	%	10.1016/j.ejmech.2017.02.031
Mus musculus	Mus musculus	Activity	0.28	ng/ml	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	0.56	%	10.1016/j.bmcl.2009.03.143
Mus musculus	Mus musculus	Activity	0.59	/mmol	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	0.97	ng/ml	10.1016/j.bmcl.2006.08.034
Mus musculus	Mus musculus	Activity	1.06	mmol/L	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	1.06	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	1.08	mM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	1.2	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	1.27	ug ml-1	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	1.29	mmol/L	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	1.29	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	1.46	/mmol	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	1.53	/mmol	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	1.84	mM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	2.27	U/L	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	2.56	%	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	2.56	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	2.6	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	4.45	/mmol	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	4.94	mmol/L	10.1021/np900346d
Mus musculus	Mus musculus	Activity	5.04	mmol/L	10.1021/np900346d
Mus musculus	Mus musculus	Activity	5.2	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	5.28	g	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	5.3	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	5.54	mmol/L	10.1021/np900346d
Mus musculus	Mus musculus	Activity	5.87	ng/ml	10.1016/j.bmc.2009.09.001
Mus musculus	Mus musculus	Activity	6.09	%	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	6.4	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	6.5	mmol/L	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	6.5	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	6.98	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	7.15	ng/ml	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Activity	7.66	mM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	7.7	mmol/L	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	7.7	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	8.0	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	8.31	mM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	8.5	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	8.9	mmol/L	10.1016/j.ejmech.2013.03.037
Mus musculus	Mus musculus	Activity	9.5	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	9.58	mmol/L	10.1021/np900346d
Mus musculus	Mus musculus	Activity	10.1	%	10.1016/j.bmcl.2012.09.092
Mus musculus	Mus musculus	Activity	10.5	g	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	11.1	g	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	11.6	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	12.0	mM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	12.5	g	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	12.81	U/L	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	13.1	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	13.9	g	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	14.0	%	10.1016/j.ejmech.2012.10.027
Mus musculus	Mus musculus	Activity	15.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	15.9	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	17.0	%	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	17.3	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	17.4	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	18.3	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	22.0	%	10.1016/j.bmc.2015.04.046
Mus musculus	Mus musculus	Activity	22.8	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Activity	24.5	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	26.3	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	26.4	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Activity	29.0	%	10.1016/j.bmcl.2006.09.028
Mus musculus	Mus musculus	Activity	30.4	None	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	32.5	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Activity	32.6	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	33.9	%	10.1016/j.bmc.2011.12.027
Mus musculus	Mus musculus	Activity	35.0	%	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	36.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	36.7	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	37.0	%	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	40.0	%	10.1016/j.bmc.2019.115263
Mus musculus	Mus musculus	Activity	40.5	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	41.0	%	10.1016/j.bmc.2008.06.050
Mus musculus	Mus musculus	Activity	41.0	%	10.1016/j.ejmech.2017.02.031
Mus musculus	Mus musculus	Activity	41.6	g	10.1016/j.bmcl.2006.08.034
Mus musculus	Mus musculus	Activity	43.0	%	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	43.3	%	10.1016/j.ejmech.2007.02.015
Mus musculus	Mus musculus	Activity	44.0	%	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	44.8	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Activity	45.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	46.0	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	46.5	%	10.1016/j.bmc.2011.12.027
Mus musculus	Mus musculus	Activity	48.0	%	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	48.0	%	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	48.4	%	10.1016/j.bmcl.2012.02.074
Mus musculus	Mus musculus	Activity	49.5	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	50.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	50.8	mg/dl	10.1016/j.bmcl.2006.08.034
Mus musculus	Mus musculus	Activity	51.0	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	51.3	%	10.1016/j.bmc.2011.12.027
Mus musculus	Mus musculus	Activity	51.6	uM	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	52.0	%	10.1016/j.ejmech.2012.10.027
Mus musculus	Mus musculus	Activity	52.0	%	10.1021/jm8001636
Mus musculus	Mus musculus	Activity	53.7	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Activity	54.0	%	10.1016/j.bmcl.2012.09.092
Mus musculus	Mus musculus	Activity	54.3	%	10.1021/jm201107g
Mus musculus	Mus musculus	Activity	55.0	%	10.1016/j.bmcl.2005.10.008
Mus musculus	Mus musculus	Activity	56.0	%	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	56.0	%	10.1021/jm100443s
Mus musculus	Mus musculus	Activity	57.3	ug ml-1	10.1021/jm900097m
Mus musculus	Mus musculus	Activity	58.0	%	10.1016/j.bmcl.2012.09.092
Mus musculus	Mus musculus	Activity	60.0	%	10.1021/jm201061j
Mus musculus	Mus musculus	Activity	65.0	%	10.1016/j.bmcl.2006.11.050
Mus musculus	Mus musculus	Activity	65.0	%	10.1016/j.ejmech.2017.02.031
Mus musculus	Mus musculus	Activity	66.0	%	10.1016/j.ejmech.2019.07.019
Mus musculus	Mus musculus	Activity	67.0	%	10.1016/j.bmc.2019.115263
Mus musculus	Mus musculus	Activity	67.0	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	67.0	%	10.1016/s0960-894x(03)00785-6
Mus musculus	Mus musculus	Activity	67.0	%	10.1021/jm100443s
Mus musculus	Mus musculus	Activity	68.0	%	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	Activity	71.0	%	10.1007/s00044-011-9764-4
Mus musculus	Mus musculus	Activity	71.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	74.0	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	74.0	%	10.1016/s0960-894x(03)00785-6
Mus musculus	Mus musculus	Activity	76.0	%	10.1021/jm900367w
Mus musculus	Mus musculus	Activity	78.0	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	79.0	%	10.1021/jm900097m
Mus musculus	Mus musculus	Activity	83.0	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	89.3	mU/L	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	90.0	%	10.1016/j.bmcl.2008.07.103
Mus musculus	Mus musculus	Activity	90.0	mg/dl	10.1016/j.ejmech.2009.03.009
Mus musculus	Mus musculus	Activity	100.0	%	10.1016/j.ejmech.2017.06.006
Mus musculus	Mus musculus	Activity	106.0	%	10.1016/j.bmcl.2006.08.105
Mus musculus	Mus musculus	Activity	107.0	mg/dl	10.1016/j.bmc.2009.09.001
Mus musculus	Mus musculus	Activity	138.0	%	10.1016/j.bmcl.2006.08.110
Mus musculus	Mus musculus	Activity	143.4	mg/dl	10.1016/j.bmcl.2006.08.034
Mus musculus	Mus musculus	Activity	148.0	mg/dl	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	188.0	mg/dl	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	228.0	%	10.1016/j.bmc.2012.11.058
Mus musculus	Mus musculus	Activity	243.0	%	10.1016/j.bmcl.2013.02.073
Mus musculus	Mus musculus	Activity	320.6	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	330.0	mg/dl	10.1016/j.bmc.2009.09.001
Mus musculus	Mus musculus	Activity	392.9	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	412.0	mg dl-1	10.1021/jm020401k
Mus musculus	Mus musculus	Activity	413.5	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	496.0	mg/hr/dl	10.1038/nature06261
Mus musculus	Mus musculus	Activity	504.9	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	593.3	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	672.3	mg/dl	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	1348.0	pg/ml	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	15956.0	pg/ml	10.1016/j.bmcl.2018.02.013
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmc.2009.05.082
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmcl.2007.03.057
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmcl.2008.08.112
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmcl.2009.03.036
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.bmcl.2018.03.051
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2009.03.009
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2016.11.015
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2018.10.006
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2020.112315
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2021.113542
Mus musculus	Mus musculus	Activity	nan	None	10.1016/j.ejmech.2021.113807
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acs.jmedchem.1c01356
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acsmedchemlett.1c00715
Mus musculus	Mus musculus	Activity	nan	None	10.1021/acsmedchemlett.5b00218
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm061299k
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm100242d
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm100443s
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm201061j
Mus musculus	Mus musculus	Activity	nan	None	10.1021/ml300352x
Mus musculus	Mus musculus	Activity	nan	None	10.1021/np900346d
Mus musculus	Mus musculus	Activity	nan	None	10.1038/nature06261
Mus musculus	Mus musculus	AUC	78636.8	ng.hr.mL-1	10.1021/jm201061j
Mus musculus	Mus musculus	AUC	113308.48	ng.hr.mL-1	10.1021/jm900367w
Mus musculus	Mus musculus	AUC	114380.8	ng.hr.mL-1	10.1021/jm900097m
Mus musculus	Mus musculus	AUC glu	1423.0	mM min	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu	2141.0	mM min	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu	2398.0	mM min	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu	2551.0	mM min	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu reduction	14.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu reduction	18.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu reduction	28.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	AUC glu reduction(mM x min)	51.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	BG	11.35	mM	10.1021/jm010964g
Mus musculus	Mus musculus	BG	11.72	mM	10.1021/jm010964g
Mus musculus	Mus musculus	BG	13.06	mM	10.1021/jm010964g
Mus musculus	Mus musculus	BG	16.08	mM	10.1021/jm010964g
Mus musculus	Mus musculus	BG reduction	25.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	BG reduction	39.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	BG reduction	45.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	BG reduction	47.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	Cmax	68000.0	nM	10.1021/jm900367w
Mus musculus	Mus musculus	Concentration	nan	None	10.1021/jm0496436
Mus musculus	Mus musculus	Corr	65.0	%	10.1016/s0960-894x(03)00115-x
Mus musculus	Mus musculus	Dec	75.0	%	10.1016/s0960-894x(03)00115-x
Mus musculus	Mus musculus	Dose	3.0	uM kg-1	10.1021/jm00049a017
Mus musculus	Mus musculus	Dose	300.0	uM kg-1	10.1021/jm00049a017
Mus musculus	Mus musculus	ED25	4.1	mg/kg/day	10.1016/j.ejmech.2017.02.031
Mus musculus	Mus musculus	ED25	30.0	mg/kg/day	10.1016/j.ejmech.2017.02.031
Mus musculus	Mus musculus	ED30	0.21	mg kg-1	10.1016/j.bmcl.2008.08.020
Mus musculus	Mus musculus	ED50	0.07	mg.kg-1	10.1021/jm010964g
Mus musculus	Mus musculus	ED50	0.1	mg.kg-1	10.1021/jm0309046
Mus musculus	Mus musculus	ED50	0.14	mg.kg-1	10.1021/jm010964g
Mus musculus	Mus musculus	ED50	0.8	mg.kg-1	10.1021/jm0309046
Mus musculus	Mus musculus	ED50	0.87	mg.kg-1	10.1021/jm010964g
Mus musculus	Mus musculus	ED50	0.9	mg.kg-1	10.1021/jm0309046
Mus musculus	Mus musculus	ED50	23.0	mg.kg-1	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	ED50	30.0	mg.kg-1	10.1016/j.bmc.2011.11.035
Mus musculus	Mus musculus	FC	10.0	None	10.1016/j.bmc.2015.04.046
Mus musculus	Mus musculus	Glucose correction	46.0	%	10.1016/s0960-894x(03)00257-9
Mus musculus	Mus musculus	Glucose correction	60.0	%	10.1016/j.bmcl.2004.10.068
Mus musculus	Mus musculus	Glucose correction	67.0	%	10.1016/s0960-894x(03)00505-5
Mus musculus	Mus musculus	Inhibition	-40.7	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Inhibition	-33.3	%	10.1016/j.ejmech.2013.01.054
Mus musculus	Mus musculus	Inhibition	72.0	%	10.1016/j.bmc.2010.04.045
Mus musculus	Mus musculus	Inhibition	nan	%	10.1016/j.bmc.2015.04.046
Mus musculus	Mus musculus	Inhibition	nan	%	10.1016/j.ejmech.2021.113807
Mus musculus	Mus musculus	Inhibition	nan	%	10.1021/jm100242d
Mus musculus	Mus musculus	Inhibition	nan	%	10.1021/jm201306q
Mus musculus	Mus musculus	Max reduction	16.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	Max reduction	16.0	%	10.1021/jm0309046
Mus musculus	Mus musculus	Max reduction	35.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	Max reduction	35.0	%	10.1021/jm0309046
Mus musculus	Mus musculus	Max reduction	43.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	Max reduction	43.0	%	10.1021/jm0309046
Mus musculus	Mus musculus	Max reduction	58.0	%	10.1021/jm010964g
Mus musculus	Mus musculus	Max reduction	58.0	%	10.1021/jm0309046
Mus musculus	Mus musculus	MED	3.0	uM kg-1	10.1016/S0960-894X(01)80325-5
Mus musculus	Mus musculus	MED	3.0	uM kg-1	10.1021/jm950395a
Mus musculus	Mus musculus	Ratio	2.9	None	10.1016/j.bmcl.2010.02.071
Mus musculus	Mus musculus	Ratio	108.7	None	10.1021/jm201107g
Mus musculus	Mus musculus	Reduction	17.0	%	10.1021/jm00049a017
Mus musculus	Mus musculus	Reduction	31.0	%	10.1021/jm00049a017
Mus musculus	Mus musculus	Reduction	35.0	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	35.25	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	40.21	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	41.0	%	10.1021/jm00049a017
Mus musculus	Mus musculus	Reduction	41.0	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	41.6	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	47.0	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	47.25	%	10.1021/jm980622j
Mus musculus	Mus musculus	Reduction	56.0	%	10.1021/jm00049a017
Mus musculus	Mus musculus	Reduction	61.0	%	10.1021/jm00049a017
Mus musculus	Mus musculus	Reduction	62.96	%	10.1016/j.bmcl.2004.04.053
Mus musculus	Mus musculus	Reduction	64.6	%	10.1021/jm980622j
Mus musculus	Mus musculus	Survival	36.5	%	10.1016/j.ejmech.2017.11.085
Mus musculus	Mus musculus	Survival	45.5	%	10.1016/j.ejmech.2017.11.085
Mus musculus	Mus musculus	T/C	0.55	None	10.1016/j.bmc.2018.10.033
Mus musculus	Mus musculus	Triglyceride correction	52.0	%	10.1016/s0960-894x(03)00257-9
Mus musculus	Mus musculus	Triglyceride correction	74.0	%	10.1016/s0960-894x(03)00505-5
Mus musculus	Mus musculus	Weight gain	10.0	%	10.1016/j.bmcl.2004.10.068
Mus musculus	Neurofibromin	FC	3.1	None	10.1021/jm301204r
Mus musculus	Nitric oxide synthase, inducible	IC50	nan	None	None
Mus musculus	Nitric oxide synthase, inducible	Ki	nan	None	None
Mus musculus	Norrin	Activity	nan	None	10.1021/jm301204r
Mus musculus	Oxysterols receptor LXR-beta	FC	1.19	None	10.1021/jm301913k
Mus musculus	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1016/j.bmc.2019.07.032
Mus musculus	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/acs.jmedchem.1c01542
Mus musculus	Peroxisome proliferator-activated receptor alpha	Activity	nan	None	10.1021/jm060617c
Mus musculus	Peroxisome proliferator-activated receptor alpha	EC50	3000.0	nM	10.1021/jm900367w
Mus musculus	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm950395a
Mus musculus	Peroxisome proliferator-activated receptor alpha	EC50	nan	nM	10.1021/jm990554g
Mus musculus	Peroxisome proliferator-activated receptor alpha	EC50	nan	None	10.1021/jm900097m
Mus musculus	Peroxisome proliferator-activated receptor alpha	IC50	80.0	nM	10.1021/acs.jmedchem.9b01701
Mus musculus	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1021/jm950395a
Mus musculus	Peroxisome proliferator-activated receptor delta	EC50	nan	nM	10.1021/jm990554g
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	20.0	%	10.1016/j.bmc.2015.11.013
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2022.117130
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2014.06.062
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2018.12.043
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2019.126664
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmcl.2022.129081
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.ejmech.2013.01.024
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.0c01555
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.1c01542
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.5b01239
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.8b00458
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jmedchem.9b02150
Mus musculus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1021/acs.jnatprod.5b00820
Mus musculus	Peroxisome proliferator-activated receptor gamma	Displacement	89.0	%	10.1021/jm950395a
Mus musculus	Peroxisome proliferator-activated receptor gamma	EC50	30.0	nM	10.1021/np500150f
Mus musculus	Peroxisome proliferator-activated receptor gamma	EC50	60.0	nM	10.1021/jm950395a
Mus musculus	Peroxisome proliferator-activated receptor gamma	EC50	76.0	nM	10.1021/jm990554g
Mus musculus	Peroxisome proliferator-activated receptor gamma	Emax	11.8	None	10.1021/np500150f
Mus musculus	Peroxisome proliferator-activated receptor gamma	FC	1.9	None	10.1021/acs.jnatprod.7b00846
Mus musculus	Peroxisome proliferator-activated receptor gamma	FC	2.3	None	10.1021/acs.jnatprod.7b00846
Mus musculus	Peroxisome proliferator-activated receptor gamma	Inhibition	nan	%	10.1016/j.bmc.2023.117238
Mus musculus	Peroxisome proliferator-activated receptor gamma	Inhibition	nan	%	10.1016/j.bmcl.2019.126664
Mus musculus	Protein kinase C and casein kinase substrate in neurons protein 2	Activity	nan	None	10.1021/jm301204r
Mus musculus	Rab11 family-interacting protein 4	FC	3.74	None	10.1021/jm301204r
Mus musculus	RAW264.7	Activity	64.8	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	99.0	%	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	99.7	%	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	140.0	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	345.6	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	416.9	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	631.3	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	1293.8	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	2783.9	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	3477.9	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	8388.6	pg/ml	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Activity	11311.3	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	20616.0	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Activity	22226.0	pg/ml	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	IC50	17500.0	nM	10.1016/j.bmcl.2008.08.107
Mus musculus	RAW264.7	Inhibition	16.6	%	10.1016/j.ejmech.2017.11.085
Mus musculus	RAW264.7	Inhibition	16.7	%	10.1016/j.ejmech.2013.10.074
Mus musculus	RAW264.7	Inhibition	nan	%	10.1016/j.ejmech.2013.10.074
Mus musculus	Retinoid X receptor alpha	Activity	nan	None	10.1021/acs.jmedchem.0c01354
Mus musculus	Serine/threonine-protein kinase MAK	Activity	nan	None	10.1021/jm301204r
Mus musculus	Serine/threonine-protein kinase WNK1	Activity	nan	None	10.1021/jm301204r
Mus musculus	Trace amine-associated receptor 7b	Activity	nan	None	10.1021/jm301204r
Mus musculus	Transcription factor SOX-5	Activity	nan	None	10.1021/jm301204r
Mus musculus	Tyrosine-protein kinase transmembrane receptor ROR1	Activity	nan	None	10.1021/jm301204r
Mus musculus	Voltage-dependent L-type calcium channel subunit alpha-1F	Activity	nan	None	10.1021/jm301204r
Oryctolagus cuniculus	Angiotensin-converting enzyme	IC50	nan	None	None
Oryctolagus cuniculus	Angiotensin-converting enzyme	Ki	nan	None	None
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	IC50	nan	None	None
Oryctolagus cuniculus	Arachidonate 15-lipoxygenase	Ki	nan	None	None
Photinus pyralis	Luciferin 4-monooxygenase	Potency	32196.8	nM	None
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	Anthranilate--CoA ligase	Inhibition	9.19	%	10.1016/j.ejmech.2017.11.085
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)	Pseudolysin	Inhibition	7.43	%	10.1016/j.ejmech.2017.11.085
Rattus norvegicus	26S proteasome non-ATPase regulatory subunit 1	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Afadin- and alpha-actinin-binding protein	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Aldose reductase	IC50	nan	None	None
Rattus norvegicus	Aldose reductase	Ki	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1a adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	IC50	nan	None	None
Rattus norvegicus	Alpha-1b adrenergic receptor	Ki	nan	None	None
Rattus norvegicus	Androgen Receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Androgen Receptor	IC50	nan	None	None
Rattus norvegicus	Androgen Receptor	Ki	nan	None	None
Rattus norvegicus	ATP synthase subunit alpha, mitochondrial	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	ATP synthase subunit beta, mitochondrial	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Bile salt export pump	IC50	40000.0	nM	10.1124/dmd.111.040758
Rattus norvegicus	Carnitine palmitoyltransferase 2	IC50	100000.0	nM	10.6019/CHEMBL3431459
Rattus norvegicus	CDGSH iron-sulfur domain-containing protein 1	IC50	1100.0	nM	10.1016/j.bmcl.2009.12.088
Rattus norvegicus	Cyclooxygenase-1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	GABA receptor alpha-1 subunit	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glyceraldehyde-3-phosphate dehydrogenase	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Glycine receptor	IC50	nan	None	None
Rattus norvegicus	Glycine receptor	Ki	nan	None	None
Rattus norvegicus	Hemi-diaphragm	Activity	15.5	mg/dl	10.1007/s00044-011-9792-0
Rattus norvegicus	Hemi-diaphragm	Activity	37.0	mg/dl	10.1007/s00044-011-9792-0
Rattus norvegicus	Hepatocyte	Activity	nan	None	10.1021/acs.jmedchem.0c01555
Rattus norvegicus	Hepatocyte	IC50	165000.0	nM	10.1039/C3MD00377A
Rattus norvegicus	Hepatocyte	IC50	225000.0	nM	10.1039/C3MD00377A
Rattus norvegicus	INS1	Activity	116.0	%	10.1007/s00044-009-9185-9
Rattus norvegicus	Insulin receptor	IC50	nan	None	None
Rattus norvegicus	Insulin receptor	Ki	nan	None	None
Rattus norvegicus	Kalirin	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Kinesin light chain 1	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	L6	Activity	54.5	%	10.1016/j.bmcl.2012.05.097
Rattus norvegicus	L6	Activity	58.0	%	10.1021/jm061202u
Rattus norvegicus	L6	Activity	61.6	%	10.1016/j.ejmech.2013.01.054
Rattus norvegicus	L6	Activity	96.5	%	10.1039/d2md00341d
Rattus norvegicus	L6	Activity	112.4	%	10.1016/j.bmcl.2014.04.059
Rattus norvegicus	L6	Activity	nan	None	10.1016/j.ejmech.2020.112315
Rattus norvegicus	L6	EC50	4490.0	nM	10.1016/j.bmcl.2013.07.067
Rattus norvegicus	L6	EC50	5000.0	nM	10.1021/jm061202u
Rattus norvegicus	L6	FC	1.8	None	10.1016/j.bmcl.2013.07.067
Rattus norvegicus	L6	IC50	4800.0	nM	10.1016/j.bmcl.2014.04.059
Rattus norvegicus	L6	Inhibition	240.0	%	10.1016/j.bmc.2010.04.032
Rattus norvegicus	Liver	IC50	100.0	nM	10.1002/hep.27206
Rattus norvegicus	Liver microsomes	Stability	45.0	%	10.1016/j.bmcl.2009.03.143
Rattus norvegicus	L-lactate dehydrogenase B chain	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Long-chain specific acyl-CoA dehydrogenase, mitochondrial	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Malate dehydrogenase, mitochondrial	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Monoamine oxidase A	Ki	32600.0	nM	10.1021/ml200196p
Rattus norvegicus	Monoamine oxidase B	Ki	5800.0	nM	10.1021/ml200196p
Rattus norvegicus	Neuronal acetylcholine receptor protein alpha-10 subunit	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Nitric-oxide synthase, brain	IC50	nan	None	None
Rattus norvegicus	Nitric-oxide synthase, brain	Ki	nan	None	None
Rattus norvegicus	Peroxisome proliferator-activated receptor alpha	Fold activation	22.0	%	10.1021/jm0309046
Rattus norvegicus	Peroxisome proliferator-activated receptor gamma	Activity	nan	None	10.1016/j.bmc.2012.06.039
Rattus norvegicus	Plasma	Fu	0.002	None	10.1021/jm901371v
Rattus norvegicus	Prolactin-3B1	FC	3.92	None	10.1021/jm301204r
Rattus norvegicus	Protein-tyrosine kinase 2-beta	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Protein-tyrosine phosphatase 1B	Inhibition	25.2	%	10.1007/s00044-012-0007-0
Rattus norvegicus	Protein-tyrosine phosphatase 1B	Inhibition	25.2	%	10.1007/s00044-012-0165-0
Rattus norvegicus	Protein-tyrosine phosphatase 1B	Inhibition	25.2	%	10.1007/s00044-013-0528-1
Rattus norvegicus	PX domain-containing protein kinase-like protein	FC	2.64	None	10.1021/jm301204r
Rattus norvegicus	Ras GTPase-activating protein SynGAP	FC	2.12	None	10.1021/jm301204r
Rattus norvegicus	Rattus norvegicus	Activity	-31.0	%	10.1016/j.bmc.2012.11.058
Rattus norvegicus	Rattus norvegicus	Activity	-11.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	-4.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	0.41	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	0.54	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	1.26	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	1.3	mEq/L	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	1.37	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	1.39	%	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	Activity	1.9	ug/L	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	3.32	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	3.93	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	4.0	ng/ml	10.1016/j.bmc.2009.09.001
Rattus norvegicus	Rattus norvegicus	Activity	4.4	ng/ml	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	4.9	%	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	5.8	%	10.1016/j.bmc.2009.09.001
Rattus norvegicus	Rattus norvegicus	Activity	5.9	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	7.6	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	8.9	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	10.0	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	10.5	%	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	Activity	12.4	%	10.1016/j.bmc.2009.05.082
Rattus norvegicus	Rattus norvegicus	Activity	12.6	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	12.6	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	12.74	mg/dl	10.1016/j.bmcl.2012.08.052
Rattus norvegicus	Rattus norvegicus	Activity	13.0	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	13.0	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	13.6	%	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	14.0	%	10.1016/j.bmc.2009.09.001
Rattus norvegicus	Rattus norvegicus	Activity	14.2	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	14.83	mg/dl	10.1016/j.bmcl.2012.08.052
Rattus norvegicus	Rattus norvegicus	Activity	16.0	%	10.1016/j.bmc.2009.05.082
Rattus norvegicus	Rattus norvegicus	Activity	16.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	17.0	%	10.1016/j.bmc.2008.06.050
Rattus norvegicus	Rattus norvegicus	Activity	17.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	18.0	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	19.0	mg/dl	10.1021/acs.jmedchem.5b01161
Rattus norvegicus	Rattus norvegicus	Activity	20.9	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	21.0	%	10.1007/s00044-012-0007-0
Rattus norvegicus	Rattus norvegicus	Activity	22.7	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	23.0	%	10.1007/s00044-012-0007-0
Rattus norvegicus	Rattus norvegicus	Activity	24.0	%	10.1007/s00044-012-0007-0
Rattus norvegicus	Rattus norvegicus	Activity	24.7	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	25.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	26.0	%	10.1007/s00044-012-0007-0
Rattus norvegicus	Rattus norvegicus	Activity	26.0	g	10.1021/jm060617c
Rattus norvegicus	Rattus norvegicus	Activity	26.3	mg/dl	10.1021/acs.jmedchem.5b01161
Rattus norvegicus	Rattus norvegicus	Activity	27.2	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	29.0	%	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	33.0	%	10.1016/j.bmc.2012.11.058
Rattus norvegicus	Rattus norvegicus	Activity	33.1	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	36.0	mg/dl	10.1016/j.ejmech.2017.02.031
Rattus norvegicus	Rattus norvegicus	Activity	37.95	%	10.1016/j.bmc.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	38.57	mg/dl	10.1016/j.bmcl.2012.08.052
Rattus norvegicus	Rattus norvegicus	Activity	40.3	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	40.3	%	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	42.3	%	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	43.1	%	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	43.9	%	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	46.3	%	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	49.0	%	10.1016/j.bmc.2008.06.050
Rattus norvegicus	Rattus norvegicus	Activity	50.0	%	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	50.0	%	10.1021/jm060617c
Rattus norvegicus	Rattus norvegicus	Activity	50.5	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	50.5	mg/dl	10.1016/j.ejmech.2017.02.031
Rattus norvegicus	Rattus norvegicus	Activity	56.73	%	10.1007/s00044-010-9369-3
Rattus norvegicus	Rattus norvegicus	Activity	57.0	%	10.1016/j.bmc.2008.06.050
Rattus norvegicus	Rattus norvegicus	Activity	61.3	mg/dl	10.1021/acs.jmedchem.5b01161
Rattus norvegicus	Rattus norvegicus	Activity	77.0	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	78.0	%	10.1016/j.bmc.2008.06.050
Rattus norvegicus	Rattus norvegicus	Activity	89.0	%	10.1016/j.bmcl.2006.11.029
Rattus norvegicus	Rattus norvegicus	Activity	90.7	ug	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	102.5	mg	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	107.0	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	118.1	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	120.0	mg/dl	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	121.6	mg/dl	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	130.6	mg/dl	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	136.0	U/L	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	141.0	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	144.2	mg/dl	10.1016/j.ejmech.2014.09.010
Rattus norvegicus	Rattus norvegicus	Activity	147.0	U/L	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	148.4	g	10.1021/jm060617c
Rattus norvegicus	Rattus norvegicus	Activity	154.0	mg/dl	10.1016/j.bmc.2009.09.001
Rattus norvegicus	Rattus norvegicus	Activity	157.3	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	184.0	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	195.0	mg/dl	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	200.0	mg/dl	10.1016/j.ejmech.2012.05.040
Rattus norvegicus	Rattus norvegicus	Activity	213.0	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	217.6	mg/dl	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	260.0	%	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	Activity	364.0	U/L	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	366.0	U/L	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	471.7	g	10.1016/j.bmc.2008.03.043
Rattus norvegicus	Rattus norvegicus	Activity	617.0	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	679.0	10'4 /uL	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	724.0	10'4 /uL	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	727.0	10'4 /uL	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	791.0	10'4 /uL	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Activity	931.0	mg/dl	10.1016/j.bmc.2009.09.001
Rattus norvegicus	Rattus norvegicus	Activity	944.0	%	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	Activity	1248.0	g	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	2677.0	ng/ml	10.1016/j.bmcl.2009.03.036
Rattus norvegicus	Rattus norvegicus	Activity	24473.0	mg.min/dL	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	31145.0	mg.min/dL	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2009.05.082
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2007.10.047
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2009.03.036
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2014.09.044
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.bmcl.2015.08.062
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1016/j.ejmech.2012.05.040
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/acs.jmedchem.6b00892
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/acs.jmedchem.7b01285
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm060617c
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm061299k
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm101063h
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm201061j
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm300122u
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	Activity	nan	None	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	ALB	39700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	40000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALB	40200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	303.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	304.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	307.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	357.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	374.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALP	377.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	62.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	64.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	67.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	77.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	ALT	160.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	83.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	83.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	84.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	91.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	99.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AST	119.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	AUC	7.068	ng.hr.mL-1	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	AUC	3216.96	ng.hr.mL-1	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	AUC	4080.0	ng.hr.mL-1	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	AUC	5862.02	ng.hr.mL-1	10.1016/s0960-894x(03)00257-9
Rattus norvegicus	Rattus norvegicus	AUC	5862.02	ng.hr.mL-1	10.1016/s0960-894x(03)00505-5
Rattus norvegicus	Rattus norvegicus	AUC	5862.02	ng.hr.mL-1	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	AUC	6550.0	ng.hr.mL-1	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	AUC	14565.37	ng.hr.mL-1	10.1021/jm0309046
Rattus norvegicus	Rattus norvegicus	AUC	19194.53	ng.hr.mL-1	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	AUC	21839.58	ng.hr.mL-1	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	AUC	33670.85	ng.hr.mL-1	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	AUC	207672.64	ng.hr.mL-1	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	AUC	208637.73	ng.hr.mL-1	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	AUC	214464.0	ng.hr.mL-1	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	AUC	525000.0	ng.hr.mL-1	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	AUC	2308347.52	ng.hr.mL-1	10.1021/jm900097m
Rattus norvegicus	Rattus norvegicus	AUC	nan	None	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	AUC	nan	None	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	BASO	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BASOLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BAT	1.03	g	10.1021/jm0502135
Rattus norvegicus	Rattus norvegicus	BILI	0.333	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	1.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	1.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	1.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BILI	2.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Body weight	322.0	g	10.1021/jm0502135
Rattus norvegicus	Rattus norvegicus	BUN	145.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	146.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	148.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	160.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	163.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	BUN	166.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	97.0	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	98.67	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	99.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	100.5	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	101.0	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHLORIDE	103.0	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	446.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	663.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	676.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	688.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CHOL	713.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	223.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	238.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	268.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	406.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	411.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CK	501.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CL	2.1	mL.min-1.kg-1	10.1021/jm0309046
Rattus norvegicus	Rattus norvegicus	CL	2.6	mL.min-1.kg-1	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	CL	2.7	mL.min-1.kg-1	10.1016/s0960-894x(03)00257-9
Rattus norvegicus	Rattus norvegicus	CL	2.7	mL.min-1.kg-1	10.1016/s0960-894x(03)00505-5
Rattus norvegicus	Rattus norvegicus	CL	2.99	mL.min-1.kg-1	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	Cmax	2909.58	nM	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Cmax	12365.71	nM	10.1021/jm0309046
Rattus norvegicus	Rattus norvegicus	Cmax	34700.0	nM	10.1016/j.bmc.2011.11.035
Rattus norvegicus	Rattus norvegicus	Cmax	44300.0	nM	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	Cmax	189122.65	nM	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Cmax	nan	None	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Cmax	nan	None	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	CO2	26670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	29330000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	30000000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	31830000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	32670000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CO2	33330000.0	nM	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Control	113.0	%	10.1021/jm990522t
Rattus norvegicus	Rattus norvegicus	Control	119.0	%	10.1021/jm990522t
Rattus norvegicus	Rattus norvegicus	Corr	99.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	Corr	109.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	CREAT	1.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	1.6	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.5	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	CREAT	2.9	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Dec	54.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	Dec	78.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	Dec	86.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	Dec	94.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	ED30	3.0	mg/kg/day	10.1016/j.bmc.2012.11.058
Rattus norvegicus	Rattus norvegicus	ED50	0.41	mg.kg-1	10.1016/j.bmcl.2004.10.042
Rattus norvegicus	Rattus norvegicus	ED50	0.41	mg.kg-1	10.1016/j.bmcl.2006.09.011
Rattus norvegicus	Rattus norvegicus	ED50	0.41	mg.kg-1	10.1016/j.bmcl.2006.09.028
Rattus norvegicus	Rattus norvegicus	ED50	1.0	mg.kg-1	10.1016/j.bmcl.2007.10.047
Rattus norvegicus	Rattus norvegicus	ED50	25.0	uM.hr	10.1021/jm900367w
Rattus norvegicus	Rattus norvegicus	ED50	312.0	uM.hr	10.1021/jm201061j
Rattus norvegicus	Rattus norvegicus	EOS	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	14.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	16.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	26.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	37.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOS	76.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	0.5	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	EOSLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	F	64.0	%	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	F	85.0	%	10.1016/s0960-894x(03)00257-9
Rattus norvegicus	Rattus norvegicus	F	85.0	%	10.1016/s0960-894x(03)00505-5
Rattus norvegicus	Rattus norvegicus	F	100.0	%	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	FC	2.6	None	10.1016/j.ejmech.2017.07.015
Rattus norvegicus	Rattus norvegicus	GLUC	1310.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1490.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1550.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1600.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1701.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	GLUC	1705.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	31.87	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	32.32	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	32.47	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	32.63	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	33.9	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HCT	34.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Heart weight	1.37	g	10.1016/j.bmcl.2004.10.068
Rattus norvegicus	Rattus norvegicus	Heart weight	1.41	g	10.1016/j.bmcl.2004.10.068
Rattus norvegicus	Rattus norvegicus	Heart weight	1.46	g	10.1021/jm0502135
Rattus norvegicus	Rattus norvegicus	Heart weight absolute	0.76	g	10.1021/jm990522t
Rattus norvegicus	Rattus norvegicus	Hematocrit	41.3	g	10.1021/jm0502135
Rattus norvegicus	Rattus norvegicus	HGB	124300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	126000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	128300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	128700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	130200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	HGB	132700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Inhibition	nan	%	10.1016/j.bmcl.2014.09.044
Rattus norvegicus	Rattus norvegicus	LDH	63.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	81.17	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	88.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	89.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	107.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LDH	115.0	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	9.5	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	9.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	13.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	16.67	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LIPASE	23.33	U.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Liver weight	16.6	g	10.1021/jm0502135
Rattus norvegicus	Rattus norvegicus	LYM	4629.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	6940.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	8049.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	10365.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	11144.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYM	11817.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	85.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	89.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	90.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	90.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	91.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	LYMLE	94.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	23.8	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.32	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	24.77	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.37	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.77	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCH	25.9	pg	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	384200.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	387000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	388300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	390300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	393700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCHC	398500.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	61.43	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.32	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.37	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	63.58	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	65.53	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MCV	66.83	fL	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MED	0.25	mg kg-1	10.1016/j.bmcl.2006.09.028
Rattus norvegicus	Rattus norvegicus	MONO	0.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	22.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	80.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	82.83	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	125.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONO	150.67	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	0.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	MONOLE	1.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	5.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	7.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	8.17	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	8.33	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	9.67	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTLE	13.0	%	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	535.5	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	646.83	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	707.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	749.33	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	983.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	NEUTSG	1032.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	78.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	83.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	98.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	99.8	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	100.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PHOS	101.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1021330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1084000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1118670.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1134330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1207330.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PLAT	1231500.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.33	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.62	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	4.78	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.03	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.42	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	POTASSIUM	5.72	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	50700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	51000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	55000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	56300.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	56700.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	PROT	57000.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	4860000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	4980000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5030000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5080000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5360000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBC	5600000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.0	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	RBCNUC	0.17	/100WBC	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Reduction	46.0	%	10.1021/jm970444e
Rattus norvegicus	Rattus norvegicus	Reduction	55.0	%	10.1021/jm970444e
Rattus norvegicus	Rattus norvegicus	Reduction	67.0	%	10.1021/jm970444e
Rattus norvegicus	Rattus norvegicus	Reduction	71.0	%	10.1021/jm970444e
Rattus norvegicus	Rattus norvegicus	Reduction	100.0	%	10.1021/jm970444e
Rattus norvegicus	Rattus norvegicus	Relative	0.36	g %	10.1021/jm990522t
Rattus norvegicus	Rattus norvegicus	SODIUM	141.6	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	141.62	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	142.92	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	143.77	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	144.7	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	SODIUM	146.1	mEq.L-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	T1/2	1.05	hr	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	T1/2	1.2	hr	10.1016/s0960-894x(03)00257-9
Rattus norvegicus	Rattus norvegicus	T1/2	1.2	hr	10.1016/s0960-894x(03)00505-5
Rattus norvegicus	Rattus norvegicus	T1/2	3.033	hr	10.1021/jm0309046
Rattus norvegicus	Rattus norvegicus	T1/2	3.8	hr	10.1016/s0960-894x(03)00115-x
Rattus norvegicus	Rattus norvegicus	T4	70.0	ng ml-1	10.1021/jm020401k
Rattus norvegicus	Rattus norvegicus	Tissue Severity Score	nan	None	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Tissue weight	0.88	g	10.1016/j.bmcl.2004.10.068
Rattus norvegicus	Rattus norvegicus	Tmax	0.25	hr	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	Tmax	1.0	hr	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Tmax	1.6	hr	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Tmax	nan	None	10.1016/j.bmc.2018.09.005
Rattus norvegicus	Rattus norvegicus	Tmax	nan	None	10.1016/j.bmc.2018.09.006
Rattus norvegicus	Rattus norvegicus	Triglycerides	78.0	mg dl-1	10.1021/jm020401k
Rattus norvegicus	Rattus norvegicus	URATE	2.7	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	3.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	4.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	5.0	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	5.2	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	URATE	5.3	ug.mL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	Vdss	0.25	L.kg-1	10.1016/j.bmcl.2008.08.020
Rattus norvegicus	Rattus norvegicus	Vdss	0.38	L.kg-1	10.1021/jm0309046
Rattus norvegicus	Rattus norvegicus	WBC	5430.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	7770.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	8820.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	11500.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	11720.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Rattus norvegicus	WBC	13000.0	cells.uL-1	10.6019/CHEMBL3885881
Rattus norvegicus	Retinoid X receptor alpha	Ki	nan	nM	10.1021/jm020401k
Rattus norvegicus	Retinoid X receptor alpha	Synergy	nan	None	10.1021/jm020401k
Rattus norvegicus	Selenocysteine insertion sequence-binding protein 2	FC	3.22	None	10.1021/jm301204r
Rattus norvegicus	Septin-9	FC	2.08	None	10.1021/jm301204r
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Ki	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	IC50	nan	None	None
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	Ki	nan	None	None
Rattus norvegicus	Sodium-dependent multivitamin transporter	Activity	nan	None	10.1021/jm301204r
Rattus norvegicus	Type-1A angiotensin II receptor	Ki	0.23	nM	10.1007/s00044-008-9152-x
Rattus norvegicus	UMR106-06	Activity	nan	None	10.1016/j.ejmech.2021.113542
Rattus norvegicus	Voltage-gated L-type calcium channel alpha-1C subunit	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Voltage-gated N-type calcium channel alpha-1B subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	4.6	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Hit score	-0.06876	None	10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	19952.62	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	20000.0	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	0.0	%	10.6019/CHEMBL4495565
None	ADMET	Activity	6.6	g	10.1016/j.ejmech.2018.10.006
None	ADMET	Activity	8.0	mg	10.1021/acs.jmedchem.0c00524
None	ADMET	Activity	nan	None	10.1016/j.ejmech.2018.10.006
None	ADMET	Activity	nan	None	10.1016/j.ejmech.2021.113807
None	ADMET	Activity	nan	None	10.1021/acsmedchemlett.1c00715
None	ADMET	AUC	113308.48	ng.hr.mL-1	10.1016/j.bmcl.2004.10.068
None	ADMET	AUC	250208.0	ng.hr.mL-1	10.1016/j.bmcl.2005.03.092
None	ADMET	AUC	574406.08	ng.hr.mL-1	10.1016/j.bmcl.2004.10.068
None	ADMET	AUC	873922.0	ng min	10.1021/jm010964g
None	ADMET	AUC	965088.0	ng.hr.mL-1	10.1016/j.bmcl.2005.03.092
None	ADMET	AUC ED50	0.77	mg kg-1	10.1021/jm010964g
None	ADMET	Biotransformation	nan	None	10.1038/s41586-019-1291-3
None	ADMET	CL	2.8e-05	mL.min-1.g-1	10.1124/dmd.111.039180
None	ADMET	CL	0.048	uL/min	10.1124/dmd.111.039180
None	ADMET	CL	0.65	mL.min-1.kg-1	10.1124/dmd.108.020479
None	ADMET	CL	2.1	mL.min-1.kg-1	10.1021/jm010964g
None	ADMET	Cmax	2960.0	nM	10.1039/D1MD00113B
None	ADMET	Cmax	12365.71	nM	10.1021/jm010964g
None	ADMET	Decrease	35.25	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	41.0	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	41.6	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	46.0	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	47.0	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	47.25	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	65.0	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Decrease	75.5	%	10.1016/j.bmcl.2004.12.041
None	ADMET	Drug uptake	nan	None	10.1016/j.bmc.2018.09.005
None	ADMET	F	83.0	%	10.1021/jm010964g
None	ADMET	F	83.0	%	10.1021/jm0309046
None	ADMET	IC50	156600.0	nM	10.1016/j.bmcl.2010.02.071
None	ADMET	LD50	2584.7	mg.kg-1	10.1016/j.ejmech.2018.10.006
None	ADMET	MRT	5.1	hr	10.1124/dmd.108.020479
None	ADMET	PPB	99.74	%	10.6019/CHEMBL3301361
None	ADMET	Stability	20.0	%	10.1016/j.ejmech.2018.10.006
None	ADMET	Stability	39.0	%	10.1016/j.ejmech.2018.10.006
None	ADMET	Stability	nan	%	10.1016/j.bmc.2018.09.005
None	ADMET	Stability	nan	%	10.1016/j.bmc.2018.09.006
None	ADMET	T1/2	3.033	hr	10.1021/jm010964g
None	ADMET	T1/2	3.9	hr	10.1124/dmd.108.020479
None	ADMET	Vdss	0.2	L.kg-1	10.1124/dmd.108.020479
None	ADMET	Vdss	0.38	L.kg-1	10.1021/jm010964g
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx1000865
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx900326k
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1124/dmd.110.035113
None	Hepatotoxicity	HepSE_bilirubinemia	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholecystitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholelithiasis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cirrhosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_Combined Scores	3.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_elevated liver function tests	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic failure	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic necrosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatitis	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatomegaly	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_jaundice	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver disease	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver fatty	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver function tests abnormal	0.0	None	10.1371/journal.pcbi.1002310
None	Keratinocyte	IC50	8000.0	nM	10.1021/jm0510880
None	Macrophage	Activity	nan	None	10.1016/j.ejmech.2013.01.024
None	Molecular identity unknown	Activity	11.25	mg/g	10.1016/j.bmcl.2010.01.125
None	Molecular identity unknown	Activity	35.25	mg/g	10.1016/j.bmcl.2010.01.125
None	Molecular identity unknown	Activity	nan	None	10.1021/acs.jnatprod.5b00883
None	Molecular identity unknown	Activity	nan	None	10.1039/C3MD00178D
None	Molecular identity unknown	FC	1.38	None	10.1021/acs.jnatprod.5b00883
None	Molecular identity unknown	FC	1.45	None	10.1021/acs.jnatprod.5b00883
None	Molecular identity unknown	FC	2.75	None	10.1021/acs.jnatprod.5b00883
None	NON-PROTEIN TARGET	Activity	19.0	mg/dl	10.1016/j.ejmech.2010.12.019
None	NON-PROTEIN TARGET	Activity	20.36	mg/dl	10.1016/j.ejmech.2010.12.019
None	NON-PROTEIN TARGET	Activity	32.21	%	10.1016/j.bmc.2017.01.015
None	NON-PROTEIN TARGET	Activity	48.34	mg/dl	10.1016/j.ejmech.2010.12.019
None	NON-PROTEIN TARGET	Activity	50.33	mg/dl	10.1016/j.ejmech.2010.12.019
None	NON-PROTEIN TARGET	Fu	0.002	None	10.1124/dmd.108.020479
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	0.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	3.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	0.2	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	8.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.ejmech.2014.06.013
None	NON-PROTEIN TARGET	Potency	2.1	nM	None
None	NON-PROTEIN TARGET	Potency	7.5	nM	None
None	NON-PROTEIN TARGET	Potency	211.2	nM	None
None	NON-PROTEIN TARGET	Potency	5304.5	nM	None
None	No relevant target	CLogP	1.32	None	10.1016/S0960-894X(01)80325-5
None	No relevant target	CLogP	2.84	None	10.1021/jm970444e
None	No relevant target	LogD	2.49	None	10.6019/CHEMBL3431459
None	No relevant target	LogD7.4	2.5	None	10.6019/CHEMBL3301361
None	No relevant target	LogP	1.91	None	10.1021/jm0309046
None	No relevant target	LogP	2.621	None	10.1021/jm300068n
None	No relevant target	LogP	2.95	None	10.1016/j.bmc.2015.03.071
None	No relevant target	Log S	-4.58	None	10.1016/j.bmcl.2015.08.062
None	No relevant target	Permeability	76.5	nm s-1	10.6019/CHEMBL3431459
None	No relevant target	pKa	10.3	None	10.1124/dmd.112.050278
None	No relevant target	Solubility	14.0	ug.mL-1	10.1016/j.bmcl.2008.08.020
None	No relevant target	Solubility	92.0	ug.mL-1	10.6019/CHEMBL3431459
None	No relevant target	Solubility	28200.0	nM	10.6019/CHEMBL3301361
None	Osteoblast	Activity	nan	None	10.1016/j.bmcl.2006.08.003
None	Peritoneal macrophage cell	Activity	nan	None	10.1016/j.bmcl.2014.06.062
None	Platelet	IC50	5700000.0	nM	10.1016/j.ejmech.2018.10.006
None	Platelet	IC50	6400000.0	nM	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	6.1	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	14.8	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	25.3	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	28.0	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	42.2	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	43.1	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	54.4	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	64.0	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	67.2	%	10.1016/j.ejmech.2018.10.006
None	Platelet	Inhibition	68.9	%	10.1016/j.ejmech.2018.10.006
None	T-cell	Inhibition	75.0	%	10.1021/jm0510880
None	Unchecked	Ac50	0.631	uM	None
None	Unchecked	Ac50	11.22	uM	None
None	Unchecked	Ac50	17.78	uM	None
None	Unchecked	Ac50	31.62	uM	None
None	Unchecked	AC50	631.0	nM	None
None	Unchecked	AC50	11220.2	nM	None
None	Unchecked	AC50	17790.0	nM	None
None	Unchecked	AC50	31622.8	nM	None
None	Unchecked	Activity	4.58	g/day	10.1016/j.ejmech.2020.112315
None	Unchecked	Activity	5.421	mM	10.1016/j.bmcl.2022.129081
None	Unchecked	Activity	6.1	mg/day	10.1016/j.ejmech.2020.112315
None	Unchecked	Activity	6.82	g	10.1016/j.ejmech.2020.112315
None	Unchecked	Activity	7.0	%	10.1021/acs.jnatprod.5b00481
None	Unchecked	Activity	7.15	mM	10.1016/j.bmcl.2022.129081
None	Unchecked	Activity	22.74	%	10.1016/j.bmcl.2022.129081
None	Unchecked	Activity	44.58	%	10.1016/j.bmcl.2022.129081
None	Unchecked	Activity	80.0	None	10.1021/jm801594x
None	Unchecked	Activity	119.0	%	10.1016/j.ejmech.2017.06.006
None	Unchecked	Activity	224.0	%	10.1021/acsmedchemlett.9b00306
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2020.112315
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2021.113807
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2022.114240
None	Unchecked	Activity	nan	None	10.1021/acs.jmedchem.0c01555
None	Unchecked	Activity	nan	None	10.1021/acs.jmedchem.0c02063
None	Unchecked	Activity	nan	None	10.1021/acs.jmedchem.1c01542
None	Unchecked	Activity	nan	None	10.1021/jm201061j
None	Unchecked	Activity	nan	None	10.1039/C6MD00042H
None	Unchecked	Decrease	14.6	%	10.1021/jm990522t
None	Unchecked	Decrease	21.7	%	10.1021/jm990522t
None	Unchecked	EC50	2.0	nM	10.1016/j.ejmech.2013.02.015
None	Unchecked	EC50	50.0	nM	10.1016/S0960-894X(97)10017-8
None	Unchecked	EC50	116.0	nM	10.1021/acs.jmedchem.9b01786
None	Unchecked	EC50	121.0	nM	10.1021/acs.jmedchem.9b01786
None	Unchecked	EC50	207.0	nM	10.1074/jbc.m702316200
None	Unchecked	EC50	325.0	nM	10.1021/jm020401k
None	Unchecked	EC50	1000.0	nM	10.1016/j.bmc.2011.10.020
None	Unchecked	EC50	10000.0	nM	10.1074/jbc.m702316200
None	Unchecked	EC50	nan	None	10.1016/j.bmc.2017.01.015
None	Unchecked	EC50	nan	None	10.1016/j.bmc.2017.07.015
None	Unchecked	EC50	nan	None	10.1021/jm900097m
None	Unchecked	Efficacy	100.0	%	10.1021/jm020401k
None	Unchecked	Glucose correction	67.0	%	10.1016/s0960-894x(03)00257-9
None	Unchecked	Hepatotoxicity (acute)	10.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	2.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	7.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	5.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	1180.0	nM	10.1021/acs.jmedchem.9b01701
None	Unchecked	IC50	8685.1	nM	None
None	Unchecked	IC50	20000.0	nM	None
None	Unchecked	IC50	nan	None	10.1021/acs.jmedchem.2c01379
None	Unchecked	IC50	nan	None	None
None	Unchecked	Inhibition	15.51	%	10.1016/j.ejmech.2017.11.085
None	Unchecked	Inhibition	nan	%	10.1016/j.ejmech.2021.113542
None	Unchecked	Inhibition	nan	%	10.1016/j.ejmech.2021.113807
None	Unchecked	Inhibition	nan	%	10.1021/acs.jmedchem.0c01555
None	Unchecked	Kd	370.0	nM	10.1016/j.bmc.2022.116877
None	Unchecked	Ki	nan	nM	10.1021/jm020401k
None	Unchecked	Ki	nan	None	None
None	Unchecked	Ratio	0.016	None	10.1093/toxsci/kft176
None	Unchecked	Ratio	0.119	None	10.1093/toxsci/kft176
None	Unchecked	Ratio EC50	0.05	None	10.1016/j.bmcl.2007.03.015
None	Unchecked	Ratio EC50	54.0	None	10.1016/j.bmc.2009.09.001
None	Unchecked	Reduction	11.0	%	10.1021/jm010964g
None	Unchecked	Reduction	24.0	%	10.1021/jm010964g
None	Unchecked	Selectivity ratio	54.0	None	10.1016/j.bmc.2008.03.043
None	Unchecked	Selectivity ratio	100.0	None	10.1021/jm00049a017
None	Unchecked	Triglyceride correction	74.0	%	10.1016/s0960-894x(03)00257-9