Acridone
AlkaPlorer ID: AK050491
Synonym: 'SMR000112235', 'MLS000551242', 'Acridone'
IUPAC Name: 10H-acridin-9-one
Structure
SMILES: O=C1C2=CC=CC=C2NC2=CC=CC=C12
InChI: InChI=1S/C13H9NO/c15-13-9-5-1-3-7-11(9)14-12-8-4-2-6-10(12)13/h1-8H,(H,14,15)
InChIKey: FZEYVTFCMJSGMP-UHFFFAOYSA-N
Reference
Alkaloids and coumarins of Citrus grandis
PubChem CID: 2015
CAS: 578-95-0
LOTUS: LTS0193492
COCONUT: CNP0343143
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Thamnosma montana | Thamnosma | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 195.221
TPSA？: 32.86
MolLogP？: 2.6813
Number of H-Donors: 1
Number of H-Acceptors: 1
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bos taurus | Calf thymus DNA | C50 | nan | None | 10.1021/jm970114u |
| Bos taurus | Calf thymus DNA | Q | 400.0 | uM | 10.1021/jm970114u |
| Equus caballus | Ferritin light chain | Potency | 28183.8 | nM | None |
| Homo sapiens | 15-hydroxyprostaglandin dehydrogenase [NAD+] | Potency | 35481.3 | nM | None |
| Homo sapiens | A2780 | IC50 | 100000.0 | nM | 10.1021/jm970114u |
| Homo sapiens | Aldehyde dehydrogenase 1A1 | Potency | 25118.9 | nM | None |
| Homo sapiens | Alpha-galactosidase A | Potency | 28183.8 | nM | None |
| Homo sapiens | Alpha-galactosidase A | Potency | 31622.8 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 25118.9 | nM | None |
| Homo sapiens | Beta-glucocerebrosidase | Potency | 25118.9 | nM | None |
| Homo sapiens | CCRF-CEM | IC50 | 100000.0 | nM | 10.1016/j.bmc.2008.07.086 |
| Homo sapiens | CH1 | IC50 | 77000.0 | nM | 10.1021/jm970114u |
| Homo sapiens | G-361 | IC50 | 100000.0 | nM | 10.1021/jm970114u |
| Homo sapiens | Geminin | Potency | 3662.6 | nM | None |
| Homo sapiens | Geminin | Potency | 18356.4 | nM | None |
| Homo sapiens | HaCaT | Activity | nan | None | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HaCaT | IC50 | 50000.0 | nM | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HepG2-CD81 | HEPG2TOX ASSAY - CC50 | 1.57 | uM | 10.1126/science.aat9446 |
| Homo sapiens | HepG2-CD81 | HEPG2TOX ASSAY - CC90 | 1.57 | uM | 10.1126/science.aat9446 |
| Homo sapiens | Huntingtin | Potency | 35481.3 | nM | None |
| Homo sapiens | Importin subunit beta-1/Snurportin-1 | Potency | 44668.4 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 19952.6 | nM | None |
| Homo sapiens | Lysosomal alpha-glucosidase | Potency | 35481.3 | nM | None |
| Homo sapiens | Lysosomal alpha-glucosidase | Potency | 39810.7 | nM | None |
| Homo sapiens | Muscleblind-like protein 1 | Potency | 15848.9 | nM | None |
| Homo sapiens | Parathyroid hormone receptor | Potency | 31622.8 | nM | None |
| Homo sapiens | Prelamin-A/C | Potency | 31622.8 | nM | None |
| Homo sapiens | Serine-protein kinase ATM | Potency | 17782.8 | nM | None |
| Homo sapiens | SK-OV-3 | IC50 | 100000.0 | nM | 10.1021/jm970114u |
| Homo sapiens | Survival motor neuron protein | Potency | 28183.8 | nM | None |
| Homo sapiens | TAR DNA-binding protein 43 | Potency | 39810.7 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 8199.5 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 16360.1 | nM | None |
| Homo sapiens | U-937 | IC50 | nan | None | 10.1021/ml200266v |
| Mus musculus | L1210 | IC50 | 100000.0 | nM | 10.1021/jm970114u |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 3162.3 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 19952.6 | nM | None |
| Plasmodium berghei | Plasmodium berghei | LUCIFERASE EXPRESSION CONTROL - IC50 | 16.9 | uM | 10.1126/science.aat9446 |
| Plasmodium berghei | Plasmodium berghei | LUCIFERASE EXPRESSION CONTROL - IC90 | 16.9 | uM | 10.1126/science.aat9446 |
| Plasmodium berghei | Plasmodium berghei | LUCIFERASE INFECTION ASSAY - IC50 | 1.57 | uM | 10.1126/science.aat9446 |
| Plasmodium berghei | Plasmodium berghei | LUCIFERASE INFECTION ASSAY - IC90 | 5.03 | uM | 10.1126/science.aat9446 |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 1471.6 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 1651.1 | nM | None |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 50118.7 | nM | None |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 63095.7 | nM | None |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Potency | 11220.2 | nM | None |
| Trypanosoma cruzi | Cruzipain | Potency | 31622.8 | nM | None |
| None | Heme | IC50 | 55000.0 | nM | 10.1016/j.bmcl.2011.04.127 |
| None | Heme | Ka | 2.4 | 10'4/M | 10.1016/j.bmcl.2011.04.127 |
| None | No relevant target | LogP | 2.975 | None | 10.1021/jm049549p |
| None | Nucleic Acid | Q | 340.0 | uM | 10.1021/jm970114u |
| None | Nucleic Acid | Q | 500.0 | uM | 10.1021/jm970114u |
| None | Radical scavenging activity | EC50 | nan | None | 10.1016/j.ejmech.2010.08.059 |
| None | Unchecked | IC50 | 27198.0 | nM | None |
| None | Unchecked | IC50 | 36180.0 | nM | None |
| None | Unchecked | IC50 | 62030.0 | nM | None |
| None | Unchecked | Potency | 11220.2 | nM | None |
| None | Unchecked | Potency | 16360.1 | nM | None |
| None | Unchecked | Potency | 22387.2 | nM | None |