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name Structure Reference Source Properties Activities Metabolism

N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2-[(5-methyl-1,3,4-oxadiazol-2-yl)formamido]propan-2-yl}-6-oxo-1,6-dihydropyrimidine-4-carboxamide

AlkaPlorer ID: AK050620

Synonym: None

IUPAC Name: N-[2-[4-[(4-fluorophenyl)methylcarbamoyl]-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl]propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide

Structure

SMILES: CC1=NN=C(C(=O)NC(C)(C)C2=NC(C(O)=NCC3=CC=C(F)C=C3)=C(O)C(=O)N2C)O1

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InChI: InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)

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InChIKey: CZFFBEXEKNGXKS-UHFFFAOYSA-N

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Reference

PubChem CID: 54671008

CAS: 518048-05-0

NPASS: NPC478794

COCONUT: CNP0344229

Source

Species Genus Family Order Class Phylum Kingdom Domain
Salvia miltiorrhiza Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 444.4230000000002

TPSA？: 155.73000000000002

MolLogP？: 1.4863199999999994

Number of H-Donors: 3

Number of H-Acceptors: 9

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Canis lupus familiaris Canis familiaris AUC 3110.94 ng.hr.mL-1 10.1021/jm800245z
Canis lupus familiaris Canis familiaris AUC 9332.82 ng.hr.mL-1 10.1021/jm800245z
Canis lupus familiaris Canis familiaris beta t1/2 nan None 10.1021/jm800245z
Canis lupus familiaris Canis familiaris CL 6.0 mL.min-1.kg-1 10.1021/jm800245z
Canis lupus familiaris Canis familiaris Cmax 3000.0 nM 10.1021/jm800245z
Canis lupus familiaris Canis familiaris Cmax 8000.0 nM 10.1021/jm800245z
Canis lupus familiaris Canis familiaris F 45.0 % 10.1021/jm800245z
Canis lupus familiaris Canis familiaris T1/2 11.0 hr 10.1021/jm800245z
Canis lupus familiaris Canis familiaris Vd 0.9 L.kg-1 10.1021/jm800245z
Chikungunya virus Chikungunya virus Activity 58.9 % 10.1016/j.bmc.2023.117239
Feline immunodeficiency virus Feline immunodeficiency virus EC50 9.98 nM 10.1016/j.bmcl.2014.04.073
Feline immunodeficiency virus Feline immunodeficiency virus EC50 10.0 nM 10.1016/j.bmc.2019.07.047
Feline immunodeficiency virus Feline immunodeficiency virus EC50 10.0 nM 10.1016/j.bmcl.2014.12.047
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Blood Drug uptake 13.0 ng/ml 10.1128/aac.00636-10
Homo sapiens Blood Drug uptake 37.0 ng/ml 10.1128/aac.00636-10
Homo sapiens Blood Drug uptake 51.0 ng/ml 10.1128/aac.00241-10
Homo sapiens Blood Drug uptake 651.0 ng/ml 10.1128/aac.00241-10
Homo sapiens Blood Ratio 1.75 None 10.1128/aac.00636-10
Homo sapiens C-C chemokine receptor type 1 Ki 5.0 nM 10.1021/jm300682j
Homo sapiens CEM-SS CC50 10000.0 nM 10.1021/acs.jmedchem.6b00040
Homo sapiens CEM-SS CC50 nan None 10.1016/j.ejmech.2017.09.054
Homo sapiens Cyclooxygenase-1 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens Cytochrome P450 2C9 IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens Cytochrome P450 2D6 IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens Cytochrome P450 3A4 Activity 42.0 % 10.1021/acs.jmedchem.0c02245
Homo sapiens Cytochrome P450 3A4 IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens DNA polymerase beta IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HeLa CC50 50000.0 nM 10.1021/acs.jmedchem.5b00159
Homo sapiens HeLa CC50 50000.0 nM 10.1021/jm5001503
Homo sapiens HeLa CC50 250000.0 nM 10.1021/jm401040b
Homo sapiens HeLa CC50 250000.0 nM 10.1021/jm501799k
Homo sapiens HeLa IC50 100000.0 nM 10.1016/j.bmc.2012.06.038
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 50000.0 nM 10.1021/jm800245z
Homo sapiens HERG IC50 316227.77 nM 10.1016/j.vascn.2014.07.002
Homo sapiens HERG IC50 1584893.19 nM 10.1016/j.vascn.2014.07.002
Homo sapiens HERG IC50 3162277.66 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -2.0 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 37.73 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens Activity 1.26 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Activity 1.28 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Activity 25.0 % 10.1128/aac.00636-10
Homo sapiens Homo sapiens Activity 42.0 % 10.1128/aac.00636-10
Homo sapiens Homo sapiens Activity 105.5 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Activity 135.0 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Activity 143.4 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Activity nan None 10.1128/aac.00789-10
Homo sapiens Homo sapiens Activity nan None 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 342.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 377.76 ng.hr.mL-1 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 382.2 ng.hr.mL-1 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 875.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 2036.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 2048.78 ng.hr.mL-1 10.1128/aac.01468-08
Homo sapiens Homo sapiens AUC 2599.86 ng.hr.mL-1 10.1128/aac.01468-08
Homo sapiens Homo sapiens AUC 2790.96 ng.hr.mL-1 10.1128/aac.00487-08
Homo sapiens Homo sapiens AUC 3042.0 ng.hr.mL-1 10.1128/aac.00636-10
Homo sapiens Homo sapiens AUC 3115.38 ng.hr.mL-1 10.1128/aac.00487-08
Homo sapiens Homo sapiens AUC 3267.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 3296.0 ng.hr.mL-1 10.1128/aac.00636-10
Homo sapiens Homo sapiens AUC 3415.0 ng.hr.mL-1 10.1128/aac.00636-10
Homo sapiens Homo sapiens AUC 3532.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 3544.0 ng.hr.mL-1 10.1128/aac.00636-10
Homo sapiens Homo sapiens AUC 4657.0 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 6085.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Homo sapiens AUC 7337.37 ng.hr.mL-1 10.1128/aac.01468-08
Homo sapiens Homo sapiens AUC 7466.26 ng.hr.mL-1 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 7852.9 ng.hr.mL-1 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 8061.78 ng.hr.mL-1 10.1128/aac.01543-07
Homo sapiens Homo sapiens AUC 8586.19 ng.hr.mL-1 10.1128/aac.01543-07
Homo sapiens Homo sapiens AUC 8755.07 ng.hr.mL-1 10.1128/aac.01194-08
Homo sapiens Homo sapiens AUC 10168.33 ng.hr.mL-1 10.1128/aac.01543-07
Homo sapiens Homo sapiens AUC 12252.66 ng.hr.mL-1 10.1128/aac.01468-08
Homo sapiens Homo sapiens AUC nan None 10.1128/aac.00712-10
Homo sapiens Homo sapiens CL_renal 2.7 ml/min 10.1128/aac.01194-08
Homo sapiens Homo sapiens CL_renal 31.5 ml/min 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmax 1210.0 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmax 1540.0 nM 10.1128/aac.00487-08
Homo sapiens Homo sapiens Cmax 1740.0 nM 10.1128/aac.00487-08
Homo sapiens Homo sapiens Cmax 1950.0 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmax 2126.37 nM 10.1128/aac.00636-10
Homo sapiens Homo sapiens Cmax 3251.43 nM 10.1128/aac.00636-10
Homo sapiens Homo sapiens Cmax 3850.0 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmax 4410.0 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmax 5340.0 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmax 5680.0 nM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmax 6450.0 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmax 7230.0 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmax 8610.0 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmax 9570.0 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmax (Ratio) 0.63 uM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmax (Ratio) 0.68 uM 10.1128/aac.01194-08
Homo sapiens Homo sapiens Cmin 36.3 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmin 43.51 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmin 62.5 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmin 76.5 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmin 77.1 nM 10.1128/aac.01543-07
Homo sapiens Homo sapiens Cmin 92.1 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmin 92.47 nM 10.1128/aac.01468-08
Homo sapiens Homo sapiens Cmin 141.6 nM 10.1128/aac.00487-08
Homo sapiens Homo sapiens Cmin 216.0 nM 10.1128/aac.00487-08
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 7.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens FC 0.5 None 10.1128/aac.01194-08
Homo sapiens Homo sapiens FC 4.1 None 10.1128/aac.01194-08
Homo sapiens Homo sapiens Fraction excreted unchanged 2.9 % 10.1128/aac.00712-10
Homo sapiens Homo sapiens Fraction excreted unchanged 3.5 % 10.1128/aac.00712-10
Homo sapiens Homo sapiens MTD 400.0 mg 10.1128/aac.01194-08
Homo sapiens Homo sapiens Ratio 0.33 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 0.96 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 1.08 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 1.5 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 1.53 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 3.0 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens Ratio 4.0 None 10.1128/aac.00636-10
Homo sapiens Homo sapiens T1/2 0.93 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens T1/2 0.95 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 0.97 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 0.98 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 1.0 hr 10.1128/aac.00636-10
Homo sapiens Homo sapiens T1/2 1.07 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens T1/2 1.1 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens T1/2 1.38 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens T1/2 1.49 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens T1/2 7.0 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens T1/2 8.5 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens T1/2 9.0 hr 10.1128/aac.00636-10
Homo sapiens Homo sapiens T1/2 9.1 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 9.3 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens T1/2 9.6 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens T1/2 10.0 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 10.8 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens T1/2 17.2 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens Tmax 1.0 hr 10.1128/aac.00636-10
Homo sapiens Homo sapiens Tmax 1.5 hr 10.1128/aac.00487-08
Homo sapiens Homo sapiens Tmax 1.5 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens Tmax 1.5 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens Tmax 1.5 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens Tmax 1.75 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens Tmax 2.0 hr 10.1128/aac.01543-07
Homo sapiens Homo sapiens Tmax 2.5 hr 10.1128/aac.01194-08
Homo sapiens Homo sapiens Tmax 3.0 hr 10.1128/aac.00487-08
Homo sapiens Homo sapiens Tmax 3.0 hr 10.1128/aac.00636-10
Homo sapiens Homo sapiens Tmax 3.0 hr 10.1128/aac.01468-08
Homo sapiens Homo sapiens Tmax 3.5 hr 10.1128/aac.01194-08
Homo sapiens HOS CC50 100000.0 nM 10.1021/jm401902n
Homo sapiens Jurkat CC50 120000.0 nM 10.1021/acsmedchemlett.5b00230
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MT2 CC50 100000.0 nM 10.1128/aac.00984-08
Homo sapiens MT4 CC50 6510.0 nM 10.1016/j.bmc.2019.07.011
Homo sapiens MT4 CC50 8000.0 nM 10.1021/jm500109z
Homo sapiens MT4 CC50 8000.0 nM 10.1021/ml400009t
Homo sapiens MT4 CC50 18000.0 nM 10.1016/j.bmcl.2008.03.089
Homo sapiens MT4 CC50 18000.0 nM 10.1016/j.ejmech.2010.12.012
Homo sapiens MT4 CC50 18000.0 nM 10.1128/aac.00210-08
Homo sapiens MT4 CC50 55800.0 nM 10.1016/j.bmc.2017.09.006
Homo sapiens MT4 CC50 56250.0 nM 10.1016/j.ejmech.2018.06.036
Homo sapiens MT4 CC50 58200.0 nM 10.1128/aac.00984-08
Homo sapiens MT4 CC50 142730.0 nM 10.1016/j.bmcl.2009.04.132
Homo sapiens MT4 EC50 18000.0 nM 10.1016/j.bmc.2010.06.063
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens PBMC AUC 909.0 ng.hr.mL-1 10.1128/aac.00789-10
Homo sapiens PBMC Cmax 447.77 nM 10.1128/aac.00789-10
Homo sapiens PBMC Ctau 7.0 ng/ml 10.1128/aac.00789-10
Homo sapiens PBMC Ratio 0.07 None 10.1128/aac.00789-10
Homo sapiens PBMC Ratio 0.08 None 10.1128/aac.00789-10
Homo sapiens PBMC Ratio 0.18 None 10.1128/aac.00789-10
Homo sapiens PBMC T1/2 11.2 hr 10.1128/aac.00789-10
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma AUC 0.43 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Plasma AUC 0.95 ng.hr.mL-1 10.1128/aac.00712-10
Homo sapiens Plasma AUC 12200.0 ng.hr.mL-1 10.1128/aac.00789-10
Homo sapiens Plasma CL 1096.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma CL 1887.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma CL_renal 39.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma CL_renal 55.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma CL_renal 421.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma CL_renal 692.0 ml/min 10.1128/aac.00712-10
Homo sapiens Plasma Cmax 1030.56 nM 10.1128/aac.00712-10
Homo sapiens Plasma Cmax 1797.85 nM 10.1128/aac.00712-10
Homo sapiens Plasma Cmax 2286.13 nM 10.1128/aac.00712-10
Homo sapiens Plasma Cmax 3154.67 nM 10.1128/aac.00712-10
Homo sapiens Plasma Cmax 5940.33 nM 10.1128/aac.00789-10
Homo sapiens Plasma Cmin 5.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cmin 13.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cmin 39.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cmin 40.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 1.32 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 5.64 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 41.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 45.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 46.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 69.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Cp 93.0 % 10.1128/aac.00241-10
Homo sapiens Plasma Ctau 8.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Ctau 18.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Ctau 45.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Ctau 46.0 ng/ml 10.1128/aac.00712-10
Homo sapiens Plasma Ctau 89.0 ng/ml 10.1128/aac.00789-10
Homo sapiens Plasma T1/2 16.0 hr 10.1128/aac.00789-10
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Sodium channel protein type V alpha subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Sodium channel protein type V alpha subunit IC50 316227.77 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Sodium channel protein type V alpha subunit IC50 1584893.19 nM 10.1016/j.vascn.2014.07.002
Homo sapiens THP-1 EC50 50118.72 nM 10.1021/acs.jmedchem.0c00705
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens UDP-glucuronosyltransferase 1-1 Drug metabolism nan None 10.1016/j.bmcl.2015.01.050
Homo sapiens UDP-glucuronosyltransferase 1-1 IC50 170000.0 nM 10.1124/dmd.110.035030
Homo sapiens UDP-glucuronosyltransferase 1-1 IC50 190000.0 nM 10.1124/dmd.110.035030
Homo sapiens UDP-glucuronosyltransferase 1-6 Drug metabolism nan None 10.1016/j.bmcl.2015.01.050
Homo sapiens UDP-glucuronosyltransferase 1-9 Drug metabolism nan None 10.1016/j.bmcl.2015.01.050
Homo sapiens UDP-glucuronosyltransferase 1A4 Drug metabolism nan None 10.1016/j.bmcl.2015.01.050
Homo sapiens UDP-glucuronosyltransferase 2B7 Drug metabolism nan None 10.1016/j.bmcl.2015.01.050
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel IC50 246700.0 nM 10.1038/srep02100
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit AC50 50000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit pIC50 nan None 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) IC50 25118.86 nM 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) pIC50 nan None 10.1016/j.vascn.2014.07.002
Homo sapiens Voltage-gated potassium channel subunit Kv4.3 IC50 5011872.34 nM 10.1016/j.vascn.2014.07.002
Human immunodeficiency virus Human immunodeficiency virus EC50 2.0 nM 10.1128/aac.01218-07
Human immunodeficiency virus Human immunodeficiency virus EC50 8.0 nM 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus EC50 13.0 nM 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus EC50 16.0 nM 10.1016/j.bmcl.2008.01.018
Human immunodeficiency virus Human immunodeficiency virus EC50 16.0 nM 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus EC50 22.0 nM 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus FC 3.0 None 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus IC50 10.0 nM 10.1016/j.ejmech.2021.113787
Human immunodeficiency virus Human immunodeficiency virus Inhibition 95.2 % 10.1016/j.ejmech.2012.04.010
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 11.3 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 14.4 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 20.4 None 10.1128/aac.00210-08
Human immunodeficiency virus Human immunodeficiency virus Ratio EC50 412.5 None 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 1.0 % 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 6.0 % 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 8.0 % 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 9.0 % 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 10.0 % 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 19.0 % 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 50.0 % 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 50.0 /ml 10.1128/aac.01261-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 100.0 /ml 10.1128/aac.01261-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1016/j.bmc.2016.03.052
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1021/acs.jnatprod.7b00659
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity nan None 10.1021/acsmedchemlett.8b00506
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.4 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1.8 nM 10.1128/aac.01218-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1021/acs.jmedchem.9b01681
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.0 nM 10.1128/aac.01218-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2.4 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3.0 nM 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/j.bmcl.2009.02.092
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.0 nM 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4.3 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1016/j.bmcl.2008.01.018
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1021/ml400009t
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.1 nM 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 6.4 nM 10.1016/j.bmcl.2009.04.132
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.8 nM 10.1016/j.bmc.2017.09.006
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 7.9 nM 10.1016/j.ejmech.2020.112111
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1016/j.ejmech.2020.112111
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 8.0 nM 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 9.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 10.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 11.7 nM 10.1016/j.ejmech.2018.06.036
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.bmc.2010.06.063
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.bmcl.2008.03.089
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 13.0 nM 10.1016/j.ejmech.2010.12.012
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1016/j.bmc.2019.07.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1021/jm401040b
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 16.0 nM 10.1021/jm501799k
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 18.0 nM 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1016/j.bmc.2019.07.011
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 20.0 nM 10.1016/j.bmcl.2009.02.092
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.0 nM 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.6 nM 10.1021/acs.jmedchem.5b00159
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 23.6 nM 10.1021/jm5001503
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 24.0 nM 10.1021/jm401040b
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 25.0 nM 10.1016/j.bmc.2011.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 25.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1016/j.ejmech.2017.09.054
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1016/j.ejmech.2018.07.039
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1016/j.ejmech.2019.01.081
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 30.0 nM 10.1021/acs.jmedchem.7b00440
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 68.0 nM 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 77.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 150.0 nM 10.1021/acsmedchemlett.5b00230
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 154.0 nM 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 162.0 nM 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 1900.0 nM 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 2420.0 nM 10.1021/acs.jmedchem.9b01681
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 3300.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4600.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4900.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 nan None 10.1128/aac.00911-07
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC91 73.0 nM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC95 0.048 uM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC95 0.08 uM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC95 0.81 uM 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.2 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.3 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.4 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.4 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.5 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.7 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.8 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 0.9 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.0 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.06 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.1 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.15 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.2 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.3 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.5 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.6 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.7 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.7 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.8 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 1.99 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.0 None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.0 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 2.4 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 3.8 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 5.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 10.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 13.1 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 20.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 48.0 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 50.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 88.2 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 91.6 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 94.0 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 96.0 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 100.0 None 10.1021/jm400674a
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 116.0 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 200.0 None 10.1128/aac.01345-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC 768.0 None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FC nan None 10.1128/aac.01720-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FT50 12.0 hr 10.1021/acs.jnatprod.7b00659
Human immunodeficiency virus 1 Human immunodeficiency virus 1 FT50 12.2 hr 10.1016/j.ejmech.2020.112071
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 6.2 nM 10.1021/jm3010459
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1016/j.bmc.2012.06.038
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 21.0 nM 10.1016/j.bmcl.2017.03.097
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 29.0 nM 10.1021/jm3010459
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 160.0 nM 10.1016/j.ejmech.2019.111714
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 500.0 nM 10.1016/j.bmcl.2013.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 501.19 nM 10.1016/j.bmcl.2013.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 19.0 nM 10.1016/j.bmcl.2009.06.091
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 19.0 nM 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 31.0 nM 10.1016/j.bmcl.2009.06.091
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC95 31.0 nM 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition 92.0 % 10.1021/acsmedchemlett.5b00230
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Inhibition nan % 10.1021/acs.jmedchem.7b00179
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IP 9.0 nM 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IP 53.0 nM 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.429 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.596 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.724 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.726 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.8 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.815 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.94 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.955 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 0.994 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.33 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.371 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.7 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.8 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.879 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1.9 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 2.812 None 10.1128/aac.00397-09
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 3.9 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 4.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.0 None 10.1016/j.bmcl.2009.02.092
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.0 None 10.1016/j.ejmech.2016.03.083
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 5.0 None 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 6.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.0 None 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 7.5 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 9.0 None 10.1016/j.ejmech.2016.03.083
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 9.0 None 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 9.0 None 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 12.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 14.0 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 26.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 28.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 33.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 35.0 None 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 38.0 None 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 38.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 40.0 None 10.1016/j.bmcl.2012.10.088
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 41.0 None 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 53.0 None 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 59.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 61.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 145.0 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 149.0 None 10.1021/jm1014378
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 152.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 166.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 170.0 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 220.0 None 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 362.0 None 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 375.0 None 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 425.0 None 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 475.0 None 10.1021/jm401902n
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 486.0 None 10.1016/j.ejmech.2016.03.083
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 500.0 None 10.1016/j.bmcl.2012.10.088
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 547.6 None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 855.0 None 10.1021/jm1014378
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1000.0 None 10.1021/acs.jmedchem.9b01681
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1034.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1140.0 None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1375.0 None 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio EC50 1653.0 None 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.0 None 10.1016/j.bmcl.2010.07.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 1.0 None 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 3.0 None 10.1016/j.bmcl.2010.07.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 3.0 None 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 3.0 None 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 6.0 None 10.1016/j.bmcl.2010.07.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 8.0 None 10.1016/j.bmcl.2010.07.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 8.0 None 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 8.4 None 10.1021/jm301550c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 10.0 None 10.1016/j.bmcl.2010.07.042
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 13.0 None 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 16.0 None 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 16.0 None 10.1021/jm301550c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 22.0 None 10.1021/acs.jmedchem.5b01037
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Ratio IC50 83.0 None 10.1021/jm301550c
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 10.0 hr 10.1016/j.ejmech.2016.03.083
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 10.0 hr 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 10.2 hr 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 10.5 hr 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 12.0 hr 10.1016/j.ejmech.2014.07.072
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 12.7 hr 10.1128/aac.01064-10
Human immunodeficiency virus 1 Human immunodeficiency virus 1 TIME 17.78 hr 10.1021/np400683h
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Virucidal 14.6 ng/ml 10.1128/aac.01261-09
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Activity 0.67 % 10.1016/j.bmcl.2016.05.023
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase C50 0.007 uM 10.1016/j.ejmech.2010.12.012
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 2.0 nM 10.1016/j.bmc.2019.07.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 2.4 nM 10.1016/j.bmcl.2015.05.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 3.3 nM 10.1128/aac.01218-07
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 5.0 nM 10.1016/j.bmc.2011.06.054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 6.8 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1016/j.bmc.2010.06.063
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1016/j.bmcl.2008.03.089
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1021/acsmedchemlett.5b00230
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1021/jm401040b
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1021/jm501799k
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1021/jm8007085
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 7.0 nM 10.1021/ml400009t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 9.0 nM 10.1016/j.bmc.2010.06.063
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 9.0 nM 10.1016/j.bmcl.2008.03.089
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 9.0 nM 10.1016/j.ejmech.2010.12.012
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 9.0 nM 10.1021/jm8007085
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 9.0 nM 10.1128/aac.00210-08
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 10.0 nM 10.1021/jm500109z
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 10.0 nM 10.1021/ml400009t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 13.0 nM 10.1016/j.ejmech.2015.09.015
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 15.0 nM 10.1016/j.bmcl.2009.06.091
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 15.0 nM 10.1021/acs.jmedchem.2c00203
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 15.0 nM 10.1021/jm800245z
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 16.0 nM 10.1128/aac.01218-07
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 19.0 nM 10.1021/acs.jmedchem.1c00535
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 27.0 nM 10.1021/acsmedchemlett.9b00608
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 34.0 nM 10.1128/aac.00984-08
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 50.0 nM 10.1021/acsmedchemlett.5b00230
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 53.0 nM 10.1016/j.bmcl.2015.05.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 58.0 nM 10.1016/j.ejmech.2019.111617
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 67.0 nM 10.1016/j.bmcl.2009.04.132
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 67.0 nM 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 71.0 nM 10.1016/j.bmc.2019.07.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 74.0 nM 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 80.0 nM 10.1016/j.bmcl.2009.04.132
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 87.0 nM 10.1021/acs.jmedchem.5b00159
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 87.0 nM 10.1021/jm5001503
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 120.0 nM 10.1016/j.bmcl.2013.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 200.0 nM 10.1016/j.ejmech.2018.06.036
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 650.0 nM 10.1016/j.ejmech.2017.09.054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 650.0 nM 10.1016/j.ejmech.2018.07.039
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 650.0 nM 10.1016/j.ejmech.2019.01.081
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 650.0 nM 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 900.0 nM 10.1016/j.bmc.2011.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 900.0 nM 10.1021/jm8007085
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 900.0 nM 10.1021/ml400009t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 1100.0 nM 10.1016/j.bmc.2019.06.044
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 1800.0 nM 10.1016/j.bmc.2014.12.059
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 4500.0 nM 10.1016/j.bmcl.2011.03.047
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 12800.0 nM 10.1021/acs.jmedchem.5b00159
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 12800.0 nM 10.1021/jm5001503
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase IC50 100000.0 nM 10.1016/j.ejmech.2019.111617
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition 85.32 % 10.1016/j.bmc.2022.116612
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition 90.6 % 10.1016/j.bmc.2017.09.006
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition 94.7 % 10.1021/acsmedchemlett.5b00230
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition 100.0 % 10.1016/j.bmcl.2013.11.014
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition 100.0 % 10.1016/j.ejmech.2019.111617
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition nan % 10.1016/j.ejmech.2019.111699
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Inhibition nan % 10.1021/ml1002162
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase MI50 100.0 uM 10.1016/j.ejmech.2019.111617
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Ratio IC50 22.0 None 10.1016/j.bmcl.2015.05.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Ratio IC50 128.0 None 10.1021/ml400009t
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Ratio IC50 128.6 None 10.1021/jm8007085
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Activity nan None 10.1016/j.bmc.2019.06.044
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 10000.0 nM 10.1016/j.ejmech.2017.09.054
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 10000.0 nM 10.1016/j.ejmech.2018.07.039
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 10000.0 nM 10.1016/j.ejmech.2019.01.081
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 10000.0 nM 10.1021/acs.jmedchem.6b00040
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1021/acs.jmedchem.5b00159
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 100000.0 nM 10.1021/jm5001503
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.bmc.2019.07.011
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 nan None 10.1016/j.ejmech.2019.01.081
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Inhibition nan % 10.1021/jm5001503
Human immunodeficiency virus 2 Human immunodeficiency virus 2 EC50 11.0 nM 10.1016/j.bmc.2017.09.006
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Gag-Pol polyprotein IC50 nan None 10.1016/j.ejmech.2017.09.054
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Gag-Pol polyprotein IC50 nan None 10.1016/j.ejmech.2018.07.039
Leishmania donovani Leishmania donovani EC50 50118.72 nM 10.1021/acs.jmedchem.0c00705
Macaca mulatta Rhesus monkey alphat1/2 nan None 10.1021/jm800245z
Macaca mulatta Rhesus monkey AUC 799.96 ng.hr.mL-1 10.1021/jm800245z
Macaca mulatta Rhesus monkey CL 18.0 mL.min-1.kg-1 10.1021/jm800245z
Macaca mulatta Rhesus monkey Cmax 300.0 nM 10.1021/jm800245z
Macaca mulatta Rhesus monkey F 8.0 % 10.1021/jm800245z
Macaca mulatta Rhesus monkey T1/2 4.0 hr 10.1021/jm800245z
Macaca mulatta Rhesus monkey T1/2 7.0 hr 10.1021/jm800245z
Macaca mulatta Rhesus monkey Vd 1.2 L.kg-1 10.1021/jm800245z
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2012.06.038
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Rattus norvegicus alphat1/2 nan None 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus AUC 444.42 ng.hr.mL-1 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus CL 39.0 mL.min-1.kg-1 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus Cmax 1200.0 nM 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus F 37.0 % 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus t1/2 nan None 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus T1/2 2.0 hr 10.1021/jm800245z
Rattus norvegicus Rattus norvegicus Vd 2.0 L.kg-1 10.1021/jm800245z
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 5.48 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.181 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.0199 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -7.77 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.18 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.07 % 10.6019/CHEMBL4495565
None ADMET Activity 100.0 % 10.1016/j.bmcl.2014.04.073
None ADMET Activity 100.0 % 10.1016/j.bmcl.2014.12.047
None ADMET CC50 30000.0 nM 10.1016/j.bmc.2011.11.014
None ADMET CC50 100000.0 nM 10.1016/j.bmcl.2014.04.073
None ADMET CC50 100000.0 nM 10.1016/j.bmcl.2014.12.047
None ADMET CC50 100000.0 nM 10.1128/aac.01064-10
None ADMET CC50 200000.0 nM 10.1021/acsmedchemlett.5b00230
None ADMET CC50 855600.0 nM 10.1016/j.bmcl.2013.11.014
None ADMET CLH nan None 10.1021/acs.jmedchem.0c00705
None ADMET Drug uptake 0.41 mg 10.1128/aac.00712-10
None ADMET Drug uptake 7.03 mg 10.1128/aac.00712-10
None ADMET Drug uptake 10.81 mg 10.1128/aac.00712-10
None ADMET Drug uptake 11.66 mg 10.1128/aac.00712-10
None ADMET Drug uptake 82.5 mg 10.1128/aac.00712-10
None ADMET Drug uptake 84.51 mg 10.1128/aac.00712-10
None ADMET Drug uptake 212.0 ng/ml 10.1128/aac.00241-10
None ADMET Drug uptake 345.0 ng/ml 10.1128/aac.00241-10
None ADMET Drug uptake 953.0 ng/ml 10.1128/aac.00241-10
None ADMET Drug uptake nan None 10.1128/aac.00712-10
None ADMET Ratio 1.42 None 10.1128/aac.00241-10
None ADMET Ratio 1.62 None 10.1128/aac.00241-10
None ADMET Ratio 3.78 None 10.1128/aac.00241-10
None ADMET Ratio 7.08 None 10.1128/aac.00712-10
None ADMET Ratio 7.81 None 10.1128/aac.00712-10
None ADMET Ratio CC50/EC50 430.0 None 10.1021/acs.jmedchem.6b00040
None ADMET Ratio CC50/EC50 1250.0 None 10.1016/j.bmc.2011.11.014
None ADMET Ratio CC50/EC50 1300.0 None 10.1021/acsmedchemlett.5b00230
None ADMET Ratio CC50/EC50 1333.0 None 10.1021/jm500109z
None ADMET Ratio CC50/EC50 1333.0 None 10.1021/ml400009t
None ADMET Ratio CC50/EC50 10000.0 None 10.1016/j.bmc.2019.07.047
None ADMET Ratio CC50/EC50 10000.0 None 10.1016/j.bmcl.2014.12.047
None ADMET Ratio CC50/EC50 22302.0 None 10.1016/j.bmcl.2009.04.132
None ADMET Ratio CC50/EC50 100000.0 None 10.1016/j.bmcl.2014.04.073
None ADMET Ratio CC50/IC50 1711.0 None 10.1016/j.bmcl.2013.11.014
None Molecular identity unknown IC50 35200.0 nM 10.1016/j.ejmech.2020.112609
None NON-PROTEIN TARGET Potency 21.1 nM None
None NON-PROTEIN TARGET Potency 2983.0 nM None
None NON-PROTEIN TARGET Potency 23694.5 nM None
None No relevant target LogD 3.3 None 10.1021/acs.jmedchem.8b00180
None No relevant target LogD nan None 10.1021/acs.jmedchem.0c00705
None No relevant target LogP 2.4 None 10.1021/jm300682j
None No relevant target pKa_A1 3.97 None 10.6019/CHEMBL3301361
None No relevant target Solubility 250000.0 nM 10.1021/acs.jmedchem.0c00705
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 17.78 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 17782.8 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked Activity 100.0 % 10.1016/j.bmc.2019.07.047
None Unchecked CC50 100000.0 nM 10.1016/j.bmc.2019.07.047
None Unchecked CC50 nan None 10.1021/acs.jmedchem.7b00440
None Unchecked IC50 27.0 nM 10.1016/j.bmcl.2008.01.018
None Unchecked IC50 40.0 nM 10.1016/j.bmcl.2009.02.092
None Unchecked IC50 58.0 nM 10.1021/acsmedchemlett.0c00009
None Unchecked IC50 650.0 nM 10.1021/acs.jmedchem.7b00440
None Unchecked IC50 10000.0 nM 10.1021/acs.jmedchem.7b00440
None Unchecked IC50 50000.0 nM 10.1021/jm800245z
None Unchecked IC50 100000.0 nM 10.1016/j.ejmech.2019.111617
None Unchecked IC50 nan None 10.1021/acs.jmedchem.7b00440
None Unchecked Inhibition 100.0 % 10.1016/j.ejmech.2019.111617
None Unchecked LD50 50.0 uM 10.1016/j.bmcl.2017.03.097
None Unchecked Ratio 7275.0 None 10.1128/aac.00984-08
None Unchecked Ratio 33333.0 None 10.1128/aac.00984-08
None Unchecked Ratio CC50/EC50 1298.0 None 10.1128/aac.01064-10
None Unchecked Ratio CC50/EC50 1387.0 None 10.1016/j.bmcl.2008.03.089
None Unchecked Ratio CC50/EC50 1387.0 None 10.1016/j.ejmech.2010.12.012
None Unchecked Ratio CC50/EC50 2118.0 None 10.1021/acs.jmedchem.5b00159
None Unchecked Ratio CC50/EC50 2118.0 None 10.1021/jm5001503
None Unchecked Ratio CC50/EC50 5123.0 None 10.1016/j.bmc.2017.09.006
None Unchecked Ratio CC50/EC50 7146.0 None 10.1016/j.bmc.2017.09.006
None Unchecked Ratio CC50/EC50 12857.0 None 10.1128/aac.00210-08
None Unchecked Ratio CC50/EC50 15000.0 None 10.1021/jm401040b
None Unchecked Ratio CC50/EC50 15000.0 None 10.1021/jm501799k
None Unchecked Ratio CC50/EC50 25000.0 None 10.1021/jm401902n
None Unchecked Ratio CC50/IC50 10000.0 None 10.1016/j.bmc.2012.06.038
None Unchecked Ratio CC50/IC50 nan None 10.1016/j.bmc.2012.06.038
None Unchecked Ratio IC50 0.065 None 10.1016/j.ejmech.2018.07.039
None Unchecked Ratio IC50 0.065 None 10.1021/acs.jmedchem.7b00440
None Unchecked Ratio IC50 7.0 None 10.1016/j.bmcl.2011.03.047
None Unchecked Ratio IC50 8.0 None 10.1021/jm1014378
None Unchecked Ratio IC50 24.0 None 10.1021/jm1014378
None Unchecked Ratio IC50 26.0 None 10.1016/j.bmcl.2011.03.047
None Unchecked Ratio IC50 105.0 None 10.1016/j.bmcl.2011.03.047
None Unchecked Ratio IC50 139.0 None 10.1021/jm1014378
None Unchecked Selectivity Index 1387.0 None 10.1016/j.bmc.2010.06.063
None Unchecked T1/2 7.3 hr 10.1021/jm400674a

Metabolism Information