Molecule

Myxopyronin B

AlkaPlorer ID: AK051126

Synonym: None

IUPAC Name: methyl N-[(E,5R)-5-[5-[(2E,4E)-2,5-dimethylnona-2,4-dienoyl]-4-hydroxy-6-oxopyran-2-yl]hex-1-enyl]carbamate

Structure

SMILES: CCCC/C(C)=C/C=C(\C)C(=O)C1=C(O)C=C([C@H](C)CC/C=C/NC(=O)OC)OC1=O

InChI: InChI=1S/C24H33NO6/c1-6-7-10-16(2)12-13-18(4)22(27)21-19(26)15-20(31-23(21)28)17(3)11-8-9-14-25-24(29)30-5/h9,12-15,17,26H,6-8,10-11H2,1-5H3,(H,25,29)/b14-9+,16-12+,18-13+/t17-/m1/s1

InChIKey: SPQDIDVJAZFBRL-WXFBSNOUSA-N

Reference

Antibiotika aus Gleitenden Bakterien, XVII. Myxopyronin A und B – zwei neue Antibiotika aus <i>Myxococcus fulvus</i> Stamm Mx f50

PubChem CID: 135423114

CAS: 88192-99-8

LOTUS: LTS0246107

SuperNatural Ⅲ: SN0351978-02

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NPAtlas: NPA018018

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Myxococcus fulvus	Myxococcus	Myxococcaceae	Myxococcales	Myxococcia	Myxococcota	None	Bacteria

Properties Information

Molecule Weight: 431.5290000000002

TPSA？: 105.84

MolLogP？: 5.3643000000000045

Number of H-Donors: 2

Number of H-Acceptors: 6

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bacillus subtilis	Bacillus subtilis	MIC	0.9	ug.mL-1	10.1021/jm400485e
Bacillus subtilis	Bacillus subtilis	MIC	256.0	ug.mL-1	10.1021/ml200087m
Escherichia coli	Escherichia coli	MIC	0.8	ug.mL-1	10.1016/j.ejmech.2013.04.060
Escherichia coli	Escherichia coli	MIC	1.0	ug.mL-1	10.1021/jm400485e
Escherichia coli	Escherichia coli	MIC	2.0	ug.mL-1	10.1016/j.bmcl.2007.10.017
Escherichia coli	Escherichia coli	MIC	25.0	ug.mL-1	10.1016/j.ejmech.2013.04.060
Escherichia coli	Escherichia coli	MIC	25.0	ug.mL-1	10.1021/jm400485e
Escherichia coli	Escherichia coli	MIC	64.0	ug.mL-1	10.1016/j.bmcl.2007.10.017
Escherichia coli	Escherichia coli	MIC	256.0	ug.mL-1	10.1021/ml200087m
Homo sapiens	CEM-SS	Activity	nan	None	10.1016/j.bmcl.2007.10.017
Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	25.0	ug.mL-1	10.1016/j.ejmech.2013.04.060
Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	25.0	ug.mL-1	10.1021/jm400485e
Staphylococcus aureus	Staphylococcus aureus	MIC	0.5	ug.mL-1	10.1016/j.ejmech.2013.04.060
Staphylococcus aureus	Staphylococcus aureus	MIC	0.5	ug.mL-1	10.1021/jm400485e
Staphylococcus aureus	Staphylococcus aureus	MIC	1.0	ug.mL-1	10.1016/j.bmcl.2007.10.017
Staphylococcus aureus	Staphylococcus aureus	MIC	1.0	ug.mL-1	10.1021/ml200087m
Staphylococcus aureus	Staphylococcus aureus	MIC	256.0	ug.mL-1	10.1021/ml200087m
None	NON-PROTEIN TARGET	MIC	0.9	ug.mL-1	10.1016/j.ejmech.2013.04.060
None	Unchecked	IC50	350.0	nM	10.1016/j.ejmech.2013.04.060
None	Unchecked	IC50	350.0	nM	10.1021/jm400485e
None	Unchecked	IC50	920.0	nM	10.1016/j.bmcl.2007.10.017
None	Unchecked	IC50	920.0	nM	10.1021/ml200087m
None	Unchecked	IC50	24000.0	nM	10.1021/ml300350p
None	Unchecked	IC50	46500.0	nM	10.1021/ml200087m