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name Structure Reference Source Properties Activities Metabolism

366-18-7

AlkaPlorer ID: AK051540

Synonym: "2,2'-BIPYRIDINE", '37275-48-2', 'SMR000059069', 'MLS000069417'

IUPAC Name: 2-pyridin-2-ylpyridine

Structure

SMILES: C1=CC=C(C2=CC=CC=N2)N=C1

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InChI: InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H

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InChIKey: ROFVEXUMMXZLPA-UHFFFAOYSA-N

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Reference

Chemotaxonomic value of alkaloids in the genus Dichilus

PubChem CID: 176144632

CAS: 366-18-7

LOTUS: LTS0268649

SuperNatural Ⅲ: SN0330762

COCONUT: CNP0275446

data_source: manually

Source

Species Genus Family Order Class Phylum Kingdom Domain
Dichilus pilosus Dichilus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 156.18799999999996

TPSA？: 25.78

MolLogP？: 2.1436

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Escherichia coli Escherichia coli Activity 2.0 None 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 7.4 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 16.1 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 18.4 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 19.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 28.6 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 52.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 53.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity 55.0 % 10.1128/aac.01481-06
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01481-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1021/jm7013259
Escherichia coli Escherichia coli MIC 500000.0 nM 10.1128/aac.01087-08
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 44562.5 nM None
Homo sapiens A2780 IC50 20000.0 nM 10.1021/jm010997w
Homo sapiens A2780 IC50 44800.0 nM 10.1021/jm010997w
Homo sapiens Bloom syndrome protein Potency 14.1 nM None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 79432.8 nM None
Homo sapiens C-C chemokine receptor type 1 EC50 31622.78 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 1 EC50 34000.0 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 1 FC 5.2 None 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 1 IC50 125892.54 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 1 IC50 126000.0 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 1 Inhibition 253.0 % 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 EC50 19000.0 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 EC50 19952.62 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 FC 5.8 None 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 IC50 79432.82 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 IC50 84000.0 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 5 Inhibition 849.0 % 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 8 EC50 39810.72 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 8 EC50 42000.0 nM 10.1021/jm301121j
Homo sapiens C-C chemokine receptor type 8 FC 3.3 None 10.1021/jm301121j
Homo sapiens CCRF-CEM IC50 51900.0 nM 10.1021/jm010997w
Homo sapiens CCRF-CEM IC50 61700.0 nM 10.1021/jm010997w
Homo sapiens Cerebroside-sulfatase Potency 756.9 nM None
Homo sapiens Chromobox protein homolog 1 Potency 100000.0 nM None
Homo sapiens Cytochrome P450 1A2 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Deoxyhypusine hydroxylase IC50 5000.0 nM 10.1016/j.ejmech.2019.01.018
Homo sapiens DNA polymerase beta Potency 89125.1 nM None
Homo sapiens Geminin Potency 89.1 nM None
Homo sapiens HEK293 Potency 6510.4 nM None
Homo sapiens HeLa EC50 nan None 10.1021/jm400227z
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 794.3 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 14125.4 nM None
Homo sapiens HUVEC EC50 10000.0 nM 10.1021/jm400227z
Homo sapiens Hypoxia-inducible factor prolyl 4-hydroxylase IC50 34200.0 nM 10.1021/jm00076a014
Homo sapiens Importin subunit beta-1/Snurportin-1 Potency 141253.8 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 89125.1 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 39810.7 nM None
Homo sapiens Methionine aminopeptidase 1 EC50 320.0 nM 10.1021/jm400227z
Homo sapiens Methionine aminopeptidase 1 EC50 100000.0 nM 10.1021/jm400227z
Homo sapiens Methionine aminopeptidase 1 Ratio 1.2 None 10.1021/jm400227z
Homo sapiens Methionine aminopeptidase 1 Ratio 2.6 None 10.1021/jm400227z
Homo sapiens Prelamin-A/C Potency 5.0 nM None
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Prolyl 4-hydroxylase subunit alpha-1 Inhibition nan % 10.1016/j.bmc.2015.05.003
Homo sapiens Protein farnesyltransferase IC50 100000000.0 nM 10.1016/s0960-894x(03)00183-5
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 7943.3 nM None
Homo sapiens SK-OV-3 IC50 41300.0 nM 10.1021/jm010997w
Klebsiella aerogenes Klebsiella aerogenes Activity nan None 10.1128/aac.01481-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 160100.0 nM 10.1016/j.bmc.2012.01.041
Plasmodium falciparum Ferriprotoporphyrin IX Log K nan None 10.1021/jm031132g
Plasmodium falciparum Histidine-rich protein Inhibition nan % 10.1021/jm031132g
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 nan nM 10.1021/jm031132g
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1021/jm7013259
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 33.6 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 75.2 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 23109.3 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 17.91 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.12 % 10.6019/CHEMBL4495565
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/jm7013259
Trypanosoma brucei 6-phospho-1-fructokinase Potency 30131.3 nM None
None NON-PROTEIN TARGET Activity 94.0 % 10.1021/jm400227z
None NON-PROTEIN TARGET Activity nan None 10.1021/jm400227z
None NON-PROTEIN TARGET EC50 10000.0 nM 10.1021/jm400227z
None NON-PROTEIN TARGET Potency 11220.2 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None No relevant target Activity nan None 10.1016/j.bmc.2015.05.003
None No relevant target EC50 43000.0 nM 10.1016/j.bmc.2015.05.003
None No relevant target IC50 50118.72 nM 10.1021/jm301121j
None No relevant target IC50 54000.0 nM 10.1021/jm301121j
None Unchecked IC50 6670.0 nM 10.1039/C2MD20096A
None Unchecked Inhibition 75.0 % 10.1039/C2MD20096A
None Unchecked Inhibition nan % 10.1016/j.bmcl.2010.05.042
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Inhibition nan % 10.1039/C2MD20096A
None Unchecked Ki 390.0 nM 10.1016/j.ejmech.2020.112883
None Unchecked Ki 2830.0 nM 10.1016/j.ejmech.2020.112883
None Unchecked Ki 2840.0 nM 10.1016/j.ejmech.2020.112883
None Unchecked Ki 2910.0 nM 10.1016/j.ejmech.2020.112883
None Unchecked Ki 1900000.0 nM 10.1021/jm00091a009
None Unchecked Potency 4466.8 nM None

Metabolism Information