2-(4-hydroxyphenyl)-1-methylquinolin-4-one
AlkaPlorer ID: AK051770
Synonym: None
IUPAC Name: 2-(4-hydroxyphenyl)-1-methylquinolin-4-one
Structure
SMILES: CN1C(C2=CC=C(O)C=C2)=CC(=O)C2=CC=CC=C21
InChI: InChI=1S/C16H13NO2/c1-17-14-5-3-2-4-13(14)16(19)10-15(17)11-6-8-12(18)9-7-11/h2-10,18H,1H3
InChIKey: IVVGAXUISDFFMZ-UHFFFAOYSA-N
Reference
Alkaloids and coumarins of Skimmia reevesiana
PubChem CID: 11043197
CAS: 109030-96-8
LOTUS: LTS0082822
SuperNatural Ⅲ: SN0156609
COCONUT: CNP0312052
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Skimmia reevesiana | Skimmia | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 251.285
TPSA？: 42.23
MolLogP？: 2.911100000000001
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | HCT-8 | EC50 | 5.71 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | KB | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | RPMI-7951 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | Tubulin | IC50 | 40000.0 | nM | 10.1021/jm00061a005 |
| Mus musculus | P388 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Staphylococcus aureus | Quinolone resistance protein norA | Inhibition | 0.0 | % | 10.1021/jm1011963 |
| Staphylococcus aureus | Quinolone resistance protein norA | Inhibition | 0.0 | % | 10.1021/jm200370y |
| None | L1210 (1565) | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |