1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridone
AlkaPlorer ID: AK052606
Synonym: '', '5-Hydroxyarborinine'
IUPAC Name: 1,5-dihydroxy-2,3-dimethoxy-10-methylacridin-9-one
Structure
SMILES: COC1=CC2=C(C(O)=C1OC)C(=O)C1=CC=CC(O)=C1N2C
InChI: InChI=1S/C16H15NO5/c1-17-9-7-11(21-2)16(22-3)15(20)12(9)14(19)8-5-4-6-10(18)13(8)17/h4-7,18,20H,1-3H3
InChIKey: WUPPOLDDVHCHKK-UHFFFAOYSA-N
Reference
Alkaloids of the leaves of Glycosmis bilocularis
PubChem CID: 14463129
CAS: 75821-37-3
LOTUS: LTS0036256
SuperNatural Ⅲ: SN0420459
COCONUT: CNP0416548
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Glycosmis angustifolia | Glycosmis | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 301.298
TPSA？: 80.91999999999999
MolLogP？: 2.1201
Number of H-Donors: 2
Number of H-Acceptors: 6
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Chlorocebus sabaeus | Vero | IC50 | 30.5 | ug.mL-1 | 10.1021/np2004825 |
| Leishmania donovani | Leishmania donovani | EC50 | 20.4 | ug.mL-1 | 10.1021/np2004825 |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 3.0 | ug.mL-1 | 10.1021/np2004825 |
| Trypanosoma brucei brucei | Trypanosoma brucei brucei | EC50 | 125.0 | ug.mL-1 | 10.1021/np2004825 |
| None | Unchecked | Ratio IC50 | 10.0 | None | 10.1021/np2004825 |