Molecule

Salinosporamide B

AlkaPlorer ID: AK053167

Synonym: None

IUPAC Name: (1R,4R,5S)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Structure

SMILES: CC[C@H]1C(O)=N[C@@]2([C@@H](O)[C@@H]3C=CCCC3)C(=O)O[C@@]12C

InChI: InChI=1S/C15H21NO4/c1-3-10-12(18)16-15(13(19)20-14(10,15)2)11(17)9-7-5-4-6-8-9/h5,7,9-11,17H,3-4,6,8H2,1-2H3,(H,16,18)/t9-,10+,11+,14+,15+/m1/s1

InChIKey: SCJZQKFFYIGMCI-SHTIJGAHSA-N

Reference

Salinosporamides D−J from the Marine Actinomycete <i>Salinispora tropica</i>, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

PubChem CID: 11173518

LOTUS: LTS0261554

SuperNatural Ⅲ: SN0341690-02

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NPAtlas: NPA003502

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Salinispora tropica	Salinispora	Micromonosporaceae	Micromonosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 279.336

TPSA？: 79.12000000000002

MolLogP？: 1.7542

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	HEK293	IC50	1600.0	nM	10.1021/jm048995+
Homo sapiens	RPMI-8226	IC50	6100.0	nM	10.1021/jm048995+
Oryctolagus cuniculus	Oryctolagus cuniculus	IC50	27.0	nM	10.1021/jm048995+
Oryctolagus cuniculus	Oryctolagus cuniculus	IC50	640.0	nM	10.1021/jm048995+
Oryctolagus cuniculus	Oryctolagus cuniculus	IC50	1200.0	nM	10.1021/jm048995+
None	No relevant target	T1/2	3.167	hr	10.1021/jm800548b
None	Unchecked	Activity	nan	None	10.1021/jm800548b
None	Unchecked	IC50	16.0	nM	10.1021/jm800548b
None	Unchecked	IC50	26.0	nM	10.1021/jm800548b
None	Unchecked	IC50	610.0	nM	10.1021/jm800548b
None	Unchecked	IC50	1040.0	nM	10.1021/jm800548b
None	Unchecked	IC50	1200.0	nM	10.1021/jm800548b
None	Unchecked	IC50	20000.0	nM	10.1021/jm800548b