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Michler's Ketone

AlkaPlorer ID: AK053925

Synonym: None

IUPAC Name: bis[4-(dimethylamino)phenyl]methanone

Structure

SMILES: CN(C)C1=CC=C(C(=O)C2=CC=C(N(C)C)C=C2)C=C1

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InChI: InChI=1S/C17H20N2O/c1-18(2)15-9-5-13(6-10-15)17(20)14-7-11-16(12-8-14)19(3)4/h5-12H,1-4H3

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InChIKey: VVBLNCFGVYUYGU-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 268.36

TPSA？: 23.550000000000004

MolLogP？: 3.0496000000000016

Number of H-Donors: 0

Number of H-Acceptors: 3

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Hepacivirus hominis Internal ribosome entry site (IRES) IC50 10000.0 nM 10.1021/jm0400101
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Androgen Receptor Potency 4466.8 nM None
Homo sapiens Aryl hydrocarbon receptor Potency 5011.9 nM None
Homo sapiens Ataxin-2 Potency 2511.9 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 23109.3 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 29092.9 nM None
Homo sapiens Beta-glucocerebrosidase Potency 11220.2 nM None
Homo sapiens Bile acid receptor FXR Potency 31622.8 nM None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 89125.1 nM None
Homo sapiens Cellular tumor antigen p53 Potency 3981.1 nM None
Homo sapiens Cellular tumor antigen p53 Potency 6309.6 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 994.2 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Potency 3527.7 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 1575.8 nM None
Homo sapiens DNA dC->dU-editing enzyme APOBEC-3G Potency 1584.9 nM None
Homo sapiens Estrogen receptor alpha Potency 35481.3 nM None
Homo sapiens Geminin Potency 5173.5 nM None
Homo sapiens Geminin Potency 6513.1 nM None
Homo sapiens Glucagon-like peptide 1 receptor Potency 2511.9 nM None
Homo sapiens Glucocorticoid receptor Potency 7079.5 nM None
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 35481.3 nM None
Homo sapiens HEK293 Potency 3262.9 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 89125.1 nM None
Homo sapiens Huh-7 IC50 10.0 ug.mL-1 10.1016/s0960-894x(00)00217-1
Homo sapiens Importin subunit beta-1/Snurportin-1 Potency 100000.0 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 7079.5 nM None
Homo sapiens Lysine-specific demethylase 4A Potency 56234.1 nM None
Homo sapiens Microtubule-associated protein tau Potency 35481.3 nM None
Homo sapiens Muscleblind-like protein 1 Potency 31622.8 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 580.5 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 5448.3 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 76958.8 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 39810.7 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 44668.4 nM None
Homo sapiens Retinoid X receptor alpha Potency 28183.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2592.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3264.3 nM None
Mus musculus Mus musculus pTD50 3.383 None 10.1016/j.ejmech.2009.02.014
Photinus pyralis Luciferin 4-monooxygenase Potency 13459.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 8275.3 nM None
Rattus norvegicus Inositol monophosphatase 1 Potency 1122.0 nM None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 17782.8 nM None
None Molecular identity unknown Potency 50118.7 nM None
None Unchecked Potency 2511.9 nM None
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 18356.4 nM None

Metabolism Information