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Dehydroglaucine

AlkaPlorer ID: AK055978

Synonym: 5,6-Dihydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline, Didehydroglaucine 

IUPAC Name: 4,5,15,16-tetramethoxy-10-methyl-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,3,5,7,9(17),13,15-heptaene

Structure

SMILES: COC1=C(OC)C=C2C(=C1)C=C1C3=C(C=C(OC)C(OC)=C32)CCN1C

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InChI: InChI=1S/C21H23NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h8-11H,6-7H2,1-5H3

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InChIKey: RZUHGAKUNBFQJS-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 353.4180000000001

TPSA？: 40.16

MolLogP？: 4.019700000000003

Number of H-Donors: 0

Number of H-Acceptors: 5

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 31622.8 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 70794.6 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 31622.8 nM None
Homo sapiens 786-0 GI50 4285.49 nM None
Homo sapiens A498 GI50 6839.12 nM None
Homo sapiens A549 GI50 9527.96 nM None
Homo sapiens ACHN GI50 3664.38 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Alpha-galactosidase A Potency 44668.4 nM None
Homo sapiens Arachidonate 12-lipoxygenase Potency 35481.3 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 12589.3 nM None
Homo sapiens ATP-dependent DNA helicase Q1 Potency 11220.2 nM None
Homo sapiens ATP-dependent DNA helicase Q1 Potency 15848.9 nM None
Homo sapiens Bloom syndrome protein Potency 3981.1 nM None
Homo sapiens BT-549 GI50 6456.54 nM None
Homo sapiens CAKI-1 GI50 4864.07 nM None
Homo sapiens Caspase-1 Potency 12589.3 nM None
Homo sapiens Caspase-7 Potency 31622.8 nM None
Homo sapiens CCRF-CEM GI50 1361.44 nM None
Homo sapiens Cellular tumor antigen p53 Potency 31622.8 nM None
Homo sapiens COLO 205 GI50 7638.36 nM None
Homo sapiens Cytochrome P450 2C19 Potency 50.1 nM None
Homo sapiens Cytochrome P450 2C9 Potency 794.3 nM None
Homo sapiens Cytochrome P450 2D6 Potency 3981.1 nM None
Homo sapiens Cytochrome P450 3A4 Potency 3981.1 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 14125.4 nM None
Homo sapiens DNA polymerase kappa Potency 1778.3 nM None
Homo sapiens DU-145 GI50 4965.92 nM None
Homo sapiens EKVX GI50 15346.17 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens HCC 2998 GI50 7413.1 nM None
Homo sapiens HCT-116 GI50 5956.62 nM None
Homo sapiens HCT-15 GI50 6839.12 nM None
Homo sapiens HL-60 GI50 5296.63 nM None
Homo sapiens HOP-62 GI50 11885.02 nM None
Homo sapiens HOP-92 GI50 9931.16 nM None
Homo sapiens Hs-578T GI50 2630.27 nM None
Homo sapiens HT-29 GI50 6886.52 nM None
Homo sapiens IGROV-1 GI50 4207.27 nM None
Homo sapiens K562 GI50 6194.41 nM None
Homo sapiens KM12 GI50 10990.06 nM None
Homo sapiens LOX IMVI GI50 5248.07 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 28183.8 nM None
Homo sapiens M14 GI50 6902.4 nM None
Homo sapiens Malme-3M GI50 8531.0 nM None
Homo sapiens MAP kinase ERK2 Potency 25118.9 nM None
Homo sapiens MCF7 GI50 2630.27 nM None
Homo sapiens MDA-MB-231 GI50 7726.81 nM None
Homo sapiens MDA-MB-435 GI50 5559.04 nM None
Homo sapiens MDA-N GI50 13061.71 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 14125.4 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Microtubule-associated protein tau Potency 10000.0 nM None
Homo sapiens Microtubule-associated protein tau Potency 12589.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 19952.6 nM None
Homo sapiens MOLT-4 GI50 2409.91 nM None
Homo sapiens NCI/ADR-RES GI50 4197.59 nM None
Homo sapiens NCI-H226 GI50 7345.14 nM None
Homo sapiens NCI-H23 GI50 12764.39 nM None
Homo sapiens NCI-H322M GI50 35727.28 nM None
Homo sapiens NCI-H460 GI50 2654.61 nM None
Homo sapiens NCI-H522 GI50 2576.32 nM None
Homo sapiens OVCAR-3 GI50 8053.78 nM None
Homo sapiens OVCAR-4 GI50 2506.11 nM None
Homo sapiens OVCAR-5 GI50 21037.78 nM None
Homo sapiens OVCAR-8 GI50 12676.52 nM None
Homo sapiens PC-3 GI50 3515.6 nM None
Homo sapiens RPMI-8226 GI50 2722.7 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 5623.4 nM None
Homo sapiens RXF 393 GI50 1832.31 nM None
Homo sapiens SF-268 GI50 8531.0 nM None
Homo sapiens SF-295 GI50 3069.02 nM None
Homo sapiens SF-539 GI50 9246.98 nM None
Homo sapiens SK-MEL-2 GI50 10303.86 nM None
Homo sapiens SK-MEL-28 GI50 18071.74 nM None
Homo sapiens SK-MEL-5 GI50 6025.6 nM None
Homo sapiens SK-OV-3 GI50 9183.33 nM None
Homo sapiens SN12C GI50 7379.04 nM None
Homo sapiens SNB-19 GI50 12473.84 nM None
Homo sapiens SNB-75 GI50 8128.31 nM None
Homo sapiens SR GI50 1250.26 nM None
Homo sapiens SW-620 GI50 7362.07 nM None
Homo sapiens T47D GI50 1671.09 nM None
Homo sapiens Thyroid hormone receptor beta-1 Potency 6309.6 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 39810.7 nM None
Homo sapiens TK-10 GI50 4415.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 10593.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11885.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 28183.8 nM None
Homo sapiens U-251 GI50 3580.96 nM None
Homo sapiens UACC-257 GI50 9120.11 nM None
Homo sapiens UACC-62 GI50 4830.59 nM None
Homo sapiens UO-31 GI50 2108.63 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 2818.4 nM None
Rattus norvegicus Inositol monophosphatase 1 Potency 28183.8 nM None
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
None Unchecked Potency 501.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 28183.8 nM None
None Unchecked Potency 31622.8 nM None

Metabolism Information