Cyclizidine G
AlkaPlorer ID: AK056220
Synonym: None
IUPAC Name: (1S,2S,3S,8aR)-3-[(2E,4E)-7-hydroxy-2-methylhepta-2,4-dienyl]-1-methyl-3,5,6,7,8,8a-hexahydro-2H-indolizine-1,2-diol
Structure
SMILES: C/C(=C\C=C\CCO)C[C@H]1[C@H](O)[C@@](C)(O)[C@H]2CCCCN12
InChI: InChI=1S/C17H29NO3/c1-13(8-4-3-7-11-19)12-14-16(20)17(2,21)15-9-5-6-10-18(14)15/h3-4,8,14-16,19-21H,5-7,9-12H2,1-2H3/b4-3+,13-8+/t14-,15+,16-,17-/m0/s1
InChIKey: CCWBQLZOTVKFAJ-USNSYDTGSA-N
Reference
Cyclizidine-Type Alkaloids from <i>Streptomyces</i> sp. HNA39
PubChem CID: 139589905
LOTUS: LTS0248169
NPASS: NPC483518
{NPAtlas: NPA022563
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. HNA39 | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 295.42300000000006
TPSA？: 63.93
MolLogP？: 1.61
Number of H-Donors: 3
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | HCT-116 | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.7b01055 |
| Homo sapiens | PC-3 | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.7b01055 |
| Homo sapiens | Rho-associated protein kinase 2 | IC50 | 100000.0 | nM | 10.1021/acs.jnatprod.7b01055 |