Molecule

Staurosporinone; 2-Hydroxy

AlkaPlorer ID: AK056230

Synonym: 2-Hydroxystaurosporinone

IUPAC Name: 6-hydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaen-12-one

SMILES: OC1=NCC2=C3C4=CC=CC=C4NC3=C3NC4=CC(O)=CC=C4C3=C12

InChI: InChI=1S/C20H13N3O2/c24-9-5-6-11-14(7-9)23-19-16(11)17-12(8-21-20(17)25)15-10-3-1-2-4-13(10)22-18(15)19/h1-7,22-24H,8H2,(H,21,25)

InChIKey: GMSWOSYARKHCHX-UHFFFAOYSA-N

PubChem CID: 11232674

LOTUS: LTS0270603

NPASS: NPC294620

COCONUT: CNP0301743

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Perichaena chrysosperma	Perichaena	Trichiidae	Trichiida	Eumycetozoa	Evosea	None	Eukaryota
Lycogala epidendrum	Lycogala	Enteridiidae	Liceales	Eumycetozoa	Evosea	None	Eukaryota
Lycogala epidendrum	Lycogala	Enteridiidae	Liceales	Eumycetozoa	Evosea	None	Eukaryota

Molecule Weight: 327.3430000000001

TPSA？: 84.4

MolLogP？: 4.479400000000003

Number of H-Donors: 4

Number of H-Acceptors: 2

RingCount: 6

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	cAMP-dependent protein kinase (PKA)	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	cAMP-dependent protein kinase (PKA)	Inhibition	80.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Epidermal growth factor receptor erbB1	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	HeLa	IC50	5.4	ug.mL-1	10.1016/j.bmcl.2005.03.103
Homo sapiens	Jurkat	IC50	1.34	ug.mL-1	10.1016/j.bmcl.2005.03.103
Homo sapiens	KB 3-1	IC50	7.6	ug.mL-1	10.1016/j.bmcl.2005.03.103
Homo sapiens	Protein kinase C (PKC)	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Protein kinase C (PKC)	Inhibition	80.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Serine/threonine-protein kinase EEF2K	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Serine/threonine-protein kinase EEF2K	Inhibition	80.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Tyrosine-protein kinase SRC	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Tyrosine-protein kinase SRC	Inhibition	80.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Vascular endothelial growth factor receptor 1	Inhibition	50.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Vascular endothelial growth factor receptor 1	Inhibition	80.0	%	10.1016/j.bmcl.2005.03.103
Homo sapiens	Zinc finger protein GLI1	IC50	1800.0	nM	10.1021/jm801420y
Homo sapiens	Zinc finger protein GLI2	IC50	2700.0	nM	10.1021/jm801420y