Cispentacin
AlkaPlorer ID: AK056364
Synonym: None
IUPAC Name: (1R,2S)-2-aminocyclopentane-1-carboxylic acid
Structure
SMILES: N[C@H]1CCC[C@H]1C(=O)O
InChI: InChI=1S/C6H11NO2/c7-5-3-1-2-4(5)6(8)9/h4-5H,1-3,7H2,(H,8,9)/t4-,5+/m1/s1
InChIKey: JWYOAMOZLZXDER-UHNVWZDZSA-N
Reference
Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities.
PubChem CID: 36688289
CAS: 122672-46-2
LOTUS: LTS0150297
SuperNatural Ⅲ: SN0177550-03
{NPAtlas: NPA015665
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Cereus | Sagartiidae | Actiniaria | Anthozoa | Cnidaria | Metazoa | Eukaryota |
| None | Cereus | Sagartiidae | Actiniaria | Anthozoa | Cnidaria | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 129.159
TPSA？: 63.32000000000001
MolLogP？: 0.1983999999999998
Number of H-Donors: 2
Number of H-Acceptors: 2
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Acinetobacter baumannii | Acinetobacter baumannii | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Candida albicans | Candida albicans | MIC | 1.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Candida albicans | Candida albicans | MIC | 2.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Candida albicans | Candida albicans | MIC | 4.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Candida albicans | Candida albicans | MIC | 8.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Candida albicans | Candida albicans | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Cryptococcus neoformans | Cryptococcus neoformans | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Escherichia coli | Escherichia coli | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Homo sapiens | HEK293 | CC50 | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Mycobacterium tuberculosis | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | IC50 | 4000000.0 | nM | 10.1016/j.bmcl.2011.02.042 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Activity | 5.0 | uM | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Drug uptake | 1.63 | nmol/min | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Drug uptake | 1.67 | nmol/min | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Drug uptake | 1.85 | nmol/min | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Drug uptake | 2.11 | nmol/min | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Drug uptake | 32.0 | % | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 4.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 8.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 16.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 64.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 128.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 256.0 | ug.mL-1 | 10.1128/aac.01648-07 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 20000.0 | nM | 10.6019/CHEMBL4513161 |
| None | Erythrocyte | HC10 | 20.0 | uM | 10.6019/CHEMBL4513161 |