Thalicminine
AlkaPlorer ID: AK057102
Synonym: None
IUPAC Name: 7,16,17-trimethoxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1,6,8(20),9,11,14,16,18-octaen-13-one
Structure
SMILES: COC1=CC2=C(C=C1OC)C1=C3OCOC3=C(OC)C3=CC=NC(=C13)C2=O
InChI: InChI=1S/C20H15NO6/c1-23-12-6-10-11(7-13(12)24-2)17(22)16-14-9(4-5-21-16)18(25-3)20-19(15(10)14)26-8-27-20/h4-7H,8H2,1-3H3
InChIKey: GOQUMRHFJDDYAU-UHFFFAOYSA-N
Reference
Chemical and Biological Extractives of Lauraceae Species in Costa Rican Tropical Forests
PubChem CID: 167534
CAS: 16408-77-8
LOTUS: LTS0015039
SuperNatural Ⅲ: SN0111326
COCONUT: CNP0256086
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Ocotea puberula | Ocotea | Lauraceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 365.34100000000007
TPSA？: 76.11000000000001
MolLogP？: 3.200700000000001
Number of H-Donors: 0
Number of H-Acceptors: 7
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Entamoeba histolytica | Entamoeba histolytica | IC50 | 27.41 | ug.mL-1 | 10.1007/s00044-011-9767-1 |
| Entamoeba histolytica | Entamoeba histolytica | IC50 | 75100.0 | nM | 10.1021/np000144r |
| Homo sapiens | KB | IC50 | 685000.0 | nM | 10.1021/np000144r |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 16200.0 | nM | 10.1021/np000144r |