1,6-Dihydroxyphenazine
AlkaPlorer ID: AK057278
Synonym: 'Gutolactone'
IUPAC Name: phenazine-1,6-diol
Structure
SMILES: OC1=CC=CC2=NC3=C(O)C=CC=C3N=C12
InChI: InChI=1S/C12H8N2O2/c15-9-5-1-3-7-11(9)14-8-4-2-6-10(16)12(8)13-7/h1-6,15-16H
InChIKey: JOXNFMAXWAPITK-UHFFFAOYSA-N
Reference
PubChem CID: 135514780
CAS: 69-48-7
LOTUS: LTS0190839
SuperNatural Ⅲ: SN0171305
COCONUT: CNP0162400
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Nocardiopsis dassonvillei | Nocardiopsis | Nocardiopsaceae | Streptosporangiales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 212.20800000000003
TPSA？: 66.24000000000001
MolLogP？: 2.1941999999999995
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Aspergillus flavus | Aspergillus flavus | MIC | nan | None | 10.1021/np400877r |
| Aspergillus fumigatus | Aspergillus fumigatus | MIC | nan | None | 10.1021/np400877r |
| Bacillus subtilis | Bacillus subtilis | IC50 | 22000.0 | nM | 10.1021/np2009626 |
| Chromobacterium violaceum | Chromobacterium violaceum | MIC | 66.7 | ug.mL-1 | 10.1021/np400877r |
| Homo sapiens | A549 | LD50 | 5.65 | uM | 10.1021/np400877r |
| Homo sapiens | Acetylcholinesterase | IC50 | 4520.0 | nM | 10.1021/np2009626 |
| Homo sapiens | HUVEC | LD50 | 3.81 | uM | 10.1021/np400877r |
| Homo sapiens | MOLM-13 | EC50 | 100000.0 | nM | 10.1016/j.bmc.2017.02.058 |
| Homo sapiens | MOLM-13 | EC50 | 110000.0 | nM | 10.1016/j.bmc.2017.02.058 |
| Homo sapiens | SK-OV-3 | LD50 | 2.59 | uM | 10.1021/np400877r |
| Mucor hiemalis | Mucor hiemalis | MIC | 33.3 | ug.mL-1 | 10.1021/np400877r |
| Mus musculus | L929 | LD50 | 11.31 | uM | 10.1021/np400877r |
| Mycobacterium sp. | Mycobacterium sp. | MIC | 66.7 | ug.mL-1 | 10.1021/np400877r |
| Mycolicibacterium diernhoferi | Mycolicibacterium diernhoferi | MIC | 33.6 | ug.mL-1 | 10.1021/np400877r |
| Nocardia sp. | Nocardia sp. | MIC | 33.3 | ug.mL-1 | 10.1021/np400877r |
| Paenibacillus polymyxa | Paenibacillus polymyxa | MIC | 66.7 | ug.mL-1 | 10.1021/np400877r |
| Wickerhamomyces anomalus | Wickerhamomyces anomalus | MIC | 33.3 | ug.mL-1 | 10.1021/np400877r |
| None | ADMET | IC50 | 50000.0 | nM | 10.1021/np2009626 |
| None | Molecular identity unknown | MIC | nan | None | 10.1021/np400877r |
| None | NON-PROTEIN TARGET | LD50 | 5.81 | uM | 10.1021/np400877r |