Thiomuracin F
AlkaPlorer ID: AK059068
Synonym: None
IUPAC Name: 2-[[1-hydroxy-2-[[hydroxy-[2-[(18S,25S,32S,35S)-16,23,30,33-tetrahydroxy-18-(2-hydroxy-2-iminoethyl)-25-[(R)-hydroxy(phenyl)methyl]-32-[(4-hydroxyphenyl)methyl]-21-methyl-35-[(2R)-3-oxobutan-2-yl]-3,13,20,27,37-pentathia-7,17,24,31,34,39,40,41,42,43-decazaheptacyclo[34.2.1.12,5.112,15.119,22.126,29.06,11]tritetraconta-1(38),2(43),4,6(11),7,9,12(42),14,16,19(41),21,23,26(40),28,30,33,36(39)-heptadecaen-8-yl]-1,3-thiazol-4-yl]methylidene]amino]prop-2-enylidene]amino]prop-2-enoic acid
Structure
SMILES: C=C(N=C(O)C(=C)N=C(O)C1=CSC(C2=CC=C3C4=NC(=CS4)C(O)=N[C@@H](CC(=N)O)C4=NC(=C(C)S4)C(O)=N[C@@H]([C@H](O)C4=CC=CC=C4)C4=NC(=CS4)C(O)=N[C@@H](CC4=CC=C(O)C=C4)C(O)=N[C@@H]([C@@H](C)C(C)=O)C4=NC(=CS4)C4=NC(=CS4)C3=N2)=N1)C(=O)O
InChI: InChI=1S/C59H50N14O12S6/c1-24(27(4)74)42-57-70-40(23-90-57)55-66-36(19-87-55)44-32(15-16-33(63-44)54-68-37(21-88-54)49(80)61-25(2)47(78)62-26(3)59(84)85)53-67-38(20-86-53)51(82)65-35(18-41(60)76)56-73-43(28(5)91-56)52(83)72-45(46(77)30-9-7-6-8-10-30)58-69-39(22-89-58)50(81)64-34(48(79)71-42)17-29-11-13-31(75)14-12-29/h6-16,19-24,34-35,42,45-46,75,77H,2-3,17-18H2,1,4-5H3,(H2,60,76)(H,61,80)(H,62,78)(H,64,81)(H,65,82)(H,71,79)(H,72,83)(H,84,85)/t24-,34-,35-,42-,45-,46+/m0/s1
InChIKey: DRXXEEZOBQMPQN-KBXWVDHMSA-N
Reference
Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu
PubChem CID: 101463542
LOTUS: LTS0101101
{NPAtlas: NPA004167
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Nonomuraea sp. | Nonomuraea | Streptosporangiaceae | Streptosporangiales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 1339.537
TPSA？: 424.68
MolLogP？: 11.778689999999994
Number of H-Donors: 11
Number of H-Acceptors: 24
RingCount: 10
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|